3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell differentiation in cultured adipogenic cells (3T3-L1)

European Journal of Pharmacology

Volumn 301, Issue 1-3, 1996, Pages 203-206

  Nishio, Eisuke ^a   Tomiyama, Koji ^a   Nakata, Hiroko ^a   Watanabe, Yasuhiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

3T3 L1 cell; Isoprenoid; Lovastatin

Indexed keywords

CHOLESTEROL; FARNESOL; GERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONOLACTONE; MEVINOLIN; MEVOLONIC ACID; SQUALENE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030008748     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00063-5     Document Type: Article

References (15)

1. Benito, M., A. Porras, A.R. Nebreda, E. Santos, 1991, Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes, Science (August), 565.
2. Corsini, A. and R. Paoletti, 1993, Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase, Atherosclerosis 101, 117.
3. Goldstein, J.L. and M.S. Brown, 1990, Regulation of the mevalonate pathway, Nature 343, 425.
4. Green, H. and O. Kehinde, 1974, Sublines of mouse 3T3 cells that accumulate lipid, Cell 1, 113.
5. Grundy, S.M., 1988, HMG-CoA reductase inhibitors for treatment of hypercholesterolemia, New Engl. J. Med. 319, 24.
6. Kozak, L.P. and J.T. Jensen, 1974, Genetic and developmental control of multiple forms of L-glycerol 3-phosphate dehydrogenase, J. Biol. Chem. 249, 7775.
7. Maltese, W.A., 1990, Post translational modification of proteins by isoprenoids in mammalian cells, FASEB J. 3319.
8. Maltese, W.A. and K.M. Sheridan, 1985, Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis, J. Cell. Physiol. 125, 540.
9. McGuire, T.F., X.Q. Xu, S.J. Corey, G.G. Romero and S.M. Sebti, 1994, Lovastatin disrupts early events in insulin signaling: a potential mechanism of lovastatin's anti-mitogenic activity, B.B.R.C. 204, 399.
10. Novikoff, A., P.M. Novikoff, O. Rosen and C.S. Rubin, 1980, Organelle relationships in cultured 3T3-L1 preadipocytes, J.C.B. 87, 180.
11. Rosen, O.M., C.J. Smith, C. Fung and C.S. Rubin, 1978, Development of hormone receptors and hormone responsiveness in vitro, J. Biol. Chem. 253, 7579.
12. Sale, E.M., P.G.P. Atkinson and G.J. Sale, 1995, Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p60 S6 kinase and for insulin or serum stimulation of DNA synthesis, EMBO J. 14, 674.
13. Smith, P.J., L. S. Wise, R. Berkowitz, C. Wan and C.S. Rubin, 1988, Insulin-like growth factor is an essential regulator of the differentiation of 3T3-L1 adipocytes. J. Biol. Chem. 263, 9402.
14. Soma, M.R. and R. Fumagalli, 1995, In vitro enhanced antitumor activity of carmustine [N, N′-bis(2-chloroethyl)-N-nitrosourea] by simvastatin, Cancer Res. 55, 11597.
15. Tomiyama, K., H. Nakata, H. Sasa, S. Arimura, E. Nishio and Y. Watanabe, 1995, Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells, B.B.R.C. 212, 263.