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Volumn 5, Issue , 2012, Pages 199-211

Critical appraisal of bevacizumab in the treatment of metastatic colorectal cancer

Author keywords

Bevacizumab; Biomarkers; Chemotherapy; Liver metastases; Metastatic colorectal cancer

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CAPECITABINE PLUS OXALIPLATIN; CETUXIMAB; ERLOTINIB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MITOMYCIN; OXALIPLATIN; PANITUMUMAB; PLACEBO; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 84873887127     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S30581     Document Type: Review
Times cited : (10)

References (85)
  • 2
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissue in vivo. Vascular reactions of mice to wound and to normal and neoplastic transplants
    • Algire GH, Chalkley H W, Legallais FY, et al. Vascular reactions of normal and malignant tissue in vivo. Vascular reactions of mice to wound and to normal and neoplastic transplants. J Natl Cancer Inst. 1945;6: 73-85.
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3
  • 3
    • 67349286163 scopus 로고    scopus 로고
    • A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer
    • Cao Y, Tan A, Gao F, Liu L, Liao C, Mo Z. A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer. Int J Colorectal Dis. 2009;24:677-685.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 677-685
    • Cao, Y.1    Tan, A.2    Gao, F.3    Liu, L.4    Liao, C.5    Mo, Z.6
  • 4
    • 77954008527 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systemic review
    • Gastrointestinal Cancer Disease Site Group
    • Welch S, Spithoff K, Rumble B, Maroun J; Gastrointestinal Cancer Disease Site Group. Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: a systemic review. Ann Oncol. 2010;21:1152-1162.
    • (2010) Ann Oncol , vol.21 , pp. 1152-1162
    • Welch, S.1    Spithoff, K.2    Rumble, B.3    Maroun, J.4
  • 5
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 1999;77:527-543.
    • (1999) J Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 6
    • 0034000699 scopus 로고    scopus 로고
    • VEGF receptor signaling in tumor angiogenesis
    • McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist. 2000;5:3-10.
    • (2000) Oncologist , vol.5 , pp. 3-10
    • McMahon, G.1
  • 7
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997;57:4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 8
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol. 2001;19:843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 9
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the firstline treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the firstline treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2010;28:3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 10
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355: 2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 11
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with MCRC
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with MCRC. J Clin Oncol. 2003;21: 60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 12
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized Phase II trial
    • Kabbinavar F F, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized Phase II trial. J Clin Oncol. 2005;23: 3697-3704.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3704
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 13
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novontny W, et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novontny, W.3
  • 14
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Neal J, et al; Eastern Cooperative Oncology Group Study E3200. Bevacizumab in combination with oxaliplatin, fluorouracil and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25:1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Neal, J.3
  • 15
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26: 2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 16
    • 42949130734 scopus 로고    scopus 로고
    • Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer
    • Gruenberger B, Tamandl D, Schueller J, et al. Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer. J Clin Oncol. 2008;26: 1830-1835.
    • (2008) J Clin Oncol , vol.26 , pp. 1830-1835
    • Gruenberger, B.1    Tamandl, D.2    Schueller, J.3
  • 17
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • Kerbel RS. Tumor angiogenesis: past, present and the near future. Carcinogenesis. 2000;21:505-515.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 18
    • 0033565540 scopus 로고    scopus 로고
    • VEGF contributes to postnatal neovascularization by mobilizing bone marrow derived endothelial progenitor cells
    • Asahara T, Takahashi T, Masuda H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow derived endothelial progenitor cells. EMBO J. 1999;18:3964-3972.
    • (1999) EMBO J , vol.18 , pp. 3964-3972
    • Asahara, T.1    Takahashi, T.2    Masuda, H.3
  • 19
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrowderived endothelial and hematopoietic precursor cell blocks tumor angiogenesis and growth
    • Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrowderived endothelial and hematopoietic precursor cell blocks tumor angiogenesis and growth. Nat Med. 2001;7:1194-1201.
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3
  • 20
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev. 2005;15: 102-111.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 21
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 23
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H, Baluk P, Morikawa S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 2000; 156:1363-1380.
    • (2000) Am J Pathol , vol.156 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 24
    • 1542320497 scopus 로고    scopus 로고
    • Pathology: Cancer cells compress intratumor vessels
    • Abstract 695
    • Padera T P, Stoll BR, Tooredman JB, et al. Pathology: cancer cells compress intratumor vessels. Nature. 2004;427:Abstract 695.
    • (2004) Nature , vol.427
    • Padera, T.P.1    Stoll, B.R.2    Tooredman, J.B.3
  • 25
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 26
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4-25.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 27
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
    • Plouët J, Schilling J, Gospodarowicz D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO J. 1989;8:3801-3806.
    • (1989) EMBO J , vol.8 , pp. 3801-3806
    • Plouët, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 28
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368-4380.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 29
    • 0029793371 scopus 로고    scopus 로고
    • During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
    • Melder RJ, Koening GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med. 1996;2:992-997.
    • (1996) Nat Med , vol.2 , pp. 992-997
    • Melder, R.J.1    Koening, G.C.2    Witwer, B.P.3    Safabakhsh, N.4    Munn, L.L.5    Jain, R.K.6
  • 30
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 31
    • 84857951632 scopus 로고    scopus 로고
    • Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: A systematic review and meta-analysis, with emphasis on chemotherapy subgroups
    • Macedo LT, Lima A, Sasse AD. Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: a systematic review and meta-analysis, with emphasis on chemotherapy subgroups. BMC Cancer. 2012;12:89.
    • (2012) BMC Cancer , vol.12 , pp. 89
    • Macedo, L.T.1    Lima, A.2    Sasse, A.D.3
  • 32
    • 77956083776 scopus 로고    scopus 로고
    • Treatment of colorectal cancer with and without bevacizumab: A Phase III study
    • Stathopoulos G P, Batziou C, Trafalis D, et al. Treatment of colorectal cancer with and without bevacizumab: a Phase III study. Oncology. 2010;78:376-381.
    • (2010) Oncology , vol.78 , pp. 376-381
    • Stathopoulos, G.P.1    Batziou, C.2    Trafalis, D.3
  • 33
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus or oral fluoropyrimidines in first line treatment of metastatic colorectal cancer: Results from the BICC-C study
    • Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus or oral fluoropyrimidines in first line treatment of metastatic colorectal cancer: results from the BICC-C study. J Clin Oncol. 2007;25:4779-4786.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3
  • 34
    • 67650996205 scopus 로고    scopus 로고
    • Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer
    • AVIRI Trial investigators
    • Sobrero A, Ackland S, Clark S, et al; AVIRI Trial investigators. Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer. Oncolog y. 2009;77:113-119.
    • (2009) Oncolog Y , vol.77 , pp. 113-119
    • Sobrero, A.1    Ackland, S.2    Clark, S.3
  • 35
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenetic biomarkers associated with therapeutic resistance
    • AVIRI Trial investigators
    • Kopetz S, Hoff PM, Morris JS, et al; AVIRI Trial investigators. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenetic biomarkers associated with therapeutic resistance. J Clin Oncol. 2010;28:453-459.
    • (2010) J Clin Oncol , vol.28 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 36
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22:23-30.
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 37
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidines regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer
    • Results of the TREE Study
    • Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of oxaliplatin and fluoropyrimidines regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer. Results of the TREE Study. J Clin Oncol. 2008;26:3523-3529.
    • (2008) J Clin Oncol , vol.26 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 38
    • 77955497309 scopus 로고    scopus 로고
    • Capecitabine, bevacizumab and mitomycin in first line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group randomized Phase III MAX study
    • Tebbutt NC, Wilson K, Gebski VJ, et al. Capecitabine, bevacizumab and mitomycin in first line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group randomized Phase III MAX study. J Clin Oncol. 2010;28:3191-3198.
    • (2010) J Clin Oncol , vol.28 , pp. 3191-3198
    • Tebbutt, N.C.1    Wilson, K.2    Gebski, V.J.3
  • 39
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist. 2007;12:356-361.
    • (2007) Oncologist , vol.12 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 40
    • 85172044408 scopus 로고    scopus 로고
    • Bevacizumab in combination with irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) in patients with metastatic colorectal cancer who were previously treated with oxaliplatin-containing regimens: A multicenter observational cohort study (TCTG 2nd-BV study)
    • December 31, Epub ahead of print
    • Morikawi T, Bando H, Takashima A, et al. Bevacizumab in combination with irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) in patients with metastatic colorectal cancer who were previously treated with oxaliplatin-containing regimens: a multicenter observational cohort study (TCTG 2nd-BV study). Med Oncol. December 31, 2011. [Epub ahead of print.]
    • (2011) Med Oncol
    • Morikawi, T.1    Bando, H.2    Takashima, A.3
  • 41
    • 72449179365 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecanbased therapy in metastatic colorectal cancer patients previously treated with oxaliplatin-based regimens
    • Yildiz R, Buyukberber S, Uner A, et al. Bevacizumab plus irinotecanbased therapy in metastatic colorectal cancer patients previously treated with oxaliplatin-based regimens. Cancer Invest. 2010;28:33-37.
    • (2010) Cancer Invest , vol.28 , pp. 33-37
    • Yildiz, R.1    Buyukberber, S.2    Uner, A.3
  • 42
    • 84880702679 scopus 로고    scopus 로고
    • Phase II clinical trial of second-line FOLFIRI plus bevacizumab for patients with metastatic colorectal cancer: AVASIRI trial
    • October 15, Epub ahead of print
    • Horita Y, Yamada Y, Kato K, et al. Phase II clinical trial of second-line FOLFIRI plus bevacizumab for patients with metastatic colorectal cancer: AVASIRI trial. Int J Clin Oncol. October 15, 2011. [Epub ahead of print.]
    • (2011) Int J Clin Oncol
    • Horita, Y.1    Yamada, Y.2    Kato, K.3
  • 43
    • 84856625485 scopus 로고    scopus 로고
    • FOLFIRI plus bevacizumab 5 mg/kg versus 10 mg/kg as second-line therapy in patients with metastatic colorectal cancer who have failed first-line bevacizumab plus oxaliplatin-based therapy: A randomized Phase III Study (EAGLE Study)
    • Mishima H, Oba K, Sakamoto J, et al. FOLFIRI plus bevacizumab 5 mg/kg versus 10 mg/kg as second-line therapy in patients with metastatic colorectal cancer who have failed first-line bevacizumab plus oxaliplatin-based therapy: a randomized Phase III Study (EAGLE Study). Jpn J Clin Oncol. 2012;42:134-138.
    • (2012) Jpn J Clin Oncol , vol.42 , pp. 134-138
    • Mishima, H.1    Oba, K.2    Sakamoto, J.3
  • 44
    • 84861569539 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy in the second-line treatment of metastatic colorectal cancer: Results from the phase II BEVACOLOR study
    • Bennouna J, Borg C, Delord J P, et al. Bevacizumab combined with chemotherapy in the second-line treatment of metastatic colorectal cancer: results from the phase II BEVACOLOR study. Clin Colorectal Cancer. 2012;11:38-44.
    • (2012) Clin Colorectal Cancer , vol.11 , pp. 38-44
    • Bennouna, J.1    Borg, C.2    Delord, J.P.3
  • 45
    • 33746833739 scopus 로고    scopus 로고
    • Phase II multicenter trial of bevacizumab plus fluoropyrimidines and leucovorin in patients with advanced refractory colorectal cancer: An NCI Treatment Referral Center Trial TRC-0301
    • Chen HX, Mooney M, Boron M, et al. Phase II multicenter trial of bevacizumab plus fluoropyrimidines and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301. J Clin Oncol. 2006;24:3354-3360.
    • (2006) J Clin Oncol , vol.24 , pp. 3354-3360
    • Chen, H.X.1    Mooney, M.2    Boron, M.3
  • 46
    • 84863344472 scopus 로고    scopus 로고
    • Bevacizumab as a secondor later-line of treatment for metastatic colorectal cancer
    • Park LC, Lee HS, Shin SH, et al. Bevacizumab as a secondor later-line of treatment for metastatic colorectal cancer. World J Gastroenterol. 2012;18:1104-1109.
    • (2012) World J Gastroenterol , vol.18 , pp. 1104-1109
    • Park, L.C.1    Lee, H.S.2    Shin, S.H.3
  • 47
    • 70449358710 scopus 로고    scopus 로고
    • Bevacizumab plus FOLFIRI or FOLFOX in chemotherapy-refractory patients with metastatic colorectal cancer: A retrospective study
    • Lievre A, Samalin E, Mitry E, et al. Bevacizumab plus FOLFIRI or FOLFOX in chemotherapy-refractory patients with metastatic colorectal cancer: a retrospective study. BMC Cancer. 2009;9:347.
    • (2009) BMC Cancer , vol.9 , pp. 347
    • Lievre, A.1    Samalin, E.2    Mitry, E.3
  • 48
    • 65549152542 scopus 로고    scopus 로고
    • Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: A retrospective analysis
    • Kang B W, Kim T W, Lee JL, et al. Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: a retrospective analysis. Med Oncol. 2009;26: 32-37.
    • (2009) Med Oncol , vol.26 , pp. 32-37
    • Kang, B.W.1    Kim, T.W.2    Lee, J.L.3
  • 49
    • 37848999147 scopus 로고    scopus 로고
    • Bevacizumab plus infusional 5-fluorouracil, leucovorin and irinotecan for advanced colorectal cancer that progressed after oxaliplatin and irinotecan chemotherapy: A pilot study
    • Kwon HC, Oh S Y, Lee S, Kim SH, Kim HJ. Bevacizumab plus infusional 5-fluorouracil, leucovorin and irinotecan for advanced colorectal cancer that progressed after oxaliplatin and irinotecan chemotherapy: a pilot study. World J Gastroenterol. 2007;13:6231-6235.
    • (2007) World J Gastroenterol , vol.13 , pp. 6231-6235
    • Kwon, H.C.1    Oh, S.Y.2    Lee, S.3    Kim, S.H.4    Kim, H.J.5
  • 50
    • 66149120036 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study
    • First BEAT Investigators
    • Van Cutsem E, Rivera F, Berry S, et al; First BEAT Investigators. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol. 2009;20:1842-1847.
    • (2009) Ann Oncol , vol.20 , pp. 1842-1847
    • van Cutsem, E.1    Rivera, F.2    Berry, S.3
  • 51
    • 77955575817 scopus 로고    scopus 로고
    • Perioperative chemotherapy with bevacizumab (BV) for liver metastases (LM) in colorectal cancer (CRC): McGill University pilot study
    • Bouganim N, Kavan M, Eid M, Metrakos P, Chaudhury P, Batist G. Perioperative chemotherapy with bevacizumab (BV) for liver metastases (LM) in colorectal cancer (CRC): McGill University pilot study. J Clin Oncol. 2009;27:15S Suppl:e15027.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Bouganim, N.1    Kavan, M.2    Eid, M.3    Metrakos, P.4    Chaudhury, P.5    Batist, G.6
  • 52
    • 56749096759 scopus 로고    scopus 로고
    • Pathologic response to preoperative chemotherapy: A new outcome end point after resection of hepatic colorectal metastases
    • Blazer DG 3rd, Kishi Y, Maru DM, et al. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol. 2008;26: 5344-5351.
    • (2008) J Clin Oncol , vol.26 , pp. 5344-5351
    • Blazer III, D.G.1    Kishi, Y.2    Maru, D.M.3
  • 53
    • 77956189945 scopus 로고    scopus 로고
    • Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as firstline treatment for metastatic colorectal cancer: A phase 2 trial
    • Masi G, Loupakis F, Salvatore L, et al. Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as firstline treatment for metastatic colorectal cancer: a phase 2 trial. Lancet Oncol. 2010;11:845-852.
    • (2010) Lancet Oncol , vol.11 , pp. 845-852
    • Masi, G.1    Loupakis, F.2    Salvatore, L.3
  • 54
    • 79959947067 scopus 로고    scopus 로고
    • A multicentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for up-front resection
    • Wong R, Cunningham D, Barbachano Y, et al. A multicentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for up-front resection. Ann Oncol. 2011;22:2042-2048.
    • (2011) Ann Oncol , vol.22 , pp. 2042-2048
    • Wong, R.1    Cunningham, D.2    Barbachano, Y.3
  • 55
    • 70349690209 scopus 로고    scopus 로고
    • Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and randomized Phase-III NO16966 trial
    • Okines A, Puerto OD, Cunningham D, et al. Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and randomized Phase-III NO16966 trial. Br J Cancer. 2009;101:1033-1038.
    • (2009) Br J Cancer , vol.101 , pp. 1033-1038
    • Okines, A.1    Puerto, O.D.2    Cunningham, D.3
  • 56
    • 37048998995 scopus 로고    scopus 로고
    • Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases
    • Ribero D, Wang H, Donadon M, et al. Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases. Cancer. 2007;110:2761-2767.
    • (2007) Cancer , vol.110 , pp. 2761-2767
    • Ribero, D.1    Wang, H.2    Donadon, M.3
  • 57
    • 77954954904 scopus 로고    scopus 로고
    • Bevacizumab improves pathologic response of colorectal cancer liver metastases treated with XELOX/FOLFOX
    • Klinger M, Tamandl D, Eipeldauer S, et al. Bevacizumab improves pathologic response of colorectal cancer liver metastases treated with XELOX/FOLFOX. Ann Surg Oncol. 2010;17:2059-2065.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2059-2065
    • Klinger, M.1    Tamandl, D.2    Eipeldauer, S.3
  • 59
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008;26:5326-5334.
    • (2008) J Clin Oncol , vol.26 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 60
    • 84873890171 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy beyond first progression in metastatic colorectal cancer patients previously treated with bevacizumab-based therapy: TML study subgroup findings
    • Abstract O-0020
    • Andre T, Vieitez JM, Bouche O, et al. Bevacizumab plus chemotherapy beyond first progression in metastatic colorectal cancer patients previously treated with bevacizumab-based therapy: TML study subgroup findings. Ann Oncol. 2012;23 Suppl 4:Abstract O-0020.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 4
    • Andre, T.1    Vieitez, J.M.2    Bouche, O.3
  • 61
    • 84893661012 scopus 로고    scopus 로고
    • Randomised phase III study of bevacizumab plus chemotherapy beyond progression in bevacizumab-treated patients with metastatic colorectal cancer: TML study KRAS subgroup findings
    • Abstract O-0021
    • Van Cutsem E, Vieitez JM, Bouche O, et al. Randomised phase III study of bevacizumab plus chemotherapy beyond progression in bevacizumab-treated patients with metastatic colorectal cancer: TML study KRAS subgroup findings. Ann Oncol. 2012;23 Suppl 4: Abstract O-0021.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 4
    • van Cutsem, E.1    Vieitez, J.M.2    Bouche, O.3
  • 62
    • 65749088446 scopus 로고    scopus 로고
    • Intermittent oxaliplatin administration improves time to-treatment failure in metastatic colorectal cancer: Final results of the Phase III of the CONcePT Trial
    • Abstract 4010
    • Grothey A, Hart L, Rowland K, et al. Intermittent oxaliplatin administration improves time to-treatment failure in metastatic colorectal cancer: final results of the Phase III of the CONcePT Trial. J Clin Oncol. 2008;26 Suppl:Abstract 4010.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Grothey, A.1    Hart, L.2    Rowland, K.3
  • 63
    • 84856304557 scopus 로고    scopus 로고
    • First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: The Phase III MACRO TTD study
    • Spanish Cooperative Group for the Treatment of Digestive Tumors
    • Díaz-Rubio E, Gómez-España A, Massutí B, et al; Spanish Cooperative Group for the Treatment of Digestive Tumors. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the Phase III MACRO TTD study. Oncologist. 2012;17:15-25.
    • (2012) Oncologist , vol.17 , pp. 15-25
    • Díaz-Rubio, E.1    Gómez-España, A.2    Massutí, B.3
  • 64
    • 84871667344 scopus 로고    scopus 로고
    • Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients (pts) with metastatic colorectal cancer (mCRC): Efficacy and safety results of the International GERCOR DREAM Phase III trial
    • Abstract LBA3500
    • Tournigand C, Samson B, Scheithauer W, et al. Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients (pts) with metastatic colorectal cancer (mCRC): Efficacy and safety results of the International GERCOR DREAM Phase III trial. J Clin Oncol. 2012; 30 Suppl:Abstract LBA3500.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Tournigand, C.1    Samson, B.2    Scheithauer, W.3
  • 65
    • 84864473070 scopus 로고    scopus 로고
    • A randomized phase III trial on maintenance treatment with Bevacizumab (bev) alone or in combination with erlotinib (erlo) after chemotherapy and bev in metastatic colorectal cancer (mCRC)
    • abstract 3526
    • Johnsson A, Frodin J, Berglund A et al. A randomized phase III trial on maintenance treatment with Bevacizumab (bev) alone or in combination with erlotinib (erlo) after chemotherapy and bev in metastatic colorectal cancer (mCRC). J Clin Oncol. 2011;29 (Suppl.); abstract 3526.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Johnsson, A.1    Frodin, J.2    Berglund, A.3
  • 66
    • 21244450758 scopus 로고    scopus 로고
    • Association of k-ras, b-raf and p-53 status with the treatment effect of bevacizumab
    • Ince WL, Jubb AM, Holden SN, et al. Association of k-ras, b-raf and p-53 status with the treatment effect of bevacizumab. J Natl Cancer Inst. 2005;97:981-989.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 981-989
    • Ince, W.L.1    Jubb, A.M.2    Holden, S.N.3
  • 67
    • 0032521205 scopus 로고    scopus 로고
    • K-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer
    • A Southwest Oncology Group Study
    • Ahnen DJ, Feigl P, Quan G, et al. K-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer. A Southwest Oncology Group Study. Cancer Res. 1998;58:1149-1158.
    • (1998) Cancer Res , vol.58 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3
  • 68
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutation as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A, Bachet JB, Boige V, et al. KRAS mutation as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008;26:374-379.
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3
  • 69
    • 0036531949 scopus 로고    scopus 로고
    • What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?
    • Rak J, Yu JL, Kerbel RS, Coomber BL. What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors? Cancer Res. 2006;62:1931-1934.
    • (2006) Cancer Res , vol.62 , pp. 1931-1934
    • Rak, J.1    Yu, J.L.2    Kerbel, R.S.3    Coomber, B.L.4
  • 70
    • 35348909046 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 independent pathways in tumor angiogenesis
    • Mizukami Y, Kohgo Y, Chung DC. Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin Cancer Res. 2007;13: 5670-5674.
    • (2007) Clin Cancer Res , vol.13 , pp. 5670-5674
    • Mizukami, Y.1    Kohgo, Y.2    Chung, D.C.3
  • 71
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of KRAS mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz HI, Yi J, Ince W, Novotny WF, Rosen O. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of KRAS mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist. 2009;14:22-28.
    • (2009) Oncologist , vol.14 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3    Novotny, W.F.4    Rosen, O.5
  • 72
    • 79960149283 scopus 로고    scopus 로고
    • Impact of KRAS and BRAF gene mutation status on outcomes from the Phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer
    • Price TJ, Hardingham JE, Lee CK, et al. Impact of KRAS and BRAF gene mutation status on outcomes from the Phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer. J Clin Oncol. 2011;29: 2675-2682.
    • (2011) J Clin Oncol , vol.29 , pp. 2675-2682
    • Price, T.J.1    Hardingham, J.E.2    Lee, C.K.3
  • 73
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360: 563-570.
    • (2009) N Engl J Med , vol.360 , pp. 563-570
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 74
    • 59949102930 scopus 로고    scopus 로고
    • A randomized Phase IIIB trial of chemotherapy, bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized Phase IIIB trial of chemotherapy, bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27:672-680.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 75
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V, et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res. 2000;6:3739-3747.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 76
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • Shaheen RM, Ahmad SA, Liu W, et al. Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer. 2001;85:584-589.
    • (2001) Br J Cancer , vol.85 , pp. 584-589
    • Shaheen, R.M.1    Ahmad, S.A.2    Liu, W.3
  • 77
    • 35648941728 scopus 로고    scopus 로고
    • Randomized Phase II trial of cetuximab, bevacizumab and irinotecan compared with cetuximab and bevacizumab alone in irinotecan refractory colorectal cancer: The BOND-2 study
    • Saltz LB, Lenz HJ, Kindler HL, et al. Randomized Phase II trial of cetuximab, bevacizumab and irinotecan compared with cetuximab and bevacizumab alone in irinotecan refractory colorectal cancer: the BOND-2 study. J Clin Oncol. 2007;25:4557-4561.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3
  • 78
    • 56349129083 scopus 로고    scopus 로고
    • Safety and effectiveness of bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer (mCRC): Results from BRiTE observational cohort study
    • Abstract 4026
    • Kozloff M F, Sugrue M, Purdie DM, et al. Safety and effectiveness of bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer (mCRC): results from BRiTE observational cohort study. J Clin Oncol. 2008;26(15S):Abstract 4026.
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Kozloff, M.F.1    Sugrue, M.2    Purdie, D.M.3
  • 79
    • 77950494294 scopus 로고    scopus 로고
    • Effect of bevacizumab in older patients with metastatic colorectal cancer: Pooled analysis of four randomized studies
    • Cassidy J, Saltz LB, Giantonio BJ, Kabbinavar F F, Hurwitz HI, Rohr U P. Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. J Cancer Res Clin Oncol. 2010;136:737-743.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 737-743
    • Cassidy, J.1    Saltz, L.B.2    Giantonio, B.J.3    Kabbinavar, F.F.4    Hurwitz, H.I.5    Rohr, U.P.6
  • 80
    • 58249088835 scopus 로고    scopus 로고
    • Addition of bevacizumab to fluorouracil based line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized trials
    • Kabbinavar F, Hurwitz HI, Yi J, Sarkar S, Rosen O. Addition of bevacizumab to fluorouracil based line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized trials. J Clin Oncol. 2009;27:199-205.
    • (2009) J Clin Oncol , vol.27 , pp. 199-205
    • Kabbinavar, F.1    Hurwitz, H.I.2    Yi, J.3    Sarkar, S.4    Rosen, O.5
  • 81
    • 58549090953 scopus 로고    scopus 로고
    • Preoperative chemotherapy does not increase morbidity or mortality of hepatic resection for colorectal cancer metastases
    • Scoggins CR, Campbell ML, Landry CS, et al. Preoperative chemotherapy does not increase morbidity or mortality of hepatic resection for colorectal cancer metastases. Ann Surg Oncol. 2009;16:35-41.
    • (2009) Ann Surg Oncol , vol.16 , pp. 35-41
    • Scoggins, C.R.1    Campbell, M.L.2    Landry, C.S.3
  • 82
    • 37249002806 scopus 로고    scopus 로고
    • Addition of bevacizumab to irinotecan and oxaliplatin-based preoperative chemotherapy regimens does not increase morbidity after resection of colorectal liver metastases
    • Reddy SK, Morse MA, Hurwitz HI, et al. Addition of bevacizumab to irinotecan and oxaliplatin-based preoperative chemotherapy regimens does not increase morbidity after resection of colorectal liver metastases. J Am Coll Surg. 2008;206:96-106.
    • (2008) J Am Coll Surg , vol.206 , pp. 96-106
    • Reddy, S.K.1    Morse, M.A.2    Hurwitz, H.I.3
  • 83
    • 33644824747 scopus 로고    scopus 로고
    • Improving long-term outcomes for patients with liver metastases from colorectal cancer
    • Chong G, Cunningham D. Improving long-term outcomes for patients with liver metastases from colorectal cancer. J Clin Oncol. 2005;23:9063-9066.
    • (2005) J Clin Oncol , vol.23 , pp. 9063-9066
    • Chong, G.1    Cunningham, D.2
  • 84
    • 63049105306 scopus 로고    scopus 로고
    • Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases
    • Klinger M, Eipeldauer S, Hacker B, et al. Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases. Eur J Surg Oncol. 2009;35:515-520.
    • (2009) Eur J Surg Oncol , vol.35 , pp. 515-520
    • Klinger, M.1    Eipeldauer, S.2    Hacker, B.3


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