Update on adrenal insufficiency in patients with liver cirrhosis

World Journal of Gastroenterology

Volumn 19, Issue 4, 2013, Pages 445-456

  Trifan, Anca ^a   Chiriac, Stefan ^a   Stanciu, Carol ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Adrenal insufficiency; Corticosteroid therapy; Liver cirrhosis; Septic shock

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTEROID; CORTICOTROPIN; FLUDROCORTISONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; PLACEBO; TETRACOSACTIDE; TRANSCORTIN; TUMOR NECROSIS FACTOR ALPHA;

ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ARTICLE; BLOOD CLOTTING DISORDER; CORTICOTROPHIN RELEASING HORMONE TEST; CRITICALLY ILL PATIENT; DIAGNOSTIC TEST; FEEDBACK SYSTEM; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN HYPOGLYCEMIA; LIVER CELL; LIVER CIRRHOSIS; LOW DOSE SHORT SYNACTHEN TEST; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RELAPSE; SEPTIC SHOCK; STANDARD DOSE SHORT SYNACTHEN TEST;

EID: 84873618308     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i4.445     Document Type: Article

References (112)

1. Peterson RE. Adrenocortical steroid metabolism and adrenal cortical function in liver disease. J Clin Invest 1960; 39: 320-331 [PMID: 14432260 DOI: 10.1172/JCI104043]
2. Annane D, Sébille V, Troché G, Raphaël JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283: 1038-1045 [PMID: 10697064 DOI: 10.1001/jama.283.8.1038]
3. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004; 329: 480 [PMID: 15289273 DOI: 10.1136/bmj.38181.482222.55]
4. Rothwell PM, Udwadia ZF, Lawler PG. Cortisol response to corticotropin and survival in septic shock. Lancet 1991; 337: 582-583 [PMID: 1671944 DOI: 10.1016/0140-6736(91)916 41-7]
5. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003; 348: 727-734 [PMID: 12594318 DOI: 10.1056/NEJMra020529]
6. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M, American College of Critical Care Medicine. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008; 36: 1937-1949 [PMID: 18496365 DOI: 10.1097/ CCM.0b013e31817603ba]
7. Méndez-Sánchez N, Villa AR, Zamora-Valdés D, Morales-Espinosa D, Uribe M. Worldwide mortality from cirrhosis. Ann Hepatol 2007; 6: 194-195 [PMID: 17786150]
8. Tsai MH, Peng YS, Chen YC, Liu NJ, Ho YP, Fang JT, Lien JM, Yang C, Chen PC, Wu CS. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 2006; 43: 673-681 [PMID: 16557538 DOI: 10.1002/ hep.21101]
9. Gustot T, Durand F, Lebrec D, Vincent JL, Moreau R. Severe sepsis in cirrhosis. Hepatology 2009; 50: 2022-2033 [PMID: 19885876 DOI: 10.1002/hep.23264]
10. Bouachour G, Tirot P, Varache N, Gouello JP, Harry P, Alquier P. Hemodynamic changes in acute adrenal insufficiency. Intensive Care Med 1994; 20: 138-141 [PMID: 8201094 DOI: 10.1007/BF01707669]
11. Blendis L, Wong F. The hyperdynamic circulation in cirrhosis: an overview. Pharmacol Ther 2001; 89: 221-231 [PMID: 11516477 DOI: 10.1016/S0163-7258(01)00124-3]
12. Marik PE, Gayowski T, Starzl TE, Hepatic Cortisol Research and Adrenal Pathophysiology Study Group. The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med 2005; 33: 1254-1259 [PMID: 15942340 DOI: 10.1097/01.CCM.0000164541.12106.57]
13. Fernández J, Escorsell A, Zabalza M, Felipe V, Navasa M, Mas A, Lacy AM, Ginès P, Arroyo V. Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival. Hepatology 2006; 44: 1288-1295 [PMID: 17058239 DOI: 10.1002/hep.21352]
14. Harry R, Auzinger G, Wendon J. The effects of supraphysiological doses of corticosteroids in hypotensive liver failure. Liver Int 2003; 23: 71-77 [PMID: 12654129 DOI: 10.1034/ j.1600-0676.2003.00813.x]
15. Tan T, Chang L, Woodward A, McWhinney B, Galligan J, Macdonald GA, Cohen J, Venkatesh B. Characterising adrenal function using directly measured plasma free cortisol in stable severe liver disease. J Hepatol 2010; 53: 841-848 [PMID: 20739086 DOI: 10.1016/j.jhep.2010.05.020]
16. Triantos CK, Marzigie M, Fede G, Michalaki M, Giannakopoulou D, Thomopoulos K, Garcovich M, Kalafateli M, Chronis A, Kyriazopoulou V, Jelastopoulou E, Nikolopoulou V, O'Beirne J, Burroughs AK. Critical illness-related corticosteroid insufficiency in patients with cirrhosis and variceal bleeding. Clin Gastroenterol Hepatol 2011; 9: 595-601 [PMID: 21545846 DOI: 10.1016/j.cgh.2011.03.033]
17. Fede G, Spadaro L, Tomaselli T, Privitera G, Piro S, Rabuazzo AM, Sigalas A, Xirouchakis E, O'Beirne J, Garcovich M, Tsochatzis E, Purrello F, Burroughs AK. Assessment of adrenocortical reserve in stable patients with cirrhosis. J Hepatol 2011; 54: 243-250 [PMID: 21056503 DOI: 10.1016/ j.jhep.2010.06.034]
18. Risso A, Alessandria C, Elia C, Mezzabotta L, Andrealli A, Spandre M, Morgando A, Marzano A, Rizzetto M. Adrenal dysfunction in nonseptic cirrhotic patients with ascites: Impact on survival. Dig Liv Dis 2011; 43 Suppl 2: S74-75 [DOI: 10.1016/S1590-8658(11)60031-5]
19. Acevedo J, Fernandez J, Castro M, Roca D, Gines P, Arroyo V. Prognostic value of relative adrenal insufficiency in decompensated cirrhosis. J Hepatol 2010; 52 Suppl 1: S65 [DOI: 10.1016/S0168-8278(10)60148-1]
20. Graupera I, Hernandez-Gea V, Rodriguez J, Colomo A, Poca M, Llao J, Rigla M, Aracil C, Guarner C, Villanueva C. Incidence and prognostic significance of relative adrenal insufficiency in cirrhotic patients with severe variceal bleeding (abstract). The Liver Meeting® 2010 (AASLD). Hepatology 2010; 52 Suppl 1: 267A
21. Toniutto P, Fabris C, Fumolo E, Bitetto D, Fornasiere E, Falleti E, Rapetti R, Minisini R, Pirisi M. Prevalence and risk factors for delayed adrenal insufficiency after liver transplantation. Liver Transpl 2008; 14: 1014-1019 [PMID: 18581463 DOI: 10.1002/lt.21465]
22. Iwasaki T, Tominaga M, Fukumoto T, Kusunoki N, Sugimoto T, Kido M, Ogata S, Takebe A, Tanaka M, Ku Y. Relative adrenal insufficiency manifested with multiple organ dysfunction in a liver transplant patient. Liver Transpl 2006; 12: 1896-1899 [PMID: 17133575 DOI: 10.1002/lt.21006]
23. Singh N, Gayowski T, Marino IR, Schlichtig R. Acute adrenal insufficiency in critically ill liver transplant recipients. Implications for diagnosis. Transplantation 1995; 59: 1744-1745 [PMID: 7604447 DOI: 10.1097/00007890-199506270-00020]
24. Bornstein SR. Predisposing factors for adrenal insufficiency. N Engl J Med 2009; 360: 2328-2339 [PMID: 19474430 DOI: 10.1056/NEJMra0804635]
25. Gaillard RC, Turnill D, Sappino P, Muller AF. Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 1990; 127: 101-106 [PMID: 2163305 DOI: 10.1210/ endo-127-1-101]
26. Cicognani C, Malavolti M, Morselli-Labate AM, Zamboni L, Sama C, Barbara L. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997; 157: 792-796 [PMID: 9125012 DOI: 10.1001/archinte.1997.00440280120012]
27. Albillos A, de la Hera A, González M, Moya JL, Calleja JL, Monserrat J, Ruiz-del-Arbol L, Alvarez-Mon M. Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology 2003; 37: 208-217 [PMID: 12500206 DOI: 10.1053/jhep. 2003.50038]
28. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troché G, Chaumet-Riffaud P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-871 [PMID: 12186604 DOI: 10.1001/jama.288.7.862]
29. Arabi YM, Aljumah A, Dabbagh O, Tamim HM, Rishu AH, Al-Abdulkareem A, Knawy BA, Hajeer AH, Tamimi W, Cherfan A. Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 2010; 182: 1971-1977 [PMID: 21059778 DOI: 10.1503/cmaj. 090707]
30. Arlt W, Stewart PM. Adrenal corticosteroid biosynthesis, metabolism, and action. Endocrinol Metab Clin North Am 2005; 34: 293-313, viii [PMID: 15850843 DOI: 10.1016/j.ecl.2005. 01.002]
31. Snijdewint FG, Kapsenberg ML, Wauben-Penris PJ, Bos JD. Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production. Immunopharmacology 1995; 29: 93-101 [PMID: 7775161 DOI: 10.1016/0162-3109(94) 00048-K]
32. Yang S, Zhang L. Glucocorticoids and vascular reactivity. Curr Vasc Pharmacol 2004; 2: 1-12 [PMID: 15320828 DOI: 10.2174/1570161043476483]
33. Stewart PM. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, editors. Williams textbook of endocrinology. 11th ed. Philadelphia: Saunders, 2008: 445-503
34. Marik PE. Mechanisms and clinical consequences of critical illness associated adrenal insufficiency. Curr Opin Crit Care 2007; 13: 363-369 [PMID: 17599004 DOI: 10.1097/MCC. 0b013e32818a6d74]
35. Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004; 350: 1629-1638 [PMID: 15084695 DOI: 10.1056/NEJMoa020266]
36. de Jong MF, Beishuizen A, Spijkstra JJ, Groeneveld AB. Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock. Crit Care Med 2007; 35: 1896-1903 [PMID: 17568326 DOI: 10.1097/01.CCM.0000275387.51629.ED]
37. Duma D, Jewell CM, Cidlowski JA. Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J Steroid Biochem Mol Biol 2006; 102: 11-21 [PMID: 17070034 DOI: 10.1016/j.jsbmb.2006.09.009]
38. Prigent H, Maxime V, Annane D. Clinical review: corticotherapy in sepsis. Crit Care 2004; 8: 122-129 [PMID: 15025773 DOI: 10.1186/cc2374]
39. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27: 723-732 [PMID: 10321661 DOI: 10.1097/00003246-199904000-00025]
40. Oppert M, Schindler R, Husung C, Offermann K, Gräf KJ, Boenisch O, Barckow D, Frei U, Eckardt KU. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005; 33: 2457-2464 [PMID: 16276166 DOI: 10.1097/01. CCM.0000186370.78639.23]
41. Cirera I, Bauer TM, Navasa M, Vila J, Grande L, Taurá P, Fuster J, García-Valdecasas JC, Lacy A, Suárez MJ, Rimola A, Rodés J. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 2001; 34: 32-37 [PMID: 11211904 DOI: 10.1016/S0168-8278(00)00013-1]
42. Marik PE. Adrenal-exhaustion syndrome in patients with liver disease. Intensive Care Med 2006; 32: 275-280 [PMID: 16432671 DOI: 10.1007/s00134-005-0005-5]
43. O'Beirne J, Holmes M, Agarwal B, Bouloux P, Shaw S, Patch D, Burroughs A. Adrenal insufficiency in liver disease - what is the evidence? J Hepatol 2007; 47: 418-423 [PMID: 17629587 DOI: 10.1016/j.jhep.2007.06.008]
44. Thevenot T, Borot S, Remy-Martin A, Sapin R, Penfornis A, Di Martino V, Monnet E. Assessing adrenal function in cirrhotic patients: is there a reliable test? Gastroenterol Clin Biol 2009; 33: 584-588 [PMID: 19473798 DOI: 10.1016/j.gcb.2009. 03.011]
45. Galbois A, Rudler M, Massard J, Fulla Y, Bennani A, Bonnefont-Rousselot D, Thibault V, Reignier S, Bourrier A, Poynard T, Thabut D. Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. J Hepatol 2010; 52: 839-845 [PMID: 20385427 DOI: 10.1016/j.jhep. 2010.01.026]
46. O'Beirne J. Adrenal function in liver disease. In: Gines P, Forns X, Abraldes JG, Fernndez J, Bataller R, Rodes J, Arroyo V, editors. Therapy in Liver Diseases. Barcelona: Elsevier, 2011: 217-225
47. Etogo-Asse FE, Vincent RP, Hughes SA, Auzinger G, Le Roux CW, Wendon J, Bernal W. High density lipoprotein in patients with liver failure; relation to sepsis, adrenal function and outcome of illness. Liver Int 2012; 32: 128-136 [PMID: 22098564 DOI: 10.1111/j.1478-3231.2011.02657.x]
48. Amarapurkar DN. Adrenal function in cirrhosis: the pendulum swings. J Gastroenterol Hepatol 2012; 27: 1543-1544 [PMID: 22994431 DOI: 10.1111/j.1440-1746.2012.07235.x]
49. Fede G, Spadaro L, Tomaselli T, Privitera G, Germani G, Tsochatzis E, Thomas M, Bouloux PM, Burroughs AK, Purrello F. Adrenocortical dysfunction in liver disease: a systematic review. Hepatology 2012; 55: 1282-1291 [PMID: 22234976 DOI: 10.1002/hep.25573]
50. Beishuizen A, Thijs LG, Vermes I. Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve? Crit Care 2002; 6: 434-438 [PMID: 12398784 DOI: 10.1186/cc1530]
51. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 2002; 122: 1784-1796 [PMID: 12426284 DOI: 10.1378/chest.122.5.1784]
52. Marik PE, Zaloga GP. Adrenal insufficiency during septic shock. Crit Care Med 2003; 31: 141-145 [PMID: 12545007 DOI: 10.1097/00003246-200301000-00022]
53. van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 2003; 31: 1359-1366 [PMID: 12771603 DOI: 10.1097/01.CCM.0000059724.08290. 51]
54. van der Voort PH, Gerritsen RT, Bakker AJ, Boerma EC, Kuiper MA, de Heide L. HDL-cholesterol level and cortisol response to synacthen in critically ill patients. Intensive Care Med 2003; 29: 2199-2203 [PMID: 14566456 DOI: 10.1007/ s00134-003-2021-7]
55. Marik PE. Adrenal insufficiency: the link between low apolipoprotein A-I levels and poor outcome in the critically ill? Crit Care Med 2004; 32: 1977-1978; author reply 1977-1978 [PMID: 15343040 DOI: 10.1097/01.CCM.0000132895.890 19.32]
56. Chien JY, Jerng JS, Yu CJ, Yang PC. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med 2005; 33: 1688-1693 [PMID: 16096442 DOI: 10.1097/01.CCM.0000171183.79525.6B]
57. Yaguchi H, Tsutsumi K, Shimono K, Omura M, Sasano H, Nishikawa T. Involvement of high density lipoprotein as substrate cholesterol for steroidogenesis by bovine adrenal fasciculo-reticularis cells. Life Sci 1998; 62: 1387-1395 [PMID: 9585166 DOI: 10.1016/S0024-3205(98)00077-0]
58. Ettinger WH, Varma VK, Sorci-Thomas M, Parks JS, Sigmon RC, Smith TK, Verdery RB. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. Arterioscler Thromb 1994; 14: 8-13 [PMID: 8274481 DOI: 10.1161/01.ATV. 14.1.8]
59. Baranova I, Vishnyakova T, Bocharov A, Chen Z, Remaley AT, Stonik J, Eggerman TL, Patterson AP. Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells. Infect Immun 2002; 70: 2995-3003 [PMID: 12010990 DOI: 10.1128/IAI.70. 6.2995-3003.2002]
60. Vishnyakova TG, Bocharov AV, Baranova IN, Chen Z, Remaley AT, Csako G, Eggerman TL, Patterson AP. Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem 2003; 278: 22771-22780 [PMID: 12651854 DOI: 10.1074/jbc. M211032200]
61. Cervoni JP, Thévenot T, Weil D, Muel E, Barbot O, Sheppard F, Monnet E, Di Martino V. C-reactive protein predicts short-term mortality in patients with cirrhosis. J Hepatol 2012; 56: 1299-1304 [PMID: 22314431 DOI: 10.1016/j.jhep. 2011.12.030]
62. Zapater P, Francés R, González-Navajas JM, de la Hoz MA, Moreu R, Pascual S, Monfort D, Montoliu S, Vila C, Escudero A, Torras X, Cirera I, Llanos L, Guarner-Argente C, Palazón JM, Carnicer F, Bellot P, Guarner C, Planas R, Solá R, Serra MA, Muñoz C, Pérez-Mateo M, Such J. Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis. Hepatology 2008; 48: 1924-1931 [PMID: 19003911 DOI: 10.1002/hep.22564]
63. Jang JY, Cho WY, Jeong SW, Kim SG, Cheon YK, Kim YS, Cho YD, Kim H, Lee JS, Shim CS, Kim BS. Relative adrenal insufficiency in patients with chronic liver disease. Hepatology 2008; 48: 1088A
64. Thierry S, Giroux Leprieur E, Lecuyer L, Brocas E, Van de Louw A. Echocardiographic features, mortality, and adrenal function in patients with cirrhosis and septic shock. Acta Anaesthesiol Scand 2008; 52: 45-51 [PMID: 17996000 DOI: 10.1111/j.1399-6576.2007.01491.x]
65. du Cheyron D, Bouchet B, Cauquelin B, Guillotin D, Ramakers M, Daubin C, Ballet JJ, Charbonneau P. Hyperreninemic hypoaldosteronism syndrome, plasma concentrations of interleukin-6 and outcome in critically ill patients with liver cirrhosis. Intensive Care Med 2008; 34: 116-124 [PMID: 17906854 DOI: 10.1007/s00134-007-0864-z]
66. El Damarawy M, Hamed G, Heikal A, Darwish H, Badr M. Meld Score as a Predictor for Hepato Adrenal Syndrome. J Am Sci 2012; 8: 208-211
67. Thevenot T, Dorin R, Monnet E, Qualls CR, Sapin R, Grandclement E, Borot S, Sheppard F, Weil D, Degand T, Di Martino V, Kazlauskaite R. High serum levels of free cortisol indicate severity of cirrhosis in hemodynamically stable patients. J Gastroenterol Hepatol 2012; 27: 1596-1601 [PMID: 22647073 DOI: 10.1111/j.1440-1746.2012.07188.x]
68. Coolens JL, Van Baelen H, Heyns W. Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem 1987; 26: 197-202 [PMID: 3560936 DOI: 10.1016/0022-4731(87)90071-9]
69. McDonald JA, Handelsman DJ, Dilworth P, Conway AJ, McCaughan GW. Hypothalamic-pituitary adrenal function in end-stage non-alcoholic liver disease. J Gastroenterol Hepatol 1993; 8: 247-253 [PMID: 8390870 DOI: 10.1111/j.1440- 1746.1993.tb01195.x]
70. Wiest R, Moleda L, Zietz B, Hellerbrand C, Schölmerich J, Straub R. Uncoupling of sympathetic nervous system and hypothalamic-pituitary-adrenal axis in cirrhosis. J Gastroenterol Hepatol 2008; 23: 1901-1908 [PMID: 18554237 DOI: 10.1111/j.1440-1746.2008.05456.x]
71. Arafah BM. Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods. J Clin Endocrinol Metab 2006; 91: 3725-3745 [PMID: 16882746 DOI: 10.1210/jc.2006-0674]
72. Vogeser M, Groetzner J, Küpper C, Briegel J. Free serum cortisol during the postoperative acute phase response determined by equilibrium dialysis liquid chromatographytandem mass spectrometry. Clin Chem Lab Med 2003; 41: 146-151 [PMID: 12666999 DOI: 10.1515/CCLM.2003.024]
73. Vincent RP, Etogo-Asse FE, Dew T, Bernal W, Alaghband- Zadeh J, le Roux CW. Serum total cortisol and free cortisol index give different information regarding the hypothalamus- pituitary-adrenal axis reserve in patients with liver impairment. Ann Clin Biochem 2009; 46: 505-507 [DOI: 10.1258/ acb.2009.009030]
74. Thevenot T, Borot S, Remy-Martin A, Sapin R, Cervoni JP, Richou C, Vanlemmens C, Cleau D, Muel E, Minello A, Tirziu S, Penfornis A, Di Martino V, Monnet E. Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol. Liver Int 2011; 31: 425-433 [PMID: 21281437 DOI: 10.1111/j.1478-3231.2010.02431.x]
75. Cohen J, Smith ML, Deans RV, Pretorius CJ, Ungerer JP, Tan T, Jones M, Venkatesh B. Serial changes in plasma total cortisol, plasma free cortisol, and tissue cortisol activity in patients with septic shock: an observational study. Shock 2012; 37: 28-33 [PMID: 21993448 DOI: 10.1097/SHK. 0b013e318239b809]
76. Molenaar N, Johan Groeneveld AB, Dijstelbloem HM, de Jong MF, Girbes AR, Heijboer AC, Beishuizen A. Assessing adrenal insufficiency of corticosteroid secretion using free versus total cortisol levels in critical illness. Intensive Care Med 2011; 37: 1986-1993 [PMID: 21850531 DOI: 10.1007/s00 134-011-2342-x]
77. Schlienger JL, Sapin R, Gasser F, Briche-Prouveur S, Dreyfuss M. Intérêt cortisol libre plasmatique en pratique Clinique. Sem Hop Paris 1989; 65: 2067-2070
78. le Roux CW, Chapman GA, Kong WM, Dhillo WS, Jones J, Alaghband-Zadeh J. Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery. J Clin Endocrinol Metab 2003; 88: 2045-2048 [PMID: 12727952 DOI: 10.1210/ jc.2002-021532]
79. Arafah BM, Nishiyama FJ, Tlaygeh H, Hejal R. Measurement of salivary cortisol concentration in the assessment of adrenal function in critically ill subjects: a surrogate marker of the circulating free cortisol. J Clin Endocrinol Metab 2007; 92: 2965-2971 [PMID: 17535998 DOI: 10.1210/jc.2007-0181]
80. Soni A, Pepper GM, Wyrwinski PM, Ramirez NE, Simon R, Pina T, Gruenspan H, Vaca CE. Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 1995; 98: 266-271 [PMID: 7872343 DOI: 10.1016/S0002-9343(99)80373-8]
81. Fernández J, Acevedo J. Adrenal Function in Chronic Liver Failure. In: Ginès P, Kamath PS, Arroyo V, editors. Chronic Liver Failure: Mechanisms and Management. New York: Humana Press Inc., 2011: 377-391
82. Kazlauskaite R, Evans AT, Villabona CV, Abdu TA, Ambrosi B, Atkinson AB, Choi CH, Clayton RN, Courtney CH, Gonc EN, Maghnie M, Rose SR, Soule SG, Tordjman K, Consortium for Evaluation of Corticotropin Test in Hypothalamic- Pituitary Adrenal Insufficiency. Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab 2008; 93: 4245-4253 [PMID: 18697868 DOI: 10.1210/jc.2008-0710]
83. Dorin RI, Qualls CR, Crapo LM. Diagnosis of adrenal insufficiency. Ann Intern Med 2003; 139: 194-204 [PMID: 12899587]
84. Agha A, Tomlinson JW, Clark PM, Holder G, Stewart PM. The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic- pituitary-adrenal axis. J Clin Endocrinol Metab 2006; 91: 43-47 [PMID: 16249286 DOI: 10.1210/jc.2005-1131]
85. Mohamed MB, Hamed G Heikal A, Darwish H. Prevalence of adenocortical insufficiency in patients with liver cirrhosis, liver cirrhosis with septic shock and in patients with hepatorenal syndrome. J Am Sci 2011; 7: 391-400
86. Vasu TS, Stewart J, Cavallazzi RS, Hirani A, Marik PE. Hepatoadrenal syndrome: prevalence and factors predicting adrenal insufficiency in critically ill patients with liver disease. Am J Respir Crit Care Med 2009; 179: A1588
87. Sigalas A, Xirouchakis E, Manousou P, Corbani A, Calvaruso V, Patch D, Burroughs AK, O'Beirne J. Adrenal impairment is frequent finding in stable cirrhosis and is related to disease severity. Hepatology 2007; 46: 573A
88. Alessandria C, Mezzabotta L, Carello M, Debernardi-Venon W, Martini S, Rizzetto M, Marzano A. Relative adrenal insufficiency in cirrhosis: relevance in patients with ascites and treatment with hydrocortisone in refractory ascites. Digest Liver Dis 2009; 41: A13 [DOI: 10.1016/j.dld.2008.12.029]
89. Acevedo J, Fernández J, Castro M, Roca D, Ginès P, Arroyo V. Impact of relative adrenal insufficiency on circulatory function and mortality in advanced cirrhosis. J Hepatol 2011; 54 Suppl 1: S61 [DOI: 10.1016/S0168-8278(11)60141-4]
90. Patel SBR, Butt T, O'Beirne J, Mallett S. Steroid administration during liver transplantation reduces the need for physiological support post operatively - More evidence for relative adrenal insufficiency in liver failure. Eur J Anaesthesiol 2010; 27: 176 [DOI: 10.1097/00003643-201006121-00563]
91. Ullian ME. The role of corticosteriods in the regulation of vascular tone. Cardiovasc Res 1999; 41: 55-64 [PMID: 1032 5953 DOI: 10.1016/S0008-6363(98)00230-2]
92. Beishuizen A, Thijs LG. Relative adrenal failure in intensive care: an identifiable problem requiring treatment? Best Pract Res Clin Endocrinol Metab 2001; 15: 513-531 [PMID: 11800521 DOI: 10.1053/beem.2001.0167]
93. Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, Bercker S, Volk HD, Doecke WD, Falke KJ, Gerlach H. Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167: 512-520 [PMID: 12426230 DOI: 10.1164/ rccm.200205-446OC]
94. Radomski MW, Palmer RM, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990; 87: 10043-10047 [PMID: 1702214 DOI: 10.1073/pnas.87.24.10043]
95. Annane D, Bellissant E, Sebille V, Lesieur O, Mathieu B, Raphael JC, Gajdos P. Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998; 46: 589-597 [PMID: 9862249 DOI: 10.1046/j.1365-2125.1998.00833.x]
96. Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332: 1351-1362 [PMID: 7715646 DOI: 10.1056/NEJM19950518 3322008]
97. Turnbull AV, Rivier CL. Regulation of the hypothalamicpituitary- adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 1999; 79: 1-71 [PMID: 9922367]
98. Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 2004; 141: 47-56 [PMID: 15238370]
99. Bellissant E, Annane D. Effect of hydrocortisone on phenylephrine- mean arterial pressure dose-response relationship in septic shock. Clin Pharmacol Ther 2000; 68: 293-303 [PMID: 11014411 DOI: 10.1067/mcp.2000.109354]
100. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998; 26: 645-650 [PMID: 9559600 DOI: 10.1097/00003246-199804000- 00010]
101. Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen A, Bokhari F, Zaloga G, Annane D. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 2008; 34: 61-69 [PMID: 18000649 DOI: 10.1007/s00134-007-0933-3]
102. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, CORTICUS Study Groupf. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358: 111-124 [PMID: 18184957 DOI: 10.1056/NEJMoa071366]
103. Marik PE. Critical illness-related corticosteroid insufficiency. Chest 2009; 135: 181-193 [PMID: 19136406 DOI: 10.1378/ chest.08-1149]
104. Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della Porta R, Giorgio C, Blasi F, Umberger R, Meduri GU. Hydrocortisone infusion for severe communityacquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005; 171: 242-248 [PMID: 15557131 DOI: 10.1164/rccm.200406-808OC]
105. Cicarelli DD, Vieira JE, Benseñor FE. Early dexamethasone treatment for septic shock patients: a prospective randomized clinical trial. Sao Paulo Med J 2007; 125: 237-241 [PMID: 17992396 DOI: 10.1590/S1516-31802007000400009]
106. Cronin L, Cook DJ, Carlet J, Heyland DK, King D, Lansang MA, Fisher CJ. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 1995; 23: 1430-1439 [PMID: 7634816 DOI: 10.1097/00003246- 199508000-00019]
107. The Veterans Administration Systemic Sepsis Cooperative Study Group. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317: 659-665 [PMID: 2888017]
108. Lefering R, Neugebauer EA. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 1995; 23: 1294-1303 [PMID: 7600840 DOI: 10.1097/00003246-19950700 0-00021]
109. Schneider AJ, Voerman HJ. Abrupt hemodynamic improvement in late septic shock with physiological doses of glucocorticoids. Intensive Care Med 1991; 17: 436-437 [PMID: 1774 404 DOI: 10.1007/BF01720688]
110. Chawla K, Kupfer Y, Goldman I. Hydrocorticsone reverses refractory septic shock. Crit Care Med 1999; 27 Suppl 1: A33 [DOI: 10.1097/00003246-199901001-00022]
111. Yildiz O, Doganay M, Aygen B, Güven M, Keleştimur F, Tutuû A. Physiological-dose steroid therapy in sepsis [ISRCTN36253388]. Crit Care 2002; 6: 251-259 [PMID: 12133187]
112. Zietz B, Lock G, Plach B, Drobnik W, Grossmann J, Schölmerich J, Straub RH. Dysfunction of the hypothalamic-pituitary- glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. Eur J Gastroenterol Hepatol 2003; 15: 495-501 [PMID: 12702906 DOI: 10.1097/00042737-200305000-00007]