Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice

Indian Journal of Physiology and Pharmacology

Volumn 54, Issue 4, 2010, Pages 318-328

  Kothari, Saroj ^a   Minda, Manish ^a   Tonpay, S D ^a  

^a G R MEDICAL COLLEGE   (India)

Author keywords

Aegle marmelos; Antidepressant; Anxiolytic; Elevated plus maze; Tail suspension test

Indexed keywords

AEGLE MARMELOS EXTRACT; BACLOFEN; DIAZEPAM; FLUOXETINE; HALOPERIDOL; IMIPRAMINE; METHANOL; PRAZOSIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; IMMOBILIZATION; LOCOMOTION; MAZE TEST; MOUSE; NONHUMAN; PLANT LEAF; TRANQUILIZING ACTIVITY;

AEGLE; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BACLOFEN; FEMALE; HALOPERIDOL; MALE; MICE; MOTOR ACTIVITY; PLANT EXTRACTS; PLANT LEAVES; PRAZOSIN;

EID: 79956224327     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. WHO, Mental and Neurological Disorders. 1998 Factsheet no. 25 World Health organisation: Genava; 2001.
2. Gold PW, Goodwin FK, Chrousus GP. Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress: Part 1. N Engl J Med 1988; 319: 348-353.
3. Zohar J, Westenberg HG. Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta Psychiatr Scand 2000; 403: 39-49.
4. Brambilla P, Perez J, Barale F, Schettini G, Soares JC. GABAergic dysfunction in mood disorders. Mol Psychiatry 2003; 8: 721-737.
5. Mombereau C, Kaupmann K, Froestl W, Sansig G, Van der Putten H, Cryan JF. Genetic and pharmacological evidence of a role for GABA (B) receptors in the modulation of anxiety and antidepressant-like behavior. Neuropsychopharmacology 2004; 29: 1050-1062.
6. Hardman JG, Limbird LE, Goodman Gilman A. Goodman and Gilman's: The Pharmacological Basis of Therapeutics. 10th ed. The McGraw Hill Companies, Inc: New York; 2001.
7. Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci 2004; 75: 1659-1699.
8. Shobha FG, Thomas M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 2001; 76: 73-76.
9. Kamalakkannan N, Prince PS. Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats. J Ethnopharmacol 2003; 87: 207-210.
10. Lotufu LV, Khan MT, Ather A, et al. Studies of the anticancer potential of plants used in Bangladeshi folk medicine. J Ethonopharmacol 2005; 99: 21-23.
11. Jagetia GC, Venkatesh P, Balinga MS. Evaluation of radio protective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol 2004; 80: 281-290.
12. Rana BK, Jain AK. Evaluation of anti-fungal activity of essential oil isolated from leaves of the A. marmelos. J Ethnopharmacol 1997; 57: 29-37.
13. Mazumder S, Bhattacharya A, Majumder AK, Pattnaik P, Tiwari M, Chaudhary S. Anti bacterial evaluation of Aegle marmelos (Correa) Linn. Root extract. Phytother Res 2006; 20: 82-84.
14. Sahare KN, Anandhraman V, Meshram VG, et al. Antimicrofilarial activity of methanol extract of Vitex negundo and Aegle marmelos and their phytochemical analysis. Indian J Exp Biol 1981; 3: 245-249.
15. Veerappan A, Shigeru M, Rengnathan D. Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr. J Ethnopharmacol 2005; 96: 159-163.
16. Raj KPS, Patel MR. Some medicinal plants of Cambay and its immediate vicinity and their uses in Indian Indigenous system of medicine. Indian Drugs 1978; 15: 145-152.
17. Maheshwari JK, Singh JP. Plants used in ethnomedicine by the Kols of Allahabad district Uttar Pradesh. Bull Med Ethnobot Res 1984; 5: 105-121.
18. Garg SN, Siddiqui MS, Agarwal SK. p-Menth-1- en-3β,5β-diol, a new constituent of Aegle marmelos leaf oil. J Essent Oil Res 1995; 7: 283-286.
19. Sharma BR, Rattan RK, Sharma P. Constituents of leaves and fruits of Aegle marmelos. Indian J Chem 1980; 19: 162.
20. Chakravorty RN, Dasgupta B. γ-Sitosterol from the leaves of Aegle marmelos Correa. J Indian Chem Soc 1958; 35: 194-196.
21. Ali MS, Pervez M. Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos, Nat Prod Res 2004; 18: 141-146.
22. Pellow S, Chopin P, File SE, Briley M. Validation of open: closed arm entries in an elevated plusmaze as a measure of anxiety in rats. J Neurosci Methods 1985; 14: 149-167.
23. Rodgers RJ, Cao BJ, Dalvi A, Holmes A. Animal models of anxiety: An ethological perspective. Braz J Med Biol Res 1997; 30: 289-304.
24. Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology 1985; 85: 367-370.
25. Thierry B, Steru L, Simon P, Porsolt RD. The tail suspension test: Ethical considerations. Psychopharmacology (Berl) 1986; 90: 284-285.
26. Kulkarni SK. Handbook of Experimental Pharmacology (3rd edition), Vallabh Prakashan, New Delhi: 1999.
27. Shankarananth V, Balkrishnan ND, Suresh G, Sureshpandian E, Edwin E, Sheeja E. Analgesic activity of methanol extract of Aegle marmelos leaves. Fitoterapia 2007; 78: 258-259.
28. Weiss SM, Wadsworth G, Fletcher A, Dourish CT. Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety. Neurosci Biobehav Rev 1998; 2: 265-271.
29. Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci 1994; 19: 24-29.
30. Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 1997; 340: 249-258.
31. Wong DT, Bymaster FP. Engleman EA. Prozac (fluoxetine), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci 1995; 57: 411-441.
32. Stone EA, Quartermain D. Alpha-1-noradrenergic neurotransmission, corticosterone, and behavioral depression. Biol Psychiatry 1999; 46: 1287-1300.
33. Sampson D, Willner P, Muscat R. Reversal of antidepressant action by dopamine antagonists in an animal model of depression. Psychopharmacology 1991; 104: 491-495.
34. Shigeyuki C, Taketoshi O, Yoshinori S. Nonmonoamine- based approach for the treatment of depression and anxiety disorders. Recent Pat CNS Drug Discov 2006; 1: 1-27.
35. Nakagawa Y, Sasaki A, Takashima T. The GABA (B) receptor antagonist CGP 36742 improves learned helplessness in rats. Eur J Pharmacol 1999; 381: 1-7.
36. Nakagawa Y, Ishima T, Ishibashi Y, Tsuji M, Takashima T. Involvement of GABAB receptor systems in experimental depression: baclofen but not bicuculline exacerbates helplessness in rats. Brain Res 1996; 741: 240-245.