Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes

Biochemical and Biophysical Research Communications

Volumn 364, Issue 3, 2007, Pages 483-487

  Koch, Manuel ^a   May, Ulrike ^a   Kuhns, Stefanie ^a   Drechsler, Hauke ^a   Adam, Nina ^a   Hattermann, Kirsten ^a   Wirtz, Stefan ^b   Rose John, Stefan ^a   Scheller, Jürgen ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Astrocyte differentiation; C6 cells; Interleukin 27; Interleukin 6; Viral Interleukin 6

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 27; INTERLEUKIN 6; STAT PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENETIC CODE; GLIOMA CELL; HUMAN HERPESVIRUS 8; IMMUNOHISTOCHEMISTRY; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ASTROCYTES; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; INTERLEUKIN-17; INTERLEUKIN-6; MICE;

EID: 35649024165     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.053     Document Type: Article

References (26)

1. Nakashima K., and Taga T. Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system. Mol. Neurobiol. 25 (2002) 233-244
2. Pflanz S., Hibbert L., Mattson J., Rosales D.R., Vaisberg E., Bazan J.F., Phillips J.H., McClanahan T.K., de Waal Malefyt R., and Kastelein R.A. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol. 172 (2004) 2225-2231
3. Scheller J., Grötzinger J., and Rose-John S. Updating IL-6 classic- and trans-signaling. Signal Transduct. 6 (2006) 240-259
4. Batten M., and Ghilardi N. The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85 (2007) 661-672
5. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M., Mattson J., Wagner D.J.L., To W., Zurawski S., McClanahan T.K., Gorman D.M., Bazan J.F., de Waal Malefyt R., Rennick D., and Kastelein R.A. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16 (2002) 779-790
6. Müllberg J., Geib T., Jostock T., Hoischen S.H., Vollmer P., Voltz N., Heinz D., Galle P.R., Klouche M., and Rose-John S. IL-6-receptor independent stimulation of human gp130 by viral IL-6. J. Immunol. 164 (2000) 4672-4677
7. Hoischen S.H., Vollmer P., März P., Özbek S., Götze K., Jostock T., Geib T., Müllberg J., Mechtersheimer S., Fischer M., Grötzinger J., Galle P.R., and Rose-John S. Human herpes virus 8 Interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells. Eur. J. Biochem. 267 (2000) 3604-3612
8. Benda P., Lightbody J., Sato G., Levine L., and Sweet W. Differentiated rat glial cell strain in tissue culture. Science 161 (1968) 370-371
9. Takanaga H., Yoshitake T., Hara S., Yamasaki C., and Kunimoto M. cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine Interleukin-6. J. Biol. Chem. 279 (2004) 15441-15447
10. Yanagisawa M., Nakashima K., and Taga T. STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M. Neurosci. Lett. 269 (1999) 169-172
11. Fischer M., Goldschmitt J., Peschel C., Brakenhoff J.P., Kallen K.J., Wollmer A., Grotzinger J., and Rose-John S. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat. Biotechnol. 15 (1997) 142-145
12. Vollmer P., Oppmann B., Voltz N., Fischer M., and Rose-John S. A role for the immunoglobulin-like domain of the human IL-6 receptor: intracellular protein transport and shedding. Eur. J. Biochem. 263 (1999) 438-446
13. Wirtz S., Tubbe I., Galle P.R., Schild H.J., Birkenbach M., Blumberg R.S., and Neurath M.F. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J. Exp. Med. 203 (2006) 1875-1881
14. Jostock T., Blinn G., Renné C., Kallen K.-J., Rose-John S., and Müllberg J. Immunoadhesins of IL-6 and Hyper-IL-6. J. Immunol. Methods 223 (1999) 171-183
15. Scheller J., Schuster B., Holscher C., Yoshimoto T., and Rose-John S. No inhibition of IL-27 signaling by soluble gp130. Biochem. Biophys. Res. Commun. 326 (2005) 724-728
16. Bonni A., Sun Y., Nadal Vicens M., Bhatt A., Frank D.A., Rozovsky I., Stahl N., Yancopoulos G.D., and Greenberg M.E. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278 (1997) 477-483
17. Nakanishi M., Niidome T., Matsuda S., Akaike A., and Sugimoto H. Microglia-derived interleukin-6 and leukemia inhibitory factor promote astrocyte differentiation of neural stem/progenitor cells. Eur. J. Neurosci. 25 (2007) 649-658
18. Takizawa T., Yanagisawa M., Ochiai W., Yasukawa K., Ishiguro T., Nakashima K., and Taga T. Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of Stat3. Cytokine Growth Factor Rev. 13 (2001) 272-279
19. Yanagisawa M., Nakashima K., Arakawa H., Ikenaka K., Yoshida K., Kishimoto T., Hisatsune T., and Taga T. Astrocyte differentiation of fetal neuroepithelial cells by Interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor STAT3. J. Neurochem. 74 (2000) 1498-1504
20. Brunello A.G., Weissenberger J., Kappeler A., Franke S., Peters M., Rose-John S., and Weis J. Astrocytic alterations in Interleukin-6/soluble Interleukin-6 receptor a double-transgenic mice. Am. J. Pathol. 157 (2000) 1485-1493
21. Campbell I.L., Abraham C.R., Masliah E., Kemper P., Inglis J.D., Oldstone M.B., and Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 90 (1993) 10061-10065
22. Aoki Y., Yarchoan R., Wyvill K., Little O.S.R.F., and Tosato G. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 97 (2001) 2173-2176
23. Aoki Y., Yarchoan R., Braun J., Iwamoto A., and Tosato G. Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions. Blood 96 (2000) 1599-1601
24. Fitzgerald D.C., Ciric B., Touil T., Harle H., Grammatikopolou J., Sarma J.D., Gran B., Zhang G.X., and Rostami A. Suppressive effect of il-27 on encephalitogenic th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179 (2007) 3268-3275
25. Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., Lee J., de Sauvage F.J., and Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7 (2006) 929-936
26. Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., Villarino A.V., Huang Q., Yoshimura A., Sehy D., Saris C.J., O'Shea J., Hennighausen L., Ernst M., and Hunter C.A. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7 (2006) 937-945