-
1
-
-
2942548983
-
The Runx genes: Lineage-specific oncogenes and tumor suppressors
-
Cameron,E.R. and Neil,J.C. (2004) The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene, 23, 4308-4314.
-
(2004)
Oncogene
, vol.23
, pp. 4308-4314
-
-
Cameron, E.R.1
Neil, J.C.2
-
2
-
-
2942547444
-
Core-binding factors in hematopoiesis and immune function
-
de Bruijn,M.F. and Speck,N.A. (2004) Core-binding factors in hematopoiesis and immune function. Oncogene, 23, 4238-4248.
-
(2004)
Oncogene
, vol.23
, pp. 4238-4248
-
-
De Bruijn, M.F.1
Speck, N.A.2
-
3
-
-
2942512933
-
Structure and regulated expression of mammalian RUNX genes
-
Levanon,D. and Groner,Y. (2004) Structure and regulated expression of mammalian RUNX genes. Oncogene, 23, 4211-4219.
-
(2004)
Oncogene
, vol.23
, pp. 4211-4219
-
-
Levanon, D.1
Groner, Y.2
-
4
-
-
18444406568
-
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
-
Levanon,D., Bettoun,D., Harris-Cerruti,C., Woolf,E., Negreanu,V., Eilam,R., Bernstein,Y., Goldenberg,D., Xiao,C., Fliegauf,M. et al. (2002) The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J., 21, 3454-3463.
-
(2002)
EMBO J.
, vol.21
, pp. 3454-3463
-
-
Fliegauf, M.1
-
5
-
-
0035193558
-
Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis
-
Levanon,D., Brenner,O., Negreanu,V., Bettoun,D., Woolf,E., Eilam,R., Lotem,J., Gat,U., Otto,F., Speck,N. et al. (2001) Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech. Dev., 109, 413-417.
-
(2001)
Mech. Dev.
, vol.109
, pp. 413-417
-
-
Speck, N.1
-
6
-
-
0033697669
-
Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
-
Cai,Z., de Bruijn,M., Ma,X., Dortland,B., Luteijn,T., Downing,R.J. and Dzierzak,E. (2000) Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity, 13, 423-431.
-
(2000)
Immunity
, vol.13
, pp. 423-431
-
-
De Bruijn, M.1
Ma, X.2
Dortland, B.3
Luteijn, T.4
Downing, R.J.5
Dzierzak, E.6
-
7
-
-
0033036971
-
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
-
North,T., Gu,T.L., Stacy,T., Wang,Q., Howard,L., Binder,M., Marin-Padilla,M. and Speck,N.A. (1999) Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development, 126, 2563-2575.
-
(1999)
Development
, vol.126
, pp. 2563-2575
-
-
Marin-Padilla, M.1
Speck, N.A.2
-
8
-
-
0030061554
-
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
-
Okuda,T., van Deursen,J., Hiebert,S.W., Grosveld,G. and Downing,J.R. (1996) AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell, 84, 321-330.
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Van Deursen, J.1
Hiebert, S.W.2
Grosveld, G.3
Downing, J.R.4
-
9
-
-
44449104279
-
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
-
Ichikawa,M., Goyama,S., Asai,T., Kawazu,M., Nakagawa,M., Takeshita,M., Chiba,S., Ogawa,S. and Kurokawa,M. (2008) AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. J. Immunol., 180, 4402-4408.
-
(2008)
J. Immunol.
, vol.180
, pp. 4402-4408
-
-
Ogawa, S.1
Kurokawa, M.2
-
10
-
-
33748439252
-
AML1/Runx1 as a versatile regulator of hematopoiesis: Regulation of its function and a role in adult hematopoiesis
-
Kurokawa,M. (2006) AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis. Int. J. Hematol., 84, 136-142.
-
(2006)
Int. J. Hematol.
, vol.84
, pp. 136-142
-
-
Kurokawa, M.1
-
11
-
-
0029987143
-
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions
-
Ghozi,M.C., Bernstein,Y., Negreanu,V., Levanon,D. and Groner,Y. (1996) Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. Proc. Natl Acad. Sci. USA, 93, 1935-1940.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1935-1940
-
-
Levanon, D.1
Groner, Y.2
-
12
-
-
34547842483
-
Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis
-
Pozner,A., Lotem,J., Xiao,C., Goldenberg,D., Brenner,O., Negreanu,V., Levanon,D. and Groner,Y. (2007) Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis. BMC Dev. Biol., 7, 84.
-
(2007)
BMC Dev. Biol.
, vol.7
, pp. 84
-
-
Levanon, D.1
Groner, Y.2
-
13
-
-
0035862878
-
Expression and function of a stem cell promoter for the murine CBFalpha2 gene: Distinct roles and regulation in natural killer and T cell development
-
Telfer,J.C. and Rothenberg,E.V. (2001) Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development. Dev. Biol., 229, 363-382.
-
(2001)
Dev. Biol.
, vol.229
, pp. 363-382
-
-
Telfer, J.C.1
Rothenberg, E.V.2
-
14
-
-
1642357581
-
Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes
-
Telfer,J.C., Hedblom,E.E., Anderson,M.K., Laurent,M.N. and Rothenberg,E.V. (2004) Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J. Immunol., 172, 4359-4370.
-
(2004)
J. Immunol.
, vol.172
, pp. 4359-4370
-
-
Laurent, M.N.1
Rothenberg, E.V.2
-
15
-
-
0036232830
-
Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype
-
Spender,L.C., Cornish,G.H., Sullivan,A. and Farrell,P.J. (2002) Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype. J. Virol., 76, 4919-4927.
-
(2002)
J. Virol.
, vol.76
, pp. 4919-4927
-
-
Sullivan, A.1
Farrell, P.J.2
-
16
-
-
16244388945
-
Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells
-
Spender,L.C., Whiteman,H.J., Karstegl,C.E. and Farrell,P.J. (2005) Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Oncogene, 24, 1873-1881.
-
(2005)
Oncogene
, vol.24
, pp. 1873-1881
-
-
Karstegl, C.E.1
Farrell, P.J.2
-
17
-
-
67449098554
-
Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation
-
Brady,G., Whiteman,H.J., Spender,L.C. and Farrell,P.J. (2009) Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation. J. Virol., 83, 6909-6916.
-
(2009)
J. Virol.
, vol.83
, pp. 6909-6916
-
-
Spender, L.C.1
Farrell, P.J.2
-
18
-
-
0017329178
-
Establishment in continuous culture of a new type of lymphocyte from a "burkitt like" malignant lymphoma (line D.G.-75
-
Ben-Bassat,H., Goldblum,N., Mitrani,S., Goldblum,T., Yoffey,J.M., Cohen,M.M., Bentwich,Z., Ramot,B., Klein,E. and Klein,G. (1977) Establishment in continuous culture of a new type of lymphocyte from a "Burkitt like" malignant lymphoma (line D.G.-75). Int. J. Cancer, 19, 27-33.
-
(1977)
Int. J. Cancer
, vol.19
, pp. 27-33
-
-
Klein, E.1
Klein, G.2
-
19
-
-
0020611415
-
RNA encoded by the IR1-U2 region of Epstein-Barr virus DNA in latently infected, growth-transformed cells
-
van Santen,V., Cheung,A., Hummel,M. and Kieff,E. (1983) RNA encoded by the IR1-U2 region of Epstein-Barr virus DNA in latently infected, growth-transformed cells. J. Virol., 46, 424-433.
-
(1983)
J. Virol.
, vol.46
, pp. 424-433
-
-
Van Santen, V.1
Cheung, A.2
Hummel, M.3
Kieff, E.4
-
20
-
-
0026058670
-
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia
-
Young,L.S., Lau,R., Rowe,M., Niedobitek,G., Packham,G., Shanahan,F., Rowe,D.T., Greenspan,D., Greenspan,J.S., Rickinson,A.B. et al. (1991) Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. J. Virol., 65, 2868-2874.
-
(1991)
J. Virol.
, vol.65
, pp. 2868-2874
-
-
Rickinson, A.B.1
-
21
-
-
0034810126
-
Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development
-
Fujita,Y., Nishimura,M., Taniwaki,M., Abe,T. and Okuda,T. (2001) Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development. Biochem. Biophys. Res. Commun., 281, 1248-1255.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.281
, pp. 1248-1255
-
-
Abe, T.1
Okuda, T.2
-
22
-
-
33846707591
-
RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation
-
Cammenga,J., Niebuhr,B., Horn,S., Bergholz,U., Putz,G., Buchholz,F., Lohler,J. and Stocking,C. (2007) RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation. Cancer Res., 67, 537-545.
-
(2007)
Cancer Res.
, vol.67
, pp. 537-545
-
-
Lohler, J.1
Stocking, C.2
-
23
-
-
12644284483
-
Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors
-
Zeng,C., van Wijnen,A.J., Stein,J.L., Meyers,S., Sun,W., Shopland,L., Lawrence,J.B., Penman,S., Lian,J.B., Stein,G.S. et al. (1997) Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc. Natl Acad. Sci. USA, 94, 6746-6751.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6746-6751
-
-
Van Wijnen, A.J.1
Stein, J.L.2
Meyers, S.3
Sun, W.4
Shopland, L.5
Lawrence, J.B.6
Penman, S.7
Lian, J.B.8
Stein, G.S.9
-
24
-
-
85044684278
-
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins
-
Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and Artavanis-Tsakonas,S. (1992) Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat. Genet., 2, 343.
-
(1992)
Nat. Genet.
, vol.2
, pp. 343
-
-
Hill, R.E.1
Artavanis-Tsakonas, S.2
-
25
-
-
0032578394
-
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
-
Levanon,D., Goldstein,R.E., Bernstein,Y., Tang,H., Goldenberg,D., Stifani,S., Paroush,Z. and Groner,Y. (1998) Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc. Natl Acad. Sci. USA, 95, 11590-11595.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 11590-11595
-
-
Paroush, Z.1
Groner, Y.2
-
26
-
-
0037020837
-
AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
-
Schwieger,M., Lohler,J., Friel,J., Scheller,M., Horak,I. and Stocking,C. (2002) AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J. Exp. Med., 196, 1227-1240.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1227-1240
-
-
Horak, I.1
Stocking, C.2
-
27
-
-
0038300361
-
The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo
-
de Guzman,C.G., Johnson,A. and Klug,C.A. (2003) The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo. Blood Cells Mol. Dis., 30, 201-206.
-
(2003)
Blood Cells Mol. Dis.
, vol.30
, pp. 201-206
-
-
De Guzman, C.G.1
Johnson, A.2
Klug, C.A.3
-
28
-
-
6344282193
-
Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice
-
Fenske,T.S., Pengue,G., Mathews,V., Hanson,P.T., Hamm,S.E., Riaz,N. and Graubert,T.A. (2004) Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice. Proc. Natl Acad. Sci. USA, 101, 15184-15189.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15184-15189
-
-
Riaz, N.1
Graubert, T.A.2
-
29
-
-
17944376561
-
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
-
Yuan,Y., Zhou,L., Miyamoto,T., Iwasaki,H., Harakawa,N., Hetherington,C.J., Burel,S.A., Lagasse,E., Weissman,I.L., Akashi,K. et al. (2001) AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc. Natl Acad. Sci. USA, 98, 10398-10403.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 10398-10403
-
-
Akashi, K.1
-
30
-
-
0033991667
-
Lineage specificity of CBFA2 fusion transcripts
-
Dann,E.J., Fears,S., Arad-Dann,H., Nucifora,G. and Rowley,J.D. (2000) Lineage specificity of CBFA2 fusion transcripts. Leuk. Res., 24, 11-17.
-
(2000)
Leuk. Res.
, vol.24
, pp. 11-17
-
-
Nucifora, G.1
Rowley, J.D.2
-
31
-
-
2342512105
-
TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity
-
Morrow,M., Horton,S., Kioussis,D., Brady,H.J. and Williams,O. (2004) TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity. Blood, 103, 3890-3896.
-
(2004)
Blood
, vol.103
, pp. 3890-3896
-
-
Morrow, M.1
Horton, S.2
Kioussis, D.3
Brady, H.J.4
Williams, O.5
-
32
-
-
33745959553
-
Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development
-
Kanatani,N., Fujita,T., Fukuyama,R., Liu,W., Yoshida,C.A., Moriishi,T., Yamana,K., Miyazaki,T., Toyosawa,S. and Komori,T. (2006) Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev. Biol., 296, 48-61.
-
(2006)
Dev. Biol.
, vol.296
, pp. 48-61
-
-
Toyosawa, S.1
Komori, T.2
-
33
-
-
0035066381
-
The leukemia-associated AML1 (Runx1)-CBF beta complex functions as a DNA-induced molecular clamp
-
Bravo,J., Li,Z., Speck,N.A. and Warren,A.J. (2001) The leukemia-associated AML1 (Runx1)-CBF beta complex functions as a DNA-induced molecular clamp. Nat. Struct. Biol., 8, 371-378.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 371-378
-
-
Speck, N.A.1
Warren, A.J.2
-
34
-
-
0035865459
-
Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin- proteasome-mediated degradation
-
Huang,G., Shigesada,K., Ito,K., Wee,H.J., Yokomizo,T. and Ito,Y. (2001) Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome- mediated degradation. EMBO J., 20, 723-733.
-
(2001)
EMBO J.
, vol.20
, pp. 723-733
-
-
Yokomizo, T.1
Ito, Y.2
-
35
-
-
0035831044
-
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta
-
Tahirov,T.H., Inoue-Bungo,T., Morii,H., Fujikawa,A., Sasaki,M., Kimura,K., Shiina,M., Sato,K., Kumasaka,T., Yamamoto,M. et al. (2001) Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell, 104, 755-767.
-
(2001)
Cell
, vol.104
, pp. 755-767
-
-
Yamamoto, M.1
-
36
-
-
84863099046
-
Cell-penetrating peptides: Breaking through to the other side
-
Koren,E. and Torchilin,V.P. (2012) Cell-penetrating peptides: breaking through to the other side. Trends Mol. Med., 18, 385-393.
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 385-393
-
-
Koren, E.1
Torchilin, V.P.2
-
37
-
-
77958127248
-
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
-
Lysakova-Devine,T., Keogh,B., Harrington,B., Nagpal,K., Halle,A., Golenbock,D.T., Monie,T. and Bowie,A.G. (2010) Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J. Immunol., 185, 4261-4271.
-
(2010)
J. Immunol.
, vol.185
, pp. 4261-4271
-
-
Monie, T.1
Bowie, A.G.2
-
38
-
-
0343517577
-
Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2
-
Strobl,L.J., Hofelmayr,H., Marschall,G., Brielmeier,M., Bornkamm,G.W. and Zimber-Strobl,U. (2000) Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2. J. Virol., 74, 1727-1735.
-
(2000)
J. Virol.
, vol.74
, pp. 1727-1735
-
-
Bornkamm, G.W.1
Zimber-Strobl, U.2
-
39
-
-
0035135322
-
Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells
-
Hofelmayr,H., Strobl,L.J., Marschall,G., Bornkamm,G.W. and Zimber-Strobl,U. (2001) Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells. J. Virol., 75, 2033-2040.
-
(2001)
J. Virol.
, vol.75
, pp. 2033-2040
-
-
Bornkamm, G.W.1
Zimber-Strobl, U.2
-
40
-
-
0029876030
-
A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1
-
Levanon,D., Bernstein,Y., Negreanu,V., Ghozi,M.C., Bar-Am,I., Aloya,R., Goldenberg,D., Lotem,J. and Groner,Y. (1996) A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1. DNA Cell Biol., 15, 175-185.
-
(1996)
DNA Cell Biol.
, vol.15
, pp. 175-185
-
-
Lotem, J.1
Groner, Y.2
-
41
-
-
77952066320
-
Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages
-
Wong,W.F., Nakazato,M., Watanabe,T., Kohu,K., Ogata,T., Yoshida,N., Sotomaru,Y., Ito,M., Araki,K., Telfer,J. et al. (2010) Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology, 130, 243-253.
-
(2010)
Immunology
, vol.130
, pp. 243-253
-
-
Telfer, J.1
-
42
-
-
0030741019
-
Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): Evidence for a new myc collaborating oncogene
-
Stewart,M., Terry,A., Hu,M., O'Hara,M., Blyth,K., Baxter,E., Cameron,E., Onions,D.E. and Neil,J.C. (1997) Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proc. Natl Acad. Sci. USA, 94, 8646-8651.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 8646-8651
-
-
Onions, D.E.1
Neil, J.C.2
-
43
-
-
0037115419
-
Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma
-
Wotton,S., Stewart,M., Blyth,K., Vaillant,F., Kilbey,A., Neil,J.C. and Cameron,E.R. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Res., 62, 7181-7185.
-
(2002)
Cancer Res.
, vol.62
, pp. 7181-7185
-
-
Neil, J.C.1
Cameron, E.R.2
|