In vitro biological activity and structural analysis of 2,4-diamino-5-(2′-arylpropargyl)pyrimidine inhibitors of Candida albicans

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 4866-4872

  Paulsen, Janet L ^a   Liu, Jieying ^a   Bolstad, David B ^a   Smith, Adrienne E ^b   Priestley, Nigel D ^b   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF MONTANA   (United States)

Author keywords

Antifolate; Candida albicans; Dihydrofolate reductase; Molecular modeling

Indexed keywords

AMPHOTERICIN; DIHYDROFOLATE REDUCTASE INHIBITOR; KETOCONAZOLE; PYRIMIDINE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDA GLABRATA; CELL LINE; CELL SURVIVAL; FOLIC ACID ANTAGONISTS; FUNGAL PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARGYLINE; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE;

CANDIDA; CANDIDA ALBICANS; MAMMALIA;

EID: 67650067461     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.021     Document Type: Article

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