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Volumn 4, Issue 2, 2013, Pages 288-292

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole

Author keywords

antifungal agents; Aspergillus; azoles; Candida; thiazolo 4,5 g quinazolin 8(7H) one; zygomycetes

Indexed keywords

ALBACONAZOLE; ITRACONAZOLE; QUINAZOLINONE DERIVATIVE; VORICONAZOLE;

EID: 84873947513     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300429p     Document Type: Article
Times cited : (48)

References (23)
  • 1
    • 84856867056 scopus 로고    scopus 로고
    • New developments in invasive fungal disease
    • Groll, A. H.; Lumb, J. New developments in invasive fungal disease Future Microbiol. 2012, 7, 179-184
    • (2012) Future Microbiol. , vol.7 , pp. 179-184
    • Groll, A.H.1    Lumb, J.2
  • 2
    • 0027739728 scopus 로고
    • Molecular genetic analysis of azole antifungal mode of action
    • Kelly, S. L.; Arnoldi, A.; Kelly, D. E. Molecular genetic analysis of azole antifungal mode of action Biochem. Soc. Trans. 1993, 21, 1034-1038
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 1034-1038
    • Kelly, S.L.1    Arnoldi, A.2    Kelly, D.E.3
  • 6
    • 40949114620 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of 1-(N -benzylamino)-2-phenyl-3-(1H -1,2,4-triazol-1-yl)propan-2-ols as antifungals agents
    • Giraud, F.; Logé, C.; Pagniez, F.; Crépin, D.; Le Pape, P.; Le Borgne, M. Design, synthesis and evaluation of 1-(N -benzylamino)-2-phenyl- 3-(1H -1,2,4-triazol-1-yl)propan-2-ols as antifungals agents Bioorg. Med. Chem. Lett. 2008, 18, 1820-1824
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1820-1824
    • Giraud, F.1    Logé, C.2    Pagniez, F.3    Crépin, D.4    Le Pape, P.5    Le Borgne, M.6
  • 7
    • 57849127112 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols as antifungal agents
    • Giraud, F.; Guillon, R.; Logé, C.; Pagniez, F.; Picot, C.; Le Borgne, M.; Le Pape, P. Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1 H -1,2,4-triazol-1-yl) propan-2-ols as antifungal agents Bioorg. Med. Chem. Lett. 2009, 19, 301-304
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 301-304
    • Giraud, F.1    Guillon, R.2    Logé, C.3    Pagniez, F.4    Picot, C.5    Le Borgne, M.6    Le Pape, P.7
  • 8
    • 70349254794 scopus 로고    scopus 로고
    • Design of new antifungal agents: Synthesis and evaluation of 1-[(1 H -indol-5-ylmethyl)amino]-2-phenyl-3-(1H -1,2,4-triazol-1-yl)propan-2-ols
    • Guillon, R.; Giraud, F.; Logé, C.; Le Borgne, M.; Picot, C.; Pagniez, F.; Le Pape, P. Design of new antifungal agents: synthesis and evaluation of 1-[(1 H -indol-5-ylmethyl)amino]-2-phenyl-3-(1H -1,2,4-triazol-1-yl)propan-2-ols Bioorg. Med. Chem. Lett. 2009, 19, 5833-5836
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5833-5836
    • Guillon, R.1    Giraud, F.2    Logé, C.3    Le Borgne, M.4    Picot, C.5    Pagniez, F.6    Le Pape, P.7
  • 9
    • 79954997194 scopus 로고    scopus 로고
    • Design, synthesis and in vitro antifungal activity of 1-[(4-substituted benzyl)methyl amino]-2-(2,4-difluorophenyl)-3-(1H -1,2,4-triazol-1-yl)propan-2- ols
    • Guillon, R.; Pagniez, F.; Giraud, F.; Crépin, D.; Picot, C.; Le Borgne, M.; Morio, F.; Duflos, M.; Logé, C.; Le Pape, P. Design, synthesis and in vitro antifungal activity of 1-[(4-substituted benzyl)methyl amino]-2-(2,4-difluorophenyl)-3-(1H -1,2,4-triazol-1-yl)propan-2-ols ChemMedChem 2011, 6, 816-825
    • (2011) ChemMedChem , vol.6 , pp. 816-825
    • Guillon, R.1    Pagniez, F.2    Giraud, F.3    Crépin, D.4    Picot, C.5    Le Borgne, M.6    Morio, F.7    Duflos, M.8    Logé, C.9    Le Pape, P.10
  • 10
    • 80053404739 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of 1-[(biarylmethyl) methylamino]-2-(2,4-difluorophenyl)-3-(1H -1,2,4-triazol-1-yl)propan-2-ols as potent antifungal agents: New insights into structure-activity relationships
    • Guillon, R.; Pagniez, F.; Rambaud, C.; Picot, C.; Duflos, M.; Logé, C.; Le Pape, P. Design, synthesis and biological evaluation of 1-[(biarylmethyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H -1,2,4-triazol-1-yl) propan-2-ols as potent antifungal agents: New insights into structure-activity relationships ChemMedChem 2011, 6, 1806-1815
    • (2011) ChemMedChem , vol.6 , pp. 1806-1815
    • Guillon, R.1    Pagniez, F.2    Rambaud, C.3    Picot, C.4    Duflos, M.5    Logé, C.6    Le Pape, P.7
  • 11
    • 38349112023 scopus 로고    scopus 로고
    • One-pot reductive cyclization to antitumor quinazoline precursors
    • Kundu, S.; Mahindaratne, M.; Quintero, M.; Bao, A.; Negretea, G. One-pot reductive cyclization to antitumor quinazoline precursors Arkivoc 2008, ii, 33-42
    • (2008) Arkivoc , vol.2 , pp. 33-42
    • Kundu, S.1    Mahindaratne, M.2    Quintero, M.3    Bao, A.4    Negretea, G.5
  • 12
    • 13344262678 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor
    • Rewcastle, G. W.; Palmer, B. D.; Bridges, A. J.; Showalter, H. D. H.; Sun, L.; Nelson, J.; McMichael, A.; Kraker, A. J.; Fry, D. W.; Denny, W. A. Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor J. Med. Chem. 1996, 39, 918-928
    • (1996) J. Med. Chem. , vol.39 , pp. 918-928
    • Rewcastle, G.W.1    Palmer, B.D.2    Bridges, A.J.3    Showalter, H.D.H.4    Sun, L.5    Nelson, J.6    McMichael, A.7    Kraker, A.J.8    Fry, D.W.9    Denny, W.A.10
  • 13
    • 0023889587 scopus 로고
    • Palladium-catalyzed coupling of 2-bromoanilines with vinylstannanes. A regiocontrolled synthesis of substituted indoles
    • Krolski, M. E.; Renaldo, A. F.; Rudisill, D. E.; Stille, J. K. Palladium-catalyzed coupling of 2-bromoanilines with vinylstannanes. A regiocontrolled synthesis of substituted indoles J. Org. Chem. 1988, 53, 1170-1176
    • (1988) J. Org. Chem. , vol.53 , pp. 1170-1176
    • Krolski, M.E.1    Renaldo, A.F.2    Rudisill, D.E.3    Stille, J.K.4
  • 17
    • 0027183990 scopus 로고
    • Optically active antifungal azoles. I. Synthesis and antifungal activity of (2 R,3 R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1 H -1,2,4-triazol-1-yl)-2- butanol and its stereoisomers
    • Tasaka, A.; Tamura, N.; Matsushita, Y.; Teranishi, K.; Hayashi, R.; Okonogi, K.; Itoh, K. Optically active antifungal azoles. I. Synthesis and antifungal activity of (2 R,3 R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1 H -1,2,4-triazol-1-yl)-2-butanol and its stereoisomers Chem. Pharm. Bull. 1993, 41, 1035-1041
    • (1993) Chem. Pharm. Bull. , vol.41 , pp. 1035-1041
    • Tasaka, A.1    Tamura, N.2    Matsushita, Y.3    Teranishi, K.4    Hayashi, R.5    Okonogi, K.6    Itoh, K.7
  • 18
    • 0034778010 scopus 로고    scopus 로고
    • New fluorometric screening test for possible antifungal drugs
    • Pagniez, F.; Le Pape, P. New fluorometric screening test for possible antifungal drugs J. Mycol. Med. 2001, 11, 73-78
    • (2001) J. Mycol. Med. , vol.11 , pp. 73-78
    • Pagniez, F.1    Le Pape, P.2
  • 21
    • 47749142093 scopus 로고    scopus 로고
    • Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
    • Dunkel, N.; Blass, J.; Rogers, P. D.; Morschhäuser, J. Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains Mol. Microbiol. 2008, 69, 827-840
    • (2008) Mol. Microbiol. , vol.69 , pp. 827-840
    • Dunkel, N.1    Blass, J.2    Rogers, P.D.3    Morschhäuser, J.4
  • 22
    • 73949113518 scopus 로고    scopus 로고
    • Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites
    • Ben-Ami, R.; Lewis, R. E.; Leventakos, K.; Kontoyiannis, D. P. Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites Blood 2009, 114, 5393-5399
    • (2009) Blood , vol.114 , pp. 5393-5399
    • Ben-Ami, R.1    Lewis, R.E.2    Leventakos, K.3    Kontoyiannis, D.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.