Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice

PLoS Genetics

Volumn 9, Issue 1, 2013, Pages

  Stefanov, Anguel N ^a   Fox, Jessica ^a   Haston, Christina K ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HOMOZYGOSITY; LUNG FIBROSIS; LUNG LAVAGE; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; TRIM16 GENE;

ANIMALS; BLEOMYCIN; CARRIER PROTEINS; CHROMOSOME MAPPING; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG; MICE; MICE, INBRED STRAINS; PHENOTYPE; PULMONARY FIBROSIS;

EID: 84873490177     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003203     Document Type: Article

References (42)

1. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, et al. (2011) An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183: 788-824.
2. King TE Jr, Pardo A, Selman M, (2011) Idiopathic pulmonary fibrosis. Lancet 378: 1949-61.
3. Wynn TA, (2011) Integrating mechanisms of pulmonary fibrosis. J Exp Med 208: 1339-50.
4. Nuovo GJ, Hagood JS, Magro CM, Chin N, Kapil R, et al. (2012) The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis. Mod Pathol 25: 416-33.
5. Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, et al. (2006) ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis. Am J Hum Genet 79: 149-54.
6. Garcia CK, (2011) Idiopathic pulmonary fibrosis: update on genetic discoveries. Proc Am Thorac Soc 8: 158-62.
7. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, et al. (2011) A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364: 1503-12.
8. Zhang Y, Noth I, Garcia JG, Kaminski N, (2011) A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med 364: 1576-7.
9. Todd JL, Goldstein DB, Ge D, Christie J, Palmer SM, (2011) The State of Genome-Wide Association Studies in Pulmonary Disease: A New Perspective. Am J Respir Crit Care Med 184: 873-80.
10. Gross TJ, Hunninghake GW, (2001) Idiopathic pulmonary fibrosis. N Engl J Med 345: 517-25.
11. Harrison JH Jr, Lazo JS, (1987) High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J Pharmacol Exp Ther 243: 1185-94.
12. Lemay AM, Haston CK, (2005) Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice. Physiol Genomics 23: 54-61.
13. Haston CK, Tomko TG, Godin N, Kerckhoff L, Hallett MT, (2005) Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions. J Med Genet 42: 464-473.
14. Gabazza EC, Taguchi O, Adachi Y, (2002) Bleomycin-induced lung fibrosis: the authors should have used another method to induce pulmonary lesions resembling human idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 165: 845-6.
15. Aono Y, Ledford JG, Mukherjee S, Ogawa H, Nishioka Y, et al. (2012) Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury. Am J Respir Crit Care Med 185: 525-36.
16. Haston CK, Amos CI, King TM, Travis EL, (1996) Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse. Cancer Res 56: 2596-601.
17. Haston CK, Wang M, Dejournett RE, Zhou X, Ni D, et al. (2002) Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Hum Mol Genet 11: 1855-63.
18. Kumar P, Henikoff S, Ng PC, (2009) Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 4: 1073-81.
19. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, et al. (2010) A method and server for predicting damaging missense mutations. Nat Methods 7: 248-9.
20. Munding C, Keller M, Niklaus G, Papin S, Tschopp J, et al. (2006) The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ 13: 1938-49.
21. Keane TM, Goodstadt L, Danecek P, White MA, Wong K, et al. (2011) Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477: 289-94.
22. Messeguer X, Escudero R, Farré D, Núñez O, Martínez J, et al. (2002) PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics 18: 333-4.
23. Farré D, Roset R, Huerta M, Adsuara JE, Roselló L, et al. (2003) Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res 31: 3651-3.
24. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, et al. (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 26: 362-7.
25. Kel AE, Gössling E, Reuter I, Cheremushkin E, Kel-Margoulis OV, et al. (2003) MATCH: A tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res 31: 3576-9.
26. Goula D, Benoist C, Mantero S, Merlo G, Levi G, et al. (1998) Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 5: 1291-5.
27. Goula D, Becker N, Lemkine GF, Normandie P, Rodrigues J, et al. (2000) Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes. Gene Ther 7: 499-504.
28. Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, et al. (2007) IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol 179: 8274-9.
29. Huaux F, Lardot C, Arras M, Delos M, Many MC, et al. (1999) Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations. Am J Respir Cell Mol Biol 20: 561-72.
30. Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, et al. (2002) A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 169: 2653-61.
31. Mouratis MA, Aidinis V, (2011) Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med 17: 355-61.
32. Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, et al. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet 41: 688-95.
33. Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, et al. (2011) Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet 10: e1002323 doi:10.1371/journal.pgen.1002323.
34. Oh YK, Kim JP, Yoon H, Kim JM, Yang JS, et al. (2001) Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes. Gene Ther 8: 1587-92.
35. Bonnet ME, Erbacher P, Bolcato-Bellemin AL, (2008) Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm Res 25: 2972-82.
36. Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, et al. (2010) Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207: 535-52.
37. Kinder BW, Brown KK, Schwarz MI, Ix JH, Kervitsky A, et al. (2008) Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis. Chest 133: 226-32.
38. Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, et al. (2009) Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med 206: 1661-71.
39. Edwards CA, O'Brien WD Jr, (1980) "Modified assay for determination of hydroxyproline in a tissue hydrolyzate.". Clin Chim Acta 104: 161-167.
40. Paun A, Fox J, Balloy V, Chignard M, Qureshi ST, et al. (2010) Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Int J Radiat Oncol Biol Phys 77: 1198-205.
41. Thomas DM, Fox J, Haston CK, (2010) Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse. Int J Radiat Biol 86: 436-44.
42. Blanchette M, Kent WJ, Riemer C, Elnitski L, Smit AF, et al. (2004) Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 14: 708-15.