Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase

Journal of Medicinal Chemistry

Volumn 54, Issue 18, 2011, Pages 6399-6403

  Xue, Fengtian ^a   Kraus, James M ^a   Labby, Kristin Jansen ^a   Ji, Haitao ^a   Mataka, Jan ^a   Xia, Guoyao ^a   Li, Huiying ^b   Delker, Silvia L ^b   Roman, Linda J ^c   Martásek, Pavel ^c,d   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

6 [(4 (2 ((2,2 DIFLUORO 2 (3 FLUOROPHENYL)ETHYL) AMINO)ETHOXY)PYRROLIDIN 3 YL)METHYL]4 METHYLPYRIDIN 2 AMINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORINE; MOLECULAR SCAFFOLD; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SYNTHESIS;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN BINDING; PYRROLIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052814470     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200411j     Document Type: Article

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