-
1
-
-
0014477396
-
Drugs and heredity. Pharmacogenetics - The study of heritable variations in drug response
-
Schimke RN. Drugs and heredity. Pharmacogenetics - the study of heritable variations in drug response. J. Kans. Med. Soc. 70(3), 146-150 (1969).
-
(1969)
J. Kans. Med. Soc.
, vol.70
, Issue.3
, pp. 146-150
-
-
Schimke, R.N.1
-
2
-
-
0034660560
-
Pharmacogenetics and the practice of medicine
-
Roses AD. Pharmacogenetics and the practice of medicine. Nature 405(6788), 857-865 (2000).
-
(2000)
Nature
, vol.405
, Issue.6788
, pp. 857-865
-
-
Roses, A.D.1
-
3
-
-
79952116283
-
Pharmacogenomics: A systems approach. Wiley Interdiscip
-
Wang L. Pharmacogenomics: a systems approach. Wiley Interdiscip. Rev. Syst. Biol. Med. 2(1), 3-22 (2010).
-
(2010)
Rev. Syst. Biol. Med.
, vol.2
, Issue.1
, pp. 3-22
-
-
Wang, L.1
-
4
-
-
84887402493
-
The anticancer drug development pipeline of the pharmaceutical (P) and biotech (B) industries
-
Abstract e14589
-
Thomas F, Thomas C. The anticancer drug development pipeline of the pharmaceutical (P) and biotech (B) industries. J. Clin. Oncol. 27(Suppl.), Abstract e14589 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.SUPPL.
-
-
Thomas, F.1
Thomas, C.2
-
5
-
-
40849097776
-
Heritability in the genomics era - Concepts and misconceptions
-
Visscher PM, Hill WG, Wray NR. Heritability in the genomics era - concepts and misconceptions. Nat. Rev. Genet. 9(4), 255-266 (2008).
-
(2008)
Nat. Rev. Genet.
, vol.9
, Issue.4
, pp. 255-266
-
-
Visscher, P.M.1
Hill, W.G.2
Wray, N.R.3
-
6
-
-
77955466657
-
Genetics of caffeine consumption and responses to caffeine
-
Yang A, Palmer AA, De Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology 211(3), 245-257 (2010).
-
(2010)
Psychopharmacology
, vol.211
, Issue.3
, pp. 245-257
-
-
Yang, A.1
Palmer, A.A.2
De Wit, H.3
-
7
-
-
34248547883
-
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
-
Faraday N, Yanek LR, Mathias R et al. Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation 115(19), 2490-2496 (2007).
-
(2007)
Circulation
, vol.115
, Issue.19
, pp. 2490-2496
-
-
Faraday, N.1
Yanek, L.R.2
Mathias, R.3
-
8
-
-
3042616025
-
Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity
-
Dolan ME, Newbold KG, Nagasubramanian R et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 64(12), 4353-4356 (2004).
-
(2004)
Cancer Res.
, vol.64
, Issue.12
, pp. 4353-4356
-
-
Dolan, M.E.1
Newbold, K.G.2
Nagasubramanian, R.3
-
9
-
-
4143078229
-
Genome-wide discovery of loci influencing chemotherapy cytotoxicity
-
Watters JW, Kraja A, Meucci MA, Province MA, Mc Leod HL. Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Proc. Natl Acad. Sci. USA 101(32), 11809-11814 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.32
, pp. 11809-11814
-
-
Watters, J.W.1
Kraja, A.2
Meucci, M.A.3
Province, M.A.4
Mc Leod, H.L.5
-
10
-
-
80054935563
-
Pharmacogenomic characterization of US FDA-approved cytotoxic drugs
-
Peters EJ, Motsinger-Reif A, Havener TM et al. Pharmacogenomic characterization of US FDA-approved cytotoxic drugs. Pharmacogenomics 12(10), 1407-1415 (2011).
-
(2011)
Pharmacogenomics
, vol.12
, Issue.10
, pp. 1407-1415
-
-
Peters, E.J.1
Motsinger-Reif, A.2
Havener, T.M.3
-
11
-
-
58849149494
-
Pharmacogenetics and pharmacogenomics of anticancer agents
-
Huang RS, Ratain MJ. Pharmacogenetics and pharmacogenomics of anticancer agents. CA Cancer J. Clin. 59(1), 42-55 (2009).
-
(2009)
CA Cancer J. Clin.
, vol.59
, Issue.1
, pp. 42-55
-
-
Huang, R.S.1
Ratain, M.J.2
-
12
-
-
0242667828
-
Analysing differential gene expression in cancer
-
Liang P, Pardee AB. Analysing differential gene expression in cancer. Nat. Rev. Cancer. 3(11), 869-876 (2003).
-
(2003)
Nat. Rev. Cancer.
, vol.3
, Issue.11
, pp. 869-876
-
-
Liang, P.1
Pardee, A.B.2
-
13
-
-
35348847064
-
SNP genotyping: Technologies and biomedical applications
-
Kim S, Misra A. SNP genotyping: technologies and biomedical applications. Annu. Rev. Biomed. Eng. 9, 289-320 (2007).
-
(2007)
Annu. Rev. Biomed. Eng.
, vol.9
, pp. 289-320
-
-
Kim, S.1
Misra, A.2
-
14
-
-
0035654137
-
Accessing genetic variation: Genotyping single nucleotide polymorphisms
-
Syvanen AC. Accessing genetic variation: genotyping single nucleotide polymorphisms. Nat. Rev. Genet. 2(12), 930-942 (2001).
-
(2001)
Nat. Rev. Genet.
, vol.2
, Issue.12
, pp. 930-942
-
-
Syvanen, A.C.1
-
15
-
-
34249723655
-
Advanced sequencing technologies and their wider impact in microbiology
-
Hall N. Advanced sequencing technologies and their wider impact in microbiology. J. Exp. Biol. 210(Pt 9), 1518-1525 (2007).
-
(2007)
J. Exp. Biol.
, vol.210
, Issue.PART 9
, pp. 1518-1525
-
-
Hall, N.1
-
16
-
-
77950353917
-
Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020
-
Huang RS, Dolan ME. Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020. Pharmacogenomics 11(4), 471-474 (2010).
-
(2010)
Pharmacogenomics
, vol.11
, Issue.4
, pp. 471-474
-
-
Huang, R.S.1
Dolan, M.E.2
-
17
-
-
0025331198
-
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
-
Lennard L, Lilleyman JS, van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 336(8709), 225-229 (1990).
-
(1990)
Lancet
, vol.336
, Issue.8709
, pp. 225-229
-
-
Lennard, L.1
Lilleyman, J.S.2
Van Loon, J.3
Weinshilboum, R.M.4
-
18
-
-
33845219798
-
Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil olerance
-
Morel A, Boisdron-Celle M, Fey L et al. Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil olerance. Mol. Cancer Ther. 5(11), 2895-2904 (2006).
-
(2006)
Mol. Cancer Ther.
, vol.5
, Issue.11
, pp. 2895-2904
-
-
Morel, A.1
Boisdron-Celle, M.2
Fey, L.3
-
19
-
-
35348860753
-
Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer
-
Hsu DS, Balakumaran BS, Acharya CR et al. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J. Clin. Oncol. 25(28), 4350-4357 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.28
, pp. 4350-4357
-
-
Hsu, D.S.1
Balakumaran, B.S.2
Acharya, C.R.3
-
20
-
-
33747168764
-
Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe
-
Van Den Akker-van Marle ME, Gurwitz D, Detmar SB et al. Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe. Pharmacogenomics 7(5), 783-792 (2006).
-
(2006)
Pharmacogenomics
, vol.7
, Issue.5
, pp. 783-792
-
-
Van Den Akker-Van Marle, M.E.1
Gurwitz, D.2
Detmar, S.B.3
-
21
-
-
77957995461
-
Cost effectiveness of pharmacogenomics: A critical and systematic review
-
Wong WB, Carlson JJ, Thariani R, Veenstra DL. Cost effectiveness of pharmacogenomics: a critical and systematic review. Pharmacoeconomics 28(11), 1001-1013 (2010).
-
(2010)
Pharmacoeconomics
, vol.28
, Issue.11
, pp. 1001-1013
-
-
Wong, W.B.1
Carlson, J.J.2
Thariani, R.3
Veenstra, D.L.4
-
22
-
-
0038397495
-
Pharmacogenetics and pharmacogenomics in drug discovery and development: An overview
-
Lindpaintner K. Pharmacogenetics and pharmacogenomics in drug discovery and development: an overview. Clin. Chem. Lab. Med. 41(4), 398-410 (2003).
-
(2003)
Clin. Chem. Lab. Med.
, vol.41
, Issue.4
, pp. 398-410
-
-
Lindpaintner, K.1
-
23
-
-
58149352685
-
Pharmacogenomics: Candidate gene identification, functional validation and mechanisms
-
Wang L, Weinshilboum RM. Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Hum. Mol. Genet. 17(R2), R174-R179 (2008).
-
(2008)
Hum. Mol. Genet.
, vol.17
, Issue.R2
-
-
Wang, L.1
Weinshilboum, R.M.2
-
25
-
-
0030934850
-
Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
-
Yates CR, Krynetski EY, Loennechen T et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 126(8), 608-614 (1997).
-
(1997)
Ann. Intern. Med.
, vol.126
, Issue.8
, pp. 608-614
-
-
Yates, C.R.1
Krynetski, E.Y.2
Loennechen, T.3
-
26
-
-
20144365645
-
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
-
Stanulla M, Schaeffeler E, Flohr T et al. Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. JAMA 293(12), 1485-1489 (2005).
-
(2005)
JAMA
, vol.293
, Issue.12
, pp. 1485-1489
-
-
Stanulla, M.1
Schaeffeler, E.2
Flohr, T.3
-
27
-
-
0036009619
-
The thiopurine S-methyltransferase gene locus - Implications for clinical pharmacogenomics
-
Mc Leod HL, Siva C. The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics 3(1), 89-98 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, Issue.1
, pp. 89-98
-
-
Mc Leod, H.L.1
Siva, C.2
-
28
-
-
4344604014
-
Pharmacogenomics in cancer therapy: Is host genome variability important?
-
Petros WP, Evans WE. Pharmacogenomics in cancer therapy: is host genome variability important? Trends Pharmacol. Sci. 25(9), 457-464 (2004).
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, Issue.9
, pp. 457-464
-
-
Petros, W.P.1
Evans, W.E.2
-
29
-
-
78650447994
-
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics
-
Becquemont L, Alfirevic A, Amstutz U et al. Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. Pharmacogenomics 12(1), 113-124 (2011).
-
(2011)
Pharmacogenomics
, vol.12
, Issue.1
, pp. 113-124
-
-
Becquemont, L.1
Alfirevic, A.2
Amstutz, U.3
-
30
-
-
0026793052
-
Purification and characterization of dihydropyrimidine dehydrogenase from human liver
-
Lu ZH, Zhang R, Diasio RB. Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J. Biol. Chem. 267(24), 17102-17109 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.24
, pp. 17102-17109
-
-
Zh, L.1
Zhang, R.2
Diasio, R.B.3
-
31
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X, Mc Leod HL, Mc Murrough J, Gonzalez FJ, Fernandez-Salguero P. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J. Clin. Invest. 98(3), 610-615 (1996).
-
(1996)
J. Clin. Invest.
, vol.98
, Issue.3
, pp. 610-615
-
-
Wei, X.1
Mc Leod, H.L.2
Mc Murrough, J.3
Gonzalez, F.J.4
Fernandez-Salguero, P.5
-
32
-
-
34447321898
-
Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity
-
Magne N, Etienne-Grimaldi MC, Cals L et al. Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity. Br. J. Clin. Pharmacol. 64(2), 237-240 (2007).
-
(2007)
Br. J. Clin. Pharmacol.
, vol.64
, Issue.2
, pp. 237-240
-
-
Magne, N.1
Etienne-Grimaldi, M.C.2
Cals, L.3
-
33
-
-
80052944892
-
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity
-
Amstutz U, Froehlich TK, Largiader CR. Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity. Pharmacogenomics 12(9), 1321-1336 (2011).
-
(2011)
Pharmacogenomics
, vol.12
, Issue.9
, pp. 1321-1336
-
-
Amstutz, U.1
Froehlich, T.K.2
Largiader, C.R.3
-
34
-
-
78049435885
-
Intragenic deletions and a deep intronic mutation affecting pre-m RNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity
-
van Kuilenburg AB, Meijer J, Mul AN et al. Intragenic deletions and a deep intronic mutation affecting pre-m RNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity. Hum. Genet. 128(5), 529-538 (2010).
-
(2010)
Hum. Genet.
, vol.128
, Issue.5
, pp. 529-538
-
-
Van Kuilenburg, A.B.1
Meijer, J.2
Mul, A.N.3
-
35
-
-
69049114190
-
Dihydropyrimidine dehydrogenase gene variation and severe 5-fluorouracil toxicity: A haplotype assessment
-
Amstutz U, Farese S, Aebi S, Largiader CR. Dihydropyrimidine dehydrogenase gene variation and severe 5-fluorouracil toxicity: a haplotype assessment. Pharmacogenomics 10(6), 931-944 (2009).
-
(2009)
Pharmacogenomics
, vol.10
, Issue.6
, pp. 931-944
-
-
Amstutz, U.1
Farese, S.2
Aebi, S.3
Largiader, C.R.4
-
36
-
-
43749114271
-
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A prospective clinical trial by the German 5-FU Toxicity Study Group
-
Schwab M, Zanger UM, Marx C et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J. Clin. Oncol. 26(13), 2131-2138 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.13
, pp. 2131-2138
-
-
Schwab, M.1
Zanger, U.M.2
Marx, C.3
-
37
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66(8), 3992-3995 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
38
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359(17), 1757-1765 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
39
-
-
28844481452
-
The KRAS oncogene: Past, present, and future
-
Kranenburg O. The KRAS oncogene: past, present, and future. Biochim. Biophys. Acta 1756(2), 81-82 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, Issue.2
, pp. 81-82
-
-
Kranenburg, O.1
-
40
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(10), 1626-1634 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
41
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448(7153), 561-566 (2007).
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
42
-
-
81355124049
-
Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen
-
Zhang S, Wang F, Keats J et al. Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem. Biol. Drug Des. 78(6), 999-1005 (2011).
-
(2011)
Chem. Biol. Drug Des.
, vol.78
, Issue.6
, pp. 999-1005
-
-
Zhang, S.1
Wang, F.2
Keats, J.3
-
43
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin. Cancer Res. 18(5), 1472-1482 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, Issue.5
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
44
-
-
84857820489
-
Tumor heterogeneity and personalized medicine
-
Longo DL. Tumor heterogeneity and personalized medicine. N. Engl. J. Med. 366(10), 956-957 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.10
, pp. 956-957
-
-
Longo, D.L.1
-
45
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490(7418), 61-70 (2012).
-
(2012)
Nature
, vol.490
, Issue.7418
, pp. 61-70
-
-
|