Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 7, 2003, Pages 3190-3195

  Kawano, Hiroaki ^a,b   Yasue, Hirofumi ^b   Kitagawa, Akira ^a   Hirai, Nobutaka ^a   Yoshida, Toshiaki ^a   Soejima, Hirofumi ^a   Miyamoto, Shinzo ^a   Nakano, Masahiro ^c   Ogawa, Hisao ^a  

^a Dept of Cardiovascular Medicine ^*  (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c SHIZUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRASTERONE;

ADULT; AGING; ANALYSIS OF VARIANCE; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTICLE; ATTENUATION; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; ENDOTHELIUM CELL; FIBRINOLYSIS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; STEADY STATE; VASCULAR ENDOTHELIUM;

ADJUVANTS, IMMUNOLOGIC; BRACHIAL ARTERY; DEHYDROEPIANDROSTERONE; ENDOTHELIUM, VASCULAR; HUMANS; HYPERCHOLESTEROLEMIA; INSULIN RESISTANCE; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; VASODILATION;

EID: 0037622798     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021603     Document Type: Article

References (44)

1. Iamberts SW, van den Beld AW, van der Lely AJ 1997 The endocrinology of aging. Science 278:419-424
2. Barrett-Connor E, Khaw KT, Yen SSC 1986 A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease. N Engl J Med 315:1519-1524
3. Alexander RW, Schlant RC, Fuster V 1994 The heart, 9th Ed. New York: McGraw-Hill
4. Arad Y, Badimon JJ, Badimon L, Hembree WC, Ginsberg HN 1989 Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit. Arteriosclerosis 9:159-166
5. Gordon GB, Bush DE, Weisman HF 1988 Reduction of atherosclerosis by administration of dehydroepiandrosterone. J Clin Invest 82:712-720
6. Hayashi T, Esaki T, Muto E, Kano H, Asai Y, Thakur NK, Sumi D, Jayachandran M, Iguchi A 2000 Dehydroepiandrosterone retards a therosclerosis formation through its conversion to estrogen. Arteriosder Thromb Vasc Biol 20:782-792
7. Yasue H, Matsuyama K, Matsuyama K, Okumura K, Morikami Y, Ogawa H 1990 Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis. Circulation 81:482-490
8. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE 1994 Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24: 1468-1474
9. Libby P 2001 Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104:365-372
10. Pinkney JH, Stehouwer CDA, Coppack SW, Yudkin JS 1997 Endothelial dysfunction: case of the insulin resistance syndrome. Diabetes 46:S9-S13
11. Davidson MB 1979 The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 28:687-705
12. DeFronzo RA 1979 Glucose intolerance of aging. Evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101
13. Reaven GM 1995 Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486
14. Kohler HP, Grant PJ 2000 Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med 342:1792-1801
15. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus 1997 Diabetes Care 20:1183-1197
16. Baulieu E, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, Faucounau V, Girard L, Hervy M, Latour F, Leaud M, Mokrane A, Pitti-Ferrandi H, Trivalle C, de Lacharriere O, Nouveau S, Rakoto-Arison B, Souberbielle J, Raison J, Le Bouc Y, Raynaud A, Direrd X, Forette F 2000 Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the AHEAging Study to a sociobiomedical issue. Proc Natl Acad Sci USA 97:4279-4284
17. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF 1995 Nitric oxide is responsible for flow-dependent dilation of human peripheral conduct arteries in vivo. Circulation 91:1314-1319
18. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, Selwyn AP 1995 Close relation of endothelial function in human coronary and peripheral circulations. J Am Coll Cardiol 26:1235-1241
19. Motoyama T, Kawano H, Kugiyama K, Hirashima O, Ohgushi M, Tsunoda R, Moriyama Y, Miyao Y, Yoshimura M, Ogawa H, Yasue H 1998 Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol 32:1672-1679
20. Hirai N, Kawano H, Hirashima O, Motoyama T, Moriyama Y, Sakamoto T, Kugiyama K, Ogawa H, Nakao K, Yasue H 2000 Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. Am J Physiol 279: H1172-H1178
21. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, Yasue H 2000 Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol 35:1860-1866
22. Ikebuchi M, Suzuki M, Kageyama A, Hirose J, Yokota C, Ikeda K, Shinozaki K, Todi R, Harano Y 1996 Modified method using a somatostatin analogue, octreotide acetate (Sandostatin) to assess in vivo insulin sensitivity. Endocr J 43:125-130
23. Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K 2000 The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure. J Clin Endocrinol Metab 85:1834-1840
24. Takazoe K, Ogawa H, Yasue H, Sakamoto T, Soejima H, Miyao Y, Kawano H, Mriyama Y, Misumi K, Suefuji H, Kugiyama K, Yoshimura M 2001 Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with angina pectoris. Ann Med 33:206-212
25. Jesse RL, Loesser K, Eich DM, Qian YZ, Hess ML, Nestler JE 1995 Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo. Ann NY Acad Sci 774:271-280
26. Williams MR, Ling S, Dawood T, Hashimura K, Dai A, Li H, Liu JP, Funder JW, Sudhir K, Komesaroff PA 2002 Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs. J Clin Endocrinol Metab 87:176-181
27. Schachinger V, Britten MB, Zeiher AM 2000 Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101:1899-1906
28. Hata T, Senoh D, Hata K, Kitao M, Masumura S 1995 Effects of dehydroepiandrosterone sulfate on uterine artery flow velocity waveforms in term pregnancy. Obstet Gynecol 85:118-121
29. Hata T, Hashimoto M, Senoh D, Hata K, Kitao M, Masumura S 1995 Effects of dehydroepiandrosterone sulfate on ophthalmic artery flow velocity waveforms in full-term pregnant women. Am J Perinatol 12:135-137
30. Tsai MJ, O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
31. Mendelsohn ME, Karas RH 1999 The protective effects of estrogen on the cardiovascular system. N Engl J Med 340:1801-1811
32. i2,3. J Biol Chem 277:21379-21388
33. Labrie F, Belanger A, Simard J, Luu-The V, Labrie C 1995 DHEA and peripheral androgen and estrogen formation: intracrinology. Ann NY Acad Sci 774:16-28
34. Beer NA, Jakubowicz DJ, Matt DW, Beer RM, Nestler JE 1996 Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. Am J Med Sci 311:205-210
35. Mukasa K, Kanesiro M, Aoki K, Okamura J, Saito T, Satoh S, Sekihara H 1998 Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats. J Steroid Biochem Mol Biol 67:355-358
36. Kroboth PD, Salek FS, Pittenger AL, Fabian TJ, Frye RF 1999 DHEA and DHEA-S: a review. J Clin Pharmacol 39:327-348
37. Petrie JR, Ueda S, Webb DJ, Elliot HL, Connell JMC 1996 Endothelial nitric oxide production and insulin sensitivity. Circulation 93:1331-1333
38. Laine H, Yki-Jarvinen H, Kirvela O, Tolvanen T, Raitakari M, Solin O, Haaparanta M, Knuuti J, Nuutila P 1998 Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. J Clin Invest 101:1156-1162
39. Schriock ED, Buffington CK, Givens JR, Buster JE 1994 Enhanced potreceptor insulin effects in women following dehydroepiandrosterone infusion. J Soc Gynecol Invest 1:74-78
40. Casson PR, Andersen RN, Faquin LC, Abraham GE, Stentz FB, Buster JE, Straughn AB 1995 Replacement of dehydroepiandrosterone enhances T-lymphocyte insulin binding in postmenopausal women. Fertil Steril 63:1027-1031
41. Morales AJ, Nolan JJ, Nelson JC, Yen SSC 1994 Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 78:1360-1367
42. Mortola JF, Yen SSC 1990 The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 71:696-704
43. Usiskin KS, Butterworth S, Clore JN, Arad Y, Ginsberg HN, Blackard WG, Nestler JE 1990 Lack of effect of dehydroepiandrosterone in obese men. Int J Obesity 14:457-463
44. Nestler JE, Barlascini CO, Clore JN, Blackard WG 1988 Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66: 57-61