Covalent linkage of recombinant hirudin to a novel ionic poly(carbonate) urethane polymer with protein binding sites: Determination of surface antithrombin activity

Artificial Organs

Volumn 22, Issue 8, 1998, Pages 657-665

  Phaneuf, Matthew D ^a,c   Szycher, Michael ^b   Berceli, Scott A ^a   Dempsey, Donald J ^b   Quist, William C ^a   LoGerfo, Frank W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CardioTech International Inc ^*  (United States)

^c HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Albumin; Antithrombin; Biomaterial; Immobilization; Polyurethane; Recombinant hirudin

Indexed keywords

BIOSYNTHESIS; BODY FLUIDS; CROSSLINKING; ENZYMES; MAMMALS; POLYMERIC IMPLANTS; POLYURETHANES; RECOMBINANT PROTEINS; SURFACE TREATMENT;

ALBUMIN; ANTITHROMBIN; BOVINE SERUM ALBUMINS; COVALENT LINKAGE; COVALENTLY BOUND; IMMOBILISATION; POLYCARBONATE URETHANE; RECOMBINANT HIRUDIN; THROMBIN INHIBITION; THROMBUS FORMATION;

BINDING SITES;

LEPIRUDIN; POLYCARBONATE; POLYURETHAN;

ANTICOAGULATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVITY; FIBRINOLYTIC THERAPY; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOSIS;

BOVINAE; THROMBUS;

EID: 0031852871     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1594.1998.05091.x     Document Type: Article

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