The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Liu, Lin ^a   Nie, Jing ^a   Chen, Lin ^a   Dong, Guanglong ^a   Du, Xiaohui ^a   Wu, Xin ^a   Tang, Yun ^a   Han, Weidong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 130A; MICRORNA 301A; MICRORNA 454; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CARCINOGENICITY; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; SEQUENCE ANALYSIS; UPREGULATION;

ANIMALS; CELL MOVEMENT; CELL SURVIVAL; COLORECTAL NEOPLASMS; FEMALE; HCT116 CELLS; HUMANS; IMMUNOBLOTTING; MICE; MICE, NUDE; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD4 PROTEIN;

EID: 84873518138     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055532     Document Type: Article

References (40)

1. Weitz J, Koch M, Debus J, Hohler T, Galle PR, et al. (2005) Colorectal cancer. Lancet 365: 153-165.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. (2007) Cancer statistics. CA Cancer J Clin 57: 43-66.
3. Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM, (2003) bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113: 25-36.
4. Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, et al. (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432: 226-230.
5. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, et al. (2007) Regulation of the germinal center response by microRNA-155. Science 316: 604-608.
6. Pillai RS, (2005) MicroRNA function: multiple mechanisms for a tiny RNA? RNA 11: 1753-1761.
7. Zamore PD, Haley B, (2005) Ribo-gnome: the big world of small RNAs. Science 309: 1519-1524.
8. Slaby O, Svoboda M, Michalek J, Vyzula R, (2009) MicroRNAs in colorectal cancer: translation of molecular biology into clinical application. Mol Cancer 8: 102.
9. Schimanski CC, Frerichs K, Rahman F, Berger M, Lang H, et al. (2009) High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 15: 2089-2096.
10. Bandres E, Cubedo E, Agirre X, Malumbres R, Zarate R, et al. (2006) Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer 5: 29.
11. Motoyama K, Inoue H, Takatsuno Y, Tanaka F, Mimori K, et al. (2009) Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol 34: 1069-1075.
12. Nie J, Liu L, Zheng W, Chen L, Wu X, et al. (2012) microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. Carcinogenesis 33: 220-225.
13. Liu L, Chen L, Xu Y, Li R, Du X, (2010) microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun 400: 236-240.
14. Calin GA, Croce CM, (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866.
15. Wang X, Tian L, Wu H, Jiang X, Du L, et al. (2010) Expression of miRNA-130a in nonsmall cell lung cancer. Am J Med Sci 340: 385-388.
16. Chen Y, Gorski DH, (2008) Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood 111: 1217-1226.
17. Suresh S, McCallum L, Lu W, Lazar N, Perbal B, et al. (2011) MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML. J Cell Commun Signal 5: 183-191.
18. Zhou P, Jiang W, Wu L, Chang R, Wu K, et al. (2012) miR-301a is a candidate oncogene that targets the homeobox gene Gax in human hepatocellular carcinoma. Dig Dis Sci 57: 1171-1180.
19. Chen Z, Chen L, Dai H, Wang P, Gao S, et al. (2012) miR-301a promotes pancreatic cancer cell proliferation by directly inhibiting bim expression. J Cell Biochem 113: 3229-3235.
20. Shi W, Gerster K, Alajez NM, Tsang J, Waldron L, et al. (2011) MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer Res 71: 2926-2937.
21. Lu Z, Li Y, Takwi A, Li B, Zhang J, et al. (2011) miR-301a as an NF-kappaB activator in pancreatic cancer cells. EMBO J 30: 57-67.
22. Kovaleva V, Mora R, Park YJ, Plass C, Chiramel AI, et al. (2012) miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. Cancer Res 72: 1763-1772.
23. Patel N, Tahara SM, Malik P, Kalra VK, (2011) Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J 434: 473-482.
24. Nie J, Xie P, Liu L, Xing G, Chang Z, et al. (2010) Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem 285: 22818-22830.
25. Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, et al. (2011) miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2. EMBO Rep 12: 1153-1159.
26. Lee YH, Na HS, Jeong SY, Jeong SH, Park HR, et al. (2011) Comparison of inflammatory microRNA expression in healthy and periodontitis tissues. Biocell 35: 43-49.
27. Mycko MP, Cichalewska M, Machlanska A, Cwiklinska H, Mariasiewicz M, et al. (2012) MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Proc Natl Acad Sci U S A 109: E1248-1257.
28. Wang Y, Zhang X, Zhang B, Yang C, Chen X, et al. (2010) Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis. J Dig Dis 11: 50-54.
29. Somel M, Liu X, Tang L, Yan Z, Hu H, et al. (2011) MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol 9: e1001214.
30. Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, et al. (1999) Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18: 3098-3103.
31. Hahn SA, Bartsch D, Schroers A, Galehdari H, Becker M, et al. (1998) Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. Cancer Res 58: 1124-1126.
32. Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, et al. (2010) Antimetastatic role of Smad4 signaling in colorectal cancer. Gastroenterology 138: 969-980.
33. Genovese G, Ergun A, Shukla SA, Campos B, Hanna J, et al. (2012) microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-beta Signaling in Glioblastoma. Cancer Discov 2: 736-749.
34. Xiao B, Zhu E, Li N, Lu D, Li W, et al. (2012) Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis. Oncol Rep 27: 559-566.
35. Zhang Y, Fan K, Sun Q, Chen A, Shen W, et al. (2012) Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway. Nucleic Acids Res 40: 9286-9297.
36. Takahashi K, Yamanaka S, (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
37. Judson RL, Babiarz JE, Venere M, Blelloch R, (2009) Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 27: 459-461.
38. Lin S, Chang D, Lin C, Ying S, Leu D, et al. (2011) Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res 39: 1054-1065.
39. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, et al. (2011) Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8: 376-388.
40. Li R, Liang J, Ni S, Zhou T, Qing X, et al. (2010) A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7: 51-63.