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Volumn 33, Issue 4, 2013, Pages 1041-1049

Chronic administration of dimebon ameliorates pathology in Tau P301S transgenic mice

Author keywords

Alzheimer's disease; dimebolin; latrepirdine; tauopathy; therapeutics; transgenic mice

Indexed keywords

DIMEBON; GAMMA CARBOLINE DERIVATIVE;

EID: 84873642177     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-121732     Document Type: Article
Times cited : (49)

References (36)
  • 2
    • 47149108940 scopus 로고    scopus 로고
    • Effect of Dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-To-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, Seely L, Hung D (2008) Effect of Dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-To-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study. Lancet 372, 207-215
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7    Hung, D.8
  • 3
    • 77956666900 scopus 로고    scopus 로고
    • Dimebon disappointment
    • Jones RW (2010) Dimebon disappointment. Alzheimers Res Ther 2, 25
    • (2010) Alzheimers Res Ther , vol.2 , pp. 25
    • Jones, R.W.1
  • 4
    • 3242887701 scopus 로고    scopus 로고
    • Comparative study of action mechanisms of Dimebon and memantine on AMPA-And NMDA-subtypes glutamate receptors in rat cerebral neurons
    • Grigorev VV, Dranyi OA, Bachurin SO (2003) Comparative study of action mechanisms of Dimebon and memantine on AMPA-And NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136, 474-477
    • (2003) Bull Exp Biol Med , vol.136 , pp. 474-477
    • Grigorev, V.V.1    Dranyi, O.A.2    Bachurin, S.O.3
  • 8
    • 79952707903 scopus 로고    scopus 로고
    • Dimebon inhibits calciuminduced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release
    • Naga KK, Geddes JW (2011) Dimebon inhibits calciuminduced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release. Neuromolecular Med 13, 31-36
    • (2011) Neuromolecular Med , vol.13 , pp. 31-36
    • Naga, K.K.1    Geddes, J.W.2
  • 9
    • 77956214193 scopus 로고    scopus 로고
    • Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death
    • Zhang S, Hedskog L, Petersen CA,Winblad B, AnkarcronaM (2010) Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J Alzheimers Dis 21, 389-402
    • (2010) J Alzheimers Dis , vol.21 , pp. 389-402
    • Zhang, S.1    Hedskog, L.2    Petersen, C.A.3    Winblad, B.4    Ankarcrona, M.5
  • 24
    • 2642553802 scopus 로고    scopus 로고
    • Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    • Robertson DC, Schmidt O, Ninkina N, Jones PA, Sharkey J, Buchman VL (2004) Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. J Neurochem 89, 1126-1136
    • (2004) J Neurochem , vol.89 , pp. 1126-1136
    • Robertson, D.C.1    Schmidt, O.2    Ninkina, N.3    Jones, P.A.4    Sharkey, J.5    Buchman, V.L.6
  • 25
    • 0028946744 scopus 로고
    • Monoclonal antibodyAT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
    • Goedert M, Jakes R, Vanmechelen E (1995) Monoclonal antibodyAT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 189, 167-169
    • (1995) Neurosci Lett , vol.189 , pp. 167-169
    • Goedert, M.1    Jakes, R.2    Vanmechelen, E.3
  • 26
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3, 542-545
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 27
    • 80052027012 scopus 로고    scopus 로고
    • Astrocytic neuroprotection through induction of cytoprotective molecules A proteomic analysis of mutant P301S tau-Transgenic mouse
    • Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, TomimotoH(2011) Astrocytic neuroprotection through induction of cytoprotective molecules; A proteomic analysis of mutant P301S tau-Transgenic mouse. Brain Res 1410, 12-23
    • (2011) Brain Res , vol.1410 , pp. 12-23
    • Yata, K.1    Oikawa, S.2    Sasaki, R.3    Shindo, A.4    Yang, R.5    Murata, M.6    Kanamaru, K.7    Tomimoto, H.8
  • 28
    • 7244242262 scopus 로고    scopus 로고
    • Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein
    • Bellucci A,Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG (2004) Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 165, 1643-1652
    • (2004) Am J Pathol , vol.165 , pp. 1643-1652
    • Bellucci, A.1    Westwood, A.J.2    Ingram, E.3    Casamenti, F.4    Goedert, M.5    Spillantini, M.G.6
  • 31
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Brunden KR (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32, 3601-3611
    • (2012) J Neurosci , vol.32 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3    Yao, Y.4    Iba, M.5    Potuzak, J.S.6    Hogan, A.M.7    Xie, S.X.8    Ballatore, C.9    Smith Iii, A.B.10    Lee, V.M.11    Brunden, K.R.12
  • 32
    • 84864389698 scopus 로고    scopus 로고
    • Degradation of tau protein by autophagy and proteasomal pathways
    • Wang Y, Mandelkow E (2012) Degradation of tau protein by autophagy and proteasomal pathways. Biochem Soc Trans 40, 644-652
    • (2012) Biochem Soc Trans , vol.40 , pp. 644-652
    • Wang, Y.1    Mandelkow, E.2
  • 35
    • 80053243942 scopus 로고    scopus 로고
    • Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
    • Majumder S, Richardson A, Strong R, Oddo S (2011) Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One 6, e25416
    • (2011) PLoS One , vol.6
    • Majumder, S.1    Richardson, A.2    Strong, R.3    Oddo, S.4
  • 36
    • 84863210676 scopus 로고    scopus 로고
    • Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
    • Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, GoedertM(2012) Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain 135, 2169-2177
    • (2012) Brain , vol.135 , pp. 2169-2177
    • Schaeffer, V.1    Lavenir, I.2    Ozcelik, S.3    Tolnay, M.4    Winkler, D.T.5    Goedert, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.