The long-term predictive accuracy of the short Synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 1, 2006, Pages 43-47

  Agha, Amar ^a   Tomlinson, Jeremy W ^a   Clark, Penelope M ^b   Holder, Geoff ^b   Stewart, Paul M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID; HYDROCORTISONE; TETRACOSACTIDE;

ADOLESCENT; ADRENAL INSUFFICIENCY; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIAGNOSTIC ACCURACY; ENDOCRINE SURGERY; FEMALE; FOLLOW UP; FUNCTION TEST; HUMAN; HYPOPHYSIS; HYPOPHYSIS DISEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SAFETY;

ADENOMA; ADOLESCENT; ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; AGED, 80 AND OVER; EMPTY SELLA SYNDROME; FALSE NEGATIVE REACTIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; HYPOPHYSECTOMY; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFARCTION; MALE; MIDDLE AGED; PITUITARY DISEASES; PITUITARY FUNCTION TESTS; PITUITARY NEOPLASMS; PITUITARY-ADRENAL FUNCTION TESTS; PREDICTIVE VALUE OF TESTS; PREGNANCY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 30344453640     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1131     Document Type: Article

References (25)

1. Plumpton FS, Besser GM 1969 The adrenocortical response to surgery and insulin-induced hypoglycaemia in corticosteroid-treated and normal subjects. Br J Surg 56:216-219
2. Shah A, Stanhope R, Matthew D 1992 Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ 304:173-174
3. Jones SL, Trainer PJ, Perry L, Wass JA, Bessser GM, Grossman A 1994 An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin Endocrinol (Oxf) 41:123-128
4. Stewart PM, Corrie J, Seckl JR, Edwards CR, Padfield PL 1988 A rational approach for assessing the hypothalamo-pituitary-adrenal axis. Lancet 1:1208-1210
5. Kane KF, Emery P, Sheppard MC, Stewart PM 1995 Assessing the hypothalamo-pituitary-adrenal axis in patients on long-term glucocorticoid therapy: the short Synacthen versus the insulin tolerance test. QJM 88:263-267
6. Clayton RN 1996 Short Synacthen test versus insulin stress test for assessment of the hypothalamo-pituitary-adrenal axis: controversy revisited. Clin Endocrinol (Oxf) 44:147-149
7. Hurel SJ, Thompson CJ, Watson MJ, Harris MM, Baylis PH, Kendall-Taylor P 1996 The short Synacthen and insulin stress tests in the assessment of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf) 44:141-146
8. Rasmuson S, Olsson T, Hagg E 1996 A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf) 44:151-156
9. Abdu TA, Elhadd TA, Neary R, Clayton RN 1999 Comparison of the low-dose SST (1 μg), the conventional-dose SST (250 μg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. J Clin Endocrinol Metab 84:838-843
10. Bangar V, Clayton RN 1998 How reliable is the short Synacthen test for the investigation of the hypothalamic-pituitary-adrenal axis? Eur J Endocrinol 139:580-583
11. Courtney CH, McAllister AS, Bell PM, McCance DR, Leslie H, Sheridan B, Atkinson AB 2004 Low- and standard-dose corticotropin and insulin hypoglycemic testing in the assessment of hypothalamic-pituitary adrenal function after pituitary surgery. J Clin Endocrinol Metab 89:1712-1717
12. Lindholm J, Kehlet H 1987 Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitary-adrenocortical function. Clin Endocrinol (Oxf) 26:53-59
13. Tordjman K, Jaffe A, Grazas N, Apter C, Stern N 1995 The role of the low dose (1 microgram) adrenocorticotropin test in the evaluation of patients with pituitary diseases. J Clin Endocrinol Metab 80:1301-1305
14. Orme SM, Peacey SR, Barth JH, Belchetz PE 1996 Comparison of tests of stress-released cortisol secretion in pituitary disease. Clin Endocrinol (Oxf) 45:135-140
15. Ammari F, Issa BG, Millward E, Scanion MF 1996 A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. Clin Endocrinol (Oxf) 44:473-476
16. Dokmetas HS, Colak R, Kelestimur F, Selcuklu A, Unluhizarci K, Bayram F 2000 A comparison between the 1-μg adrenocorticotropin (ACTH) test, the short ACTH (250 μg) test, and the insulin tolerance test in the assessment of hypothalamo-pituitary-adrenal axis immediately after pituitary surgery. J Clin Endocrinol Metab 85:3713-3719
17. Soule SG, Fahie-Wilson M, Tomlinson S 1996 Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. Clin Endocrinol (Oxf) 44:137-140
18. Pfeifer M, Kanc K, Verhovec R, Kocijancic A 2001 Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men. Clin Endocrinol (Oxf) 54:17-22
19. Courtney CH, McAllister AS, McCance DR, Bell PM, Hadden DR, Leslie H, Sheridan B, Atkinson AB 2000 Comparison of one week 0900 h serum cortisol, low- and standard-dose Synacthen tests with a 4 to 6 week insulin hypoglycaemia test after pituitary surgery in assessing HPA axis. Clin Endocrinol (Oxf) 53:431-436
20. Clark PM, Neylon I, Raggatt PR, Sheppard MC, Stewart PM 1998 Defining the normal cortisol response to the short Synacthen test: implications for the investigation of hypothalamic-pituitary disorders. Clin Endocrinol (Oxf) 49:287-292
21. Gleeson HK, Walker BR, Seckl JR, Padfield PL 2003 Ten years on: safety of short Synacthen tests in assessing adrenocorticotropin deficiency in clinical practice. J Clin Endocrinol Metab 88:2106-2111
22. Mayenknecht J, Diederich S, Bahr V, Plockinger U, Oeklers W 1998 Comparison of low and high dose corticotropin stimulation tests in patients with pituitary disease. J Clin Endocrinol Metab 83:1558-1562
23. Tsatsoulis A, Shalet SM, Harrison J, Ratcliffe WA, Beardwell CG, Robinson EL 1988 Adrenocorticotrophin (ACTH) deficiency undetected by standard dynamic tests of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf) 28:225-232
24. Thaler LM, Blevins Jr LS 1998 The low dose (1-μg) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. J Clin Endocrinol Metab 83:2726-2729
25. Dorin RI, Qualls CR, Crapo LM 2003 Diagnosis of adrenal insufficiency. Ann Intern Med 13:194-204