Effect of cell surface deformation on synaptic factor accumulation during the early stages of T cell activation

Chemical Engineering Science

Volumn 90, Issue , 2013, Pages 275-283

  Labowsky, M ^a   Fahmy, T M ^b  

^a Ansama Research   (United States)

^b Yale University   (United States)

Author keywords

Biomedical engineering; Cell activation; Cellular biology and engineering; Diffusive interactions; Mathematical modeling; Paracrine delivery

Indexed keywords

ACTIVATION ANALYSIS; BIOMEDICAL ENGINEERING; CELL DEATH; CELL MEMBRANES; DEFORMATION; ESTIMATION; MATHEMATICAL MODELS; PARTIAL DIFFERENTIAL EQUATIONS;

ANALYTICAL EXPRESSIONS; BIOLOGICAL PROBLEMS; CELL ACTIVATION; CELL DEFORMATION; CELL DIFFERENTIATION; CELL SURFACES; CELLULAR BIOLOGY; CHEMICAL FACTORS; DEGREE OF DEFORMATIONS; DIFFUSION EQUATIONS; EDGE POINT; EMISSION RATES; GEOMETRICAL FEATURES; PARACRINE; QUASI-STEADY; RADIAL VARIATIONS; REACTIVE SYSTEM; SIGNALING PROCESS; SINGULARITY METHOD; SPHERICAL SHAPE; SURFACE RECEPTORS; T CELL ACTIVATION;

CELL ENGINEERING;

EID: 84873833122     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.12.011     Document Type: Article

References (17)

1. Burack W.R., Lee R.H., Holdorf A.D., Dustin M.L., Shaw A.S. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J. Immunol. 2002, 169:2837-2841.
2. Carlsson R., Sjogren H.O. Kinetics of IL-2 and interferon-y production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to straphylococcal enterotoxin A. Cell Immunol. 1985, 96:175-183.
3. Demento S., Steenblock E., Fahmy T.M. Biomimetric approaches to modulating the T cell immune response with nano- and micro- particles. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2009, 2009:1161-1166.
4. Dustin M.L., Cooper J.A. The immunological synapse and the actin cytoskeleton:molecular hardware for T cell signaling. Nat. Immunol. 2000, 1:23-29.
5. Dustin M.L. Impact of the immunological synapse on T cell signaling. Results Probl. Cell 2006, 43:175-198.
6. Dustin M.L. A dynamic view of the immunological synapse. Semin. Immunol. 2005, 17:175-198.
7. Fahmy T.M., Bieler J.G., Edidin M., Schneck J.P. Increased TCR avidity after T cell activation: a mechanism for sensing low density antigen. Immunity 2001, 14:135-143.
8. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse: a molecular machine controlling T cell activation. Science 1999, 285:221-227.
9. Hess J.L., Smith J.O. Calculation of potential flow about arbitrary bodies. Prog. Aeronaut. Sci. 1967, 8:1-137.
10. Labowsky M., Fahmy T.M. Diffusive transfer between two intensely interacting cells with limited surface kinetics. Chem. Eng. Sci. 2012, 74:114-123.
11. Malek T.R. The biology of interleukin-2. Annu. Rev. Immunol. 2008, 26:453-479.
12. Monks C.R., Freiberg B.A., Kupfer H., Sciaky N., Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998, 395:82-86.
13. Pihlgren M., Dubois P.M., Tomkowiak M., Sjogren T., Marvel J. Resting memory CD8+ T cells are hyperreactive to antigen challenge in vitro. J. Exp. Med. 1996, 184:2141-2151.
14. Sabatos C.A., Doh J., Chakravarti S., Friedman R.S., Pandurangi P.G., Tooley A.J., Krummel M.F. A synaptic basis for paracrine Interleukin-2 signaling during homotypic T cell activation. Immunity 2008, 29:238-248.
15. Steenblock E., Fahmy T.M. A comprehensive platform for T cell stimulation based on biodegradable artificial antigen-presenting cell microparticles. Mol. Ther. 2008, 16:765-772.
16. Steenblock E., Wrzesinski S.H., Flavell R.A., Fahmy T.M. Antigen presentation on artiificial acellular substrates: modular systems for flexible, adaptable immunotherapy. Expert Opin. Biol. Ther. 2009, 9:451-464.
17. Steenblock E.R., Fadel T., Labowsky M., Pober J.S., Fahmy T.M. An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response. J. Biol. Chem. 2011, 286:34883-34892.