The WNT inhibitor dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans

Diabetes

Volumn 61, Issue 5, 2012, Pages 1217-1224

  Gustafson D, Birgit ^a   Smith, Ulf ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CD14 ANTIGEN; CD31 ANTIGEN; CD45 ANTIGEN; DICKKOPF 1 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NOGGIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; WNT PROTEIN;

ADIPOGENESIS; ADIPOSE TISSUE CELL; ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC OBESITY; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; SUBCUTANEOUS TISSUE; WESTERN BLOTTING;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADULT; AGED; ANIMALS; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; HUMANS; HYPERTROPHY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; MIDDLE AGED; OBESITY; PPAR GAMMA; WNT PROTEINS; YOUNG ADULT;

EID: 84860591046     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1419     Document Type: Article

References (36)

1. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008;453:783-787 (Pubitemid 351793777)
2. Arner E, Westermark PO, Spalding KL, et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 2010;59:105-109
3. Arner P, Arner E, Hammarstedt A, Smith U. Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS ONE 2011;6:e18284
4. Jansson PA, Pellmé F, Hammarstedt A, et al. A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J 2003;17:1434-1440 (Pubitemid 36935658)
5. Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 1997;94: 4171-4175 (Pubitemid 27180518)
6. Isakson P, Hammarstedt A, Gustafson B, Smith U. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 2009;58:1550-1557
7. Bowers RR, Lane MD. Wnt signaling and adipocyte lineage commitment. Cell Cycle 2008;7:1191-1196 (Pubitemid 351749272)
8. Krishnan V, Bryant HU, Macdougald OA. Regulation of bone mass by Wnt signaling. J Clin Invest 2006;116:1202-1209
9. Otto TC, Lane MD. Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Biol 2005;40:229-242 (Pubitemid 41140883)
10. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79:1147-1156
11. Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003;116:2627-2634 (Pubitemid 36857216)
12. Bennett CN, Ross SE, Longo KA, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem 2002;277:30998-31004 (Pubitemid 34970803)
13. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 2008;121:737-746 (Pubitemid 351578109)
14. Abdallah BM, Kassem M. New factors controlling the balance between osteoblastogenesis and adipogenesis. Bone 2012;50:540-545
15. Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 2008;283:23371-23375
16. Park JR, Jung JW, Lee YS, Kang KS. The roles of Wnt antagonists Dkk1 and sFRP4 during adipogenesis of human adipose tissue-derived mesenchymal stem cells. Cell Prolif 2008;41:859-874
17. Christodoulides C, Laudes M, Cawthorn WP, et al. The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. J Cell Sci 2006;119:2613-2620 (Pubitemid 44070442)
18. Gustafson B, Smith U. Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases betacatenin levels and leads to cell dedifferentiation and insulin resistance. J Biol Chem 2010;285:14031-14041
19. Gustafson B, Eliasson B, Smith U. Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis. Diabetologia 2010;53:536-540
20. Bowers RR, Kim JW, Otto TC, Lane MD. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene. Proc Natl Acad Sci U S A 2006;103:13022-13027 (Pubitemid 44338910)
21. Ahrens M, Ankenbauer T, Schröder D, Hollnagel A, Mayer H, Gross G. Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA Cell Biol 1993;12:871-880 (Pubitemid 24293712)
22. Tang QQ, Otto TC, Lane MD. Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A 2004;101:9607-9611 (Pubitemid 38869283)
23. Böttcher Y, Unbehauen H, Klöting N, et al. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes 2009;58:2119-2128
24. Chen D, Ji X, Harris MA, et al. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 1998;142:295-305 (Pubitemid 28341159)
25. Schleinitz D, Klöting N, Böttcher Y, et al. Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity. PLoS ONE 2011;6:e16155
26. Zaragosi LE, Wdziekonski B, Villageois P, et al. Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes 2010;59:2513-2521
27. Tang QQ, Lane MD. Activation and centromeric localization of CCAAT/ enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev 1999;13:2231-2241 (Pubitemid 29426728)
28. Gustafson B, Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006;281:9507-9516 (Pubitemid 43864668)
29. Taipaleenmäki H, Abdallah BM, AlDahmash A, Säämänen AM, Kassem M. Wnt signalling mediates the cross-talk between bone marrow derived preadipocytic and pre-osteoblastic cell populations. Exp Cell Res 2011;317: 745-756
30. Bowers RR, Lane MD. A role for bone morphogenetic protein-4 in adipocyte development. Cell Cycle 2007;6:385-389 (Pubitemid 46393437)
31. Lönn M, Mehlig K, Bengtsson C, Lissner L. Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 2010;24:326-331
32. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 2000;43: 1498-1506 (Pubitemid 32734855)
33. Kim JY, van de Wall E, Laplante M, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007;117:2621-2637 (Pubitemid 47494363)
34. Speliotes EK, Willer CJ, Berndt SI, et al.; MAGIC; Procardis Consortium. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010;42:937-948
35. Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006;38:320-323
36. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808 (Pubitemid 38063703)