Structural insight for the roles of fas death domain binding to fadd and oligomerization degree of the fas-fadd complex in the death-inducing signaling complex formation: A computational study

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 3, 2013, Pages 377-385

  Yan, Qi ^a   Mcdonald, Jay M ^b,c   Zhou, Tong ^d   Song, Yuhua ^a  

^a and Radiation Oncology   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

Conformational and dynamical motion analysis; Death inducing signaling complex; Fas FADD binding; Molecular dynamics; Oligomeric Fas FADD complex

Indexed keywords

FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN 1 PROTEIN; FAS ASSOCIATED DEATH DOMAIN 2 PROTEIN; FAS ASSOCIATED DEATH DOMAIN 3 PROTEIN; FAS ASSOCIATED DEATH DOMAIN 4 PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROCASPASE 8; TETRAMER; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATION; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; BINDING SITES; CASPASE 8; COMPUTATIONAL BIOLOGY; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; MOLECULAR DYNAMICS SIMULATION; MULTIPROTEIN COMPLEXES; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SIGNAL TRANSDUCTION; STATIC ELECTRICITY;

EID: 84873870541     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24193     Document Type: Article

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