Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria

Oral Microbiology and Immunology

Volumn 24, Issue 2, 2009, Pages 170-172

  Isogai, E ^a   Isogai, H ^b   Takahashi, K ^b   Okumura, K ^a   Savage, P B ^c  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c Brigham Young University   (United States)

Author keywords

Antimicrobial activity; Ceragenin CSA 13; Lipopolysaccharide binding activity; Porphyromonas; Streptococcus mutans

Indexed keywords

ANTIINFECTIVE AGENT; CSA 13; UNCLASSIFIED DRUG;

ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DENTAL CARIES; DRUG BINDING; DRUG POTENCY; DRUG SENSITIVITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERIODONTAL DISEASE; PORPHYROMONAS; PORPHYROMONAS CANGINGIVALIS; PORPHYROMONAS CIRCUMDENTARIA; PORPHYROMONAS GINGIVALIS; STREPTOCOCCUS MUTANS;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS, LOCAL; ANTIMICROBIAL CATIONIC PEPTIDES; DENTAL PLAQUE; DISK DIFFUSION ANTIMICROBIAL TESTS; HUMANS; MOLECULAR SEQUENCE DATA; PERIODONTAL DISEASES; PORPHYROMONAS; STEROIDS; STREPTOCOCCUS MUTANS;

EID: 60349129570     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2008.00464.x     Document Type: Article

References (11)

1. Chin JN, Rybak MJ, Cheung CM, Savage PB. Antimicrobial activity of ceragenins against clinical isolates of resistant Staphylococcus aureus. Antimicrob Agens Chemother 2007 : 51 : 1268 1271.
2. Ding B, Guan Q, Walsh JP et al. Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. J Med Chem 2002 : 45 : 663 669.
3. Guthmilller JM, Vargas KG, Srikantha R et al. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001 : 45 : 3216 3219.
4. Isogai E, Isogai H, Matuo K et al. Sensitivity of genera Porphyromonas and Prevotella to the bactericidal action of C-terminal domain of human CAP18 and its analogues. Oral Microbial Immunol 2003 : 18 : 329 332.
5. Isogai H, Isogai E, Fujii N, Oguma K, Kagota W, Takano K. Histological changes and some biological activities induced by lipopolysaccharide from Bacteroides gingivalis. Zbl Bakt Hyg 1988 : A269 : 64 77.
6. Larrick JW, Hirata M, Balint RF, Lee J, Zhong Z, Wright SC. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun 1995 : 63 : 1291 1297.
7. LeBlanc DJ, Flynn TR, Simos C. Lantz MS. Antibiotics and the treatment of infectious diseases. In : Lamont RJ, Lantz MS, Burne RA, LeBlanc DJ eds. Oral Microbiology and Immunology. Washington NW : ASM Press, 2006 : 377 422.
8. Matsuo K, Isogai E, Araki Y. Structural characterization of the O-antigenic polysaccharide chain of Porphyromonas circumdentaria NCTC12469. Microbiol Immunol 2001 : 45 : 299 306.
9. Savage PB, Li C, Taotafa U, Ding B, Guan Q. Antibacterial properties of cationic steroid antibiotics: a minireview. FEMS Microbiol Lett 2002 : 217 : 1 7.
10. Van't Hof W, Veerman EC, Helmerhorst EJ, Amerongen AV. Antimicrobial peptides: properties and applicability. Biol Chem 2001 : 382 : 597 619.
11. Zasloff M. Innate immunity, antimicrobial peptides, and protection of the oral cavity. Lancet 2002 : 360 : 1116 1117.