Activity of Crude Extract of Rubus crataegifolius Roots as a Potent Apoptosis Inducer and DNA Topoisomerase I Inhibitor

Archives of Pharmacal Research

Volumn 23, Issue 4, 2000, Pages 338-343

  Lee, Ji Hyeon ^a   Ham, Yoon Ah ^a   Choi, Sang Ho ^a   Im, Eun Ok ^a   Jung, Jee H ^a   Im, Kwang Sik ^a   Kim, Dong Kyoo ^b   Xu, Ying ^c   Wang, Min Wei ^c   Kim, Nam Deuk ^a  

^a Pusan National University   (South Korea)

^b Inje University   (South Korea)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; DNA fragmentation; MCF 7 cells; Rubus crategifolius roots; Topoisomerase I inhibitor

Indexed keywords

CAMPTOTHECIN; DNA FRAGMENT; DNA TOPOISOMERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; IRINOTECAN; PLANT EXTRACT;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIVISION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MEDICINAL PLANT;

APOPTOSIS; CAMPTOTHECIN; CELL CYCLE; CELL DIVISION; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; PLANT EXTRACTS; PLANTS, MEDICINAL; TUMOR CELLS, CULTURED;

EID: 0034251789     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975444     Document Type: Article

References (39)

1. Chen, A. Y. and Liu, L. F., DNA topoisomerase: Essential enzymes and lethal targets. Annu. Rev. Pharmacol. Toxicol., 34, 191-218 (1994).
2. Choi, Y. S., Son, K. H., and Do, J. C., Triterpenoids from the roots of Rubus parvifolius. Arch. Pharm. Res., 14, 225-230 (1991).
3. Chou, W. H., Oinaka, T., Kanamaru, F., Mizutani, K., Chen., F. H., and Tanaka, O., Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus and identification of the source plant of the Chinese folk medicine "Fu-pen-zi". Chem. Pharm. Bull., 35, 3021-3024 (1987).
4. Constantino, L., Albasini, A., Rastelli, C., and Benvenuti, S., Activity of polyphenolic crude extracts as scavengers of Superoxide radicals and inhibitors of xanthin oxidase. Planta Med., 58, 342-344 (1992).
5. Cunningham, D., Current status of colorectal cancer: CPT-11 (irinotecan), a therapeutic innovation, Eur. J. Cancer, 32A, S1-S8 (1996).
6. Cunningham, D., Pyrhonen, S., James, R. D., Punt, C. J., Hickish, T. R., Heikkila, R., Johannesen, T. B., Starkhammar, H., Topham, C. A., Awad, L., Jacques, C., and Herait, P., Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet, 352, 1413-1418 (1998).
7. Cusack, J. C., Liu, R., and Baldwin, A. S. Jr., Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-B activation. Cancer Res., 60, 2323-2330 (2000).
8. Do, J. C., Son, K. H., and Kang, S. S., Studies on the constituents of the roots of Rubus parvifolius. Isolation of (-)-epicatechin. Kor. J. Pharmacogn., 19, 170-173 (1988).
9. de Forni, M., Bugat, R., Chabot, G. G., Culine, S., Extra, J. M., Gouyette, A., Madelaine, I., Marty, M. E., and Mathieu-Boue, A., Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res., 54, 4347-4354 (1994).
10. Ganguly, S. N., Sterols and triterpenes from Rubus fruticosus. Phytochemistry, 11, 2893-2896 (1972).
11. Gao, F., Chen, F. H., Tanaka, T., Kasai, R., Seto, T., and Tanaka, O., 19-Hydroxyursane-type triterpene glucosyl esters from the roots of Rubus suavissimus S. Lee. Chem. Pharm. Bull., 33, 37-40 (1985).
12. Coldwasser, F., Bae, I. S., Torres, K., and Pommier, Y., Topoisomerase-l-reated parameters and camptothecin activity in the colon cell lines from the National Cancer Institute anti-cancer scree. Cancer Res., 55, 2116-2121 (1995).
13. Goldwasser, F., Shimizu, T., Jackman, J., Hoki, Y., O'Connor, P. M., Kohn, K. W., and Pommier, Y., Correlation between S- and G2-phase arrest and cytotoxicity of camptothecin in human colon-carcinoma cells. Cancer Res., 56, 4430-4437 (1996).
14. Hattori, M., Kuo, K. -P., Shu, Y. Z., Tezuka, Y., Kikuchi, T., and Namba, T., A triterpene from the fruits of Rubus chingii, Phytochemistry, 27, 3975-3976 (1988).
15. Henning, W., Flavonol glycosides of strawberries, raspberries and blackberries. Z. Lebensm. Unters. Forsch., 173, 180-187 (1981).
16. Hsiang, Y. -H., Herzberg, R., Hecht, S., and Liu, L. F., Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem., 260, 14873-14878 (1985).
17. Im, E. O., Lee, S., Suh, H., Kim, K. W., Bae, Y. T., and Kim, N. D., A novel ursodeoxycholic acid derivative induced apoptosis in MCF-7 human breast cancer cells. Pharm. Pharmacol. Commun., 5, 1-7 (1999).
18. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W., Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51, 6304-6311 (1991).
19. Kim, D. K., Lim, Y. J., Kim, J. S., Park, J. H., Kim, N. D., Im, K. S., Hong, J., and Jung, J. H., A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.. J. Nat. Prod., 62, 773-776 (1999a).
20. Kim, D. K., Lee, J. R., Kim, A., Lee, S., Yoo, M. A., Kim, K. W., Kim, N. D., and Suh, S., Inhibition of initiation of simian virus 40 DNA replication in vitro by the ursodeoxycholic acid and its derivatives. Cancer Lett., 146, 147-153 (1999b).
21. Kim, E. and Kim, Y. C., A triterpene glycoside in berries of Rubus coreanus. Kor. J. Pharmacogn., 18, 188-190 (1987).
22. Kudoh, S., Fujiwara, Y., Takada, Y., Yamamoto, H., Kinoshita, A., Ariyoshi Y., Furuse, K., and Fukuoka, M., Phase II study of irinotecan combined with cisplatin in patients with previously untreated small-cell lung cancer. West Japan Lung Cancer Group. J. Clin. Oncol., 16, 1068-1074 (1998).
23. Liu, L. F., DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 35-371 (1989).
24. Masuda, N., Fukuoka, M., Takada, M., Kusunoki, Y., Negoro, S., Matsui, K., Kudoh, S., Takifuji, N., Nakagawa, K., and Kishimoto, S., CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer, J. Clin. Oncol., 10, 1775-1780 (1992).
25. Mukherjee, M., Ghatak, K. L., Ganguly, S. N., and Antoulas, S., Rubinic acid, a triterpene acid from Rubus fruiticosus. Phytochemistry, 23, 2581-2582 (1984).
26. Nelson, W. G. and Kastan, M. B., DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage responses pathways. Mol. Cell. Biol., 14, 1815-1823 (1994).
27. Oh, M., Choi, Y. H., Choi, S. H., Chung, H. Y., Kim, K. W., Kim, S. I., Kim, D. K., and Kim, N. D., Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int. J. Oncol., 14, 869-875 (1999).
28. Ohmori, T., Podack, E. R., Nishio, K., Takahashi, M., Miyahara, Y., Takeda, Y., Kubota, N., Funayama, Y., Ogasawara, H., Ohira, T., Ohta, S., and Saijo, N., Apoptosis of lung-cancer cells caused by some anti-cancer agents (MMC, CPT11, ADM) is inhibited by bcl-2. Biochem. Biophys. Res. Commun., 192, 30-36 (1993).
29. Ohtani, K., Yang, C. R., Miyajima, C., Zhou, J., and Tanaka, O., Labdane-type diterpene glycosides from fruits of Rubus foliolosus. Chem. Pharm. Bull., 39, 2443-2445 (1991).
30. Ohtani, K., Aikawa, Y., Kasai, R., Chou, W. H., Yamasaki, K., and Tanaka, O., Minor diterpene glycosides from sweet leaves of Rubus suavissimus. Phytochemistry, 31, 1553-1559 (1992).
31. Oshita, R., Noda, K., Nishiwaki, Y., Fujita, A., Kurita, Y., Nakabayashi, T., Tobise, K., Abe, S., Suzuki, S., Hayashi, I., Kawakami, Y., Matsuda, T., Tsuchiya, S., Takahashi, S., Tamura, T., and Saijo, N., Phase II study of irino-tecan and etoposide in patients with metastatic non-small-cell lung cancer. J. Clin. Oncol., 15, 304-309 (1997).
32. Pabst, A., Barren, D., Semon, E., and Schreier, P., A 4-hydroxy-β-lonone disaccharide glycoside from Raspberry fruits. Phytochemistry, 31, 3105-3107 (1992).
33. Pramod, T. J., Frank A. F., Joyce, K. R., Michael, S. O., and David, G., Induction of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, Camptothecin, in MCF-7 human breast tumor cells. Biochem. Pharm., 55, 1263-1269 (1998).
34. Richard, R. M. E., Durham, D. C., and Liu, X., Antibacterial activity of compounds from Rubus pinfaensis. Planta Med., 60, 471-474 (1994).
35. Sarkar, A. and Ganguly S. N., Rubitic acid, a new triterpene acid from Rubus fruiticosus. Phytochemistry, 17, 1983-1985 (1978).
36. Sogawa K., Yamada, T., Sumida, T., Hamakawa, H., Kuwabara, H., Mastuda, M., Muramatsu, Y., Kose, H., Matsumoto, K., Sasaki, Y., Okutani, K., Kondo, K., and Monden, Y., Induction of apoptosis and inhibition of DNA topoisomerase-l in K-562 cells by a marine rnicroalgal polysaccharide. Life Sci., 66, PL227-231 (2000).
37. Solary, E., Bertrand, R., and Pommier, Y., Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL-60 cells. Leuk. Lymphoma, 15, 21-32 (1994).
38. Steller, H., Mechanisms and genes of cellular suicide. Science, 267, 1445-1448 (1995).
39. Zhou, X. H., Kasai, R., Ohtani, K., Tanaka, O., Nie, R. L., Yang, C. R., Zhou, J., and Yamasaki, K., Oleanane and ursane glycosides from Rubus species. Phytochemistry, 31, 3642-3644 (1992).