Effect of germinated soy protein on the growth of HeLa cervical cancer cells in female athymic mice

Nutrition and Cancer

Volumn 64, Issue 8, 2012, Pages 1261-1268

  Robles Ramírez, María Del Carmen ^a   Ramón Gallegos, Eva ^a   Reyes Duarte, Francisco J ^b   Mora Escobedo, Rosalva ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b Metropolitana University   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; APROTININ; BOWMAN BIRK INHIBITOR; CASEIN; HEMAGGLUTININ; NAPIN; PEPTIDE; PLANT MEDICINAL PRODUCT; SOYBEAN AGGLUTININ; SOYBEAN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DIET; DRUG EFFECT; FEMALE; GERMINATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INOCULATION; LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; TANDEM MASS SPECTROMETRY; TUMOR NECROSIS; TUMOR VOLUME; UTERINE CERVIX CANCER;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; FEMALE; GERMINATION; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SEEDS; SOYBEAN PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 84873690775     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2012.717681     Document Type: Article

References (41)

1. Kennedy AR: The evidence for soybean products as cancer preventive agents. J Nutr 125, 733S-743S, 1995.
2. Messina MJ, Persky V, Setchell KD, and Barnes S: Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 21, 113-131, 1994.
3. Hernández-Ledesma B, Hsieh C, and De Lumen BO: Lunasin, a novel seed peptide for cancer prevention. Peptides 30, 426-430, 2009.
4. Singh AV, Franke AA, Blackburn GL, and Zhou JR: Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res 66, 1851-1858, 2006.
5. Wang J, Eltoum IE, and Lamartiniere CA: Genistein chemoprevention of prostate cancer in TRAMP mice. J Carcinogenesis 6, 3, 2007.
6. Gallo D, Zannoni GF, De Estefano I, Mosca M, Ferlini C, et al.: Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. J Nutr 138, 1360-1364, 2008.
7. Davila M, Sangronis E, and Granito M: Leguminosas germinadas o fermentadas: alimentos o ingredientes de alimentos funcionales. Arch Latinoam Nutr 53, 348-354, 2003.
8. Mora-Escobedo R, Robles-Ramírez MC, and Ramón-Gallegos E: Effect of protein hydrolysates from germinated soybean on cancerous cells of the human cervix: an in vitro study. Plant Food Hum Nutr 64, 271-278, 2009.
9. Robles-Ramírez MC, Mora-Escobedo R, and Ramón-Gallegos E: A peptide fraction from germinated soybean protein down-regulates PTTG1 and TOP2A mRNA expression, inducing apoptosis in cervical cancer cells. J Exp Ther Oncol 9, 255-263, 2012.
10. Rickert DA, Meyer MA, Hu J, and Murphy PA: Effect of extraction pH and temperature on isoflavone and saponin partitioning and profile during soy protein isolate production. J Food Sci 69, 623-631, 2004.
11. Setchell KD and Cole SJ: Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labelling. J Agric Food Chem 51, 4146-4155, 2003.
12. Carrao MC, Pedroso S, and Kikuchi A: Extraction time for soybean isoflavone determination. Braz Arch Biol Technol 45, 515-518, 2002.
13. Lin P and Lai H: Bioactive compounds in legumes and their germinated products. J Agric Food Chem 54, 3807-3814, 2006.
14. Hiai S, Oura H, and Nakajima T: Color reaction of some sapogenins and saponins with vanillin and sulphuric acid. Planta Med 29, 116-122, 1976.
15. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685, 1970.
16. Altschul S, Madden T, Schaffer A, Zhang J, Zhang Z, et al.: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25, 3389-3402, 1997.
17. Kruczynski A and Hill BT: Classic in vivo cancer models: three examples of mouse models used in experimental therapeutics. Curr Protoc Pharmacol 5.24.1-5.24.16, 2001.
18. Kobayashi H, Suzuki M, Kanayama N, and Terao T: A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation. Clinical and Experimental Metastasis 21, 159-166, 2004.
19. Kobayashi H, Fukuda Y, Yoshida R, Kanada Y, Nishiyama S, et al.: Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model. Int J Cancer 112, 519-524, 2004.
20. Papastoitsis G and Wilson KA: Initiation of the degradation of the soybean Kunitz and Bowman-Birk trypsin inhibitors by a cystein protease. Plant Physiol 96, 1086-1092, 1991.
21. Tan-Wilson AL, Rightmire BR, and Wilson KA: Different rates of metabolism of soybean proteinase inhibitors during germination. Plant Physiol 70, 493-497, 1982.
22. Kumar V, Rani A, Pandey V, and Chauhan GS: Changes in lypoxygenase isozymes and trypsin inhibitor activity in soybean during germination at different temperatures. Food Chem 99, 563-568, 2006.
23. Kennedy AR: The Bowman-Birk inhibitor from soybeans an anticarcinogenic agent. Am J Clin Nutr 68S, 1406S-1412S, 1998.
24. Paucar-Menacho LM, Berhow MA, Montijo MJM, González de Mejiá E, and Chang YK: Optimization of germination time and temperature on the concentration of bioactive compounds in Brazilian soybean cultivar BRS 133 using response surface methodology. Food Chem 119, 636-642, 2010.
25. Park JH, Jeong HJ, and de Lumen BO: Contents and bioactivities of lunasin, Bowman-Birk inhibitor, and isoflavones in soybean seed. J Agric Food Chem 53, 7686-7690, 2005.
26. Watanabe Y, Barbashov FS, Komatzu S, Hemmings AM, Miyagi M, et al.: A peptide that stimulates phosphorylation of the plant insulin-binding protein isolation, primary structure and cDNA cloning. Eur J Biochem 224, 167-172, 1994.
27. Hanada K and Hirano H: Interaction of a 43-kDa receptor-like protein with a 4-kDa hormone-like peptide in soybean. Biochem 43, 12105-12112, 2004.
28. Papo N and Shai Y: Host defense peptides as new weapons in cancer treatment. Cell Mol Life Sci (CMLS) 62, 784-790, 2005.
29. Wang W, Bringe NA, Berhow MA, and González de Mejía E: β-Conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leucemia cells in vitro. J Agr Food Chem 56, 4012-4020, 2008
30. Barnes S: Effect of genistein on in vitro and in vivo models of cancer. J Nutr 125, 777S-781S, 1995.
31. Yan L, Li D, and Yee JA: Dietary supplementation with isolated soy protein reduces metastasis of mammary carcinoma cells in mice. Clin Exp Metastas 19, 535-540, 2002.
32. Zhou J, Gugger ET, Tanaka T, Guo Y, Blackburn GL, et al.: Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 129, 1628-1635, 1999.
33. Hewitt AL and Singletary KW: Soy extract inhibits mammary adenocarcinoma growth in a syngeneic mouse model. Cancer Lett 192, 133-143, 2003.
34. Li D, Yee JA, McGuire MH, Murphy PA, and Yan L: Soybean isoflavones reduce experimental metastasis in mice. J Nutr 129, 1075-1078, 1999.
35. MacDonald RS, Guo J, Copeland J, Browning JD, Sleper D, et al.: Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer. J Nutr 135, 1239-1242, 2005.
36. Kanga J, Hanb I, Sungb M, Yooc H, Kimd Y, et al.: Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP-2. Cancer Lett 261, 84-92, 2008.
37. Robles-Ramírez MC, Ramón E, and Mora-Escobedo R: Soybeans germination and cancer disease. In: Soybeans: Cultivation, Uses and Nutrition, Maxwell JE (ed.). New York: Nova Science Publishers Inc., 2011, pp. 223-250.
38. Liss MA, Schlicht M, Degueme A, Hessner M, and Datta MW: Use of cross species genomic profiling identifies pathways and genes differentially regulated in prostate cancer cells treated with soy protein isolates or purified genistein. Cancer Genomics and Proteomics 7, 111-128, 2010.
39. Ganguli C and Das S: Plant lectins as inhibitors of tumor growth and modulators of host immune response. Chemotherapy 40, 272-278, 1994.
40. Wang Wand González de Mejiá E: A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Comp Rev Food Sci Food Safety 4, 63-78, 2005.
41. Park JH, Jeong HJ, and De Lumen BO: In vitro digestibility of the cancer-preventive soy peptides lunasin and BBI. J Agric Food Chem 55, 10703-10706, 2007.