Hirsutine, an indole alkaloid of Uncaria rhynchophylla, inhibits inflammation-mediated neurotoxicity and microglial activation

Molecular Medicine Reports

Volumn 7, Issue 1, 2013, Pages 154-158

  Jung, Hwan Yong ^a   Nam, Kyong Nyon ^b   Woo, Byung Choel ^a   Kim, Kyoo Pil ^a   Kim, Sung Ok ^c   Lee, Eunjoo H ^b  

^a Kyung Hee University College of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

Brain inflammation; Hirsutine; Microglia; Mitogen activated protein kinase; Neurotoxicity; Nitric oxide; Organotypic hippocampal slice culture; Reactive oxygen species; Uncaria rhynchophylla

Indexed keywords

ANTIINFLAMMATORY AGENT; HIRSUTINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVE CELL PLASTICITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; SIGNAL TRANSDUCTION; UNCARIA; UNCARIA RHYNCHOPHYLLA; WESTERN BLOTTING;

ALKALOIDS; ANIMALS; DINOPROSTONE; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84873815529     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1135     Document Type: Article

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