IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages

  Ruscic, Katarina J ^a,b   Miceli, Francesco ^b,c   Villalba Galea, Carlos A ^b,d   Dai, Hui ^a   Mishina, Yukiko ^b,e   Bezanilla, Francisco ^b   Goldstein, Steve A N ^a,b  

^a BRANDEIS UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Arrhythmia; Heart; Kv7.1; MinK; Site directed fluorimetry

Indexed keywords

FLUORESCENT DYE; POTASSIUM CHANNEL; POTASSIUM CHANNEL I KS; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNE1 PROTEIN, HUMAN; KCNQ1 PROTEIN, HUMAN; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CORRELATION ANALYSIS; EXCITATION CONTRACTION COUPLING; ION CURRENT; PRIORITY JOURNAL; ELECTRIC CONDUCTIVITY; FLUORESCENCE; GENETICS; HEART MUSCLE; HUMAN; INNER EAR; MEMBRANE POTENTIAL; METABOLISM; OOCYTE; PHYSIOLOGY; PROTEIN SUBUNIT; SITE DIRECTED MUTAGENESIS; VOLTAGE SENSITIVE DYE IMAGING;

EAR, INNER; ELECTRIC CONDUCTIVITY; FLUORESCENCE; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; OOCYTES; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN SUBUNITS; VOLTAGE-SENSITIVE DYE IMAGING;

MLCS; MLOWN;

EID: 84873704321     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222616110     Document Type: Article

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