Synthesis of perspicamide A and related diverse analogues: Their bioevaluation as potent antileishmanial agents

Journal of Organic Chemistry

Volumn 78, Issue 4, 2013, Pages 1534-1546

  Pandey, Anand Kumar ^a   Sharma, Rashmi ^a   Shivahare, Rahul ^a   Arora, Ashish ^a   Rastogi, Neeraj ^b   Gupta, Suman ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIO-EVALUATION; LEISHMANIA DONOVANI; POTENT ACTIVITY; SELECTIVITY INDEX;

CHEMISTRY;

ORGANIC COMPOUNDS;

1 (BENZYLOXY) 4 (2 IODOVINYL)BENZENE; 2 (BENZYLOXY)NITROBENZENE; 3 [4 (BENZYLOXY)PHENYL]ACRYLIC ACID; 4 (BENZYLOXY) 8 BROMO QUINOLINE 2 CARBOXAMIDE; 4 (BENZYLOXY) 8 METHOXYQUINOLINE 2 CARBOXAMIDE; 4 ETHOXY 8 METHOXYQUINOLINE 2 CARBOXAMIDE; 4,8 BIS(BENZYLOXY)N[4 (BENZYLOXY) STYRYL]QUINOLINE 2 CARBOXAMIDE; 4,8 BIS(BENZYLOXY)QUINOLINE 2 CARBOXAMIDE; 4,8 DIHYDROXY N(4 HYDROXYSTYRYL)QUINOLINE 2 CARBOXAMIDE; 4,8 DIMETHOXY N(4 METHOXY STYRYL)QUINOLINE 2 CARBOXAMIDE; 4,8 EIMETHOXY QUINOLINE 2 CARBOXAMIDE; 8 CHLORO 4 ETHOXYQUINOLINE 2 CARBOXAMIDE; 8 CHLORO 4 METHOXYQUINOLINE 2 CARBOXAMIDE; 8 CHLORO N(4 ISOPROPYLSTYRYL) 4 METHOXYQUINOLINE 2 CARBOXAMIDE; ANTILEISHMANIAL AGENT; BENZYL DERIVATIVE; DIETHYL 2 (2 BROMOPHENYLAMINO)MALEATE; DIETHYL 2 [2 (BENZYLOXY)PHENYLAMINO]MALEATE; ETHYL 4 (BENZYLOXY) 8 BROMO QUINOLINE 2 CARBOXYLATE; ETHYL 4 (BENZYLOXY) 8 METHOXYQUINOLINE 2 CARBOXYLATE; ETHYL 4 ETHOXY 8 METHOXY QUINOLINE 2 CARBOXYLATE; ETHYL 4,8 BIS(BENZYLOXY)QUINOLINE 2 CARBOXYLATE; ETHYL 8 (BENZYLOXY) 4 OXO 1,4 DIHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 8 BROMO 4 OXO 1,4 DIHYDROQUINOLINE 2 CARBOXYLATE; ETHYL 8 CHLORO 4 ETHOXY QUINOLINE 2 CARBOXYLATE; ETHYL 8 CHLORO 4 METHOXY QUINOLINE 2 CARBOXYLATE; MILTEFOSINE; N[4 (BENZYLOXY)STYRYL] 4,8 DIMETHOXY QUINOLINE 2 CARBOXAMIDE; PERSPICAMIDE A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DEPROTECTION REACTION; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; IC 50; LEISHMANIA DONOVANI; NONHUMAN;

ANTIPROTOZOAL AGENTS; CARBOXYLIC ACIDS; LEISHMANIA DONOVANI; MOLECULAR STRUCTURE; PHOSPHORYLCHOLINE; QUINOLINES;

EID: 84873966328     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo3025626     Document Type: Article

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