Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro

Molecular Medicine Reports

Volumn 7, Issue 2, 2013, Pages 608-612

  Liu, Zhi Li ^a   Mao, Jian Hua ^a   Peng, Ai Fen ^b   Yin, Qing Shui ^c   Zhou, Yang ^a   Long, Xin Hua ^a   Huang, Shan Hu ^a  

^a NANCHANG UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Fatty acid synthase; Metastasis; Osteosarcoma; PI3K Akt

Indexed keywords

FATTY ACID SYNTHASE; GELATINASE A; GELATINASE B; MESSENGER RNA; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA;

ARTICLE; CANCER INHIBITION; CANCER INVASION; ENZYME INHIBITION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECOMBINANT PLASMID; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FATTY ACID SYNTHETASE COMPLEX; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICRORNAS; OSTEOSARCOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84873843604     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1220     Document Type: Article

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