Effect of the antiobesity agent garcinia cambogia extract on serum lipoprotein (a), apolipoproteins a1 and b, and total cholesterol levels in female rats fed atherogenic diet

Journal of Animal and Plant Sciences

Volumn 22, Issue 4, 2012, Pages 872-877

  Altiner, A ^a   Ates, A ^a   Gursel, F Esen ^a   Bilal, T ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Apolipoprotein; Garcinia cambogia; Holesterol; Lipoprotein (a); Rat

Indexed keywords

AVES; GARCINIA CAMBOGIA; RATTUS;

EID: 84873557921     PISSN: 10187081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Adaramoye, O. A., V. O. Nwaneri, K. C. Anyanwu, E. O. Farombi and G. O. Emerole (2005). Possible anti atherogenic effect of kolaviron (a garcinia kola seed extract) in hypercholesterolaemic rats. Clin. Exp. Pharmacol. Physiol. 32: 40-46.
2. Akman, L., M. Ulukus, H. Duygu, M. Ulukus, F. Özerkan and M. Akin (2008). Effect of different hormone replacement therapies on serum lipid, lipoprotein levels and inflammation markers in postmenopausal women. J. Turkish-German Gynecol. Assoc. 9: 97-102.
3. Barth, C., H. Ullmann, J. Hackenschmidt and K. Decker (1972). Inhibition of cholesterol-synthesis by (-)- hydroxycitrate in perfused rat-liver. Evidence for an extramitochondrial mevalonate synthesis from acetyl coenzyme A. F.E.B.S. Lett. 22: 343-346.
4. Berg, A., D. König, P. Deibert, D. Grathwohl, A. Berg, M. W. Baumstark and I. W. Franz (2003). Effect of an oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. Ann. Nutr. Metab. 47: 306-311.
5. Boerwinkle, E. (1992). Genetics of plasma lipoprotein (a) concentrations. Curr. Opin. Lipidol. 3:128-136.
6. Brandt, K., W. Langhans, N. Geary and M. Leonhardt (2006). Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition. 22: 905-912.
7. Catapano, A. L. (1997). Antioxidant effect of flavonoids. Angiology. 48: 39-44.
8. Champe, P. C. and R. A. Harvey (1994). Cholesterol metabolism. Lippincott's Illustrated Reviews:Biochemistry, 2nd Ed. JB Lippincott. Kendallville (USA). 210-225 p.
9. Clarkson, T. B., R. W. Prichard, H. B. Lofland and H. O. Goodman (1962). Interactions among dietary fat, protein and cholesterol in atherosclerosissusceptible pigeons. Circ. Res. 11: 400-404.
10. Dange, N. S., A. Nagdeote and K. Deshpande (2011). Serum apolipoprotein a1 and b, lipoproteins, lipids levels in indian patients with angiographically defined coronary artery disease. Int. J. Pharm. Bio. Sci. 1: 255-264.
11. Diaz, M. N., B. Frei, J. A. Vita and J. F. Keaney (1997). Antioxidants and atherosclerotic heart disease. N. Engl. J. Med. 337: 408-416.
12. Ergün, G. and S. Aktas (2009). ANOVA modellerinde kareler toplami{dotless} yöntemlerinin karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}. Kafkas Univ. Vet. Fak. Derg. 15:481-484.
13. Fillias, L. C., S. B. Andrus, G. V. Mann and F. J. Stare (1956). Experimental production of gross atherosclerosis in the rat. J. Exp. Med. 104:539-554.
14. Fless, G. M., M. E. ZumMallen and A. M. Scanu (1986). Physiochemical properties of apolipoprotein (a) and lipoprotein (a-) derived from the dissociation of human plasma lipoprotein (a). J. Biol. Chem. 261: 8712-8718.
15. Fujioka, T., F. Nara, Y. Tsujita, J. Fukushige, M. Fukami and M. Kuroda (1995). The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats. Biochim. Biophys. Acta. 1254: 7-12.
16. Fungwe, T. V., L. M. Cagen, G. A. Cook, H. G. Wilcox and M. Heimberg (1993). Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat. J. Lipid Res. 34: 933-941.
17. Golay, A. and E. Bobbioni (1997). The role of dietary fat in obesity. Int. J. Obes. Relat. Metab. Disord. 21:2-11.
18. Guyton, A. C. and J. E. Hall (1994). Lipid metabolism. In: Guyton AC (ed.). Textbook of Medical Physiology. Toronto (USA), pp: 865-875.
19. Hamon, N. W. (1996). Hawthorns: The genus Crataegus. Can. Pharm. J. 121: 708-709.
20. Hayamizu, K., Y. Ishii, I. Kaneko, M. Shen, Y. Okuhara, N. Shigematsu, H. Tomi, M. Furuse, G. Yoshino and H. Shimasaki (2003a). Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. Curr. Therap. Res. 64:551-567.
21. Hayamizu, K., H. Hirakawa, D. Oikawa, T. Nakanishi, T. Takagi, T. Tachibana, M. Furuse (2003b). Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia. 74: 267-273.
22. Heinecke, J. W. (1998). Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low-density lipoprotein hypothesis. Atherosclerosis. 141: 1-15.
23. Hellerstein, M. K. and Y. Xie (1993). The indirect pathway of hepatic glycogen synthesis and reduction of food intake by metabolic inhibitors. Life Sci. 53: 1833-1845.
24. Heymsfield, S. B., D. B. Allison, J. R. Vasselli, A. Pietrobelli, D. Greenfield and C. Nunez (1998).Garcinia cambogia (hydroxycitric acid) as a potent antiobesity agent. J. Am. Med. Assoc.280: 1596-1600.
25. Ichi, I., K. Nakahara, K. Kiso and S. Kojo (2007). Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues. Nutrition. 23: 570- 574.
26. Jebb, S. A. (1999). Obesity: from molecules to man. Proc. Nutr. Soc. 58: 1-14.
27. Smith, J., M. Al-Amri, A. Sniderman and K. Cianflone (2006): Visfatin concentration in Asian Indians is correlated with high density lipoprotein cholesterol and apolipoprotein A1. Clin. Endocrinol. 65, 667-672.
28. Koshy, A.S., L. Anila and N.R. Vijayalakshmi (2001). Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food. Chem. 72: 289-294.
29. Kovacs, E.M.R., M.S. Westerterp-Plantenga and W.H.M. Saris (2001). Effects of 2-week ingestion of (-)- hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight.Int. J. Obes. 25: 1087-1094.
30. Krauss, R. M. (1991). The tangled web of coronary risk actors. Am. J. Med. 90 (suppl 2A): 36-41.
31. Leonhardt, M., B. Hrupka and W. Langhans (2001).Effects of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats. Physiol. Behav. 74: 191-196.
32. Leonhardt, M., S. Münch, M. Westerterp-Plantenga and W. Langhans (2004). Effects of hydroxycitrate, conjugated linoleic acid, and guar gum on food intake, body weight regain, and metabolism after body weight loss in male rats. Nutr. Res. 24: 659-669.
33. Lewis, Y. S. and S. Neelakantan (1965). (-)- Hydroxycitric acid-The principal acid in the fruits of Garcinia cambogia desr. Phytochemistry, 4: 619-625.
34. Loon, L. J. C., J. J. M. Rooijen, B. Niesen, H. Verhagen, W. H. M. Saris and A. J. M. Wagenmakers (2000). Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans. Am. J. Clin. Nutr. 72: 1445-1450.
35. Minhajuddin, M., Z. H. Beg and J. Iqbal (2005). Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem. Toxicol. 43: 747-753.
36. Ohia, S.E., C.A. Opere, A.M. LeDay, M. Bagchi, D. Bagchi and S.J. Stohs (2002). Safety and mechanism of appetite suppression by novel hydroxycitric acid extract (HCA-SX). Mol. Cel. Biochem. 238: 89-103.
37. Preuss, H.G., D. Bagchi, M. Bagchi, C.V.S. Rao, D.K. Dey and S. Satyanarayana (2004). Effects of a natural extract of (-)-hydroxycitric acid (HCASX) and a combination of HCA-SX plus niacinbound chromium and Gymnema sylvestre extract on weight loss. Diab. Obes. Metab. 6: 171-180.
38. Saito, M., M. Ueno, S. Ogino, K. Kubo, J. Nagata and M. Takeuchi (2005). High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem. Toxicol. 43: 411-419.
39. Schaefer, E. J., A. H. Lichtenstein, S. Lamon-Fava, J. F. McNamara and J. M. Ordovas (1995). Lipoproteins, nutrition, aging, and atherosclerosis. Am. J. Clin. Nutr. 61 (Suppl.): 726-740.
40. Schaller, J. L. (1999). Garcinia cambogia for weight loss [letter]. J. Am. Med. Assoc. 282: 234.
41. Sreenivasan, R. S., A. Kavitha, A. R. Anusa, P. Krishna Moorthy and N. G. Renganathan (2011). Identifi{dotless}cation and prediction of coronary heart disease in patients with apolipoprotein levels. Int. J. Pharm. Bio. Sci. 1: 31-42.
42. Stamler, J. and R. Shekelle (1988). Dietary cholesterol and human coronary heart disease. Arch. Pathol. Lab. Med. 112: 1032-1040.
43. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo and J. L. Witztum (1989). Beyond cholesterol: modification of LDL that increase its atherogenecity. N. Engl. J. Med. 320: 915-924.
44. Sullivan, A. C., M. Singh, P. A. Srere and J. P. Glusker (1977). Reactivity and inhibitor potential of hydroxycitrate isomers with citrate synthase, citrate lyase, and ATP citrate lyase. J. Biol. Chem. 252: 7583-7590.
45. Verschuren, W. M. M., D. R. Jacobs, B. P. M. Bloemberg, D. Kromhout, A. Menotti, A. Nissinen and H. Blackburn (1995). Serum total cholesterol and long term coronary heart disease mortality in different cultures: Twenty-five years follow up of the seven countries study. J. Am.Med. Assoc. 274: 131-136.
46. Wang, W., E. T. Lee, P. Alaupovic, P. Blackett and K.S. Blevins (2005). Correlation between lipoprotein(a) and other risk factors for cardiovascular disease and diabetes in Cherokee indians: The Cherokee diabetes study. Ann. Epidemiol. 15: 390-397.
47. Yuan, Y. Y., D. D. Kilts and D. V. Golin (1997). Influence of dietary cholesterol and fat source on atherosclerosis in the Japanese quail. Br. J. Nutr. 78: 1003-1014.
48. Zollner, N., G. Wolfram and C. H. Keller (1997). Nutrition and metabolism. J. Am. Med. Assoc. 21: 1-3.