A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes

Biochemical and Biophysical Research Communications

Volumn 421, Issue 3, 2012, Pages 418-424

  Hattori, Yosuke ^a   Kojima, Toshihisa ^a   Kato, Daizo ^a   Matsubara, Hiroyuki ^a   Takigawa, Masaharu ^b   Ishiguro, Naoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Chondrocyte; ERK1 2; Selective estrogen receptor modulators; TNF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; CELL DNA; DNA FRAGMENT; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHONDROCYTES; ENZYME ACTIVATION; HUMANS; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RALOXIFENE; RNA, SMALL INTERFERING; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860657505     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.111     Document Type: Article

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