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Volumn 15, Issue 1, 2007, Pages 142-159

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder

Author keywords

FSAD; Glutaramides; NEP; Neutral endopeptidase

Indexed keywords

4 CHLOROPHENPROPYLAMIDE; CANDOXATRILAT; ENKEPHALINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 33751096990     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.002     Document Type: Article
Times cited : (16)

References (29)
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    • Presented in part at the RSC-SCI Medicinal Chemistry Conference, Cambridge, UK, September 2005.
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    • 33751093472 scopus 로고    scopus 로고
    • Presented in part at the SMR Conference, London, UK, December 2005.
  • 11
    • 33751091888 scopus 로고    scopus 로고
    • Barber, C. G.; Cook, A. S.; Maw, G. N.; Pryde, D. C.; Stobie, A. World Patent Application, WO2002002513, 2002, 169 pp.
  • 12
    • 33751098930 scopus 로고    scopus 로고
    • Barnish, I. T.; James, K.; Terrett, N. K.; Danilewicz, J. C.; Samuels, G. M. R.; Wythes, M. J. European Patent Application, EP 274234, 1988, 119 pp.
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    • note
    • A fuller exploration of the in vitro and in vivo metabolism of these compounds will be disclosed in due course.
  • 21
    • 33751081678 scopus 로고    scopus 로고
    • note
    • It is most likely that carboxylic acids will be absorbed high up in the GI tract, where the pH is still quite low, and certainly lower than neutral pH. Repeating the Caco-2 flux experiment with S-19 at pH 6.5 gives a higher flux value of around 5, more in keeping with the observed in vivo absorption.
  • 23
    • 0003099766 scopus 로고    scopus 로고
    • Transporters for Bile Acids and Organic Anions
    • Amidon G., and Sadee W. (Eds), Plenum Publishing, New York
    • Suzuki H., and Sugiyama Y. Transporters for Bile Acids and Organic Anions. In: Amidon G., and Sadee W. (Eds). Membrane Transporters as Drug Targets (1999), Plenum Publishing, New York
    • (1999) Membrane Transporters as Drug Targets
    • Suzuki, H.1    Sugiyama, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.