WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2563-2568

  Hammarstedt, Ann ^a   Hedjazifar, Shahram ^a   Jenndahl, Lachmi ^a   Gogg, Silvia ^a   Grun̈berg, John ^a   Gustafson, Birgit ^a   Klimcakova, Eva ^b   Stich, Vladimir ^b   Langin, Dominique ^c,d   Laakso, Markku ^e   Smith, Ulf ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Université de Toulouse   (France)

^d TOULOUSE UNIVERSITY HOSPITAL   (France)

^e KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adipogenesis; Mesenchymal stem cells

Indexed keywords

ADIPONECTIN; BONE MORPHOGENETIC PROTEIN 4; CYCLIN D1; GLUCOSE TRANSPORTER 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; UNCLASSIFIED DRUG; WNT1 INDUCIBLE SIGNALING PATHWAY PROTEIN 1;

ABDOMINAL OBESITY; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; METABOLIC SYNDROME X; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CCN INTERCELLULAR SIGNALING PROTEINS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MESENCHYMAL STROMAL CELLS; MICE; MICROSCOPY, FLUORESCENCE; NIH 3T3 CELLS; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; TRANSCRIPTION FACTORS;

EID: 84873712772     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211255110     Document Type: Article

References (37)

1. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414(6865):782-787. (Pubitemid 34000780)
2. Stefan N, et al. (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168(15):1609-1616.
3. Marini MA, et al. (2007) Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 30(8):2145-2147. (Pubitemid 47219439)
4. Smith U, Hammarstedt A (2010) Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity. Biochim Biophys Acta 1801(3):377-380.
5. Weisberg SP, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112(12):1796-1808. (Pubitemid 38063703)
6. Nishimura S, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15(8):914-920.
7. Isakson P, Hammarstedt A, Gustafson B, Smith U (2009) Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 58(7):1550-1557.
8. Arner E, et al. (2010) Adipocyte turnover: Relevance to human adipose tissue morphology. Diabetes 59(1):105-109.
9. Jansson PA, et al. (2003) A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J 17(11):1434-1440.
10. Spalding KL, et al. (2008) Dynamics of fat cell turnover in humans. Nature 453(7196):783-787. (Pubitemid 351793777)
11. Gavrilova O, et al. (2000) Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105(3):271-278. (Pubitemid 30094446)
12. Kim JY, et al. (2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117(9):2621-2637.
13. Després JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444(7121):881-887.
14. Vidal-Puig A, Unger RH (2010) Special issue on lipotoxicity. Biochim Biophys Acta 1801 (3):207-208.
15. Chandalia M, et al. (2007) Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS ONE 2(8):e812.
16. Anand SS, et al. (2011) Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE). PLoS ONE 6(7):e22112.
17. Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A (2009) Adipogenesis and WNT signalling. Trends Endocrinol Metab 20(1):16-24.
18. Ross SE, et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289(5481):950-953. (Pubitemid 30659947)
19. Gustafson B, Smith U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281(14):9507-9516. (Pubitemid 43864668)
20. Cawthorn WP, Heyd F, Hegyi K, Sethi JK (2007) Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ 14(7):1361-1373. (Pubitemid 46965265)
21. Gustafson B, Smith U (2010) Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance. J Biol Chem 285(18):14031-14041.
22. Tang QQ, Otto TC, Lane MD (2004) Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 101(26):9607-9611. (Pubitemid 38869283)
23. Bowers RR, Lane MD (2007) A role for bone morphogenetic protein-4 in adipocyte development. Cell Cycle 6(4):385-389. (Pubitemid 46393437)
24. Gupta RK, et al. (2010) Transcriptional control of preadipocyte determination by Zfp423. Nature 464(7288):619-623.
25. Waki H, et al. (2007) The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5(5):357-370. (Pubitemid 46667757)
26. Choi JH, et al. (2010) Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 466(7305):451-456.
27. Carvalho E, Jansson PA, Nagaev I, Wenthzel AM, Smith U (2001) Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J 15(6):1101-1103.
28. Arner P, Arner E, Hammarstedt A, Smith U (2011) Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS ONE 6(4):e18284.
29. Grant SF, et al. (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38(3):320-323.
30. MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell 17(1):9-26.
31. Gustafson B, Smith U (2012) The WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans. Diabetes 61(5):1217-1224.
32. Gustafson B, Eliasson B, Smith U (2010) Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: A link with osteogenesis. Diabetologia 53(3):536-540.
33. Liu J, Wang H, Zuo Y, Farmer SR (2006) Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol Cell Biol 26(15):5827-5837. (Pubitemid 44134337)
34. Liu H, et al. (2011) Wnt signaling regulates hepatic metabolism. Sci Signal 4(158):ra6.
35. Inadera H, Shimomura A, Tachibana S (2009) Effect of Wnt-1 inducible signaling pathway protein-2 (WISP-2/CCN5), a downstream protein of Wnt signaling, on adipocyte differentiation. Biochem Biophys Res Commun 379(4):969-974.
36. Lehr S, et al. (2012) Identification and validation of novel adipokines released from primary human adipocytes. Mol Cell Proteomics 11(1):M111.010504.
37. Sabbah M, et al. (2011) CCN5, a novel transcriptional repressor of the transforming growth factor β signaling pathway. Mol Cell Biol 31(7):1459-1469.