메뉴 건너뛰기




Volumn 85, Issue 3, 2013, Pages 303-314

Treatment of metastatic cervical cancer: Future directions involving targeted agents

Author keywords

Angiogenesis; Clinical trial; Human papilloma virus; Metastatic cervical cancer; Targeted therapy

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADXS 001; ANGIOPOIETIN; BEVACIZUMAB; BRIVANIB; CANCER VACCINE; CEDIRANIB; CETUXIMAB; CISPLATIN; CVX 060; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MAPATUMUMAB; MK 1775; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLAPARIB; PACLITAXEL; PAZOPANIB; PF 4856884; SUNITINIB; TEMSIROLIMUS; TOPOTECAN; TREBANANIB; UNCLASSIFIED DRUG; VELIPARIB;

EID: 84873527086     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.07.006     Document Type: Review
Times cited : (80)

References (106)
  • 1
    • 34648816771 scopus 로고    scopus 로고
    • The evolution of cost-effective screening and prevention of cervical carcinoma: implications of the 2006 consensus guidelines and human papillomavirus vaccination
    • Monk B.J., Herzog T.J. The evolution of cost-effective screening and prevention of cervical carcinoma: implications of the 2006 consensus guidelines and human papillomavirus vaccination. American Journal of Obstetrics and Gynecology 2007, 197:337-339.
    • (2007) American Journal of Obstetrics and Gynecology , vol.197 , pp. 337-339
    • Monk, B.J.1    Herzog, T.J.2
  • 2
    • 0037830009 scopus 로고    scopus 로고
    • Cervical cancer
    • Waggoner S.E. Cervical cancer. Lancet 2003, 361:2217-2225.
    • (2003) Lancet , vol.361 , pp. 2217-2225
    • Waggoner, S.E.1
  • 3
    • 4143135504 scopus 로고    scopus 로고
    • Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent, or persistent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study
    • Moore D.H., Blessing J.A., McQuellon R.P., et al. Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent, or persistent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Journal of Clinical Oncology 2004, 22:3113-3119.
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 3113-3119
    • Moore, D.H.1    Blessing, J.A.2    McQuellon, R.P.3
  • 4
    • 33646392467 scopus 로고    scopus 로고
    • Quality of life (QOL) outcomes from a randomized trial of cisplatin versus cisplatin plus paclitaxel in advanced cervical cancer: a Gynecologic Oncology Group study
    • McQuellon R.P., Thaler H.T., Cella D., Moore D.H. Quality of life (QOL) outcomes from a randomized trial of cisplatin versus cisplatin plus paclitaxel in advanced cervical cancer: a Gynecologic Oncology Group study. Gynecologic Oncology 2006, 101:296-304.
    • (2006) Gynecologic Oncology , vol.101 , pp. 296-304
    • McQuellon, R.P.1    Thaler, H.T.2    Cella, D.3    Moore, D.H.4
  • 5
    • 70350433286 scopus 로고    scopus 로고
    • Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study
    • Monk B.J., Sill M.W., McMeekin D.S., et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. Journal of Clinical Oncology 2009, 27:4649-4655.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 4649-4655
    • Monk, B.J.1    Sill, M.W.2    McMeekin, D.S.3
  • 7
    • 1242287067 scopus 로고    scopus 로고
    • Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000
    • Wang S.S., Sherman M.E., Hildesheim A., Lacey J.V., Devesa S. Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000. Cancer 2004, 100:1035-1044.
    • (2004) Cancer , vol.100 , pp. 1035-1044
    • Wang, S.S.1    Sherman, M.E.2    Hildesheim, A.3    Lacey, J.V.4    Devesa, S.5
  • 9
    • 14744280487 scopus 로고    scopus 로고
    • Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival
    • Sherman M.E., Wang S.S., Carreon J., Devesa S.S. Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival. Cancer 2005, 103:1258-1264.
    • (2005) Cancer , vol.103 , pp. 1258-1264
    • Sherman, M.E.1    Wang, S.S.2    Carreon, J.3    Devesa, S.S.4
  • 11
    • 84873523329 scopus 로고    scopus 로고
    • KRAS and EGFR mutations to distinguish adenocarcinomas and squamous cell carcinomas of the cervix
    • Wright A.A., Hirsch M.S., Wagle N., et al. KRAS and EGFR mutations to distinguish adenocarcinomas and squamous cell carcinomas of the cervix. Journal of Clinical Oncology 2012, 30:5011.
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 5011
    • Wright, A.A.1    Hirsch, M.S.2    Wagle, N.3
  • 13
    • 34548152357 scopus 로고    scopus 로고
    • Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins
    • Narisawa-Saito M., Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Science 2007, 98:1505-1511.
    • (2007) Cancer Science , vol.98 , pp. 1505-1511
    • Narisawa-Saito, M.1    Kiyono, T.2
  • 14
    • 1242338787 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins
    • Patel D., Incassati A., Wang N., McCance D.J. Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins. Cancer Research 2004, 64:1299-1306.
    • (2004) Cancer Research , vol.64 , pp. 1299-1306
    • Patel, D.1    Incassati, A.2    Wang, N.3    McCance, D.J.4
  • 15
    • 64849096447 scopus 로고    scopus 로고
    • Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
    • Nakamura M., Bodily J.M., Beglin M., Kyo S., Inoue M., Laimins L.A. Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses. Virology 2009, 387:442-448.
    • (2009) Virology , vol.387 , pp. 442-448
    • Nakamura, M.1    Bodily, J.M.2    Beglin, M.3    Kyo, S.4    Inoue, M.5    Laimins, L.A.6
  • 16
    • 78049451565 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment
    • Kim M.K., Kim H.S., Kim S.H., et al. Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment. Biochemical Pharmacology 2010, 80:1930-1935.
    • (2010) Biochemical Pharmacology , vol.80 , pp. 1930-1935
    • Kim, M.K.1    Kim, H.S.2    Kim, S.H.3
  • 17
    • 0035956257 scopus 로고    scopus 로고
    • Mechanisms of cell transformation by papillomavirus E5 proteins
    • DiMaio D., Mattoon D. Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene 2001, 20:7866-7873.
    • (2001) Oncogene , vol.20 , pp. 7866-7873
    • DiMaio, D.1    Mattoon, D.2
  • 18
    • 0027958101 scopus 로고
    • Demonstration and characterization of the angiogenic properties of cervical dysplasia
    • Smith-McCune K.K., Weidner N. Demonstration and characterization of the angiogenic properties of cervical dysplasia. Cancer Research 1994, 54:800-804.
    • (1994) Cancer Research , vol.54 , pp. 800-804
    • Smith-McCune, K.K.1    Weidner, N.2
  • 19
    • 0004011756 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is implicated in early invasion in cervical cancer
    • Kodama J., Seki N., Tokumo K., et al. Vascular endothelial growth factor is implicated in early invasion in cervical cancer. European Journal of Cancer 1999, 35:485-489.
    • (1999) European Journal of Cancer , vol.35 , pp. 485-489
    • Kodama, J.1    Seki, N.2    Tokumo, K.3
  • 20
    • 69249104203 scopus 로고    scopus 로고
    • Cervical cancer therapy: current, future and anti-angiogensis targeted treatment
    • Willmott L.J., Monk B.J. Cervical cancer therapy: current, future and anti-angiogensis targeted treatment. Expert Review of Anticancer Therapy 2009, 9:895-903.
    • (2009) Expert Review of Anticancer Therapy , vol.9 , pp. 895-903
    • Willmott, L.J.1    Monk, B.J.2
  • 21
    • 0033054313 scopus 로고    scopus 로고
    • Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix
    • Santin A.D., Hermonat P.L., Ravaggi A., Pecorelli S., Cannon M.J., Parham G.P. Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. Obstetrics and Gynecology 1999, 94:78-82.
    • (1999) Obstetrics and Gynecology , vol.94 , pp. 78-82
    • Santin, A.D.1    Hermonat, P.L.2    Ravaggi, A.3    Pecorelli, S.4    Cannon, M.J.5    Parham, G.P.6
  • 22
    • 0037188424 scopus 로고    scopus 로고
    • Serum VEGF levels in patients undergoing primary radiotherapy for cervical cancer: impact on progression-free survival
    • Bachtiary B., Selzer E., Knocke T.H., Potter R., Obermair A. Serum VEGF levels in patients undergoing primary radiotherapy for cervical cancer: impact on progression-free survival. Cancer Letters 2002, 179:197-203.
    • (2002) Cancer Letters , vol.179 , pp. 197-203
    • Bachtiary, B.1    Selzer, E.2    Knocke, T.H.3    Potter, R.4    Obermair, A.5
  • 23
    • 18744415196 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor in Stage IB carcinoma of the uterine cervix
    • Lee I.J., Park K.R., Lee K.K., et al. Prognostic value of vascular endothelial growth factor in Stage IB carcinoma of the uterine cervix. International Journal of Radiation Oncology, Biology, Physics 2002, 54:768-779.
    • (2002) International Journal of Radiation Oncology, Biology, Physics , vol.54 , pp. 768-779
    • Lee, I.J.1    Park, K.R.2    Lee, K.K.3
  • 24
    • 0033899157 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix
    • Loncaster J.A., Cooper R.A., Logue J.P., Davidson S.E., Hunter R.D., West C.M. Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. British Journal of Cancer 2000, 83:620-625.
    • (2000) British Journal of Cancer , vol.83 , pp. 620-625
    • Loncaster, J.A.1    Cooper, R.A.2    Logue, J.P.3    Davidson, S.E.4    Hunter, R.D.5    West, C.M.6
  • 25
    • 13444291033 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor (VEGF) and VEGF-C levels as tumor markers in patients with cervical carcinoma
    • Mitsuhashi A., Suzuka K., Yamazawa K., Matsui H., Seki K., Sekiya S. Serum vascular endothelial growth factor (VEGF) and VEGF-C levels as tumor markers in patients with cervical carcinoma. Cancer 2005, 103:724-730.
    • (2005) Cancer , vol.103 , pp. 724-730
    • Mitsuhashi, A.1    Suzuka, K.2    Yamazawa, K.3    Matsui, H.4    Seki, K.5    Sekiya, S.6
  • 26
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. New England Journal of Medicine 2004, 350:2335-2342.
    • (2004) New England Journal of Medicine , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 27
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., Gray R., Perry M.C., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. New England Journal of Medicine 2006, 355:2542-2550.
    • (2006) New England Journal of Medicine , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 28
    • 61549141361 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study
    • Monk B.J., Sill M.W., Burger R.A., Gray H.J., Buekers T.E., Roman L.D. Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Journal of Clinical Oncology 2009, 27:1069-1074.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 1069-1074
    • Monk, B.J.1    Sill, M.W.2    Burger, R.A.3    Gray, H.J.4    Buekers, T.E.5    Roman, L.D.6
  • 29
    • 28044461278 scopus 로고    scopus 로고
    • Gynecologic Oncology Group trials of chemotherapy for metastatic and recurrent cervical cancer
    • Tewari K.S., Monk B.J. Gynecologic Oncology Group trials of chemotherapy for metastatic and recurrent cervical cancer. Current Oncology Reports 2005, 7:419-434.
    • (2005) Current Oncology Reports , vol.7 , pp. 419-434
    • Tewari, K.S.1    Monk, B.J.2
  • 30
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clinical Cancer Research 2003, 9:327-337.
    • (2003) Clinical Cancer Research , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 31
    • 74249122456 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184
    • Mackay H.J., Tinker A., Winquist E., et al. A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184. Gynecologic Oncology 2010, 116:163-167.
    • (2010) Gynecologic Oncology , vol.116 , pp. 163-167
    • Mackay, H.J.1    Tinker, A.2    Winquist, E.3
  • 32
    • 67449164582 scopus 로고    scopus 로고
    • Phase I trial of pazopanib in patients with advanced cancer
    • Hurwitz H.I., Dowlati A., Saini S., et al. Phase I trial of pazopanib in patients with advanced cancer. Clinical Cancer Research 2009, 15:4220-4227.
    • (2009) Clinical Cancer Research , vol.15 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 33
    • 77955874058 scopus 로고    scopus 로고
    • Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer
    • Monk B.J., Mas Lopez L., Zarba J.J., et al. Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer. Journal of Clinical Oncology 2010, 28:3562-3569.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3562-3569
    • Monk, B.J.1    Mas Lopez, L.2    Zarba, J.J.3
  • 34
    • 84555197179 scopus 로고    scopus 로고
    • Survival data from a phase II, open-label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer
    • Monk B.J., Pandite L.N. Survival data from a phase II, open-label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer. Journal of Clinical Oncology 2011, 29:4845.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 4845
    • Monk, B.J.1    Pandite, L.N.2
  • 37
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: from development to cancer
    • Turner N., Grose R. Fibroblast growth factor signalling: from development to cancer. Nature Reviews Cancer 2010, 10:116-129.
    • (2010) Nature Reviews Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 38
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8:299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 39
    • 76649108900 scopus 로고    scopus 로고
    • The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases
    • Bhide R.S., Lombardo L.J., Hunt J.T., et al. The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases. Molecular Cancer Therapeutics 2010, 9:369-378.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 369-378
    • Bhide, R.S.1    Lombardo, L.J.2    Hunt, J.T.3
  • 40
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nature Reviews Cancer 2008, 8:592-603.
    • (2008) Nature Reviews Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 42
    • 60549103097 scopus 로고    scopus 로고
    • Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth
    • Nasarre P., Thomas M., Kruse K., et al. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Research 2009, 69:1324-1333.
    • (2009) Cancer Research , vol.69 , pp. 1324-1333
    • Nasarre, P.1    Thomas, M.2    Kruse, K.3
  • 43
    • 0036405427 scopus 로고    scopus 로고
    • Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice
    • Shim W.S., Teh M., Bapna A., et al. Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Experimental Cell Research 2002, 279:299-309.
    • (2002) Experimental Cell Research , vol.279 , pp. 299-309
    • Shim, W.S.1    Teh, M.2    Bapna, A.3
  • 45
    • 0033042754 scopus 로고    scopus 로고
    • Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis
    • Kersemaekers A.M., Fleuren G.J., Kenter G.G., et al. Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis. Clinical Cancer Research 1999, 5:577-586.
    • (1999) Clinical Cancer Research , vol.5 , pp. 577-586
    • Kersemaekers, A.M.1    Fleuren, G.J.2    Kenter, G.G.3
  • 47
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    • Sequist L.V., Martins R.G., Spigel D., et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. Journal of Clinical Oncology 2008, 26:2442-2449.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 48
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New England Journal of Medicine 2004, 350:2129-2139.
    • (2004) New England Journal of Medicine , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 50
    • 69449086850 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study
    • Schilder R.J., Sill M.W., Lee Y.C., Mannel R. A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. International Journal of Gynecological Cancer 2009, 19:929-933.
    • (2009) International Journal of Gynecological Cancer , vol.19 , pp. 929-933
    • Schilder, R.J.1    Sill, M.W.2    Lee, Y.C.3    Mannel, R.4
  • 51
    • 37449004176 scopus 로고    scopus 로고
    • A phase II trial to evaluate gefitinib as second- or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer
    • Goncalves A., Fabbro M., Lhomme C., et al. A phase II trial to evaluate gefitinib as second- or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer. Gynecologic Oncology 2008, 108:42-46.
    • (2008) Gynecologic Oncology , vol.108 , pp. 42-46
    • Goncalves, A.1    Fabbro, M.2    Lhomme, C.3
  • 52
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes R.A., Towers T.L., Presta L.G., Ravetch J.V. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nature Medicine 2000, 6:443-446.
    • (2000) Nature Medicine , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 53
    • 0032407024 scopus 로고    scopus 로고
    • Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
    • Prewett M., Rothman M., Waksal H., Feldman M., Bander N.H., Hicklin D.J. Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clinical Cancer Research 1998, 4:2957-2966.
    • (1998) Clinical Cancer Research , vol.4 , pp. 2957-2966
    • Prewett, M.1    Rothman, M.2    Waksal, H.3    Feldman, M.4    Bander, N.H.5    Hicklin, D.J.6
  • 54
    • 34548124985 scopus 로고    scopus 로고
    • Overexpression of epidermal growth factor type-1 receptor (EGF-R1) in cervical cancer: implications for Cetuximab-mediated therapy in recurrent/metastatic disease
    • Bellone S., Frera G., Landolfi G., et al. Overexpression of epidermal growth factor type-1 receptor (EGF-R1) in cervical cancer: implications for Cetuximab-mediated therapy in recurrent/metastatic disease. Gynecologic Oncology 2007, 106:513-520.
    • (2007) Gynecologic Oncology , vol.106 , pp. 513-520
    • Bellone, S.1    Frera, G.2    Landolfi, G.3
  • 55
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken J.B., Mesia R., Rivera F., et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. New England Journal of Medicine 2008, 359:1116-1127.
    • (2008) New England Journal of Medicine , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 56
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. New England Journal of Medicine 2004, 351:337-345.
    • (2004) New England Journal of Medicine , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 57
    • 79955481029 scopus 로고    scopus 로고
    • Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study
    • Farley J., Sill M.W., Birrer M., et al. Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study. Gynecologic Oncology 2011, 121:303-308.
    • (2011) Gynecologic Oncology , vol.121 , pp. 303-308
    • Farley, J.1    Sill, M.W.2    Birrer, M.3
  • 58
    • 80051551247 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study
    • Santin A.D., Sill M.W., McMeekin D.S., et al. Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecologic Oncology 2011, 122:495-500.
    • (2011) Gynecologic Oncology , vol.122 , pp. 495-500
    • Santin, A.D.1    Sill, M.W.2    McMeekin, D.S.3
  • 59
    • 62749156047 scopus 로고    scopus 로고
    • Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: a phase II GINECO trial
    • Kurtz J.E., Hardy-Bessard A.C., Deslandres M., et al. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: a phase II GINECO trial. Gynecologic Oncology 2009, 113:16-20.
    • (2009) Gynecologic Oncology , vol.113 , pp. 16-20
    • Kurtz, J.E.1    Hardy-Bessard, A.C.2    Deslandres, M.3
  • 61
    • 67149137763 scopus 로고    scopus 로고
    • Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions
    • Feng W., Duan X., Liu J., Xiao J., Brown R.E. Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions. International Journal of Clinical and Experimental Pathology 2009, 2:249-260.
    • (2009) International Journal of Clinical and Experimental Pathology , vol.2 , pp. 249-260
    • Feng, W.1    Duan, X.2    Liu, J.3    Xiao, J.4    Brown, R.E.5
  • 63
    • 4143098350 scopus 로고    scopus 로고
    • Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin
    • Lu Z., Hu X., Li Y., et al. Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. Journal of Biological Chemistry 2004, 279:35664-35670.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 35664-35670
    • Lu, Z.1    Hu, X.2    Li, Y.3
  • 64
    • 33745813943 scopus 로고    scopus 로고
    • Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein
    • Oh K.J., Kalinina A., Park N.H., Bagchi S. Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein. Journal of Virology 2006, 80:7079-7088.
    • (2006) Journal of Virology , vol.80 , pp. 7079-7088
    • Oh, K.J.1    Kalinina, A.2    Park, N.H.3    Bagchi, S.4
  • 65
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall A.H., Alexander K.A. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. Journal of Virology 2003, 77:6066-6069.
    • (2003) Journal of Virology , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 66
    • 84861701377 scopus 로고    scopus 로고
    • Preliminary activity of temsirolimus, an mTOR inhibitor, in patients with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix: a NCIC-CTG Phase II Clinical Trial
    • Tinker A.M.H., Ellard S., Welch S., Eisenhauer E. Preliminary activity of temsirolimus, an mTOR inhibitor, in patients with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix: a NCIC-CTG Phase II Clinical Trial. Molecular Cancer Therapeutics 2011.
    • (2011) Molecular Cancer Therapeutics
    • Tinker, A.M.H.1    Ellard, S.2    Welch, S.3    Eisenhauer, E.4
  • 67
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 69
    • 0034541210 scopus 로고    scopus 로고
    • Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer
    • Pulido H.A., Fakruddin M.J., Chatterjee A., et al. Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer. Cancer Research 2000, 60:6677-6682.
    • (2000) Cancer Research , vol.60 , pp. 6677-6682
    • Pulido, H.A.1    Fakruddin, M.J.2    Chatterjee, A.3
  • 70
    • 2342633174 scopus 로고    scopus 로고
    • Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer
    • Narayan G., Arias-Pulido H., Nandula S.V., et al. Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer. Cancer Research 2004, 64:2994-2997.
    • (2004) Cancer Research , vol.64 , pp. 2994-2997
    • Narayan, G.1    Arias-Pulido, H.2    Nandula, S.V.3
  • 71
    • 1342301467 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival
    • Marsit C.J., Liu M., Nelson H.H., Posner M., Suzuki M., Kelsey K.T. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 2004, 23:1000-1004.
    • (2004) Oncogene , vol.23 , pp. 1000-1004
    • Marsit, C.J.1    Liu, M.2    Nelson, H.H.3    Posner, M.4    Suzuki, M.5    Kelsey, K.T.6
  • 72
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: a changing paradigm
    • Malumbres M., Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nature Reviews Cancer 2009, 9:153-166.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 73
    • 0042698478 scopus 로고    scopus 로고
    • Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function
    • Dixon H., Norbury C.J. Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function. Cell Cycle 2002, 1:362-368.
    • (2002) Cell Cycle , vol.1 , pp. 362-368
    • Dixon, H.1    Norbury, C.J.2
  • 74
    • 65249161106 scopus 로고    scopus 로고
    • Integrated functional, gene expression and genomic analysis for the identification of cancer targets
    • Iorns E., Lord C.J., Grigoriadis A., et al. Integrated functional, gene expression and genomic analysis for the identification of cancer targets. PLoS One 2009, 4:e5120.
    • (2009) PLoS One , vol.4
    • Iorns, E.1    Lord, C.J.2    Grigoriadis, A.3
  • 75
    • 16544392882 scopus 로고    scopus 로고
    • Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis
    • Wang Y., Decker S.J., Sebolt-Leopold J. Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis. Cancer Biology and Therapy 2004, 3:305-313.
    • (2004) Cancer Biology and Therapy , vol.3 , pp. 305-313
    • Wang, Y.1    Decker, S.J.2    Sebolt-Leopold, J.3
  • 76
    • 70949083026 scopus 로고    scopus 로고
    • Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
    • Hirai H., Iwasawa Y., Okada M., et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Molecular Cancer Therapeutics 2009, 8:2992-3000.
    • (2009) Molecular Cancer Therapeutics , vol.8 , pp. 2992-3000
    • Hirai, H.1    Iwasawa, Y.2    Okada, M.3
  • 77
    • 15044361867 scopus 로고    scopus 로고
    • Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1
    • Palmer B.D., Smaill J.B., Rewcastle G.W., et al. Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorganic and Medicinal Chemistry Letters 2005, 15:1931-1935.
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , pp. 1931-1935
    • Palmer, B.D.1    Smaill, J.B.2    Rewcastle, G.W.3
  • 78
    • 33746891507 scopus 로고    scopus 로고
    • 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution
    • Palmer B.D., Thompson A.M., Booth R.J., et al. 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. Journal of Medicinal Chemistry 2006, 49:4896-4911.
    • (2006) Journal of Medicinal Chemistry , vol.49 , pp. 4896-4911
    • Palmer, B.D.1    Thompson, A.M.2    Booth, R.J.3
  • 79
    • 44349183668 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases
    • Smaill J.B., Baker E.N., Booth R.J., et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. European Journal of Medical Chemistry 2008, 43:1276-1296.
    • (2008) European Journal of Medical Chemistry , vol.43 , pp. 1276-1296
    • Smaill, J.B.1    Baker, E.N.2    Booth, R.J.3
  • 80
    • 38749138123 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases
    • Smaill J.B., Lee H.H., Palmer B.D., et al. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorganic and Medicinal Chemistry Letters 2008, 18:929-933.
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , pp. 929-933
    • Smaill, J.B.1    Lee, H.H.2    Palmer, B.D.3
  • 81
    • 84858833041 scopus 로고    scopus 로고
    • Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors
    • Schellens J.H.M., Shapiro G., Pavlick A.C., et al. Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors. American Society of Clinical Oncology Meeting Abstracts 2011, 29:3068.
    • (2011) American Society of Clinical Oncology Meeting Abstracts , vol.29 , pp. 3068
    • Schellens, J.H.M.1    Shapiro, G.2    Pavlick, A.C.3
  • 82
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness B.A., Levine A.J., Howley P.M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990, 248:76-79.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 83
  • 84
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • Ashkenazi A., Holland P., Eckhardt S.G. Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). Journal of Clinical Oncology 2008, 26:3621-3630.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 85
    • 33645243818 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis
    • Hougardy B.M., Maduro J.H., van der Zee A.G., et al. Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis. International Journal of Cancer 2006, 118:1892-1900.
    • (2006) International Journal of Cancer , vol.118 , pp. 1892-1900
    • Hougardy, B.M.1    Maduro, J.H.2    van der Zee, A.G.3
  • 86
    • 21044441651 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
    • Pukac L., Kanakaraj P., Humphreys R., et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. British Journal of Cancer 2005, 92:1430-1441.
    • (2005) British Journal of Cancer , vol.92 , pp. 1430-1441
    • Pukac, L.1    Kanakaraj, P.2    Humphreys, R.3
  • 87
    • 50349092260 scopus 로고    scopus 로고
    • A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
    • Hotte S.J., Hirte H.W., Chen E.X., et al. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clinical Cancer Research 2008, 14:3450-3455.
    • (2008) Clinical Cancer Research , vol.14 , pp. 3450-3455
    • Hotte, S.J.1    Hirte, H.W.2    Chen, E.X.3
  • 88
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher A.W., Mita M., Meropol N.J., et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. Journal of Clinical Oncology 2007, 25:1390-1395.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3
  • 89
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
    • Greco F.A., Bonomi P., Crawford J., et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008, 61:82-90.
    • (2008) Lung Cancer , vol.61 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3
  • 90
    • 34548666183 scopus 로고    scopus 로고
    • CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia
    • Molling J.W., de Gruijl T.D., Glim J., et al. CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia. International Journal of Cancer 2007, 121:1749-1755.
    • (2007) International Journal of Cancer , vol.121 , pp. 1749-1755
    • Molling, J.W.1    de Gruijl, T.D.2    Glim, J.3
  • 91
    • 33745941651 scopus 로고    scopus 로고
    • Immunohistochemical analysis of CD4+ and CD8+ T-cell subsets in high risk human papillomavirus-associated pre-malignant and malignant lesions of the uterine cervix
    • Monnier-Benoit S., Mauny F., Riethmuller D., et al. Immunohistochemical analysis of CD4+ and CD8+ T-cell subsets in high risk human papillomavirus-associated pre-malignant and malignant lesions of the uterine cervix. Gynecologic Oncology 2006, 102:22-31.
    • (2006) Gynecologic Oncology , vol.102 , pp. 22-31
    • Monnier-Benoit, S.1    Mauny, F.2    Riethmuller, D.3
  • 93
    • 34250871751 scopus 로고    scopus 로고
    • Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses
    • Tuve S., Chen B.M., Liu Y., et al. Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses. Cancer Research 2007, 67:5929-5939.
    • (2007) Cancer Research , vol.67 , pp. 5929-5939
    • Tuve, S.1    Chen, B.M.2    Liu, Y.3
  • 94
    • 78449251207 scopus 로고    scopus 로고
    • Clinical studies with anti-CTLA-4 antibodies in non-melanoma indications
    • Calabro L., Danielli R., Sigalotti L., Maio M. Clinical studies with anti-CTLA-4 antibodies in non-melanoma indications. Seminars in Oncology 2010, 37:460-467.
    • (2010) Seminars in Oncology , vol.37 , pp. 460-467
    • Calabro, L.1    Danielli, R.2    Sigalotti, L.3    Maio, M.4
  • 95
    • 33846921847 scopus 로고    scopus 로고
    • Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer
    • Souders N.C., Sewell D.A., Pan Z.K., et al. Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer. Cancer Immunity 2007, 7:2.
    • (2007) Cancer Immunity , vol.7 , pp. 2
    • Souders, N.C.1    Sewell, D.A.2    Pan, Z.K.3
  • 96
    • 67349153373 scopus 로고    scopus 로고
    • The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix
    • Maciag P.C., Radulovic S., Rothman J. The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix. Vaccine 2009, 27:3975-3983.
    • (2009) Vaccine , vol.27 , pp. 3975-3983
    • Maciag, P.C.1    Radulovic, S.2    Rothman, J.3
  • 97
    • 84856695586 scopus 로고    scopus 로고
    • Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft
    • Morelli M.P., Calvo E., Ordonez E., et al. Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft. Journal of Clinical Oncology 2012, 30:e45-e48.
    • (2012) Journal of Clinical Oncology , vol.30
    • Morelli, M.P.1    Calvo, E.2    Ordonez, E.3
  • 98
    • 80051588648 scopus 로고    scopus 로고
    • A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
    • Hidalgo M., Bruckheimer E., Rajeshkumar N.V., et al. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Molecular Cancer Therapeutics 2011, 10:1311-1316.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 1311-1316
    • Hidalgo, M.1    Bruckheimer, E.2    Rajeshkumar, N.V.3
  • 99
    • 48249143703 scopus 로고    scopus 로고
    • Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression
    • Scotto L., Narayan G., Nandula S.V., et al. Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression. Genes, Chromosomes and Cancer 2008, 47:755-765.
    • (2008) Genes, Chromosomes and Cancer , vol.47 , pp. 755-765
    • Scotto, L.1    Narayan, G.2    Nandula, S.V.3
  • 100
    • 49149090064 scopus 로고    scopus 로고
    • Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha
    • Scotto L., Narayan G., Nandula S.V., et al. Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. Molecular Cancer 2008, 7:58.
    • (2008) Molecular Cancer , vol.7 , pp. 58
    • Scotto, L.1    Narayan, G.2    Nandula, S.V.3
  • 101
    • 77949673913 scopus 로고    scopus 로고
    • The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee
    • Seymour L., Ivy S.P., Sargent D., et al. The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee. Clinical Cancer Research 2010, 16:1764-1769.
    • (2010) Clinical Cancer Research , vol.16 , pp. 1764-1769
    • Seymour, L.1    Ivy, S.P.2    Sargent, D.3
  • 102
  • 104
    • 41649118967 scopus 로고    scopus 로고
    • Review of phase II trial designs used in studies of molecular targeted agents: outcomes and predictors of success in phase III
    • El-Maraghi R.H., Eisenhauer E.A. Review of phase II trial designs used in studies of molecular targeted agents: outcomes and predictors of success in phase III. Journal of Clinical Oncology 2008, 26:1346-1354.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1346-1354
    • El-Maraghi, R.H.1    Eisenhauer, E.A.2
  • 105
    • 79957928826 scopus 로고    scopus 로고
    • Treatment for advanced cervical cancer: impact on quality of life
    • Davidson S. Treatment for advanced cervical cancer: impact on quality of life. Critical Reviews in Oncology/Hematology 2011, 79:24-30.
    • (2011) Critical Reviews in Oncology/Hematology , vol.79 , pp. 24-30
    • Davidson, S.1
  • 106
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F., Dores G.M., Anderson W.F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. Journal of Clinical Oncology 2006, 24:2137-2150.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.