-
1
-
-
9744227183
-
Ubiquitin: Structures, functions, mechanisms
-
PMID:15571809
-
Pickart CM, Eddins MJ. Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 2004; 1695:55-72; PMID:15571809; http://dx.doi.org/10.1016/ j.bbamcr.2004.09.019.
-
(2004)
Biochim Biophys Acta
, vol.1695
, pp. 55-72
-
-
Pickart, C.M.1
Eddins, M.J.2
-
2
-
-
27144529182
-
Ubiquitylation and cell signaling
-
PMID:16148945
-
Haglund K, Dikic I. Ubiquitylation and cell signaling. EMBO J 2005; 24:3353-9; PMID:16148945; http://dx.doi.org/10.1038/sj.emboj.7600808.
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
3
-
-
0034602845
-
Recognition of the polyubiquitin proteolytic signal
-
PMID:10619848
-
Thrower JS, Hoffman L, Rechsteiner M, Pickart CM. Recognition of the polyubiquitin proteolytic signal. EMBO J 2000; 19:94-102; PMID:10619848; http://dx.doi.org/10.1093/emboj/19.1.94.
-
(2000)
EMBO J
, vol.19
, pp. 94-102
-
-
Thrower, J.S.1
Hoffman, L.2
Rechsteiner, M.3
Pickart, C.M.4
-
4
-
-
33646196532
-
Regulation of DNA repair by ubiquitylation
-
PMID:16633336
-
Huang TT, D'Andrea AD. Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol 2006; 7:323- 34; PMID:16633336; http://dx.doi.org/10.1038/ nrm1908.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 323-334
-
-
Huang, T.T.1
D'andrea, A.D.2
-
5
-
-
77649175453
-
Genomic instability-an evolving hallmark of cancer
-
PMID:20177397
-
Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability-an evolving hallmark of cancer. Nat Rev Mol Cell Biol 2010; 11:220-8; PMID:20177397; http://dx.doi.org/10.1038/nrm2858.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 220-228
-
-
Negrini, S.1
Gorgoulis, V.G.2
Halazonetis, T.D.3
-
6
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
PMID:19847258
-
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461:1071- 8; PMID:19847258; http://dx.doi.org/10.1038/ nature08467.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
7
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
PMID:20965415
-
Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40:179- 204; PMID:20965415; http://dx.doi.org/10. 1016/j.molcel.2010.09.019.
-
(2010)
Mol Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
8
-
-
75949124023
-
Assembly of checkpoint and repair machineries at DNA damage sites
-
PMID:19875294
-
Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci 2010; 35:101-8; PMID:19875294; http://dx.doi.org/10.1016/j.tibs.2009.09.001.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 101-108
-
-
Huen, M.S.1
Chen, J.2
-
9
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
-
PMID:21363960
-
Polo SE, Jackson SP. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 2011; 25:409-33; PMID:21363960; http://dx.doi.org/10.1101/gad.2021311.
-
(2011)
Genes Dev
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
10
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
PMID:18001825
-
Huen MSY, Grant R, Manke I, Minn K, Yu XC, Yaffe MB, et al. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 2007; 131:901-14; PMID:18001825; http://dx.doi.org/10. 1016/j.cell.2007.09.041.
-
(2007)
Cell
, vol.131
, pp. 901-914
-
-
Huen, M.S.Y.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.C.5
Yaffe, M.B.6
-
11
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
PMID:18001824
-
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, et al. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007; 131:887- 900; PMID:18001824; http://dx.doi.org/10.1016/j.cell.2007.09.040.
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
-
12
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
PMID:18006705
-
Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 2007; 318:1637-40; PMID:18006705http://dx.doi.org/10.1126/science.1150034.
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
-
13
-
-
36749025467
-
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
-
PMID:18077395
-
Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci USA 2007; 104:20759-63; PMID:18077395; http://dx.doi.org/10.1073/pnas. 0710061104.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20759-20763
-
-
Wang, B.1
Elledge, S.J.2
-
14
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
PMID:19203579
-
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, et al. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 2009; 136:435-46; PMID:19203579; http://dx.doi.org/10.1016/j.cell.2008.12.041.
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
-
15
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
PMID:19203578
-
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, et al. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell 2009; 136:420- 34; PMID:19203578; http://dx.doi.org/10.1016/j.cell.2008.12.042.
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
-
16
-
-
79959326643
-
Critical roles of ring finger protein RNF8 in replication stress responses
-
PMID:21558560
-
Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, et al. Critical roles of ring finger protein RNF8 in replication stress responses. J Biol Chem 2011; 286:22355- 61; PMID:21558560; http://dx.doi.org/10.1074/jbc.M111.232041.
-
(2011)
J Biol Chem
, vol.286
, pp. 22355-22361
-
-
Sy, S.M.1
Jiang, J.2
Dong, S.S.3
Lok, G.T.4
Wu, J.5
Cai, H.6
-
17
-
-
84862777619
-
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
-
PMID:22266820
-
Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol 2012; 19:201-6; PMID:22266820; http://dx.doi.org/10. 1038/nsmb.2211.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 201-206
-
-
Feng, L.1
Chen, J.2
-
18
-
-
84861948252
-
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
-
PMID:22492721
-
Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N. Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. J Cell Biol 2012; 197:189- 99; PMID:22492721; http://dx.doi.org/10.1083/ jcb.201109100.
-
(2012)
J Cell Biol
, vol.197
, pp. 189-199
-
-
Poulsen, M.1
Lukas, C.2
Lukas, J.3
Bekker-Jensen, S.4
Mailand, N.5
-
19
-
-
84865232294
-
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
-
PMID:22884692
-
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, et al. TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell 2012; 150:697-709; PMID:22884692; http://dx.doi.org/10.1016/ j.cell.2012.06.039.
-
(2012)
Cell
, vol.150
, pp. 697-709
-
-
Gudjonsson, T.1
Altmeyer, M.2
Savic, V.3
Toledo, L.4
Dinant, C.5
Grøfte, M.6
-
20
-
-
84864977706
-
Ring finger protein RNF169 antagonizes the ubiquitindependent signaling cascade at sites of DNA damage
-
PMID:22733822
-
Chen J, Feng W, Jiang J, Deng Y, Huen MS. Ring finger protein RNF169 antagonizes the ubiquitindependent signaling cascade at sites of DNA damage. J Biol Chem 2012; 287:27715-22; PMID:22733822; http://dx.doi.org/10.1074/jbc.M112. 373530.
-
(2012)
J Biol Chem
, vol.287
, pp. 27715-27722
-
-
Chen, J.1
Feng, W.2
Jiang, J.3
Deng, Y.4
Huen, M.S.5
-
21
-
-
84864919890
-
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks
-
PMID:22742833
-
Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, et al. Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol Cell 2012; 47:383-95; PMID:22742833; http://dx.doi.org/10.1016/j.molcel.2012.05.045.
-
(2012)
Mol Cell
, vol.47
, pp. 383-395
-
-
Panier, S.1
Ichijima, Y.2
Fradet-Turcotte, A.3
Leung, C.C.4
Kaustov, L.5
Arrowsmith, C.H.6
-
22
-
-
77955867565
-
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
-
PMID:20725033
-
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, et al. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 2010; 466:941-6; PMID:20725033; http://dx.doi.org/10.1038/nature09297.
-
(2010)
Nature
, vol.466
, pp. 941-946
-
-
Nakada, S.1
Tai, I.2
Panier, S.3
Al-Hakim, A.4
Iemura, S.5
Juang, Y.C.6
-
23
-
-
0029977716
-
The RING finger domain: A recent example of a sequence-structure family
-
PMID:8804826
-
Borden KL, Freemont PS. The RING finger domain: a recent example of a sequence-structure family. Curr Opin Struct Biol 1996; 6:395-401; PMID:8804826; http://dx.doi.org/10.1016/S0959-440X(96)80060-1.
-
(1996)
Curr Opin Struct Biol
, vol.6
, pp. 395-401
-
-
Borden, K.L.1
Freemont, P.S.2
-
24
-
-
70449564474
-
RING finger E(3) ubiquitin ligases: Structure and drug discovery
-
PMID:19925422
-
Chasapis CT, Spyroulias GA. RING finger E(3) ubiquitin ligases: structure and drug discovery. Curr Pharm Des 2009; 15:3716-31; PMID:19925422; http://dx.doi.org/10.2174/138161209789271825.
-
(2009)
Curr Pharm des
, vol.15
, pp. 3716-3731
-
-
Chasapis, C.T.1
Spyroulias, G.A.2
-
25
-
-
67349242723
-
E2 interaction and dimerization in the crystal structure of TRAF6
-
PMID:19465916
-
Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, et al. E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol 2009; 16:658- 66; PMID:19465916; http://dx.doi.org/10.1038/nsmb.1605.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 658-666
-
-
Yin, Q.1
Lin, S.C.2
Lamothe, B.3
Lu, M.4
Lo, Y.C.5
Hura, G.6
-
26
-
-
27944495299
-
Chaperoned ubiquitylation- -crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
-
PMID:16307917
-
Zhang M, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, et al. Chaperoned ubiquitylation- -crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell 2005; 20:525-38; PMID:16307917; http://dx.doi.org/10.1016/j.molcel.2005.09.023.
-
(2005)
Mol Cell
, vol.20
, pp. 525-538
-
-
Zhang, M.1
Windheim, M.2
Roe, S.M.3
Peggie, M.4
Cohen, P.5
Prodromou, C.6
-
27
-
-
84863611076
-
Molecular insights into the function of RING finger (RNF)- containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation
-
PMID:22589545
-
Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, et al. Molecular insights into the function of RING finger (RNF)- containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J Biol Chem 2012; 287:23900-10; PMID:22589545; http://dx.doi.org/10.1074/jbc.M112.359653.
-
(2012)
J Biol Chem
, vol.287
, pp. 23900-23910
-
-
Campbell, S.J.1
Edwards, R.A.2
Leung, C.C.3
Neculai, D.4
Hodge, C.D.5
Dhe-Paganon, S.6
-
28
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
PMID:19203578
-
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, et al. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell 2009; 136:420- 34; PMID:19203578; http://dx.doi.org/10.1016/j.cell.2008.12.042.
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
-
29
-
-
82955164827
-
Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation
-
PMID:21911360
-
Lok GT, Sy SM, Dong SS, Ching YP, Tsao SW, Thomson TM, et al. Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation. Nucleic Acids Res 2012; 40:196-205; PMID:21911360; http://dx.doi.org/10.1093/nar/gkr655.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 196-205
-
-
Lok, G.T.1
Sy, S.M.2
Dong, S.S.3
Ching, Y.P.4
Tsao, S.W.5
Thomson, T.M.6
-
30
-
-
33144459648
-
The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation
-
PMID:16215985
-
Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. J Cell Biochem 2006; 97:572-82; PMID:16215985; http://dx.doi.org/10.1002/jcb. 20587.
-
(2006)
J Cell Biochem
, vol.97
, pp. 572-582
-
-
Plans, V.1
Scheper, J.2
Soler, M.3
Loukili, N.4
Okano, Y.5
Thomson, T.M.6
-
31
-
-
52649105473
-
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly
-
PMID:18678647
-
Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, et al. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol 2008; 28:6104- 12; PMID:18678647; http://dx.doi.org/10.1128/MCB.00987-08.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6104-6112
-
-
Huen, M.S.1
Huang, J.2
Yuan, J.3
Yamamoto, M.4
Akira, S.5
Ashley, C.6
-
32
-
-
36749029369
-
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
-
PMID:17940005
-
Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, et al. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci USA 2007; 104:16910-5; PMID:17940005; http://dx.doi.org/10.1073/pnas.0708408104.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 16910-16915
-
-
Stewart, G.S.1
Stankovic, T.2
Byrd, P.J.3
Wechsler, T.4
Miller, E.S.5
Huissoon, A.6
-
33
-
-
84862986431
-
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
-
sup1-12
-
Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, et al. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol 2010; 12:80-6; sup pp 1-12.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 80-86
-
-
Bekker-Jensen, S.1
Rendtlew, D.J.2
Fugger, K.3
Gromova, I.4
Nerstedt, A.5
Lukas, C.6
-
34
-
-
84866388311
-
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
-
PMID:22980979
-
Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, et al. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 2012; 150:1182-95; PMID:22980979; http://dx.doi.org/10.1016/j.cell.2012.08.005.
-
(2012)
Cell
, vol.150
, pp. 1182-1195
-
-
Mattiroli, F.1
Vissers, J.H.2
Van Dijk, W.J.3
Ikpa, P.4
Citterio, E.5
Vermeulen, W.6
-
35
-
-
0031059866
-
Processing of x-ray diffraction data collected in oscillation mode
-
Otwinowski Z, Minor W. Processing of X-Ray Diffraction Data Collected in Oscillation Mode. Methods Enzymol 1997; 276:307-26; http://dx.doi.org/10.1016/ S0076-6879(97)76066-X.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
36
-
-
14244272868
-
PHENIX: Building new software for automated crystallographic structure determination
-
PMID:12393927
-
Adams PD, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, Moriarty NW, et al. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr 2002; 58:1948-54; PMID:12393927; http://dx.doi.org/10.1107/S0907444902016657.
-
(2002)
Acta Crystallogr D Biol, Crystallogr
, vol.58
, pp. 1948-1954
-
-
Adams, P.D.1
Grosse-Kunstleve, R.W.2
Hung, L.W.3
Ioerger, T.R.4
McCoy, A.J.5
Moriarty, N.W.6
-
37
-
-
16644364842
-
REFMAC5 dictionary: Organization of prior chemical knowledge and guidelines for its use
-
PMID:15572771
-
Vagin AA, Steiner RA, Lebedev AA, Potterton L, McNicholas S, Long F, et al. REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use. Acta Crystallogr D Biol Crystallogr 2004; 60:2184-95; PMID:15572771; http://dx.doi.org/10.1107/S0907444904023510.
-
(2004)
Acta Crystallogr D Biol Crystallogr
, vol.60
, pp. 2184-2195
-
-
Vagin, A.A.1
Steiner, R.A.2
Lebedev, A.A.3
Potterton, L.4
McNicholas, S.5
Long, F.6
-
38
-
-
13244281317
-
Coot: Model-building tools for molecular graphics
-
PMID:15572765
-
Emsley P, Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 2004; 60:2126-32; PMID:15572765; http://dx.doi.org/10.1107/S0907444904019158.
-
(2004)
Acta Crystallogr D Biol Crystallogr
, vol.60
, pp. 2126-2132
-
-
Emsley, P.1
Cowtan, K.2
-
39
-
-
0000243829
-
Procheck: A program to check the stereochemical quality of protein structures
-
Laskowski RA, MacArthur MW, Moss DS, Thornton JM. PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Cryst 1993; 26:283-91; http://dx.doi.org/10.1107/S0021889892009944.
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(1993)
J Appl Cryst
, vol.26
, pp. 283-291
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Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
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