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Volumn 38, Issue 1, 2013, Pages 135-147

Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: An in vitro model study

Author keywords

Agarose; cartilage; chondroprotective; in vitro models; osteoarthritis; Raloxifene

Indexed keywords

AGGRECAN; ALKALINE PHOSPHATASE; CASPASE 3; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGENASE 3; GELATINASE A; MESSENGER RNA; RALOXIFENE; STROMELYSIN;

EID: 84873706380     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-012-9282-7     Document Type: Article
Times cited : (19)

References (53)
  • 1
    • 0035677833 scopus 로고    scopus 로고
    • Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology
    • 11762938 10.1002/1529-0131(200112)44:12<2777: AID-ART465>3.0.CO;2-H 1:CAS:528:DC%2BD38XislClsg%3D%3D
    • Aigner T, Zien A, Gehrsitz A, Gebhard PM and McKenna L 2001 Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum. 44 2777-2789
    • (2001) Arthritis Rheum. , vol.44 , pp. 2777-2789
    • Aigner, T.1    Zien, A.2    Gehrsitz, A.3    Gebhard, P.M.4    McKenna, L.5
  • 2
    • 84873717193 scopus 로고    scopus 로고
    • A significant improvement of womac and lequesne indexes after treatment with raloxifene in women with knee osteoarthritis [abstract]
    • Badurski JE, Daniluk S, Dobrenko A, Nowak NA, Jeziernicka EZ and Holiczer W 2005 A significant improvement of womac and lequesne indexes after treatment with raloxifene in women with knee osteoarthritis [abstract]. Osteoarthritis Cartilage 13 (Suppl 1) S82
    • (2005) Osteoarthritis Cartilage , vol.13 , Issue.SUPPL. 1 , pp. 82
    • Badurski, J.E.1    Daniluk, S.2    Dobrenko, A.3    Nowak, N.A.4    Jeziernicka, E.Z.5    Holiczer, W.6
  • 4
    • 34548140154 scopus 로고    scopus 로고
    • Raloxifene inhibits matrix metalloproteinases expression and activity in macrophages and smooth muscle cells
    • 17582780 10.1016/j.phrs.2007.05.004 1:CAS:528:DC%2BD2sXpvF2rtLo%3D
    • Bellosta S, Baetta R, Canavesi R, Comparato C, Granata A, Monetti M, Cairoli F, Eberini I, et al. 2007 Raloxifene inhibits matrix metalloproteinases expression and activity in macrophages and smooth muscle cells. Pharmacol. Res. 56 160-167
    • (2007) Pharmacol. Res. , vol.56 , pp. 160-167
    • Bellosta, S.1    Baetta, R.2    Canavesi, R.3    Comparato, C.4    Granata, A.5    Monetti, M.6    Cairoli, F.7    Eberini, I.8
  • 5
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • 7127471 10.1016/0092-8674(82)90027-7 1:CAS:528:DyaL38XlsVanur8%3D
    • Benya PD and Shaffer JD 1982 Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30 215-224
    • (1982) Cell , vol.30 , pp. 215-224
    • Benya, P.D.1    Shaffer, J.D.2
  • 7
    • 0031886742 scopus 로고    scopus 로고
    • Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology
    • 9485086 10.1002/1529-0131(199802)41:2<284: AID-ART12>3.0.CO;2-T 1:STN:280:DyaK1c7ktlKhsg%3D%3D
    • Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ and Galdo F 1998 Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum. 41 284-289
    • (1998) Arthritis Rheum. , vol.41 , pp. 284-289
    • Blanco, F.J.1    Guitian, R.2    Vazquez-Martul, E.3    De Toro, F.J.4    Galdo, F.5
  • 8
    • 79955859547 scopus 로고    scopus 로고
    • SERMs and SERMs with estrogen for postmenopausal osteoporosis
    • 20446043 10.1007/s11154-010-9137-1 1:CAS:528:DC%2BC3MXht1eqs74%3D
    • Bolognese MA 2010 SERMs and SERMs with estrogen for postmenopausal osteoporosis. Rev. Endocr. Metab. Disord. 11 253-259
    • (2010) Rev. Endocr. Metab. Disord. , vol.11 , pp. 253-259
    • Bolognese, M.A.1
  • 9
    • 0035070732 scopus 로고    scopus 로고
    • The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I
    • 11332605 10.1016/S0736-0266(00)00004-8 1:CAS:528:DC%2BD3MXjvVChtLs%3D
    • Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR and Trippel SB 2001 The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J. Orthop. Res. 19 11-17
    • (2001) J. Orthop. Res. , vol.19 , pp. 11-17
    • Bonassar, L.J.1    Grodzinsky, A.J.2    Frank, E.H.3    Davila, S.G.4    Bhaktav, N.R.5    Trippel, S.B.6
  • 10
    • 72449205067 scopus 로고    scopus 로고
    • Proteinases involved in matrix turnover during cartilage and bone breakdown
    • 19915869 10.1007/s00441-009-0887-6 1:CAS:528:DC%2BD1MXhsVymtrfJ
    • Cawston TE and Young DA 2010 Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell Tissue Res. 339 221-235
    • (2010) Cell Tissue Res. , vol.339 , pp. 221-235
    • Cawston, T.E.1    Young, D.A.2
  • 12
    • 84860299273 scopus 로고    scopus 로고
    • Recent advances in the synthesis of raloxifene: A selective estrogen receptor modulator
    • 22405286 10.1016/j.ejmech.2012.02.021 1:CAS:528:DC%2BC38XmtlSls7c%3D
    • Dadiboyena S 2012 Recent advances in the synthesis of raloxifene: a selective estrogen receptor modulator. Eur. J. Med. Chem. 51 17-34
    • (2012) Eur. J. Med. Chem. , vol.51 , pp. 17-34
    • Dadiboyena, S.1
  • 13
    • 33746836954 scopus 로고    scopus 로고
    • Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation
    • 16697175 10.1016/j.matbio.2006.03.005
    • De Croos JNA, Dhaliwal SS, Grynpas MD, Pilliar RM and Kandel RA 2006 Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol. 25 323-331
    • (2006) Matrix Biol. , vol.25 , pp. 323-331
    • De Croos, J.N.A.1    Dhaliwal, S.S.2    Grynpas, M.D.3    Pilliar, R.M.4    Kandel, R.A.5
  • 14
    • 0015894161 scopus 로고
    • Isolation and characterization of cyanogen bromide peptides from the collagen of bovine articular cartilage
    • 4270660 1:CAS:528:DyaE3sXlt1arsLs%3D
    • Deshmukh K and Nimni ME 1973 Isolation and characterization of cyanogen bromide peptides from the collagen of bovine articular cartilage. Biochem. J. 133 615-622
    • (1973) Biochem. J. , vol.133 , pp. 615-622
    • Deshmukh, K.1    Nimni, M.E.2
  • 15
    • 33744479689 scopus 로고    scopus 로고
    • Chondrocyte gene expression in osteoarthritis: Correlation with disease severity
    • 16583443 10.1002/jor.20137
    • Eid K, Thornhill TS and Glowacki J 2006 Chondrocyte gene expression in osteoarthritis: correlation with disease severity. J. Orthop. Res. 24 1062-1068
    • (2006) J. Orthop. Res. , vol.24 , pp. 1062-1068
    • Eid, K.1    Thornhill, T.S.2    Glowacki, J.3
  • 16
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim
    • 10.1016/0304-4165(86)90306-5 1:CAS:528:DyaL28Xls1yhsrs%3D
    • Farndale RW, Buttle DJ and Barrett AJ 1986 Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim. Biophys. Acta 883 173-177
    • (1986) Biophys. Acta , vol.883 , pp. 173-177
    • Farndale, R.W.1    Buttle, D.J.2    Barrett, A.J.3
  • 17
    • 0026196246 scopus 로고
    • Localization of type X collagen in canine growth plate and adult canine articular cartilage
    • 2045975 10.1002/jor.1100090404 1:CAS:528:DyaK3MXltFWisL4%3D
    • Gannon JM, Walker G, Fischer M, Carpenter R, Thompson RC and Oegema TR 1991 Localization of type X collagen in canine growth plate and adult canine articular cartilage. J. Orthop. Res. 9 485-494
    • (1991) J. Orthop. Res. , vol.9 , pp. 485-494
    • Gannon, J.M.1    Walker, G.2    Fischer, M.3    Carpenter, R.4    Thompson, R.C.5    Oegema, T.R.6
  • 18
    • 33644673439 scopus 로고    scopus 로고
    • Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis
    • 16277677 10.1186/ar1815 1:CAS:528:DC%2BD2MXht1Wmsr7M
    • Guiducci S, Del Rosso A, Cinelli M, Perfetto F, Livi R, Rossi A, Gabrielli A, Giacomelli R, et al. 2005 Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis. Arthritis Res. Ther. 7 R1244-R1253
    • (2005) Arthritis Res. Ther. , vol.7
    • Guiducci, S.1    Del Rosso, A.2    Cinelli, M.3    Perfetto, F.4    Livi, R.5    Rossi, A.6    Gabrielli, A.7    Giacomelli, R.8
  • 19
    • 0034982488 scopus 로고    scopus 로고
    • Combination of reduced oxygen tension and intermittent hydrostatic pressure: A useful tool in articular cartilage tissue engineering
    • 11410177 10.1016/S0021-9290(01)00050-1 1:STN:280:DC%2BD3MzkslGqsw%3D%3D
    • Hansen U, Schünke M, Domm C, Ioannidis N, Hassenpflug J, Gehrke T and Kurz B 2001 Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering. J. Biomech. 34 941-949
    • (2001) J. Biomech. , vol.34 , pp. 941-949
    • Hansen, U.1    Schünke, M.2    Domm, C.3    Ioannidis, N.4    Hassenpflug, J.5    Gehrke, T.6    Kurz, B.7
  • 20
    • 0031658981 scopus 로고    scopus 로고
    • Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis
    • 9751096 10.1002/1529-0131(199809)41:9<1632: AID-ART14>3.0.CO;2-A 1:STN:280:DyaK1cvitFOitA%3D%3D
    • Hashimoto S, Ochs RL, Komiya S and Lotz M 1998 Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum. 41 1632-1638
    • (1998) Arthritis Rheum. , vol.41 , pp. 1632-1638
    • Hashimoto, S.1    Ochs, R.L.2    Komiya, S.3    Lotz, M.4
  • 21
    • 84860657505 scopus 로고    scopus 로고
    • A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes
    • 22480687 10.1016/j.bbrc.2012.03.111 1:CAS:528:DC%2BC38Xmt1agu7Y%3D
    • Hattori Y, Kojima T, Kato D, Matsubara H, Takigawa M and Ishiguro N 2012 A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes. Biochem. Biophys. Res. Commun. 421 418-424
    • (2012) Biochem. Biophys. Res. Commun. , vol.421 , pp. 418-424
    • Hattori, Y.1    Kojima, T.2    Kato, D.3    Matsubara, H.4    Takigawa, M.5    Ishiguro, N.6
  • 23
    • 33244471142 scopus 로고    scopus 로고
    • A novel terminal differentiation model of human articular chondrocytes in three dimensional cultures mimicking chondrocytic changes in osteoarthritis
    • 16448822 10.1016/j.cellbi.2005.11.009 1:CAS:528:DC%2BD28XhvVWrtL8%3D
    • Ho ML, Chang JK, Wu SC, Chung YH, Chen CH, Hung SH and Wang GJ 2006 A novel terminal differentiation model of human articular chondrocytes in three dimensional cultures mimicking chondrocytic changes in osteoarthritis. Cell Biol. Int. 30 288-294
    • (2006) Cell Biol. Int. , vol.30 , pp. 288-294
    • Ho, M.L.1    Chang, J.K.2    Wu, S.C.3    Chung, Y.H.4    Chen, C.H.5    Hung, S.H.6    Wang, G.J.7
  • 24
    • 0036145817 scopus 로고    scopus 로고
    • A multivalent assay to detect glycosaminoglycan, protein, collagen, RNA, and DNA content in milligram samples of cartilage or hydrogel-based repair cartilage
    • 11743684 10.1006/abio.2001.5436 1:CAS:528:DC%2BD3MXptVOmt7c%3D
    • Hoemann CD, Sun J, Chrzanowski V and Buschmann MD 2002 A multivalent assay to detect glycosaminoglycan, protein, collagen, RNA, and DNA content in milligram samples of cartilage or hydrogel-based repair cartilage. Anal. Biochem. 300 1-10
    • (2002) Anal. Biochem. , vol.300 , pp. 1-10
    • Hoemann, C.D.1    Sun, J.2    Chrzanowski, V.3    Buschmann, M.D.4
  • 25
    • 79953801777 scopus 로고    scopus 로고
    • Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis
    • 21442745
    • Jiang T, Petersen RR, Call G, Ofek G, Gao J and Yao JQ 2011 Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis. J. Biomed. Mater. Res. B Appl. Biomater. 97 355-363
    • (2011) J. Biomed. Mater. Res. B Appl. Biomater. , vol.97 , pp. 355-363
    • Jiang, T.1    Petersen, R.R.2    Call, G.3    Ofek, G.4    Gao, J.5    Yao, J.Q.6
  • 26
    • 35348922481 scopus 로고    scopus 로고
    • Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis
    • 17907171 10.1002/art.22873 1:CAS:528:DC%2BD2sXht12rtLnJ
    • Jochems C, Islander U, Kallkopf A, Lagerquist M, Ohlsson C and Carlsten H 2007 Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. Arthritis Rheum. 56 3261-3270
    • (2007) Arthritis Rheum. , vol.56 , pp. 3261-3270
    • Jochems, C.1    Islander, U.2    Kallkopf, A.3    Lagerquist, M.4    Ohlsson, C.5    Carlsten, H.6
  • 27
    • 81155151425 scopus 로고    scopus 로고
    • In vitro investigation and biomechanical modeling of the effects of PLF-68 on osteoarthritis in a three-dimensional model
    • 20967483 10.1007/s10237-010-0262-2
    • Kavas A, Ozdemir M, Gürses S, Keskin D and Tezcaner A 2011 In vitro investigation and biomechanical modeling of the effects of PLF-68 on osteoarthritis in a three-dimensional model. Biomech. Model. Mechanobiol. 10 641-650
    • (2011) Biomech. Model. Mechanobiol. , vol.10 , pp. 641-650
    • Kavas, A.1    Ozdemir, M.2    Gürses, S.3    Keskin, D.4    Tezcaner, A.5
  • 28
    • 0033861276 scopus 로고    scopus 로고
    • Activation of annexin II and v expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage
    • 10903884 10.1053/joca.1999.0304 1:STN:280:DC%2BD3cvisFKitw%3D%3D
    • Kirsch T, Swoboda B and Nah H 2000 Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthritis Cartilage 8 294-302
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 294-302
    • Kirsch, T.1    Swoboda, B.2    Nah, H.3
  • 29
    • 33744798189 scopus 로고    scopus 로고
    • Osteoarthritis: Cellular and molecular changes in degenerating cartilage
    • 16759941 10.1016/j.proghi.2006.02.003 1:CAS:528:DC%2BD28XnvFOht70%3D
    • Lorenz H and Richter W 2006 Osteoarthritis: Cellular and molecular changes in degenerating cartilage. Prog. Histochem. Cytochem. 40 135-163
    • (2006) Prog. Histochem. Cytochem. , vol.40 , pp. 135-163
    • Lorenz, H.1    Richter, W.2
  • 30
    • 33748779541 scopus 로고    scopus 로고
    • Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site
    • 16919424 10.1016/j.bbadis.2006.06.007 1:CAS:528:DC%2BD28XptVGmtbs%3D
    • Lu T, Achari Y, Sciore P and Hart DA 2006 Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site. Biochim. Biophys. Acta 1762 719-731
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 719-731
    • Lu, T.1    Achari, Y.2    Sciore, P.3    Hart, D.A.4
  • 31
    • 0038653361 scopus 로고    scopus 로고
    • Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies
    • 10.1159/000070573
    • Malemud CJ, Islam N and Haqqi TM 2003 Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cell. Tiss. Org. 174 34-48
    • (2003) Cell. Tiss. Org. , vol.174 , pp. 34-48
    • Malemud, C.J.1    Islam, N.2    Haqqi, T.M.3
  • 32
    • 0036451417 scopus 로고    scopus 로고
    • Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels
    • 12449765 10.1114/1.1512676
    • Mauck RL, Seyhan SL, Ateshian GA and Hung CT 2002 Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels. Ann. Biomed. Eng. 30 1046-1056
    • (2002) Ann. Biomed. Eng. , vol.30 , pp. 1046-1056
    • Mauck, R.L.1    Seyhan, S.L.2    Ateshian, G.A.3    Hung, C.T.4
  • 33
    • 0034210117 scopus 로고    scopus 로고
    • Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels
    • 10923293 10.1115/1.429656 1:STN:280:DC%2BD3M%2Fkt1WmtQ%3D%3D
    • Mauck RL, Soltz MA, Wang CCB, Wong DD, Chao PHGC, Valhmu WB, Hung CT and Ateshian GA 2000 Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J. Biomech. Eng. 122 252-260
    • (2000) J. Biomech. Eng. , vol.122 , pp. 252-260
    • Mauck, R.L.1    Soltz, M.A.2    Wang, C.C.B.3    Wong, D.D.4    Chao, P.5    Valhmu, W.B.6    Hung, C.T.7    Ateshian, G.A.8
  • 34
    • 33748475162 scopus 로고    scopus 로고
    • Delivery of dexamethasone, ascorbate, and growth factor (TGF beta-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes
    • 16949668 10.1016/j.biomaterials.2006.08.012 1:CAS:528: DC%2BD28Xpt1yjt7o%3D
    • Na K, Park JH, Sun BK, Woo DG, Chung HM and Park KH 2006 Delivery of dexamethasone, ascorbate, and growth factor (TGF beta-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes. Biomaterials 27 5951-5957
    • (2006) Biomaterials , vol.27 , pp. 5951-5957
    • Na, K.1    Park, J.H.2    Sun, B.K.3    Woo, D.G.4    Chung, H.M.5    Park, K.H.6
  • 36
    • 0025281850 scopus 로고
    • Influence of cyclic loading on the nutrition of articular cartilage
    • 2383080 10.1136/ard.49.7.536
    • O'Hara BP, Urban JP and Maroudas A 1990 Influence of cyclic loading on the nutrition of articular cartilage. Ann. Rheum. Dis. 49 536-539
    • (1990) Ann. Rheum. Dis. , vol.49 , pp. 536-539
    • O'Hara, B.P.1    Urban, J.P.2    Maroudas, A.3
  • 37
    • 0038077281 scopus 로고    scopus 로고
    • What type of cartilage repair are we attempting to attain?
    • 12721344
    • Poole AR 2003 What type of cartilage repair are we attempting to attain? J. Bone Joint Surg. Am. 85-A Suppl 2 40-44
    • (2003) J. Bone Joint Surg. Am. , vol.85 , Issue.SUPPL. 2 , pp. 40-44
    • Poole, A.R.1
  • 38
    • 0023736898 scopus 로고
    • Ultrastructural localisation of alkaline phosphatase activity in osteoarthritic human articular cartilage
    • 3178315 10.1136/ard.47.9.747 1:CAS:528:DyaL1cXlvVyhtLk%3D
    • Rees JA and Ali SY 1988 Ultrastructural localisation of alkaline phosphatase activity in osteoarthritic human articular cartilage. Ann. Rheum. Dis. 47 747-753
    • (1988) Ann. Rheum. Dis. , vol.47 , pp. 747-753
    • Rees, J.A.1    Ali, S.Y.2
  • 39
    • 0038494028 scopus 로고    scopus 로고
    • Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: A comprehensive meta-analysis
    • 12860572 10.1001/archinte.163.13.1514 1:CAS:528:DC%2BD3sXmtFGisb0%3D
    • Richy F, Bruyere O, Elthgen O, Cucherat M, Henrotin Y and Reginster JY 2003 Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch. Intern. Med. 163 1514-1522
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1514-1522
    • Richy, F.1    Bruyere, O.2    Elthgen, O.3    Cucherat, M.4    Henrotin, Y.5    Reginster, J.Y.6
  • 41
    • 0032562401 scopus 로고    scopus 로고
    • Involvement of MMP-1 and MMP-3 in collagen degradation induced by IL-1 in rabbit cartilage explants culture
    • 1:STN:280:DyaK1c3ovVGqsQ%3D%3D
    • Saito S, Katoh M, Masumoto M, Matsumoto S and Macho Y 1998 Involvement of MMP-1 and MMP-3 in collagen degradation induced by IL-1 in rabbit cartilage explants culture. Life Sci. 62 359-365
    • (1998) Life Sci. , vol.62 , pp. 359-365
    • Saito, S.1    Katoh, M.2    Masumoto, M.3    Matsumoto, S.4    MacHo, Y.5
  • 42
    • 0035076295 scopus 로고    scopus 로고
    • Articular cartilage and changes in arthritis. An introduction: Cell biology of osteoarthritis
    • 11178118 10.1186/ar148 1:CAS:528:DC%2BD3MXhsValtLw%3D
    • Sandell LJ and Aigner T 2001 Articular cartilage and changes in arthritis. An introduction: Cell biology of osteoarthritis. Arthritis Res. 3 107-113
    • (2001) Arthritis Res. , vol.3 , pp. 107-113
    • Sandell, L.J.1    Aigner, T.2
  • 43
    • 0030014349 scopus 로고    scopus 로고
    • Activation of human progelatinase A by collagenase and matrilysin: Activation of procollagenase by matrilysin
    • 8804571 10.1007/BF01887112 1:CAS:528:DyaK28Xjs1Kns7w%3D
    • Sang QA, Bodden MK and Windson LJ 1996 Activation of human progelatinase A by collagenase and matrilysin: activation of procollagenase by matrilysin. J. Protein Chem. 15 243-253
    • (1996) J. Protein Chem. , vol.15 , pp. 243-253
    • Sang, Q.A.1    Bodden, M.K.2    Windson, L.J.3
  • 44
    • 33845921785 scopus 로고    scopus 로고
    • Differential effects of cyclic and static pressure on biochemical and morphological properties of chondrocytes from articular cartilage
    • 10.1016/j.clinbiomech.2006.09.008
    • Sharma G, Saxena RK and Mishra P 2007 Differential effects of cyclic and static pressure on biochemical and morphological properties of chondrocytes from articular cartilage. Clin. Biomech. 22 248-255
    • (2007) Clin. Biomech. , vol.22 , pp. 248-255
    • Sharma, G.1    Saxena, R.K.2    Mishra, P.3
  • 45
    • 42149112853 scopus 로고    scopus 로고
    • Animal models for osteoarthritis: The effect of ovariectomy and estrogen treatment- A systematic approach
    • 10.1016/j.joca.2008.01.002
    • Snikers YH, Weinans H, Bierma-Zeinstra SM, van Leuwen JP, van Osch GJ 2008 Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment- a systematic approach. Osteoarthritis Cartilage 16 533-541
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 533-541
    • Snikers, Y.H.1    Weinans, H.2    Bierma-Zeinstra, S.M.3    Van Leuwen, J.P.4    Van Osch, G.J.5
  • 47
    • 80054722398 scopus 로고    scopus 로고
    • Raloxifene protects cultured human chondrocytes from IL-1beta induced damage: A biochemical and morphological study
    • 21920358 10.1016/j.ejphar.2011.08.027 1:CAS:528:DC%2BC3MXhtlejur3E
    • Tinti L, Niccolini S, Lamboglia A, Pascarelli NA, Cervone R and Fioravanti A 2011 Raloxifene protects cultured human chondrocytes from IL-1beta induced damage: a biochemical and morphological study. Eur. J. Pharmacol. 670 67-73
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 67-73
    • Tinti, L.1    Niccolini, S.2    Lamboglia, A.3    Pascarelli, N.A.4    Cervone, R.5    Fioravanti, A.6
  • 48
    • 0142103961 scopus 로고    scopus 로고
    • Hydrostatic pressure modulates proteoglycan metabolism in chondrocytes seeded in agarose
    • 14558092 10.1002/art.11250 1:CAS:528:DC%2BD3sXpt1Srsrg%3D
    • Toyoda T, Seedhom BB, Yao JQ, Kirkham J, Brookes S and Bonass WA 2003 Hydrostatic pressure modulates proteoglycan metabolism in chondrocytes seeded in agarose. Arthritis Rheum. 48 2865-2872
    • (2003) Arthritis Rheum. , vol.48 , pp. 2865-2872
    • Toyoda, T.1    Seedhom, B.B.2    Yao, J.Q.3    Kirkham, J.4    Brookes, S.5    Bonass, W.A.6
  • 49
    • 0036192519 scopus 로고    scopus 로고
    • Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat
    • 11882461 10.1016/S8756-3282(01)00703-7
    • van der Eerden BC, Gevers EF, Lövik CW, Karperien M and Wit JM 2002 Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat. Bone 30 478-485
    • (2002) Bone , vol.30 , pp. 478-485
    • Van Der Eerden, B.C.1    Gevers, E.F.2    Lövik, C.W.3    Karperien, M.4    Wit, J.M.5
  • 50
    • 0035216630 scopus 로고    scopus 로고
    • Compressive properties and function composition relationships of developing bovine articular cartilage
    • 11781013 10.1016/S0736-0266(01)00052-3 1:STN:280:DC%2BD38%2FlsFCqsw%3D%3D
    • Williamson AK, Chen AC and Sah RL 2001 Compressive properties and function composition relationships of developing bovine articular cartilage. J. Orthop. Res. 19 1113-1121
    • (2001) J. Orthop. Res. , vol.19 , pp. 1113-1121
    • Williamson, A.K.1    Chen, A.C.2    Sah, R.L.3
  • 51
    • 0034940628 scopus 로고    scopus 로고
    • Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells
    • 11447735
    • Wołczynski S, Surazyński A, Swiatecka J and Pałka J 2001 Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells. Gynecol. Endocrinol. 15 225-233
    • (2001) Gynecol. Endocrinol. , vol.15 , pp. 225-233
    • Wołczynski, S.1    Surazyński, A.2    Swiatecka, J.3    Pałka, J.4
  • 52
    • 0025949206 scopus 로고
    • Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage
    • 2005102 1:CAS:528:DyaK3MXit1Cgur8%3D
    • Wu JJ, Lark MW, Chun LE and Eyre DR 1991 Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage. J. Biol. Chem. 266 5625-5628
    • (1991) J. Biol. Chem. , vol.266 , pp. 5625-5628
    • Wu, J.J.1    Lark, M.W.2    Chun, L.E.3    Eyre, D.R.4


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