메뉴 건너뛰기




Volumn 15, Issue 1-2, 2008, Pages 2-15

Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties

Author keywords

Antidepressant; Anxiolytic; Elevated plus maze; Locomotor activity; Myorelaxant; Sedative; Valeriana officinalis L.s.l.

Indexed keywords

ALCOHOL; DIAZEPAM; ETHER; METHANOL; PHYTOFIN VALERIAN 368; SOLVENT; UNCLASSIFIED DRUG; VALERIAN;

EID: 37549018503     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2007.11.027     Document Type: Article
Times cited : (131)

References (62)
  • 2
    • 0028043157 scopus 로고
    • Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal
    • Andreatini R., and Leite J.R. Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal. Eur. J. Pharmacol. 260 2-3 (1994) 233-235
    • (1994) Eur. J. Pharmacol. , vol.260 , Issue.2-3 , pp. 233-235
    • Andreatini, R.1    Leite, J.R.2
  • 3
    • 0036846483 scopus 로고    scopus 로고
    • Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study
    • Andreatini R., Sartori V.A., Seabra M.L., and Leite J.R. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother. Res. 16 7 (2002) 650-654
    • (2002) Phytother. Res. , vol.16 , Issue.7 , pp. 650-654
    • Andreatini, R.1    Sartori, V.A.2    Seabra, M.L.3    Leite, J.R.4
  • 5
    • 0024344174 scopus 로고
    • 6-cyclohexyladenosine binding to rat cortical membranes by an hydroalcoholic extract of Valeriana officinalis
    • 6-cyclohexyladenosine binding to rat cortical membranes by an hydroalcoholic extract of Valeriana officinalis. Med. Sci. Res. 17 (1989) 639-640
    • (1989) Med. Sci. Res. , vol.17 , pp. 639-640
    • Balduini, W.1    Cattabeni, F.2
  • 6
    • 0031131665 scopus 로고    scopus 로고
    • [Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis L
    • Bodesheim U., and Hölzl J. [Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis L. Pharmazie 52 5 (1997) 386-391
    • (1997) Pharmazie , vol.52 , Issue.5 , pp. 386-391
    • Bodesheim, U.1    Hölzl, J.2
  • 7
    • 0001653140 scopus 로고
    • L′utilisation du test de la traction, (Test de JULOU-COURVOISIER) pour l′etude des psycholeptiques
    • Boissier J.R., and Simon P. L′utilisation du test de la traction, (Test de JULOU-COURVOISIER) pour l′etude des psycholeptiques. Therapie 15 (1960) 1170-1174
    • (1960) Therapie , vol.15 , pp. 1170-1174
    • Boissier, J.R.1    Simon, P.2
  • 8
    • 0029067853 scopus 로고
    • Role of the serotonergic system in the forced swimming test
    • Borsini F. Role of the serotonergic system in the forced swimming test. Neurosci. Biobehav. Rev. 19 3 (1995) 377-395
    • (1995) Neurosci. Biobehav. Rev. , vol.19 , Issue.3 , pp. 377-395
    • Borsini, F.1
  • 9
    • 0029063620 scopus 로고
    • In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain
    • Cavadas C., Araujo I., Cotrim M.D., Amaral T., Cunha A.P., Macedo T., and Ribeiro C.F. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. Arzneimittelforschung/Drug Res. 45 7 (1995) 753-755
    • (1995) Arzneimittelforschung/Drug Res. , vol.45 , Issue.7 , pp. 753-755
    • Cavadas, C.1    Araujo, I.2    Cotrim, M.D.3    Amaral, T.4    Cunha, A.P.5    Macedo, T.6    Ribeiro, C.F.7
  • 10
    • 37549024297 scopus 로고    scopus 로고
    • Committee on Herbal Medicinal Products (HMPC/EMEA). Community Monograph on Valeriana officinalis L, radix, 2006.
  • 11
    • 0036165581 scopus 로고    scopus 로고
    • Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions
    • Cropley M., Cave Z., Ellis J., and Middleton R.W. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions. Phytother. Res. 16 1 (2002) 23-27
    • (2002) Phytother. Res. , vol.16 , Issue.1 , pp. 23-27
    • Cropley, M.1    Cave, Z.2    Ellis, J.3    Middleton, R.W.4
  • 12
    • 23744455203 scopus 로고    scopus 로고
    • Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro
    • Dietz B.M., Mahady G.B., Pauli G.F., and Farnsworth N.R. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res. Mol. Brain Res. 138 2 (2005) 191-197
    • (2005) Brain Res. Mol. Brain Res. , vol.138 , Issue.2 , pp. 191-197
    • Dietz, B.M.1    Mahady, G.B.2    Pauli, G.F.3    Farnsworth, N.R.4
  • 13
    • 0034098748 scopus 로고    scopus 로고
    • Critical evaluation of the effect of valerian extract on sleep structure and sleep quality
    • Donath F., Quispe S., Diefenbach K., Maurer A., Fietze I., and Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry 33 2 (2000) 47-53
    • (2000) Pharmacopsychiatry , vol.33 , Issue.2 , pp. 47-53
    • Donath, F.1    Quispe, S.2    Diefenbach, K.3    Maurer, A.4    Fietze, I.5    Roots, I.6
  • 14
    • 9444277298 scopus 로고    scopus 로고
    • Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers
    • Donovan J.L., DeVane C.L., Chavin K.D., Wang J.S., Gibson B.B., Gefroh H.A., and Markowitz J.S. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab. Dispos. 32 12 (2004) 1333-1336
    • (2004) Drug Metab. Dispos. , vol.32 , Issue.12 , pp. 1333-1336
    • Donovan, J.L.1    DeVane, C.L.2    Chavin, K.D.3    Wang, J.S.4    Gibson, B.B.5    Gefroh, H.A.6    Markowitz, J.S.7
  • 15
    • 0033624013 scopus 로고    scopus 로고
    • [Efficacy and tolerability of Baldrian versus oxazepam in non-organic and non-psychiatric insomniacs: a randomised, double-blind, clinical, comparative study]
    • Dorn M. [Efficacy and tolerability of Baldrian versus oxazepam in non-organic and non-psychiatric insomniacs: a randomised, double-blind, clinical, comparative study]. Forsch Komplementarmed Klass Naturheilkd 7 2 (2000) 79-84
    • (2000) Forsch Komplementarmed Klass Naturheilkd , vol.7 , Issue.2 , pp. 79-84
    • Dorn, M.1
  • 16
    • 2442600667 scopus 로고    scopus 로고
    • ESCOP, Thieme, Stuttgart
    • ESCOP. ESCOP Monographs (2003), Thieme, Stuttgart
    • (2003) ESCOP Monographs
  • 17
    • 1642575173 scopus 로고    scopus 로고
    • Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
    • Fernandez S., Wasowski C., Paladini A.C., and Marder M. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol. Biochem. Behav. 77 2 (2004) 399-404
    • (2004) Pharmacol. Biochem. Behav. , vol.77 , Issue.2 , pp. 399-404
    • Fernandez, S.1    Wasowski, C.2    Paladini, A.C.3    Marder, M.4
  • 18
    • 17444424615 scopus 로고    scopus 로고
    • Synergistic interaction between hesperidin, a natural flavonoid, and diazepam
    • Fernandez S.P., Wasowski C., Paladini A.C., and Marder M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur. J. Pharmacol. 512 2-3 (2005) 189-198
    • (2005) Eur. J. Pharmacol. , vol.512 , Issue.2-3 , pp. 189-198
    • Fernandez, S.P.1    Wasowski, C.2    Paladini, A.C.3    Marder, M.4
  • 20
    • 0025368727 scopus 로고
    • Characterisation of the phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze
    • File S.E., Mabbutt P.S., and Hitchcott P.K. Characterisation of the phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze. Psychopharmacology (Berlin) 102 1 (1990) 98-101
    • (1990) Psychopharmacology (Berlin) , vol.102 , Issue.1 , pp. 98-101
    • File, S.E.1    Mabbutt, P.S.2    Hitchcott, P.K.3
  • 22
    • 0038384131 scopus 로고    scopus 로고
    • Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects
    • Glass J.R., Sproule B.A., Herrmann N., Streiner D., and Busto U.E. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J. Clin. Psychopharmacol. 23 3 (2003) 260-268
    • (2003) J. Clin. Psychopharmacol. , vol.23 , Issue.3 , pp. 260-268
    • Glass, J.R.1    Sproule, B.A.2    Herrmann, N.3    Streiner, D.4    Busto, U.E.5
  • 23
    • 13444301320 scopus 로고    scopus 로고
    • Anxiolytic-like action in mice treated with nitrous oxide and oral triazolam or diazepam
    • Gries D.A., Condouris G.A., Shey Z., and Houpt M. Anxiolytic-like action in mice treated with nitrous oxide and oral triazolam or diazepam. Life Sci. 76 15 (2005) 1667-1674
    • (2005) Life Sci. , vol.76 , Issue.15 , pp. 1667-1674
    • Gries, D.A.1    Condouris, G.A.2    Shey, Z.3    Houpt, M.4
  • 24
    • 19144363905 scopus 로고    scopus 로고
    • In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
    • Gurley B.J., Gardner S.F., Hubbard M.A., Williams D.K., Gentry W.B., Khan I.A., and Shah A. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin. Pharmacol. Ther. 77 5 (2005) 415-426
    • (2005) Clin. Pharmacol. Ther. , vol.77 , Issue.5 , pp. 415-426
    • Gurley, B.J.1    Gardner, S.F.2    Hubbard, M.A.3    Williams, D.K.4    Gentry, W.B.5    Khan, I.A.6    Shah, A.7
  • 25
    • 2442639941 scopus 로고    scopus 로고
    • Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers
    • Gutierrez S., Ang-Lee M.K., Walker D.J., and Zacny J.P. Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. Pharmacol. Biochem. Behav. 78 1 (2004) 57-64
    • (2004) Pharmacol. Biochem. Behav. , vol.78 , Issue.1 , pp. 57-64
    • Gutierrez, S.1    Ang-Lee, M.K.2    Walker, D.J.3    Zacny, J.P.4
  • 26
    • 58149421999 scopus 로고
    • Emotional behavior in the rat: I. Defecation and urination as measures of individual differences in emotionality
    • Hall C.S. Emotional behavior in the rat: I. Defecation and urination as measures of individual differences in emotionality. J. Comp. Psychol. 18 (1934) 385-403
    • (1934) J. Comp. Psychol. , vol.18 , pp. 385-403
    • Hall, C.S.1
  • 27
    • 0346339683 scopus 로고    scopus 로고
    • Comparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers
    • Hallam K.T., Olver J.S., McGrath C., and Norman T.R. Comparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers. Hum. Psychopharmacol. 18 8 (2003) 619-625
    • (2003) Hum. Psychopharmacol. , vol.18 , Issue.8 , pp. 619-625
    • Hallam, K.T.1    Olver, J.S.2    McGrath, C.3    Norman, T.R.4
  • 28
    • 0019425493 scopus 로고
    • Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis
    • Hendriks H., Bos R., Allersma D.P., Malingre T.M., and Koster A.S. Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis. Planta Med. 42 1 (1981) 62-68
    • (1981) Planta Med. , vol.42 , Issue.1 , pp. 62-68
    • Hendriks, H.1    Bos, R.2    Allersma, D.P.3    Malingre, T.M.4    Koster, A.S.5
  • 29
    • 37549036017 scopus 로고    scopus 로고
    • Hiller, K.O., Kato, G., 1996. Anxiolytic Activity of Psychotropric Plant Extracts. I. Test of Ethanolic Valeriana Extract STEI Val. Posterpräsentation: 44th Annual Congress of the Society for Medical Plant Research 1996.
  • 30
    • 0029868613 scopus 로고    scopus 로고
    • Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties
    • Hiller K.O., and Zetler G. Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties. Phytother. Res. 10 (1996) 145-151
    • (1996) Phytother. Res. , vol.10 , pp. 145-151
    • Hiller, K.O.1    Zetler, G.2
  • 31
    • 0031758868 scopus 로고    scopus 로고
    • The inhibition of lidocaine metabolism by various barbiturates in rat hepatic microsome
    • Kakinohana M., Taira Y., Kakinohana O., and Okuda Y. The inhibition of lidocaine metabolism by various barbiturates in rat hepatic microsome. Masui 47 11 (1998) 1302-1310
    • (1998) Masui , vol.47 , Issue.11 , pp. 1302-1310
    • Kakinohana, M.1    Taira, Y.2    Kakinohana, O.3    Okuda, Y.4
  • 32
    • 0021198667 scopus 로고
    • Moderne Baldriantherapie gegen nervöse Störungen
    • Kamm-Kohl A.V., and Jansen W. Moderne Baldriantherapie gegen nervöse Störungen. Die Med. Welt 35 (1984) 1450-1454
    • (1984) Die Med. Welt , vol.35 , pp. 1450-1454
    • Kamm-Kohl, A.V.1    Jansen, W.2
  • 34
    • 0032735879 scopus 로고    scopus 로고
    • The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers
    • Kuhlmann J., Berger W., Podzuweit H., and Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 32 6 (1999) 235-241
    • (1999) Pharmacopsychiatry , vol.32 , Issue.6 , pp. 235-241
    • Kuhlmann, J.1    Berger, W.2    Podzuweit, H.3    Schmidt, U.4
  • 35
    • 0019992625 scopus 로고
    • Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man
    • Leathwood P.D., Chauffard F., Heck E., and Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol. Biochem. Behav. 17 1 (1982) 65-71
    • (1982) Pharmacol. Biochem. Behav. , vol.17 , Issue.1 , pp. 65-71
    • Leathwood, P.D.1    Chauffard, F.2    Heck, E.3    Munoz-Box, R.4
  • 36
    • 0027193526 scopus 로고
    • Characterisation of the central nervous depressant activity of a commercially available valerian root extract
    • Leuschner J., Muller J., and Rudmann M. Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittelforschung 43 6 (1993) 638-641
    • (1993) Arzneimittelforschung , vol.43 , Issue.6 , pp. 638-641
    • Leuschner, J.1    Muller, J.2    Rudmann, M.3
  • 37
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berlin) 92 2 (1987) 180-185
    • (1987) Psychopharmacology (Berlin) , vol.92 , Issue.2 , pp. 180-185
    • Lister, R.G.1
  • 38
    • 18044395502 scopus 로고    scopus 로고
    • Participation of adenosine system in the ketamine-induced motor activity in mice
    • Mandryk M., Fidecka S., Poleszak E., and Malec D. Participation of adenosine system in the ketamine-induced motor activity in mice. Pharmacol. Rep. 57 1 (2005) 55-60
    • (2005) Pharmacol. Rep. , vol.57 , Issue.1 , pp. 55-60
    • Mandryk, M.1    Fidecka, S.2    Poleszak, E.3    Malec, D.4
  • 40
    • 0027514880 scopus 로고
    • In vitro study on the interaction of extracts and pure compounds from Valeriana officinalis roots with GABA, benzodiazepine and barbiturate receptors in rat brain
    • Mennini T., and Bernasconi P. In vitro study on the interaction of extracts and pure compounds from Valeriana officinalis roots with GABA, benzodiazepine and barbiturate receptors in rat brain. Fitoterapia 64 4 (1993) 291-300
    • (1993) Fitoterapia , vol.64 , Issue.4 , pp. 291-300
    • Mennini, T.1    Bernasconi, P.2
  • 41
    • 0037031791 scopus 로고    scopus 로고
    • Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors
    • Müller C.E., Schumacher B., Brattstrom A., Abourashed E.A., and Koetter U. Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors. Life Sci. 71 16 (2002) 1939-1949
    • (2002) Life Sci. , vol.71 , Issue.16 , pp. 1939-1949
    • Müller, C.E.1    Schumacher, B.2    Brattstrom, A.3    Abourashed, E.A.4    Koetter, U.5
  • 42
    • 0032589593 scopus 로고    scopus 로고
    • Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release
    • Ortiz J.G., Nieves-Natal J., and Chavez P. Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release. Neurochem. Res. 24 11 (1999) 1373-1378
    • (1999) Neurochem. Res. , vol.24 , Issue.11 , pp. 1373-1378
    • Ortiz, J.G.1    Nieves-Natal, J.2    Chavez, P.3
  • 43
    • 33748784053 scopus 로고    scopus 로고
    • Commercial valerian interactions with [(3)H]Flunitrazepam and [(3)H]MK-801 binding to rat synaptic membranes
    • Ortiz J.G., Rassi N., Maldonado P.M., Gonzalez-Cabrera S., and Ramos I. Commercial valerian interactions with [(3)H]Flunitrazepam and [(3)H]MK-801 binding to rat synaptic membranes. Phytother. Res. (2006)
    • (2006) Phytother. Res.
    • Ortiz, J.G.1    Rassi, N.2    Maldonado, P.M.3    Gonzalez-Cabrera, S.4    Ramos, I.5
  • 44
    • 22444445952 scopus 로고    scopus 로고
    • Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds
    • Patterson J.P., Markgraf C.G., Cirino M., and Bass A.S. Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds. J. Pharmacol. Toxicol. Methods 52 1 (2005) 159-167
    • (2005) J. Pharmacol. Toxicol. Methods , vol.52 , Issue.1 , pp. 159-167
    • Patterson, J.P.1    Markgraf, C.G.2    Cirino, M.3    Bass, A.S.4
  • 45
    • 0022374863 scopus 로고
    • Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow S., Chopin P., File S.E., and Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14 3 (1985) 149-167
    • (1985) J. Neurosci. Methods , vol.14 , Issue.3 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 46
    • 0017618768 scopus 로고
    • Depression: a new animal model sensitive to antidepressant treatments
    • Porsolt R.D., Le Pichon M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 5604 (1977) 730-732
    • (1977) Nature , vol.266 , Issue.5604 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 47
    • 0018268297 scopus 로고
    • Behavioural despair in rats: a new model sensitive to antidepressant treatments
    • Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 4 (1978) 379-391
    • (1978) Eur. J. Pharmacol. , vol.47 , Issue.4 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3    Jalfre, M.4
  • 48
    • 0020357403 scopus 로고
    • Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives
    • Riedel E., Hansel R., and Ehrke G. Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives. Planta Med. 46 4 (1982) 219-220
    • (1982) Planta Med. , vol.46 , Issue.4 , pp. 219-220
    • Riedel, E.1    Hansel, R.2    Ehrke, G.3
  • 49
    • 0028365501 scopus 로고
    • An aqueous extract of valerian influences the transport of GABA in synaptosomes
    • Santos M.S., Ferreira F., Cunha A.P., Carvalho A.P., and Macedo T. An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Med. 60 3 (1994) 278-279
    • (1994) Planta Med. , vol.60 , Issue.3 , pp. 278-279
    • Santos, M.S.1    Ferreira, F.2    Cunha, A.P.3    Carvalho, A.P.4    Macedo, T.5
  • 51
    • 0028063798 scopus 로고
    • The amount of GABA present in aqueous extracts of valerian is sufficient to account for [3H]GABA release in synaptosomes
    • Santos M.S., Ferreira F., Faro C., Pires E., Carvalho A.P., Cunha A.P., and Macedo T. The amount of GABA present in aqueous extracts of valerian is sufficient to account for [3H]GABA release in synaptosomes. Planta Med. 60 5 (1994) 475-476
    • (1994) Planta Med. , vol.60 , Issue.5 , pp. 475-476
    • Santos, M.S.1    Ferreira, F.2    Faro, C.3    Pires, E.4    Carvalho, A.P.5    Cunha, A.P.6    Macedo, T.7
  • 52
    • 0028887826 scopus 로고
    • Mental comorbidity of chronic insomnia in general practice attenders using DSM-III-R
    • Schramm E., Hohagen F., Kappler C., Grasshoff U., and Berger M. Mental comorbidity of chronic insomnia in general practice attenders using DSM-III-R. Acta Psychiatr. Scand. 91 1 (1995) 10-17
    • (1995) Acta Psychiatr. Scand. , vol.91 , Issue.1 , pp. 10-17
    • Schramm, E.1    Hohagen, F.2    Kappler, C.3    Grasshoff, U.4    Berger, M.5
  • 53
    • 0001242852 scopus 로고    scopus 로고
    • The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam
    • Schulz H., Jobert M., and Hübner W.D. The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam. Phytomedicine 5 6 (1998) 449-458
    • (1998) Phytomedicine , vol.5 , Issue.6 , pp. 449-458
    • Schulz, H.1    Jobert, M.2    Hübner, W.D.3
  • 55
    • 0036773110 scopus 로고    scopus 로고
    • Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors
    • Schumacher B., Scholle S., Holzl J., Khudeir N., Hess S., and Muller C.E. Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. J. Nat. Prod. 65 10 (2002) 1479-1485
    • (2002) J. Nat. Prod. , vol.65 , Issue.10 , pp. 1479-1485
    • Schumacher, B.1    Scholle, S.2    Holzl, J.3    Khudeir, N.4    Hess, S.5    Muller, C.E.6
  • 56
    • 21644432648 scopus 로고    scopus 로고
    • Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats
    • Shinomiya K., Fujimura K., Kim Y., and Kamei C. Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. Acta Med. Okayama 59 3 (2005) 89-92
    • (2005) Acta Med. Okayama , vol.59 , Issue.3 , pp. 89-92
    • Shinomiya, K.1    Fujimura, K.2    Kim, Y.3    Kamei, C.4
  • 57
    • 23644435580 scopus 로고    scopus 로고
    • Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort
    • Simmen U., Saladin C., Kaufmann P., Poddar M., Wallimann C., and Schaffner W. Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort. Planta Med. 71 7 (2005) 592-598
    • (2005) Planta Med. , vol.71 , Issue.7 , pp. 592-598
    • Simmen, U.1    Saladin, C.2    Kaufmann, P.3    Poddar, M.4    Wallimann, C.5    Schaffner, W.6
  • 58
    • 0029820971 scopus 로고    scopus 로고
    • Therapie von Insomnien-Wirksamkeit und Verträglichkeit eines Baldrianpräparats
    • Vorbach E.U., Görteleyer R., and Brüning J. Therapie von Insomnien-Wirksamkeit und Verträglichkeit eines Baldrianpräparats. Psychopharmakotherapie 3 3 (1996) 109-115
    • (1996) Psychopharmakotherapie , vol.3 , Issue.3 , pp. 109-115
    • Vorbach, E.U.1    Görteleyer, R.2    Brüning, J.3
  • 59
    • 0019046221 scopus 로고
    • Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products
    • (authors's translation)
    • Wagner H., Jurcic K., and Schaette R. Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products. Planta Med. 39 4 (1980) 358-365 (authors's translation)
    • (1980) Planta Med. , vol.39 , Issue.4 , pp. 358-365
    • Wagner, H.1    Jurcic, K.2    Schaette, R.3
  • 60
    • 0036775629 scopus 로고    scopus 로고
    • Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii
    • Wasowski C., Marder M., Viola H., Medina J.H., and Paladini A.C. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii. Planta Med. 68 10 (2002) 934-936
    • (2002) Planta Med. , vol.68 , Issue.10 , pp. 934-936
    • Wasowski, C.1    Marder, M.2    Viola, H.3    Medina, J.H.4    Paladini, A.C.5
  • 61
    • 1642541871 scopus 로고    scopus 로고
    • The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity
    • Table of contents
    • Yuan C.S., Mehendale S., Xiao Y., Aung H.H., Xie J.T., and Ang-Lee M.K. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth. Analg. 98 2 (2004) 353-358 Table of contents
    • (2004) Anesth. Analg. , vol.98 , Issue.2 , pp. 353-358
    • Yuan, C.S.1    Mehendale, S.2    Xiao, Y.3    Aung, H.H.4    Xie, J.T.5    Ang-Lee, M.K.6
  • 62
    • 0013224306 scopus 로고    scopus 로고
    • Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia - a randomized, double-blind, comparative clinical study
    • Ziegler G., Ploch M., Miettinen-Baumann A., and Collet W. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia - a randomized, double-blind, comparative clinical study. Eur. J. Med. Res. 7 11 (2002) 480-486
    • (2002) Eur. J. Med. Res. , vol.7 , Issue.11 , pp. 480-486
    • Ziegler, G.1    Ploch, M.2    Miettinen-Baumann, A.3    Collet, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.