Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-hydroxy-benzofuran-5-carboxylic acid scaffold

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 832-842

  He, Yantao ^a   Xu, Jie ^a   Yu, Zhi Hong ^a   Gunawan, Andrea M ^a   Wu, Li ^a   Wang, Lina ^a   Zhang, Zhong Yin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 FLUOROPHENETHYL) 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 (3,5 DIFLUOROSTYRYL) 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 [(2,4-DIFLUOROPHENYL)ETHYNYL] 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 [(3 CHLOROPHENYL)ETHYNYL] 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 [(3 FLUOROPHENYL)ETHYNYL] 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 [(3,5 DIFLUOROPHENYL)ETHYNYL] 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 3 ETHISTERONE 6 HYDROXY 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 (PHENYLETHYNYL)BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 [3 (TRIFLUOROMETHYL)PHENETHYL]BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 [4 (TRIFLUOROMETHOXY)PHENETHYL]BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 [4 (TRIFLUOROMETHOXY)STYRYL]BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 [[3 (TRIFLUOROMETHYL)PHENYL]ETHYNYL]BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 2 PHENYL 3 [[4 (TRIFLUOROMETHOXY)PHENYL]ETHYNYL]BENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 3 (3 HYDROXYPROP 1 YN 1 YL) 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 3 (4 PHENOXYPHENETHYL) 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 3 [(3 METHOXYPHENYL)ETHYNYL] 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; 6 HYDROXY 3 [(4 PHENOXYPHENYL)ETHYNYL] 2 PHENYLBENZOFURAN 5 CARBOXYLIC ACID; BENZOFURAN DERIVATIVE; GAMMA INTERFERON; INTERLEUKIN 6; PROTEIN TYROSINE PHOSPHATASE B INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SALICYLIC ACID; TUBERCULOSTATIC AGENT; TYROSINE PHOSPHATASE B; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANTIBACTERIAL ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL SURVIVAL; BINDING SITE; CELL SURVIVAL; CLICK CHEMISTRY; CYTOKINE RELEASE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IMMUNE RESPONSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACOPHORE;

ANIMALS; BENZOFURANS; CELL LINE; DRUG DISCOVERY; ENZYME INHIBITORS; FLOW CYTOMETRY; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TYROSINE PHOSPHATASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84873934071     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301781p     Document Type: Article

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