A novel terminal differentiation model of human articular chondrocytes in three-dimensional cultures mimicking chondrocytic changes in osteoarthritis

Cell Biology International

Volumn 30, Issue 3, 2006, Pages 288-294

  Ho, Mei Ling ^a,b   Chang, Je Ken ^a,b,c   Wu, Shun Cheng ^a,b   Chung, Ya Hui ^b   Chen, Chung Hwan ^a,b,c   Hung, Shao Hung ^b,d,e   Wang, Gwo Jaw ^a,b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e FOOYIN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Aza C; Human articular chondrocytes; Terminal differentiation; Three dimensional cell culture

Indexed keywords

ALKALINE PHOSPHATASE; AZACITIDINE; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; MESSENGER RNA;

ADULT; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL SIZE; DRUG TOLERANCE; GENETIC ANALYSIS; HUMAN; HUMAN EXPERIMENT; HYPERTROPHY; MALE; OSTEOARTHRITIS; PHENOTYPE;

ALKALINE PHOSPHATASE; APOPTOSIS; AZACITIDINE; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL SIZE; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE X; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IN SITU NICK-END LABELING; MODELS, BIOLOGICAL; OSTEOARTHRITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33244471142     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2005.11.009     Document Type: Article

References (35)

1. A. Abyad, and J.T. Boyer Arthritis and aging Curr Opin Rheumatol 4 1992 153 159
2. M. Adam, and Z. Deyl Altered expression of collagen phenotype in osteoarthrosis Clin Chim Acta 133 1983 25 32
3. C.S. Adams, and W.E. Horton Jr. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals Anat Rec 250 1998 418 425
4. T. Aigner, W. Bertling, H. Stoss, G. Weseloh, and K. von der Mark Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage J Clin Invest 91 1993 829 837
5. F.J. Blanco, R. Guitian, E. Vazquez-Martul, F.J. de Toro, and F. Galdo Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology Arthritis Rheum 41 1998 284 289
6. F.J. Blanco, R.L. Ochs, H. Schwarz, and M. Lotz Chondrocyte apoptosis induced by nitric oxide Am J Pathol 146 1995 75 85
7. J.O. Cheung, M.C. Hillarby, S. Ayad, J.A. Hoyland, C.J. Jones, and J. Denton A novel cell culture model of chondrocyte differentiation during mammalian endochondral ossification J Bone Miner Res 16 2001 309 318
8. J.K. Christman, N. Mendelsohn, D. Herzog, and N. Schneiderman Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60) Cancer Res 43 1983 763 769
9. C. Domm, M. Schunke, K. Christesen, and B. Kurz Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension Osteoarthr Cartil 10 2002 13 22
10. D. Hamerman The biology of osteoarthritis N Engl J Med 320 1989 1322 1330
11. D. Hamerman Clinical implications of osteoarthritis and ageing Ann Rheum Dis 54 1995 82 85
12. S. Hashimoto, R.L. Ochs, S. Komiya, and M. Lotz Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis Arthritis Rheum 41 1998 1632 1638
13. S. Hashimoto, R.L. Ochs, F. Rosen, J. Quach, G. Mccabe, and J. Solan Chondrocyte-derived apoptotic bodies and calcification of articular cartilage Proc Natl Acad Sci USA 95 1998 3094 3099
14. S. Hashimoto, M. Setareh, R.L. Ochs, and M. Lotz Fas/Fas ligand expression and induction of apoptosis in chondrocytes Arthritis Rheum 40 1997 1749 1755
15. S. Hashimoto, K. Takahashi, D. Amiel, R.D. Coutts, and M. Lotz Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis Arthritis Rheum 41 1998 1266 1274
16. F. Heraud, A. Heraud, and M.F. Harmand Apoptosis in normal and osteoarthritic human articular cartilage Ann Rheum Dis 59 2000 959 965
17. W.E. Horton Jr., L. Feng, and C. Adams Chondrocyte apoptosis in development, aging and disease Matrix Biol 17 1998 107 115
18. P.A. Jones, and S.M. Taylor Cellular differentiation, cytidine analogs and DNA methylation Cell 20 1980 85 93
19. P.A. Jones, S.M. Taylor, and V. Wilson DNA modification, differentiation, and transformation J Exp Zool 228 1983 287 295
20. T. Kirsch, B. Swoboda, and H. Nah Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage Osteoarthr Cartil 8 2000 294 302
21. H.M. Kronenberg Developmental regulation of the growth plate Nature 423 2003 332 336
22. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
23. F. Long, X.M. Zhang, S. Karp, Y. Yang, and A.P. McMahon Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation Development 128 2001 5099 5108
24. M. Lotz, S. Hashimoto, and K. Kuhn Mechanisms of chondrocyte apoptosis Osteoarthr Cartil 7 1999 389 391
25. J. Malda, E. Kreijveld, J.S. Temenoff, C.A. van Blitterswijk, and J. Riesle Expansion of human nasal chondrocytes on macroporous microcarriers enhances redifferentiation Biomaterials 24 2003 5153 5161
26. J. Malda, C.A. van Blitterswijk, M. Grojec, D.E. Martens, J. Tramper, and J. Riesle Expansion of bovine chondrocytes on microcarriers enhances redifferentiation Tissue Eng 9 2003 939 948
27. T.B. Morrison, J.J. Weis, and C.T. Wittwer Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification Biotechniques 24 1998 954 958 960, 962
28. M.Y. Nadkar, R.S. Samant, S.S. Vaidya, and N.E. Borges Relationship between osteoarthritis of knee and menopause J Assoc Physicians India 47 1999 1161 1163
29. K.J. Noonan, E.B. Hunziker, J. Nessler, and J.A. Buckwalter Changes in cell, matrix compartment, and fibrillar collagen volumes between growth-plate zones J Orthop Res 16 1998 500 508
30. G. Peat, R. McCarney, and P. Croft Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care Ann Rheum Dis 60 2001 91 97
31. C. Sanchez, M.M. Mateus, M.P. Defresne, J.M. Crielaard, J.Y. Reginster, and Y.E. Henrotin Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1β and nonsteroidal antiinflammatory drugs J Rheumatol 29 2002 772 782
32. L. Shum, and G. Nuckolls The life cycle of chondrocytes in the developing skeleton Arthritis Res 4 2002 94 106
33. C. Tarella, D. Ferrero, E. Gallo, G.L. Pagliardi, and F.W. Ruscetti Induction of differentiation of HL-60 cells by dimethyl sulfoxide: evidence for a stochastic model not linked to the cell division cycle Cancer Res 42 1982 445 449
34. C. Walker, D.F. Ranney, and J.W. Shay 5-Azacytidine-induced uncoupling of differentiation and tumorigenicity in a murine cell line J Natl Cancer Inst 73 1984 877 885
35. M.J. Zuscik, J.F. Baden, Q. Wu, T.J. Sheu, E.M. Schwarz, and H. Drissi 5-Azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes J Cell Biochem 92 2004 316 331