Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis

Oncology Reports

Volumn 27, Issue 2, 2012, Pages 559-566

  Xiao, Bin ^a   Zhu, En Dong ^a   Li, Na ^a   Lu, Dong Shui ^a   Li, Wei ^b   Li, Bo Sheng ^a   Zhao, Yong Liang ^a   Mao, Xu Hu ^a   Guo, Gang ^a   Yu, Pei Wu ^a   Zou, Quan Ming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHWEST HOSPITAL   (China)

Author keywords

Apoptosis; Gastric cancer; MicroRNA; miR 146a; Proliferation; SMAD4

Indexed keywords

CASPASE 3; CASPASE 7; MESSENGER RNA; MICRORNA; MICRORNA 146A; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL COUNT; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ASSOCIATION; HELICOBACTER INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH CARCINOGENESIS; UPREGULATION; WESTERN BLOTTING;

AGED; APOPTOSIS; BASE SEQUENCE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HEK293 CELLS; HELICOBACTER INFECTIONS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; SMAD4 PROTEIN; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84862908996     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1514     Document Type: Article

References (35)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Bornschein J, Rokkas T, Selgrad M and Malfertheiner P: Helico-bacter pylori and clinical aspects of gastric cancer. Helicobacter 14 (Suppl. 1): S41-S45, 2009.
3. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
4. Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005. (Pubitemid 40839735)
5. Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
6. Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10: 704-714, 2009.
7. Petrocca F, Visone R, Onelli MR, et al: E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286, 2008. (Pubitemid 351318375)
8. Zhang Z, Li Z, Gao C, et al: miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 88: 1358-1366, 2008.
9. Tie J, Pan Y, Zhao L, et al: MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 6: e1000879, 2010.
10. Wan HY, Guo LM, Liu T, Liu M, Li X and Tang H: Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma. Mol Cancer 9: 16, 2010.
11. Kim YK, Yu J, Han TS, et al: Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res 37: 1672-1681, 2009.
12. Xiao B, Liu Z, Li BS, et al: Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. J Infect Dis 200: 916-925, 2009.
13. Liu Z, Xiao B, Tang B, et al: Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect 12: 854-863, 2010.
14. Sonkoly E, Stahle M and Pivarcsi A: MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18: 131-140, 2008.
15. Williams AE, Perry MM, Moschos SA, Larner-Svensson HM and Lindsay MA: Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans 36: 1211-1215, 2008.
16. Chen XM, Splinter PL, O'Hara SP and LaRusso NF: A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem 282: 28929-28938, 2007.
17. Philippidou D, Schmitt M, Moser D, et al: Signatures of microRNAs and selected microRNA target genes in human melanoma. Cancer Res 70: 4163-4173, 2010.
18. Zhong H, Wang HR, Yang S, et al: Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line. Int J Hematol 92: 129-135, 2010.
19. Wang LH, Kim SH, Lee JH, et al: Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. Clin Cancer Res 13: 102-110, 2007. (Pubitemid 46121858)
20. He H, Jazdzewski K, Li W, et al: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA 102: 19075-19080, 2005.
21. Wang X, Tang S, Le SY, et al: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3: e2557, 2008.
22. Volinia S, Calin GA, Liu CG, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257-2261, 2006. (Pubitemid 43271657)
23. Lin SL, Chiang A, Chang D and Ying SY: Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14: 417-424, 2008. (Pubitemid 351397806)
24. Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR and de la Chapelle A: Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105: 7269-7274, 2008. (Pubitemid 351754467)
25. Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS and Welch DR: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res 69: 1279-1283, 2009.
26. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J and Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647, 2008.
27. Tsukamoto Y, Nakada C, Noguchi T, et al: MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 70: 2339-2349, 2010.
28. Hou Z, Xie L, Yu L, Qian X and Liu B: MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis. Med Oncol: Feb 24, 2011 [Epub ahead of print].
29. Katada T, Ishiguro H, Kuwabara Y, et al: microRNA expression profile in undifferentiated gastric cancer. Int J Oncol 34: 537-542, 2009.
30. Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103: 12481-12486, 2006. (Pubitemid 44267285)
31. Yang K, He YS, Wang XQ, et al: MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett 585: 854-860, 2011.
32. Lu LF, Boldin MP, Chaudhry A, et al: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142: 914-929, 2010.
33. Sinha M, Ghose J, Das E and Bhattarcharyya NP: Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP. Biochem Biophys Res Commun 396: 742-747, 2010.
34. Rom S, Rom I, Passiatore G, et al: CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells. FASEB J 24: 2292-2300, 2010.
35. Powell SM, Harper JC, Hamilton SR, Robinson CR and Cummings OW: Inactivation of Smad4 in gastric carcinomas. Cancer Res 57: 4221-4224, 1997. (Pubitemid 27413428)