Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8+ T cells

PLoS Pathogens

Volumn 6, Issue 3, 2010, Pages

  Makedonas, George ^a   Hutnick, Natalie ^a   Haney, Danielle ^a   Amick, Alexandra C ^a   Gardner, Jay ^a   Cosma, Gabriela ^a   Hersperger, Adam R ^a   Dolfi, Douglas ^b   Wherry, E John ^b   Ferrari, Guido ^c   Betts, Michael R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; INTERLEUKIN 2; PERFORIN; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR T BET; GAMMA INTERFERON; PORE FORMING CYTOTOXIC PROTEIN; PRF1 PROTEIN, HUMAN; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21;

ADENOVIRUS; AMINO ACID SEQUENCE; ARTICLE; CD8+ T LYMPHOCYTE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLUENZA VIRUS; LYMPHOCYTE FUNCTION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; VIRUS CELL INTERACTION; VIRUS REPLICATION; CYTOMEGALOVIRUS INFECTION; EPSTEIN BARR VIRUS INFECTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; INFLUENZA; LYMPHOCYTE ACTIVATION; METABOLISM; UPREGULATION; VIROLOGY; VIRUS INFECTION;

ADENOVIRIDAE; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 4;

ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS INFECTIONS; EPSTEIN-BARR VIRUS INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INFLUENZA, HUMAN; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; PORE FORMING CYTOTOXIC PROTEINS; T-BOX DOMAIN PROTEINS; UP-REGULATION; VIRUS DISEASES;

EID: 77950422606     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000798     Document Type: Article

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