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Volumn 84, Issue 2, 2006, Pages 136-142

AML1/Runx1 as a versatile regulator of hematopoiesis: Regulation of its function and a role in adult hematopoiesis

Author keywords

AML1 Runx1; Hematopoiesis; Leukemia; Transcription factor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX1;

EID: 33748439252     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.06070     Document Type: Review
Times cited : (34)

References (43)
  • 2
    • 27244435347 scopus 로고    scopus 로고
    • Runx1/AML1 in normal and abnormal hematopoiesis
    • Yamagata T, Maki K, Mitani K. Runx1/AML1 in normal and abnormal hematopoiesis. Int J Hematol. 2005;82:1-8.
    • (2005) Int J Hematol , vol.82 , pp. 1-8
    • Yamagata, T.1    Maki, K.2    Mitani, K.3
  • 3
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A. 1991;88:10431-10434.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10431-10434
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3    Maseki, N.4    Kaneko, Y.5    Ohki, M.6
  • 4
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi I, Osato M, Egawa T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 2002;111:621-633.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1    Osato, M.2    Egawa, T.3
  • 5
    • 11844259461 scopus 로고    scopus 로고
    • Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin
    • Bertrand JY, Giroux S, Golub R, et al. Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U S A. 2005;102:134-139.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 134-139
    • Bertrand, J.Y.1    Giroux, S.2    Golub, R.3
  • 6
    • 0004887468 scopus 로고    scopus 로고
    • Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura
    • Cumano A, Dieterlen-Lievre F, Godin I. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell. 1996;86:907-916.
    • (1996) Cell , vol.86 , pp. 907-916
    • Cumano, A.1    Dieterlen-Lievre, F.2    Godin, I.3
  • 7
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 8
    • 0033697669 scopus 로고    scopus 로고
    • Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
    • Cai Z, de Bruijn M, Ma X, et al. Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity. 2000;13:423-431.
    • (2000) Immunity , vol.13 , pp. 423-431
    • Cai, Z.1    De Bruijn, M.2    Ma, X.3
  • 9
    • 0030588487 scopus 로고    scopus 로고
    • The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
    • Wang Q, Stacy T, Miller JD, et al. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell. 1996;87:697-708.
    • (1996) Cell , vol.87 , pp. 697-708
    • Wang, Q.1    Stacy, T.2    Miller, J.D.3
  • 10
    • 0036282095 scopus 로고    scopus 로고
    • Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo
    • North TE, de Bruijn MF, Stacy T, et al. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity. 2002;16:661-672.
    • (2002) Immunity , vol.16 , pp. 661-672
    • North, T.E.1    De Bruijn, M.F.2    Stacy, T.3
  • 11
    • 0034697966 scopus 로고    scopus 로고
    • A role for hematopoietic stem cells in promoting angiogenesis
    • Takakura N, Watanabe T, Suenobu S, et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell. 2000;102:199-209.
    • (2000) Cell , vol.102 , pp. 199-209
    • Takakura, N.1    Watanabe, T.2    Suenobu, S.3
  • 12
    • 0036899190 scopus 로고    scopus 로고
    • Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators
    • Burns CE, DeBlasio T, Zhou Y, Zhang J, Zon L, Nimer SD. Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Exp Hematol. 2002;30:1381-1389.
    • (2002) Exp Hematol , vol.30 , pp. 1381-1389
    • Burns, C.E.1    Deblasio, T.2    Zhou, Y.3    Zhang, J.4    Zon, L.5    Nimer, S.D.6
  • 13
    • 0036337052 scopus 로고    scopus 로고
    • Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
    • Kalev-Zylinska ML, Horsfield JA, Flores MV, et al. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development. 2002;129:2015-2030.
    • (2002) Development , vol.129 , pp. 2015-2030
    • Kalev-Zylinska, M.L.1    Horsfield, J.A.2    Flores, M.V.3
  • 14
    • 0027373893 scopus 로고
    • Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia
    • Liu P, Tarle SA, Hajra A, et al. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041-1044.
    • (1993) Science , vol.261 , pp. 1041-1044
    • Liu, P.1    Tarle, S.A.2    Hajra, A.3
  • 15
    • 0029004541 scopus 로고
    • Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
    • Golub TR, Barker GF, Bohlander SK, et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 1995;92:4917-4921.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4917-4921
    • Golub, T.R.1    Barker, G.F.2    Bohlander, S.K.3
  • 16
    • 0028069226 scopus 로고
    • Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
    • Mitani K, Ogawa S, Tanaka T, et al. Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 1994;13:504-510.
    • (1994) EMBO J , vol.13 , pp. 504-510
    • Mitani, K.1    Ogawa, S.2    Tanaka, T.3
  • 17
    • 9044231364 scopus 로고    scopus 로고
    • The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription
    • Hiebert SW, Sun W, Davis JN, et al. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol. 1996;16:1349-1355.
    • (1996) Mol Cell Biol , vol.16 , pp. 1349-1355
    • Hiebert, S.W.1    Sun, W.2    Davis, J.N.3
  • 18
    • 0028943758 scopus 로고
    • Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias
    • Tanaka T, Mitani K, Kurokawa M, et al. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias. Mol Cell Biol. 1995;15:2383-2392.
    • (1995) Mol Cell Biol , vol.15 , pp. 2383-2392
    • Tanaka, T.1    Mitani, K.2    Kurokawa, M.3
  • 19
    • 0032079424 scopus 로고    scopus 로고
    • Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors
    • Okuda T, Cai Z, Yang S, et al. Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood. 1998;91:3134-3143.
    • (1998) Blood , vol.91 , pp. 3134-3143
    • Okuda, T.1    Cai, Z.2    Yang, S.3
  • 20
    • 16144362555 scopus 로고    scopus 로고
    • Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
    • Castilla LH, Wijmenga C, Wang Q, et al. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell. 1996;87:687-696.
    • (1996) Cell , vol.87 , pp. 687-696
    • Castilla, L.H.1    Wijmenga, C.2    Wang, Q.3
  • 21
    • 0036137654 scopus 로고    scopus 로고
    • Runx1/AML1 in leukemia: Disrupted association with diverse protein partners
    • Perry C, Eldor A, Soreq H. Runx1/AML1 in leukemia: disrupted association with diverse protein partners. Leuk Res. 2002;26:221-228.
    • (2002) Leuk Res , vol.26 , pp. 221-228
    • Perry, C.1    Eldor, A.2    Soreq, H.3
  • 22
    • 0032101379 scopus 로고    scopus 로고
    • Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
    • Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J. 1998;17:2994-3004.
    • (1998) EMBO J , vol.17 , pp. 2994-3004
    • Kitabayashi, I.1    Yokoyama, A.2    Shimizu, K.3    Ohki, M.4
  • 23
    • 2442500635 scopus 로고    scopus 로고
    • AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues
    • Yamaguchi Y, Kurokawa M, Imai Y, et al. AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem. 2004;279:15630-15638.
    • (2004) J Biol Chem , vol.279 , pp. 15630-15638
    • Yamaguchi, Y.1    Kurokawa, M.2    Imai, Y.3
  • 24
    • 0032573465 scopus 로고    scopus 로고
    • TLE, the human homolog of Groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation
    • Imai Y, Kurokawa M, Tanaka K, et al. TLE, the human homolog of Groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation. Biochem Biophys Res Commun. 1998;252:582-589.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 582-589
    • Imai, Y.1    Kurokawa, M.2    Tanaka, K.3
  • 25
    • 0034614382 scopus 로고    scopus 로고
    • A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
    • Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J Biol Chem. 2000;275:651-656.
    • (2000) J Biol Chem , vol.275 , pp. 651-656
    • Lutterbach, B.1    Westendorf, J.J.2    Linggi, B.3    Isaac, S.4    Seto, E.5    Hiebert, S.W.6
  • 26
    • 8944230662 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability
    • Tanaka T, Kurokawa M, Ueki K, et al. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. Mol Cell Biol. 1996;16:3967-3979.
    • (1996) Mol Cell Biol , vol.16 , pp. 3967-3979
    • Tanaka, T.1    Kurokawa, M.2    Ueki, K.3
  • 27
    • 9144235404 scopus 로고    scopus 로고
    • The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1
    • Imai Y, Kurokawa M, Yamaguchi Y, et al. The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1. Mol Cell Biol. 2004;24:1033-1043.
    • (2004) Mol Cell Biol , vol.24 , pp. 1033-1043
    • Imai, Y.1    Kurokawa, M.2    Yamaguchi, Y.3
  • 28
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38-51.
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 29
    • 0034671625 scopus 로고    scopus 로고
    • Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells
    • Hayashi K, Natsume W, Watanabe T, et al. Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells. J Immunol. 2000;165:6816-6824.
    • (2000) J Immunol , vol.165 , pp. 6816-6824
    • Hayashi, K.1    Natsume, W.2    Watanabe, T.3
  • 30
    • 0035501077 scopus 로고    scopus 로고
    • Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage
    • Hayashi K, Abe N, Watanabe T, et al. Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage. J Immunol. 2001;167:4957-4965.
    • (2001) J Immunol , vol.167 , pp. 4957-4965
    • Hayashi, K.1    Abe, N.2    Watanabe, T.3
  • 31
    • 0037815268 scopus 로고    scopus 로고
    • + T cells into the Th2 lineage by repressing GATA3 expression
    • + T cells into the Th2 lineage by repressing GATA3 expression. J Exp Med. 2003;198:51-61.
    • (2003) J Exp Med , vol.198 , pp. 51-61
    • Komine, O.1    Hayashi, K.2    Natsume, W.3
  • 32
    • 2342451948 scopus 로고    scopus 로고
    • AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    • Ichikawa M, Asai T, Saito T, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004;10:299-304.
    • (2004) Nat Med , vol.10 , pp. 299-304
    • Ichikawa, M.1    Asai, T.2    Saito, T.3
  • 33
    • 22144447520 scopus 로고    scopus 로고
    • Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
    • Growney JD, Shigematsu H, Li Z, et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood. 2005;106:494-504.
    • (2005) Blood , vol.106 , pp. 494-504
    • Growney, J.D.1    Shigematsu, H.2    Li, Z.3
  • 34
    • 0031951550 scopus 로고    scopus 로고
    • In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region
    • Mukouyama Y, Hara T, Xu M, et al. In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad- mesonephros region. Immunity. 1998;8:105-114.
    • (1998) Immunity , vol.8 , pp. 105-114
    • Mukouyama, Y.1    Hara, T.2    Xu, M.3
  • 35
    • 0033988191 scopus 로고    scopus 로고
    • Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy
    • Okuda T, Takeda K, Fujita Y, et al. Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Mol Cell Biol. 2000;20:319-328.
    • (2000) Mol Cell Biol , vol.20 , pp. 319-328
    • Okuda, T.1    Takeda, K.2    Fujita, Y.3
  • 36
    • 0030029385 scopus 로고    scopus 로고
    • In vitro development of primitive and definitive erythrocytes from different precursors
    • Nakano T, Kodama H, Honjo T. In vitro development of primitive and definitive erythrocytes from different precursors. Science. 1996;272:722-724.
    • (1996) Science , vol.272 , pp. 722-724
    • Nakano, T.1    Kodama, H.2    Honjo, T.3
  • 37
    • 9444283775 scopus 로고    scopus 로고
    • The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
    • Goyama S, Yamaguchi Y, Imai Y, et al. The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region. Blood. 2004;104:3558-3564.
    • (2004) Blood , vol.104 , pp. 3558-3564
    • Goyama, S.1    Yamaguchi, Y.2    Imai, Y.3
  • 38
    • 0942287734 scopus 로고    scopus 로고
    • VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development
    • Nishimura M, Fukushima-Nakase Y, Fujita Y, et al. VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood. 2004;103:562-570.
    • (2004) Blood , vol.103 , pp. 562-570
    • Nishimura, M.1    Fukushima-Nakase, Y.2    Fujita, Y.3
  • 39
    • 19344368461 scopus 로고    scopus 로고
    • Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development
    • Fukushima-Nakase Y, Naoe Y, Taniuchi I, Hosoi H, Sugimoto T, Okuda T. Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood. 2005;105:4298-4307.
    • (2005) Blood , vol.105 , pp. 4298-4307
    • Fukushima-Nakase, Y.1    Naoe, Y.2    Taniuchi, I.3    Hosoi, H.4    Sugimoto, T.5    Okuda, T.6
  • 40
    • 0036916440 scopus 로고    scopus 로고
    • Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro
    • Schmitt TM, Zuniga-Pflucker JC. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity. 2002;17:749-756.
    • (2002) Immunity , vol.17 , pp. 749-756
    • Schmitt, T.M.1    Zuniga-Pflucker, J.C.2
  • 41
    • 20144367473 scopus 로고    scopus 로고
    • Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development
    • Kawazu M, Asai T, Ichikawa M, et al. Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development. J Immunol. 2005;174:3526-3533.
    • (2005) J Immunol , vol.174 , pp. 3526-3533
    • Kawazu, M.1    Asai, T.2    Ichikawa, M.3
  • 42
    • 9444264705 scopus 로고    scopus 로고
    • Haploinsufflciency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors
    • Sun W, Downing JR. Haploinsufflciency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood. 2004;104:3565-3572.
    • (2004) Blood , vol.104 , pp. 3565-3572
    • Sun, W.1    Downing, J.R.2
  • 43
    • 0037472895 scopus 로고    scopus 로고
    • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    • Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421:547-551.
    • (2003) Nature , vol.421 , pp. 547-551
    • Mikkola, H.K.1    Klintman, J.2    Yang, H.3


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