Bioengineered surfaces to improve the blood compatibility of biomaterials through direct thrombin inactivation

Acta Biomaterialia

Volumn 8, Issue 11, 2012, Pages 4101-4110

  Freitas, S C ^a,b   Cereija, T B ^c   Figueiredo, A C ^c   Osorio H ^b   Pereira, P J B ^c   Barbosa, M A ^a,b   Martins, M C L ^a,b  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Coagulation; Hemocompatibility; Protein adsorption; Surface functionalization; Thrombin

Indexed keywords

ADSORPTION; BIOMEDICAL EQUIPMENT; BLOOD; COAGULATION; DESORPTION; MASS SPECTROMETRY; RECOMBINANT PROTEINS; SELF ASSEMBLED MONOLAYERS;

BIOTINYLATIONS; BLOOD COMPATIBILITY; HAEMOCOMPATIBILITY; IMMOBILISATION; MEDICAL DEVICES; NATURALLY OCCURRING; PROTEIN ADSORPTION; SURFACE FUNCTIONALIZATION; THROMBIN GENERATION; THROMBUS FORMATION;

ENZYMES;

BIOTIN; NEUTRAVIDIN; RECOMBINANT BOOPHILIN; RECOMBINANT PROTEIN; SELF ASSEMBLED MONOLAYER; THROMBIN; THROMBIN I 125; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; ANTITHROMBIN; BIOMATERIAL; IMMOBILIZED PROTEIN;

ARTICLE; BIOENGINEERING; BIOTINYLATION; BLOOD CLOTTING TIME; BLOOD COMPATIBILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; HUMAN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NANOPHARMACEUTICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; QUARTZ CRYSTAL MICROBALANCE; SPECTROPHOTOMETRY; SURFACE PROPERTY; ADSORPTION; AMINO ACID SEQUENCE; ANIMAL; BLOOD CLOTTING; CATTLE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; HYDROLYSIS; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; MATERIALS TESTING; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT;

BOOPHILUS MICROPLUS; PICHIA PASTORIS; RHIPICEPHALUS;

ADSORPTION; AMINO ACID SEQUENCE; ANIMALS; ANTITHROMBINS; BIOCOMPATIBLE MATERIALS; BIOENGINEERING; BIOTINYLATION; BLOOD COAGULATION; CATTLE; ENZYME ACTIVATION; HUMANS; HYDROLYSIS; IMMOBILIZED PROTEINS; MATERIALS TESTING; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PROPERTIES; THROMBIN;

EID: 84873959808     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.07.020     Document Type: Article

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