Uniform polymer microspheres: Monodispersity criteria, methods of formation and applications

Nanomedicine

Volumn 8, Issue 2, 2013, Pages 265-285

  De La Vega, José Carlos ^a   Elischer, Philipp ^a   Schneider, Thomas ^a   Häfeli, Urs O ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

coefficient of variation; microsphere; monodispersity; monosized; polydispersity index; polymer; preparation method; uniform particle size

Indexed keywords

MICROSPHERE; POLYMER;

DISPERSION; DRUG DEGRADATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; STATISTICAL ANALYSIS;

EID: 84873601069     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.210     Document Type: Review

References (74)

1. Huck P, Emelko M. Filter Operation Effects on Pathogen Passages. American Water Works Association, Denver, CO, USA (2001).
2. Troy DB, Beringer P. The Science and Practice of Pharmacy. Remington JP (Ed.). Lippincott Williams & Wilkins, MA, USA (2005).
3. Brown DM. Drug Delivery Systems in Cancer Therapy. Humana Press, New York, NY, USA (2004).
4. Szycher M. High Performance Biomaterials: A Comprehensive Guide to Medical and Pharmaceutical Applications. CRC Press, Boca Raton, FL, USA (1991).
5. Akbuga J. Effect of microsphere size and formulation factors on drug release from controlled-release furosemide microspheres. Drug Dev. Ind. Pharm. 17(4), 593-607 (1991).
6. Kelly TL, Wolf MO. Template approaches to conjugated polymer micro-and nanoparticles. Chem. Soc. Rev. 39(39), 1526-1535 (2010).
7. Yanagishita T, Fujimura R, Nishio K, Masuda H. Fabrication of monodisperse polymer nanoparticles by membrane emulsification using ordered anodic porous alumina. Langmuir 26, 1516-1519 (2010).
8. Musyanovych A, Schmitz-Wienke J, Mailander V, Walther P, Landfester K. Preparation of biodegradable polymer nanoparticles by miniemulsion technique and their cell interactions. Macromol. Biosci. 8, 127-139 (2008).
9. Park J, Joo J, Kwon SG, Jang Y, Hyeon T. Synthesis of monodisperse spherical nanocrystals. Angew. Chem. Int. Ed. 46, 4630-4660 (2007).
10. Dave SR, Gao X. Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: A versatile and evolving technology. WIREs Nanomed. Nanobiotechnol. 1, 583-609 (2009).
11. Ho D, Sun X, Sun S. Monodisperse magnetic nanoparticles for theranostic applications. Acc. Chem. Res. 44, 875-882 (2011).
12. Jillavenkatesa A, Dapkunas SJ, Lum LSH. Particle Size Characterization: A NIST Recommended Practice Guide. Special Publication 960-1. US Government Printing Office, Washington, DC, USA (2001).
13. Xu R. Particle Characterization: Light Scattering Methods. Kluwer Academic Publishers, MA, USA (2002).
14. Hackley VA. Nomenclature for Ceramic Particle Dispersion Systems. US Government Printing Office, Washington, DC, USA (1999).
15. Izumida Y, Sugiura S, Oda T, Satake M, Nakajima M. Production of quasi-monodisperse emulsions with large droplets using a micromachined device. J. Am. Oil Chemists Soc. 82(1), 73-78 (2005).
16. Tran V-T, Benoît J-P, Venier-Julienne M-C. Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy? Int. J. Pharmaceut. 407(1-2), 1-11 (2011).
17. Sambe H, Hoshina K, Moaddel R, Wainer I, Haginaka J. Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization. J. Chromatogr. A 1134(1-2), 88-94 (2006).
18. Odian G Principles of Polymerization (4th Edition). Wiley-Interscience, New York, NY, USA, 811 (2004).
19. Bai F, Yang X, Huang W. Synthesis of narrow or monodisperse poly(divinylbenzene) microspheres by distillation-precipitation polymerization. Macromolecules 37, 9746-9752 (2004).
20. Li WH, Stöver HDH. Porous monodisperse poly(divinylbenzene) microspheres by precipitation polymerization. J. Polym. Sci. Part A: Pofym. Chem. 36(10), 1543-1551 (1998).
21. Takekoh R, Li WH, Burke NA, Stover HD. Multilayered polymer microspheres by thermal imprinting during microsphere growth. J. Am. Chem. Soc. 128(1), 240-244 (2006).
22. Jiang H, Chen H, Liang Y, Liu X. Preparation of monodisperse poly(ST-co-PETEA) microspheres by precipitation polymerization using ethanol as solvent. Polym. Adv. Technol. 22(12), 1555-1562 (2010).
23. Macková H, Proks V, Horák D, Kučka J, Trchová M. Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions. J. Polym. Sci. Part A: Pofym. Chem. 49(22), 4820-4829 (2011).
24. Kawaguchi S, Ito K. Dispersion polymerization. Adv. Polym. Sci. 175, 299-328 (2005).
25. Salamone JC. Concise Polymeric Materials Encyclopedia (1st Edition). Bausch & Lomb, New York, NY, USA, 1760 (1998).
26. Zhou L-M, Shi S, Kuroda S-I, Kubota H. Popcorn-like morphology of poly(methyl methacrylate) particles formed in dispersion polymerization of methyl methacrylate. Chem. Lett. 36(5), 624-625 (2007).
27. Shi S, Zhou L, Wang T, Bian L, Tang Y, Kuroda S-I. Preparation of raspberry-like poly(methyl methacrylate) particles by seeded dispersion polymerization. J. Appl. Polym. Sci. 20(1), 501-508 (2010).
28. Zhu M-Q, Chen G-C, Li Y-M, Fan J-B, Zhu M-F, Tang Z. One-step template-free synthesis of monoporous polymer microspheres with uniform sizes via microwave-mediated dispersion polymerization. Nanoscale 3, 4608-4612 (2011).
29. Ugelstad J, Berge A, Ellingsen T et al. Preparation and application of new monosized polymer particles. Prog. Polym. Sci. 17, 87-161 (1992).
30. Chem CS. Emulsion polymerization mechanisms and kinetics. Progress Polym. Sci. 31, 443-486 (2006).
31. Okubo M, Ikegami K, Yamanoto Y. Preparation of micron-size monodisperse polymer microspheres having chloromethyl group. Colloid Polym. Sci. 267, 193-200 (1989).
32. Bamnolker H, Nitzan B, Gura S, Margel S. New solid and hollow, magnetic and non-magnetic, organic-inorganic monodispersed hybrid microspheres: Synthesis and characterization. J. Mater. Sci. Lett. 16, 1412-1415 (1997).
33. Kim JW, Suh KD. Highly monodisperse crosslinked polymethylmethacrylate microparticles by dispersion polymerization. Colloid Polym. Sci. 277, 66-72 (1999).
34. Xu Z-S, Deng Z-W, Hu X-X, Li L, Yi C-F. Monodisperse polystyrene microspheres prepared by dispersion polymerization with microwave irradiation. J. Polym. Sci. Part A Polym. Chem. 43(11), 2368-2376 (2005).
35. Kim SH, Sim JY, Lim JM, Yang SM. Magnetoresponsive microparticles with nanoscopic surface structures for remote-controlled locomotion. Angew. Chem. Int. Ed. 49, 3786-3790 (2010).
36. Macková H, Horák D. Effects of the reaction parameters on the properties of thermosensitive poly(n-isopropylacrylamide) microspheres prepared by precipitation and dispersion polymerization. J. Polym. Sci. Part A: Pofym. Chem. 44(2), 968-982 (2006).
37. Crespy D, Landfester K. Miniemulsion polymerization as a versatile tool for the synthesis of functionalized polymers. Beilstein J. Organic Chem. 6, 1132-1148 (2010).
38. Harkins WD. A general theory of the mechanism of emulsion polymerization. J. Am. Chem. Soc. 69, 1428-1444 (1947).
39. Du X, He J. Facile size-controllable syntheses of highly monodisperse polystyrene nano-and microspheres by polyvinylpyrrolidone-mediated emulsifier-free emulsion polymerization. J. Appl. Polym. Sci. 108(3), 1755-1760 (2008).
40. Xie G, Zhang Q, Luo Z, Wu M, Li T. Preparation and characterization of monodisperse magnetic poly(styrene butyl acrylate methacrylic acid) microspheres in the presence of a polar solvent. J. Appl. Polym. Sci. 87, 1733-1738 (2003).
41. Muramatsu N, Shiga K, Kondo T. Preparation of polyamide microcapsules having narrow size distributions. J. Microencaps. 11(2), 171-178 (1994).
42. Muramatsu N, Shiga K, Kondo T. A novel method to prepare monodisperse microparticles. J. Microencaps. 15(6), 715-723 (1998).
43. Akamatsu K, Ikeuchi Y, Nakao A, Nakao S. Size-controlled and monodisperse enzyme-encapsulated chitosan microspheres developed by the SPG membrane emulsification technique. J. Colloid Interf. Sci. 371, 46-51 (2012).
44. Zhao C-X, Middelberg APJ. Two-phase microfluidic flows. Chem. Eng. Sci. 66(7), 1394-1411 (2011).
45. Nisisako T, Torii T, Higuchi T. Novel microreactors for functional polymer beads. Chem. Eng. J. 101(1-3), 23-29 (2004).
46. Martín-Banderas L, Flores-Mosquera M, Riesco-Chueva P et al. Flow focusing: A versatile technology to produce size-controlled and specific-morphology microparticles. Small 1, 2-6 (2005).
47. Xu S, Nie Z, Seo M et al. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew. Chem. Int. Ed. 44(5), 724-728 (2005).
48. Anna SL, Mayer HC. Microscale tipstreaming in a microfluidic flow focusing device. Phys. Fluids 18, 121512 (2006).
49. Choi C-H, Jung J-H, Rhee YW, Kim D-P, Shim S-E, Lee C-S. Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed. Microdevices 9(6), 855-862 (2007).
50. Breslauer DN, Muller SJ, Lee LP. Generation of monodisperse silk microspheres prepared with microfluidics. Biomacromolecules 11(3), 643-647 (2010).
51. Shah RK, Shum HC, Rowat AC et al. Designer emulsions using microfluidics. Mater. Today 11(4), 18-27 (2008).
52. Ko SH, Kim SJ, Cheow LF, Li LD, Kang KH, Han J. Massively parallel concentration device for multiplexed immunoassays. Lab Chip 11(7), 1351-1358 (2011).
53. Cleland JL. Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines. Biotechnol. Progress 14(1), 102-107 (1998).
54. Freitas S, Merkle HP, Gander B. Microencapsulation by solvent extraction/ evaporation: reviewing the state of the art of microsphere preparation process technology. J. Control. Release 102(2), 313-332 (2005).
55. Gañán-Calvo AM, Martín-Banderas L, González-Prieto R et al. Straightforward production of encoded microbeads by flow focusing: potential applications for biomolecule detection. Int. J. Pharmaceut. 324(1), 19-26 (2006).
56. Häfeli UO, Saatchi K, Elischer P et al. Lung perfusion imaging with monosized biodegradable microspheres. Biomacromolecules 11(3), 561-567 (2010).
57. Saatchi K, Häfeli UO. One-pot syntheses, coordination, and characterization of application-specific biodegradable ligand-polymers. Dalton Trans. 39, 4439 (2007).
58. Letchford K, Zastre J, Liggins R, Burt H. Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers. Colloids Surf. B Biointerfaces 35(2), 81-91 (2004).
59. Abate AR, Kutsovsky M, Seiffert S et al. Synthesis of monodisperse microparticles from non-newtonian polymer solutions with microfluidic devices. Adv. Mater. 23(15), 1757-1760 (2011).
60. Zhu L, Li Y, Zhang Q, Wang H, Zhu M. Fabrication of monodisperse, large-sized, functional biopolymeric microspheres using a low-cost and facile microfluidic device. Biomed. Microdevices 12(1), 169-177 (2009).
61. Radulescu D, Schwade N, Wavro D. Uniform paclitaxel-loaded biodegradable microspheres manufactured by ink-jet technology. Proceedings of the 11th International Symposium on Recent Advances in Drug Delivery Systems. Salt-lake City, UT, USA, 3-6 March 2003.
62. Fulwyler MJ, Perrings JD, Cram LS. Production of uniform microspheres. Rev. Sci. Instrum. 44(2), 204-206 (1973).
63. Berkland C, Kim K, Pack DW. Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. J. Control. Release 73, 59-74 (2001).
64. Berkland C, Pollauf E, Pack DW, Kim K. Uniform double-walled polymer microspheres of controllable shell thickness. J. Control. Release 96(1), 101-111 (2004).
65. Berkland C, Pollauf E, Varde N, Pack DW, Kim K. Monodisperse liquid-filled biodegradable microcapsules. Pharm. Res. 24(5), 1007-1013 (2007).
66. Haeberle S, Naegele L, Burger R, Stetten FV, Zengerle R, Ducrée J. Alginate bead fabrication and encapsulation of living cells under centrifugally induced artificial gravity conditions. J. Microencaps. 25(4), 267-274 (2008).
67. Matsumoto S, Kobayashi H, Takashima Y. Production of monodispersed capsules. J. Microencaps. 3(1), 25-31 (1986).
68. Staymates M, Fletcher R, Staymates J, Gillen G, Berkland C. Production and characterization of polymer microspheres containing trace explosives using precision particle fabrication technology. J. Microencaps. 27(5), 426-435 (2010).
69. Lin Y-H, Chen C-T, Huang LLH, Lee G-B. Multiple-channel emulsion chips utilizing pneumatic choppers for biotechnology applications. Biomed. Microdevices 9(6), 833-843 (2007).
70. Sugiura S. Preparation of monodispersed solid lipid microspheres using a microchannel emulsification technique. J. Colloid Interf. Sci. 227(1), 95-103 (2000).
71. Kobayashi I, Nakajima M. Silicon array of elongated through-holes for monodisperse emulsion droplets. AIChE J. 48(8), 1639-1644 (2002).
72. Liu R, Ma G, Meng F-T, Su Z-G. Preparation of uniform-sized Pla microcapsules by combining Shirasu porous glass membrane emulsification technique and multiple emulsion-solvent evaporation method. J. Control. Release 103(1), 31-43 (2005).
73. Meyer RF, Rogers WB, Mcclendon MT, Crocker JC. Producing monodisperse drug-loaded polymer microspheres via cross-flow membrane emulsification: the effects of polymers and surfactants. Langmuir 26(18), 14479-14487 (2010).
74. Veldhuis G, Gironès M, Bingham D. Monodisperse microspheres for parenteral drug delivery. Drug Delivery Technol. 9(1), 1-5 (2009).