Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection

Journal of Immunology

Volumn 177, Issue 10, 2006, Pages 7406-7415

  Horton, Helen ^a,b   Frank, Ian ^a   Baydo, Ruth ^a   Jalbert, Emilie ^a   Penn, Justin ^a   Wilson, Sean ^a   McNevin, John P ^a   McSweyn, Matthew D ^a   Lee, Deborah ^a   Huang, Yunda ^a   De Rosa, Stephen C ^a,b   McElrath, M Juliana ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA ANTIGEN; HLA B27 ANTIGEN; HLA B57 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ANTIVIRAL ACTIVITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FLOW CYTOMETRY; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOREGULATION; INFECTION PREVENTION; LONG TERM NON PROGRESSION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; POLYCHROMATIC FLOW CYTOMETRY; PRIORITY JOURNAL; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; VACCINATION;

EID: 33750822983     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.10.7406     Document Type: Article

References (31)

1. Kaslow, R. A., M. Carrington, R. Apple, L. Park, A. Munoz, A. J. Saah, J. J. Goedert, C. Winkler, S. J. O'Brien, C. Rinaldo, et al. 1996. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat. Med. 2: 405-411.
2. Carrington, M., and S. O'Brien. 2003. The Influence of HLA genotype on AIDS. Annu. Rev. Med. 54: 535-551.
3. Hendel, H., S. Caillat-Zucman, H. Lebuanec, M. Carrington, S. J. O'Brien, J.-M. Andrieu, F. Schachter, D. Zagury, J. Rappaport, C. Winkler, et al. 1999. New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J. Immunol. 162: 6942-6946.
4. + T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189: 991-998.
5. Borrow, P., H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer, H. Meyers, J. A. Nelson, J. E. Gairin, B. H. Hahn, M. B. Oldstone, and G. M. Shaw. 1997. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3: 205-211.
6. Goulder, P. J., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, et al. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3: 212-217.
7. Price, D. A., P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 94: 1890-1895.
8. + T cell immunity and viral escape following acute HIV-1 infection. J. Immunol. 171: 3837-3846.
9. + T cell proliferation is coupled to perform expression and is maintained in nonprogressors. Nat. Immunol. 3: 1061-1068.
10. Harrer, T., E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. 1996. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection: breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 156: 2616-2623.
11. Harrer, T., E. Harrer, S. A. Kalams, T. Elbeik, S. I. Staprans, M. B. Feinberg, Y. Cao, D. D. Ho, T. Yilma, A. M. Caliendo, et al. 1996. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res. Hum. Retroviruses 12: 585-592.
12. Musey, L. K., J. N. Krieger, J. P. Hughes, T. W. Schacker, L. Corey, and M. J. McElrath. 1999. Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection. J. Infect. Dis. 180: 278-284.
13. Malhotra, U., M. M. Berrey, Y. Huang, J. Markee, D. J. Brown, S. Ap, L. Musey, T. Schacker, L. Corey, and M. J. McElrath. 2000. Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection. J. Infect. Dis. 181: 121-131.
14. + T cells. J. Exp. Med. 200: 701-712.
15. + T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192: 63-75.
16. + T cells in primary HIV-1 infection. J. Virol. 77: 6867-6878.
17. + T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281: 65-78.
18. Altfeld, M., M. M. Addo, E. S. Rosenberg, F. M. Hecht, P. K. Lee, M. Vogel, X. G. Yu, R. Draenert, M. N. Johnston, D. Strick, et al. 2003. Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS 17: 2581-2591.
19. + T cells: efficacy is limited by migration away from the site and induction of nonresponsiveness. J. Immunol. 162: 2858-2866.
20. Tham, E. L., and M. F. Mescher. 2001. Signaling alterations in activation-induced nonresponsive CD8 T cells. J. Immunol. 167: 2040-2048.
21. Tham, E. L., P. Shrikant, and M. F. Mescher. 2002. Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response. J. Immunol. 168: 1190-1197.
22. + T cells. Eur. J. Immunol. 30: 883-891.
23. + T cells maintain tolerance to myelin basic protein by "epitope theft." Nat. Immunol. 5: 606-614.
24. Zimmerli, S. C., A. Harari, C. Cellerai, F. Vallelian, P.-A. Bart, and G. Pantaleo. 2005. HIV-1-specific IFN-γ/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc. Natl. Acad. Sci. USA 102: 7239-7244.
25. + T cells. Blood 107: 4791-4789.
26. Kaech, S. M., S. Hemby, E. Kersh, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111: 837-851.
27. Wherry, E. J., V. Teichgraber, T. C. Becker, D. Masopust, S. M. Kaech, R. Antia, U. H. von Andrian, and R. Ahmed. 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4: 225-234.
28. + T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis. J. Clin. Invest. 106: 47-53.
29. Vasilca, V., A. Vasilca, D. Munteanu, D. Constantinescu, C. Livideanu, M. Tepelus, F. Zugun, and E. Carasevici. 2002. HLA-B57 is significantly associated with psoriasis in Northeast Romania. Roum. Arch. Microbiol. Immunol. 61: 259-265.
30. Vejbaesya, S., T. H. Eiermann, P. Suthipinititharm, C. Bancha, H. A. Stephens, K. Luangtrakool, and D. Chandanayingyong. 1998. Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris. Tissue Antigens 52: 389-392.
31. McKiernan, S. M., R. Hagan, M. Curry, G. S. A. McDonald, A. Kelly, N. Nolan, A. Walsh, J. Hegarty, E. Lawlor, and D. Kelleher. 2004. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology 40: 108-114.