Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1279-1284

  Paulsen, Janet L ^a   Viswanathan, Kishore ^a   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Antifolate; DHFR; Molecular dynamics; Protein flexibility; X ray crystallography

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; LIGAND; PHENYLALANINE; THREONINE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; FUNGAL STRAIN; HUMAN; IC 50; MOLECULAR DYNAMICS; MOLECULAR PROBE; NONHUMAN;

AMINO ACID SEQUENCE; CANDIDA; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA;

EID: 84873707989     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.008     Document Type: Article

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