Circulating Angiopoietin-2 Is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Shroff, Rukshana C ^a   Price, Karen L ^a   Kolatsi Joannou, Maria ^a   Todd, Alexandra F ^a   Wells, David ^b   Deanfield, John ^c   Johnson, Richard J ^d   Rees, Lesley ^a   Woolf, Adrian S ^e   Long, David A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; URATE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ADOLESCENT; ANTIANGIOGENIC ACTIVITY; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD VESSEL BIOPSY; CARDIOVASCULAR DISEASE; CELLULAR DISTRIBUTION; CHILD; CHILD HEALTH; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DOWN REGULATION; EARLY DIAGNOSIS; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; IMMUNODETECTION; IMMUNOLOCALIZATION; INFLAMMATION; MALE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; UPREGULATION; URIC ACID BLOOD LEVEL;

ADOLESCENT; ANGIOPOIETIN-2; ARTERIES; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CELL ADHESION MOLECULES; CHILD; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; SOLUBILITY; TIME FACTORS; URIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84873626036     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056273     Document Type: Article

References (53)

1. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, et al. (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342: 1478-1483.
2. Covic A, Mardare N, Gusbeth-Tatomir P, Brumaru O, Gavrilovici C, et al. (2006) Increased arterial stiffness in children on haemodialysis. Nephrol Dial Transplant 21: 729-735.
3. Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, et al. (2008) Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 118: 1748-1757.
4. Dursun I, Poyrazoglu HM, Gunduz Z, Ulger H, Yykylmaz A, et al. (2009) The relationship between endothelial microparticles and arterial stiffness and atherosclerosis in children with chronic kidney disease. Nephrol Dial Transplant 24: 2511-2518.
5. Mitsnefes MM, Barletta GM, Dresner IG, Chand DH, Geary D, et al. (2006) Severe cardiac hypertrophy and long-term dialysis: the Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol 21: 1167-1170.
6. McDonald SP, Craig JC, Australian and New Zealand Paediatric Nephrology Association, (2004) Long-term survival of children with end-stage renal disease. N Engl J Med 350: 2654-2662.
7. Oh J, Wunsch R, Turzer M, Bahner M, Raggi P, et al. (2002) Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 106: 100-105.
8. Lilien MR, Groothoff JW, (2009) Cardiovascular disease in children with CKD or ESRD. Nat Rev Nephrol 5: 229-235.
9. Kari JA, Donald AE, Vallance DT, Bruckdorfer KR, Leone A, et al. (1997) Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 52: 468-472.
10. Long DA, Norman JT, Fine LG, (2012) Restoring the renal microvasculature to treat chronic kidney disease. Nat Rev Nephrol 8: 244-250.
11. Kim KT, Choi HH, Steinmetz MO, Maco B, Kammerer RA, et al. (2005) Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2. J Biol Chem 280: 20126-20131.
12. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, et al. (2004) The Tie-2 ligand angiopoietin-2 is stored and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 4150-4156.
13. Kuo MC, Patschan D, Patschan S, Cohen-Gould L, Park HC, et al. (2008) Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells. J Am Soc Nephrol 19: 2321-2330.
14. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, et al. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60.
15. Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, et al. (2011) Angiopoietin-2 promotes myeloid cell infiltration in a β2-integrin-dependent manner. Blood 118: 5050-5059.
16. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, et al. (2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 12: 235-239.
17. Felcht M, Luck R, Schering A, Seidel P, Srivastava K, et al. (2012) Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 122: 1991-2005.
18. Krausz S, Garcia S, Ambarus CA, de Launay D, Foster M, et al. (2012) Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis. Ann Rheum Dis 71: 1402-1417.
19. David S, Kumpers P, Lukasz A, Fliser D, Martens-Lobenhoffer J, et al. (2010) Circulating angiopoietin-2 levels increase with progress of chronic kidney disease. Nephrol Dial Transplant 25: 2571-2576.
20. David S, Kümpers P, Hellpap J, Horn R, Leitolf H, et al. (2009) Angiopoietin-2 and cardiovascular disease in dialysis and kidney transplantation. Am J Kidney Dis 53: 770-778.
21. David S, John SG, Jefferies HJ, Sigrist MK, Kümpers P, et al. (2012) Angiopoietin-2 levels predict mortality in CKD patients. Nephrol Dial Transplant 27: 1867-1872.
22. Kracht D, Shroff R, Baig S, Doyon A, Jacobi C, et al. (2011) Validating a new oscillometric device for aortic pulse wave velocity measurements in children and adolescents. Am J Hypertens 24: 1294-1299.
23. Cole TJ, Green PJ, (1992) Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11: 1305-1319.
24. Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, et al. (2007) Mineral metabolism and vascular damage in children on dialysis. J Am Soc Nephrol 18: 2996-3003.
25. Jourdan C, Wühl E, Litwin M, Fahr K, Trelewicz J, et al. (2005) Normative values for intima-media thickness and distensibility of large arteries in healthy adolescents. J Hypertens 23: 1707-1715.
26. Reusz GS, Cseprekal O, Temmar M, Kis E, Cherif AB, et al. (2010) Reference values of pulse wave velocity in healthy children and teenagers. Hypertension 56: 217-224.
27. Long DA, Woolf AS, Suda T, Yuan HT, (2001) Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice. J Am Soc Nephrol 12: 2721-2731.
28. Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, et al. (2006) Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 17: 1791-1795.
29. Mestas J, Ley K, (2008) Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends Cardiovasc Med 18: 228-232.
30. Litwin M, Wuhl E, Jourdan C, Trelewicz J, Niemirska A, et al. (2005) Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation. J Am Soc Nephrol 16: 1494-1500.
31. Lieb W, Zachariah JP, Xanthakis V, Safa R, Chen MH, et al. (2010) Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community. Circ Cardiovasc Genet 3: 300-306.
32. London GM, Marchais SJ, Guerin AP, Metivier F, Adda H, (2002) Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 17: 1713-1724.
33. Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, et al. (2003) Angiopoietins have distinct modular domains essential for receptor binding dimerization and superclustering. Nat Struct Biol 10: 38-44.
34. Lim HS, Lip GY, Blann AD, (2005) Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis. Atherosclerosis 180: 113-118.
35. Li JJ, Huang YQ, Basch R, Karpatkin S, (2001) Thrombin induces the release of angiopoietin-1 from platelets. Thromb Haemost 85: 204-206.
36. Lukasz A, Hellpap J, Horn R, Kielstein JT, David S, et al. (2008) Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care 12: R94.
37. Di Marco GS, Reuter S, Hillebrand U, Amler S, König M, et al. (2009) The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD. J Am Soc Nephrol 20: 2235-2245.
38. Futrakul N, Butthep P, Laohareungpanya N, Chaisuriya P, Ratanabanangkoon K, (2008) A defective angiogenesis in chronic kidney disease. Ren Fail 30: 215-217.
39. Lilien MR, Koomans HA, Schröder CH, (2005) Hemodialysis acutely impairs endothelial function in children. Pediatr Nephrol 20: 200-204.
40. Goldstein SL, Leung JC, Silverstein DM, (2006) Pro- and anti- inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin. Clin J Am Soc Nephrol 1: 979-986.
41. Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, et al. (2008) Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney Int 74: 300-309.
42. Murdoch C, Tazzyman S, Webster S, Lewis CE, (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol 178: 7405-7411.
43. Yuan HT, Suri C, Landon DN, Yancopoulos GD, Woolf AS, (2000) Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature. J Am Soc Nephrol 11: 1055-1066.
44. Lee SW, Moskowitz MA, Sims JR, (2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med 19: 445-451.
45. Phelps ED, Updike DL, Bullen EC, Grammas P, Howard EW, (2006) Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol 290: C352-C361.
46. Hubbard NE, Lim D, Mukutmoni M, Cai A, Erickson KL, (2005) Expression and regulation of murine macrophage angiopoietin-2. Cell Immunol 234: 102-109.
47. Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, et al. (2012) Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res 94: 510-518.
48. Otani A, Takagi H, Oh H, Koyama S, Honda Y, (2001) Angiotensin II induces expression of the Tie2 receptor ligand, angiopoietin-2, in bovine retinal endothelial cells. Diabetes 50: 867-875.
49. Nakayama T, Sato W, Yoshimura A, Zhang L, Kosugi T, et al. (2010) Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney. Am J Pathol 176: 2198-2208.
50. Matsunaga N, Tsuchimori N, Matsumoto T, Ii M, (2011) TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol 79: 34-41.
51. Yu MA, Sanchez-Lozada LG, Johnson RJ, Kang DH, (2010) Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens 28: 1234-1242.
52. Feig DI, Kang DH, Johnson RJ, (2008) Uric acid and cardiovascular risk. N Engl J Med 359: 1811-1821.
53. Silverstein DM, Srivaths PR, Mattison P, Upadhyay K, Midgley L, et al. (2011) Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients. Pediatr Nephrol 26: 1123-1128.