Therapeutic liver repopulation for metabolic liver diseases: Advances from bench to bedside

Hepatology Research

Volumn 43, Issue 2, 2013, Pages 122-130

  Wan, Zhen ^a,c   Zhang, Xiao Gang ^a,c   Liu, Zheng Wen ^b,c   Lv, Yi ^a,c  

^a Departments of Hepatobiliary Surgery   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Engraftment; Hepatocyte transplantation; Liver repopulation; Metabolic liver diseases; Proliferation

Indexed keywords

CARBON TETRACHLORIDE; LIOTHYRONINE; RETRORSINE;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; BLOOD CLOTTING FACTOR 7 DEFICIENCY; CELL MIGRATION; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; CRIGLER NAJJAR SYNDROME; ENDOTHELIUM CELL; ENGRAFTMENT; FAMILIAL HYPERCHOLESTEROLEMIA; GLYCOGEN STORAGE DISEASE TYPE 1; HEPATOCYTE TRANSPLANTATION; HOMEOSTASIS; HUMAN; INFANTILE REFSUM DISEASE; INFLAMMATION; INTRAHEPATIC CHOLESTASIS; IRRADIATION; LIVER CELL; LIVER DISEASE; LIVER SINUSOID; METABOLIC LIVER DISEASE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; THERAPEUTIC LIVER REPOPULATION; THERAPY; UREA CYCLE DISORDER;

EID: 84873949984     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2012.01081.x     Document Type: Article

References (64)

1. Grompe M. Therapeutic liver repopulation for the treatment of metabolic liver diseases. Hum Cell 1999; 12: 171-180.
2. Grompe M. Principles of therapeutic liver repopulation. J Inherit Metab Dis 2006; 29: 421-425.
3. Gupta S, Rajvanshi P, Sokhi R etal. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 1999; 29: 509-519.
4. Grossman M, Rader DJ, Muller DW etal. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med 1995; 1: 1148-1154.
5. Fox IJ, Chowdhury JR, Kaufman SS etal. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-1426.
6. Dhawan A, Puppi J, Hughes RD, Mitry RR. Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol 2010; 7: 288-298.
7. Fisher RA, Strom SC. Human hepatocyte transplantation: worldwide results. Transplantation 2006; 82: 441-449.
8. Legido-Quigley C, Cloarec O, Parker DA etal. First example of hepatocyte transplantation to alleviate ornithine transcarbamylase deficiency, monitored by NMR-based metabonomics. Bioanalysis 2009; 1: 1527-1535.
9. Hughes RD, Mitry RR, Dhawan A. Hepatocyte transplantation for metabolic liver disease: UK experience. J R Soc Med 2005; 98: 341-345.
10. Stephenne X, Vosters O, Najimi M etal. Tissue factor-dependent procoagulant activity of isolated human hepatocytes: relevance to liver cell transplantation. Liver Transpl 2007; 13: 599-606.
11. Meyburg J, Hoerster F, Schmidt J, Poeschl J, Hoffmann GF, Schenk JP. Monitoring of intraportal liver cell application in children. Cell Transplant 2010; 19: 629-638.
12. Dhawan A, Mitry RR, Hughes RD etal. Hepatocyte transplantation for inherited factor VII deficiency. Transplantation 2004; 78: 1812-1814.
13. Muraca M, Gerunda G, Neri D etal. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 2002; 359: 317-318.
14. Lee KW, Lee JH, Shin SW etal. Hepatocyte transplantation for glycogen storage disease type Ib. Cell Transplant 2007; 16: 629-637.
15. Sokal EM, Smets F, Bourgois A etal. Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up. Transplantation 2003; 76: 735-738.
16. Strom SC, Fisher RA, Thompson MT etal. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63: 559-569.
17. Hamman KJ, Winn SR, Harding CO. Hepatocytes from wild-type or heterozygous donors are equally effective in achieving successful therapeutic liver repopulation in murine phenylketonuria (PKU). Mol Genet Metab 2011; 104: 235-240.
18. Gupta S, Aragona E, Vemuru RP, Bhargava KK, Burk RD, Chowdhury JR. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology 1991; 14: 144-149.
19. Grompe M, al-Dhalimy M, Finegold M etal. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev 1993; 7: 2298-2307.
20. Overturf K, Al-Dhalimy M, Tanguay R etal. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet 1996; 12: 266-273.
21. Gupta S, Vemuru RP, Lee CD, Yerneni PR, Aragona E, Burk RD. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Hum Gene Ther 1994; 5: 959-967.
22. Joseph B, Kapoor S, Schilsky ML, Gupta S. Bile salt-induced pro-oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long-Evans Cinnamon rat model. Hepatology 2009; 49: 1616-1624.
23. Zvibel I, Smets F, Soriano H. Anoikis: roadblock to cell transplantation? Cell Transplant 2002; 11: 621-630.
24. Stephenne X, Najimi M, Ngoc DK etal. Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1. Cell Transplant 2007; 16: 409-419.
25. Yagi T, Hardin JA, Valenzuela YM, Miyoshi H, Gores GJ, Nyberg SL. Caspase inhibition reduces apoptotic death of cryopreserved porcine hepatocytes. Hepatology 2001; 33: 1432-1440.
26. Kumaran V, Joseph B, Benten D, Gupta S. Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver. Gastroenterology 2005; 129: 1643-1653.
27. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Gastroenterology 1996; 111: 1092-1102.
28. Slehria S, Rajvanshi P, Ito Y etal. Hepatic sinusoidal vasodilators improve transplanted cell engraftment and ameliorate microcirculatory perturbations in the liver. Hepatology 2002; 35: 1320-1328.
29. Malhi H, Annamaneni P, Slehria S etal. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology 2002; 36: 112-121.
30. Kim KS, Joseph B, Inada M, Gupta S. Regulation of hepatocyte engraftment and proliferation after cytotoxic drug-induced perturbation of the rat liver. Transplantation 2005; 80: 653-659.
31. Benten D, Kumaran V, Joseph B etal. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology 2005; 42: 1072-1081.
32. Enami Y, Bandi S, Kapoor S, Krohn N, Joseph B, Gupta S. Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition. Gastroenterology 2009; 136: 2356-2364.
33. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002; 123: 1677-1685.
34. Krohn N, Kapoor S, Enami Y etal. Hepatocyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells. Gastroenterology 2009; 136: 1806-1817.
35. Moberg L, Johansson H, Lukinius A etal. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360: 2039-2045.
36. Gustafson EK, Elgue G, Hughes RD etal. The instant blood-mediated inflammatory reaction characterized in hepatocyte transplantation. Transplantation 2011; 91: 632-638.
37. Laconi E, Oren R, Mukhopadhyay DK etal. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998; 153: 319-329.
38. Oren R, Dabeva MD, Karnezis AN etal. Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes. Hepatology 1999; 30: 903-913.
39. Guo D, Fu T, Nelson JA, Superina RA, Soriano HE. Liver repopulation after cell transplantation in mice treated with retrorsine and carbon tetrachloride. Transplantation 2002; 73: 1818-1824.
40. Joseph B, Kumaran V, Berishvili E, Bhargava KK, Palestro CJ, Gupta S. Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning. Hepatology 2006; 44: 1411-1420.
41. Mignon A, Guidotti JE, Mitchell C etal. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes. Nat Med 1998; 4: 1185-1188.
42. Malhi H, Gorla GR, Irani AN, Annamaneni P, Gupta S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc Natl Acad Sci U S A 2002; 99: 13114-13119.
43. Guha C, Yamanouchi K, Jiang J etal. Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias. Am J Nephrol 2005; 25: 161-170.
44. Koenig S, Yuan Q, Krause P etal. Regional transient portal ischemia and irradiation as preparative regimen for hepatocyte transplantation. Cell Transplant 2011; 20: 303-311.
45. Yamanouchi K, Zhou H, Roy-Chowdhury N etal. Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation. Hepatology 2009; 49: 258-267.
46. Puppi J, Strom SC, Hughes RD etal. Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 2011; 21: 1-10.
47. Abulkhir A, Limongelli P, Healey AJ etal. Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg 2008; 247: 49-57.
48. Aussilhou B, Lesurtel M, Sauvanet A etal. Right portal vein ligation is as efficient as portal vein embolization to induce hypertrophy of the left liver remnant. J Gastrointest Surg 2008; 12: 297-303.
49. Moscioni AD, Rozga J, Chen S, Naim A, Scott HS, Demetriou AA. Long-term correction of albumin levels in the Nagase analbuminemic rat: repopulation of the liver by transplanted normal hepatocytes under a regeneration response. Cell Transplant 1996; 5: 499-503.
50. Ilan Y, Roy-Chowdhury N, Prakash R etal. Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes. Transplantation 1997; 64: 8-13.
51. Eguchi S, Rozga J, Lebow LT etal. Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus. Transplantation 1996; 62: 588-593.
52. Dagher I, Boudechiche L, Branger J etal. Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization. Transplantation 2006; 82: 1067-1073.
53. Lainas P, Boudechiche L, Osorio A etal. Liver regeneration and recanalization time course following reversible portal vein embolization. J Hepatol 2008; 49: 354-362.
54. Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells. Am J Pathol 2001; 159: 1323-1334.
55. Li WL, Su J, Yao YC etal. Isolation and characterization of bipotent liver progenitor cells from adult mouse. Stem Cells 2006; 24: 322-332.
56. Gordon GJ, Butz GM, Grisham JW, Coleman WB. Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats. Transplantation 2002; 73: 1236-1243.
57. Shibata C, Mizuguchi T, Kikkawa Y etal. Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation. Liver Transpl 2006; 12: 78-87.
58. Stock P, Brückner S, Ebensing S, Hempel M, Dollinger MM, Christ B. The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver. Nat Protoc 2010; 5: 617-627.
59. Huang P, He Z, Ji S etal. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 2011; 475: 386-389.
60. Morata G, Ripoll P. Minutes: mutants of drosophila autonomously affecting cell division rate. Dev Biol 1975; 42: 211-221.
61. Yu CH, Chang MH, Chien CS, Chen YH, Chang MF, Chen HL. Hepatocyte transplantation and the differentiation fate of host oval cells in acute severe hepatic injury. Cell Transplant 2010; 19: 231-243.
62. Oertel M, Menthena A, Dabeva MD, Shafritz DA. Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells. Gastroenterology 2006; 130: 507-520.
63. Khan AA, Parveen N, Mahaboob VS etal. Treatment of Crigler-Najjar Syndrome type 1 by hepatic progenitor cell transplantation: a simple procedure for management of hyperbilirubinemia. Transplant Proc 2008; 40: 1148-1150.
64. Khan AA, Shaik MV, Parveen N etal. Human fetal liver-derived stem cell transplantation as supportive modality in the management of end-stage decompensated liver cirrhosis. Cell Transplant 2010; 19: 409-418.