Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases

Brazilian Journal of Medical and Biological Research

Volumn 46, Issue 1, 2013, Pages 71-78

  Lizarte Neto, F S ^a   Tirapelli, D P C ^a   Ambrosio, S R ^b   Tirapelli, C R ^a   Oliveira, F M ^a   Novais, P C ^a   Peria, F M ^a   Oliveira, H F ^a   Carlotti Junior, C G ^a   Tirapelli, L F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE DE FRANCA   (Brazil)

Author keywords

Apoptosis; c FLIP; Glioblastoma; Kaurenoic acid; miR 21

Indexed keywords

CASPASE 3; CASPASE 8; CYSTEINE PROTEINASE; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; KAURENOIC ACID; PHOSPHATIDYLSERINE;

APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; THIN LAYER CHROMATOGRAPHY;

APOPTOSIS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; FAS LIGAND PROTEIN; FLOW CYTOMETRY; GLIOBLASTOMA; HUMANS; MIKANIA; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84873913626     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20121423     Document Type: Article

References (34)

1. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002; 61: 215-225.
2. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001; 15: 1311-1333, doi: 10.1101/gad.891601.
3. Bogler O, Weller M. Apoptosis in gliomas, and its role in their current and future treatment. Front Biosci 2002; 7: e339-e353, doi: 10.2741/bogler.
4. Boon H, Wong J. Botanical medicine and cancer: a review of the safety and efficacy. Expert Opin Pharmacother 2004; 5: 2485-2501, doi: 10.1517/14656566.5.12.2485.
5. Ghisalberti EL. The biological activity of naturally occurring kaurene diterpenes. Fitoterapia 1997; 68: 303-325.
6. Slimestad R, Marston A, Mavi S, Hostettmann K. Larvicidal constituents of Melantheria albinervia. Planta Med 1995; 61: 562-563, doi: 10.1055/s-2006-959374.
7. Mitscher LA, Rao GS, Veysoglu T, Drake S, Haas T. Isolation and identification of trachyloban-19-oic and (-)-kaur-16-en-19-oic acids as antimicrobial agents from the prairie sunflower, Helianthus annuus. J Nat Prod 1983; 46: 745-746, doi: 10.1021/np50029a024.
8. Mongelli E, Pomilio AB, Sanchez JB, Guerra FM, Massanet GM. ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytother Res 2002; 16: 387-388, doi: 10.1002/ptr.955.
9. Cavalcanti BC, Costa-Lotufo LV, Moraes MO, Burbano RR, Silveira ER, Cunha KM, et al. Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil. Food Chem Toxicol 2006; 44: 388-392, doi: 10.1016/ j.fct.2005.08.011.
10. Rossi D, Gaidano G. Messengers of cell death: apoptotic signaling in health and disease. Haematologica 2003; 88: 212-218.
11. Tsuruo T, Naito M, Tomida A, Fujita N, Mashima T, Sakamoto H, et al. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci 2003; 94: 15-21, doi: 10.1111/j.1349-7006.2003.tb01345.x.
12. Debatin KM. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 2004; 53: 153-159, doi: 10.1007/s00262-003-0474-8.
13. Yinjun L, Jie J, Weilai X, Xiangming T. Homoharringtonine mediates myeloid cell apoptosis via upregulation of proapoptotic bax and inducing caspase-3-mediated cleavage of poly(ADP-ribose) polymerase (PARP). Am J Hematol 2004; 76: 199-204, doi: 10.1002/ajh.20100.
14. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297, doi: 10.1016/S0092-8674(04)00045-5.
15. Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65: 6029-6033, doi: 10.1158/0008-5472.CAN-05-0137.
16. Pelletier SW, Chokshi HP, Desai HK. Separation of diterpenoid alkaloid mixtures using vacuum liquid chromatography. J Nat Prod 1986; 49: 892-900, doi: 10.1021/ np50047a021.
17. Kuwada SK, Scaife CL, Kuang J, Li X, Wong RF, Florell SR, et al. Effects of trastuzumab on epidermal growth factor receptor-dependent and-independent human colon cancer cells. Int J Cancer 2004; 109: 291-301, doi: 10.1002/ ijc.11686.
18. Ohba S, Hirose Y, Yoshida K, Yazaki T, Kawase T. Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells. J Neurosurg 2010; 112: 33-42, doi: 10.3171/2009.3. JNS081146.
19. Ambrosio SR, Schorr K, Da Costa FB. Terpenoids of Viguiera arenaria (Asteraceae). Biochem System Ecol 2004; 32: 221-224, doi: 10.1016/S0305-1978(03)00139-X.
20. White M, Mccubrey J. Suppression of apoptosis: role in cell growth and neoplasia. Leukemia 2001; 15: 1011-1021, doi: 10.1038/sj.leu.2402143.
21. Bergeron S, Beauchemin M, Bertrand R. Camptothecinand etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and-4 aggregation but accelerates tumor necrosis factor-related apoptosis-inducing ligand-mediated cell death. Mol Cancer Ther 2004; 3: 1659-1669.
22. Malugin A, Kopeckova P, Kopecek J. HPMA copolymerbound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. Mol Pharm 2004; 1: 174-182, doi: 10.1021/mp049967q.
23. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776, doi: 10.1038/35037710.
24. Schrantz N, Bourgeade MF, Mouhamad S, Leca G, Sharma S, Vazquez A. p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFbeta-induced apoptosis in human Burkitt lymphoma B cells BL41. Mol Biol Cell 2001; 12: 3139-3151.
25. Castrillo A, de Las Heras B, Hortelano S, Rodriguez B, Villar A, Bosca L. Inhibition of the nuclear factor kappa B (NFkappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J Biol Chem 2001; 276: 15854-15860, doi: 10.1074/jbc.M100010200.
26. Ray SK, Patel SJ, Welsh CT, Wilford GG, Hogan EL, Banik NL. Molecular evidence of apoptotic death in malignant brain tumors including glioblastoma multiform: upregulation of calpain and caspase 3. J Neurosci Res 2002; 69: 197-206, doi: 10.1002/jnr.10265.
27. Kondoh M, Suzuki I, Sato M, Nagashima F, Simizu S, Harada M, et al. Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway. J Pharmacol Exp Ther 2004; 311: 115-122, doi: 10.1124/jpet.104.069690.
28. Karmakar S, Banik NL, Ray SK. Curcumin suppressed antiapoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells. Neurochem Res 2007; 32: 2103-2113, doi: 10.1007/ s11064-007-9376-z.
29. Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 2001; 276: 20633-20640, doi: 10.1074/jbc.M101780200.
30. Golks A, Brenner D, Krammer PH, Lavrik IN. The c-FLIPNH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med 2006; 203: 1295-1305, doi: 10.1084/ jem.20051556.
31. Day TW, Najafi F, Wu CH, Safa AR. Cellular FLICE-like inhibitory protein (c-FLIP): a novel target for Taxol-induced apoptosis. Biochem Pharmacol 2006; 71: 1551-1561, doi: 10.1016/j.bcp.2006.02.015.
32. Panner A, James CD, Berger MS, Pieper RO. mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol 2005; 25: 8809-8823, doi: 10.1128/MCB.25.20.8809-8823.2005.
33. Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008; 68: 8164-8172, doi: 10.1158/0008-5472.CAN-08-1305.
34. Castro MG, Cowen R, Williamson IK, David A, Jimenez-Dalmaroni MJ, Yuan X, et al. Current and future strategies for the treatment of malignant brain tumors. Pharmacol Ther 2003; 98: 71-108, doi: 10.1016/S0163-7258(03)00014-7.