메뉴 건너뛰기




Volumn 41, Issue 4, 2003, Pages 398-410

Pharmacogenetics and pharmacogenomics in drug discovery and development: An overview

Author keywords

Drug efficacy; Drug safety; Genetics; Pharmacogenetics; Pharmacogenomics

Indexed keywords

ALCOHOL DERIVATIVE; AMINOSALICYLIC ACID; AZATHIOPRINE; BENZOYLCHOLINE; BUTYRYLCHOLINE; CAFFEINE; CAPTOPRIL; CHLORZOXAZONE; COUMARIN; DEBRISOQUINE; DEXTROMETHORPHAN; ERYTHROMYCIN; FLUOROURACIL; ISONIAZID; KETOPROFEN; MEPHENYTOIN; MERCAPTOETHANOL; MERCAPTOPURINE; MIDAZOLAM; MORPHINE; NICOTINE; OMEPRAZOLE; OXAZEPAM; PARAOXON; PENICILLAMINE; SPARTEINE; SULFADIMIDINE; TIOGUANINE; UNINDEXED DRUG; WARFARIN;

EID: 0038397495     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2003.063     Document Type: Review
Times cited : (21)

References (28)
  • 1
    • 0035011217 scopus 로고    scopus 로고
    • Drug disposition: To phenotype or genotype
    • Also see
    • Dickins M, Tucker G: Drug disposition: to phenotype or genotype. Int J Pharm Med 2001; 15:70-3. Also see: http://www.imm.ki.se/CYPalleles/
    • (2001) Int. J. Pharm. Med. , vol.15 , pp. 70-73
    • Dickins, M.1    Tucker, G.2
  • 2
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapies
    • Also see
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapies. Science 1999; 206:487-91. Also see: http://www.sciencemag.org/feature/data/1044449.shl/
    • (1999) Science , vol.206 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetics study
    • Fellay J, Marzolini C, Meaden ER, Back DJ, Buclin T, Chave JP, et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002; 359:30-6.
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.R.3    Back, D.J.4    Buclin, T.5    Chave, J.P.6
  • 4
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky M, Lamothe S, Yang HY, Targan SR, Sinnett D, Theoret Y, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000; 118:705-13.
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.1    Lamothe, S.2    Yang, H.Y.3    Targan, S.R.4    Sinnett, D.5    Theoret, Y.6
  • 5
    • 0031466866 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of the beta 2-adrenoceptor and response to albuterol in children with and without a history of wheezing
    • Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta 2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-8.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3184-3188
    • Martinez, F.D.1    Graves, P.E.2    Baldini, M.3    Solomon, S.4    Erickson, R.5
  • 6
    • 0030860288 scopus 로고    scopus 로고
    • Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics
    • Tan S, Hall IP, Dewar J, Dow E, Lipworth B. Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997; 350:995-9.
    • (1997) Lancet , vol.350 , pp. 995-999
    • Tan, S.1    Hall, I.P.2    Dewar, J.3    Dow, E.4    Lipworth, B.5
  • 7
    • 0028068550 scopus 로고
    • Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    • Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33:9414-9.
    • (1994) Biochemistry , vol.33 , pp. 9414-9419
    • Green, S.A.1    Turki, J.2    Innis, M.3    Liggett, S.B.4
  • 8
    • 0029339086 scopus 로고
    • Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells
    • Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995; 13:25-33.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.13 , pp. 25-33
    • Green, S.A.1    Turki, J.2    Bejarano, P.3    Hall, I.P.4    Liggett, S.B.5
  • 9
    • 0027564307 scopus 로고
    • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects
    • Reihsaus E, Innis M, MacIntyre N and Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8:334-49.
    • (1993) Am. J. Respir. Cell Mol. Biol. , vol.8 , pp. 334-349
    • Reihsaus, E.1    Innis, M.2    MacIntyre, N.3    Liggett, S.B.4
  • 10
    • 0031596478 scopus 로고    scopus 로고
    • Beta2 adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population
    • Dewar JC, Wheatley AP, Venn A, Morrison JFJ, Britton J, Hall IP. Beta2 adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin Exp All 1998; 28:442-8.
    • (1998) Clin. Exp. All. , vol.28 , pp. 442-448
    • Dewar, J.C.1    Wheatley, A.P.2    Venn, A.3    Morrison, J.F.J.4    Britton, J.5    Hall, I.P.6
  • 11
    • 0033059209 scopus 로고    scopus 로고
    • Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
    • Drazen JM, Yandava CN, Dube L, Szczerback N, Hippensteel R, Pillari A, et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet 1999; 22:168-70.
    • (1999) Nat. Genet. , vol.22 , pp. 168-170
    • Drazen, J.M.1    Yandava, C.N.2    Dube, L.3    Szczerback, N.4    Hippensteel, R.5    Pillari, A.6
  • 12
    • 0031003816 scopus 로고    scopus 로고
    • Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
    • In KH, Asano K, Beier D, Grobholz J, Finn PW, Silverman EK, et al. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest 1997 1; 99:1130-7.
    • (1997) J. Clin. Invest. , vol.199 , pp. 1130-1137
    • In, K.H.1    Asano, K.2    Beier, D.3    Grobholz, J.4    Finn, P.W.5    Silverman, E.K.6
  • 13
    • 0032796453 scopus 로고    scopus 로고
    • Genetic factors in aminoglycoside toxicity
    • Fischel-Ghodsian N. Genetic factors in aminoglycoside toxicity. Ann NY Acad Sci 1999; 884:99-109.
    • (1999) Ann. NY Acad. Sci. , vol.884 , pp. 99-109
    • Fischel-Ghodsian, N.1
  • 14
    • 0028149270 scopus 로고
    • Proposed molecular and cellular mechanism for aminoglycoside ototoxicity
    • Hutchin T, Cortopassi G. Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob Agents Chemother 1994; 38:2517-20.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 2517-2520
    • Hutchin, T.1    Cortopassi, G.2
  • 15
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185(HER2) monoclonal anti-body in patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, et al. Phase II study of weekly intravenous recombinant humanized anti-p185(HER2) monoclonal anti-body in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996; 14:737-44.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3    Baughman, S.4    Benz, C.C.5    Dantis, L.6
  • 16
    • 0031791656 scopus 로고    scopus 로고
    • Not quite pharmacogenomics
    • [letter; comment]
    • Haseltine WA. Not quite pharmacogenomics [letter; comment]. Nat Biotechnol 1998; 16:1295.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 1295
    • Haseltine, W.A.1
  • 17
    • 0032442150 scopus 로고    scopus 로고
    • Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression
    • McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest 1998;1 02:1927-32.
    • (1999) J. Clin. Invest. , vol.102 , pp. 1927-1932
    • McGraw, D.W.1    Forbes, S.L.2    Kramer, L.A.3    Liggett, S.B.4
  • 18
    • 16044367526 scopus 로고    scopus 로고
    • The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
    • Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996; 2: 1240-3.
    • (1996) Nat. Med. , vol.2 , pp. 1240-1243
    • Huang, Y.1    Paxton, W.A.2    Wolinsky, S.M.3    Neumann, A.U.4    Zhang, L.5    He, T.6
  • 19
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion of the CKR5 structural gene
    • Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion of the CKR5 structural gene. Science 1996; 273:1856-62.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3    Huttley, G.A.4    Smith, M.W.5    Allikmets, R.6
  • 20
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382:722-5.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3    Rucker, J.4    Liesnard, C.5    Farber, C.M.6
  • 22
    • 0030976601 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for CCR5 32
    • Seroco Study Group
    • Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzious C, Seroco Study Group. HIV-1 infection in an individual homozygous for CCR5 32. Lancet 1997; 349: 1219-20.
    • (1997) Lancet , vol.349 , pp. 1219-1220
    • Theodorou, I.1    Meyer, L.2    Magierowska, M.3    Katlama, C.4    Rouzious, C.5
  • 24
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, Masel G, Martin AM, Moore C, et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002; 359:727-32.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3    Masel, G.4    Martin, A.M.5    Moore, C.6
  • 26
    • 0034655976 scopus 로고    scopus 로고
    • Pharmacogentics and future drug development and delivery
    • Roses A. Pharmacogentics and future drug development and delivery. Lancet 2000; 355:1358-61.
    • (2000) Lancet , vol.355 , pp. 1358-1361
    • Roses, A.1
  • 27
    • 0038111336 scopus 로고    scopus 로고
    • Proposed International Guidelines on Ethical Issues in Medical Genetics and Genetic Services
    • Proposed International Guidelines on Ethical Issues in Medical Genetics and Genetic Services. http://www.who.int/ncd/hgn/hgnethic.htm
  • 28
    • 0038788318 scopus 로고    scopus 로고
    • Roche Genetics Educational Program. Available upon request from
    • Roche Genetics Educational Program. Available upon request from http://www.rochegenetics.com


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.