Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors

Chemical Biology and Drug Design

Volumn 73, Issue 1, 2009, Pages 62-74

  Liu, Jieying ^a   Bolstad, David B ^a   Smith, Adrienne E ^b   Priestley, Nigel D ^b   Wright, Dennis L ^a   Anderson, Amy C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF MONTANA   (United States)

Author keywords

Antifolate; Candida glabrata; Crystallography; Dihydrofolate reductase; Structure based drug design

Indexed keywords

2,4 DIAMINO 5 [3 [3 METHOXY 5 (4 METHOXYPHENYL)PHENYL]BUT 1 YNYL] 6 METHYLPYRIMIDINE; AMPHOTERICIN; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; FUNGAL ENZYME; KETOCONAZOLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA GLABRATA; CANDIDIASIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; CANDIDA GLABRATA; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FUNGAL PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

CANDIDA GLABRATA;

EID: 58149083887     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00745.x     Document Type: Article

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