The genetic regulation of the terminating phase of liver regeneration

Comparative Hepatology

Volumn 11, Issue 1, 2012, Pages

  Nygård, Ingvild E ^a   Mortensen, Kim E ^a   Hedegaard, Jakob ^b   Conley, Lene N ^b   Kalstad, Trine ^c   Bendixen, Christian ^b   Revhaug, Arthur ^c  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Angiogenesis; Apoptosis; Cell cycle; Microarray analysis; Partial hepatectomy; Porcine genes

Indexed keywords

BMPR2 PROTEIN; CARD11 PROTEIN; CCT7 PROTEIN; CIB1 PROTEIN; CLU PROTEIN; DLEC1 PROTEIN; ELMO1 PROTEIN; ESR1 PROTEIN; GSK3A PROTEIN; MPHOSPH9 PROTEIN; OLIGONUCLEOTIDE; PRKRA PROTEIN; PROP1 PROTEIN; PROTEIN; PROTEIN MDMX; PTHLH PROTEIN; SKI PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASH2 PROTEIN; ZINC FINGER PROTEIN; ZNF490 PROTEIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXPERIMENTAL PIG; FEMALE; GENE EXPRESSION; GENE INTERACTION; GENETIC REGULATION; LIVER BIOPSY; LIVER REGENERATION; LIVER RESECTION; LIVER WEIGHT; MICROARRAY ANALYSIS; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; VASCULARIZATION;

EID: 84873466231     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-11-3     Document Type: Article

References (47)

1. Arai M, Yokosuka O, Chiba T, Imazeki F, Kato M, Hashida J, Ueda Y, Sugano S, Hashimoto K, Saisho H, Takiguchi M, Seki N. Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration. J Biol Chem 2003, 278:29813-29818. 10.1074/jbc.M212648200, 12782638.
2. Fukuhara Y, Hirasawa A, Li XK, Kawasaki M, Fujino M, Funeshima N, Katsuma S, Shiojima S, Yamada M, Okuyama T, Suzuki S, Tsujimoto G. Gene expression profile in the regenerating rat liver after partial hepatectomy. J Hepatol 2003, 38:784-792.
3. Locker J, Tian JM, Carver R, Concas D, Cossu C, Ledda-Columbano GM, Columbano A. A common set of immediate-early response genes in liver regeneration and hyperplasia. Hepatology 2003, 38:314-325.
4. Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci USA 2002, 99:11181-11186. 10.1073/pnas.122359899, 123230, 12177410.
5. White P, Brestelli JE, Kaestner KH, Greenbaum LE. Identification of transcriptional networks during liver regeneration. J Biol Chem 2005, 280:3715-3722.
6. Taub R. Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 2004, 5:836-847. 10.1038/nrm1489, 15459664.
7. Fujiyoshi M, Ozaki M. Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases. J Hepatobiliary Pancreat Sci 2011, 18:13-22. 10.1007/s00534-010-0304-2, 20607568.
8. Koniaris LG, McKillop IH, Schwartz SI, Zimmers TA. Liver regeneration. J Am Coll Surg 2003, 197:634-659. 10.1016/S1072-7515(03)00374-0, 14522336.
9. Campbell JS, Prichard L, Schaper F, Schmitz J, Stephenson-Famy A, Rosenfeld ME, Argast GM, Heinrich PC, Fausto N. Expression of suppressors of cytokine signaling during liver regeneration. J Clin Invest 2001, 107:1285-1292. 10.1172/JCI11867, 209297, 11375418.
10. Aldeguer X, Debonera F, Shaked A, Krasinkas AM, Gelman AE, Que XG, Zamir GA, Hiroyasu S, Kovalovich KK, Taub R, Olthoff KM. Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. Hepatology 2002, 35:40-48. 10.1053/jhep.2002.30081, 11786958.
11. Debonera F, Aldeguer X, Shen XD, Gelman AE, Gao F, Que XY, Greenbaum LE, Furth EE, Taub R, Olthoff KM. Activation of interleukin-6/STAT3 and liver regeneration following transplantation. J Surg Res 2001, 96:289-295. 10.1006/jsre.2001.6086, 11266286.
12. Macias-Silva M, Li W, Leu JI, Crissey MAS, Taub R. Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J Biol Chem 2002, 277:28483-28490. 10.1074/jbc.M202403200, 12023281.
13. Oe S, Lemmer ER, Conner EA, Factor VM, Leveen P, Larsson J, Karlsson S, Thorgeirsson SS. Intact signalling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004, 40:1098-1105. 10.1002/hep.20426, 15389868.
14. Mortensen KE, Conley LN, Hedegaard J, Kalstad T, Sorensen P, Bendixen C, Revhaug A. Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure. Am J Physiol 2008, 294:G819-G830.
15. Court FG, Laws PE, Morrison CP, Teague BD, Metcalfe MS, Wemyss-Holden SA, Dennison AR, Maddern GJ. Subtotal hepatectomy: A porcine model for the study of liver regeneration. J Surg Res 2004, 116:181-186. 10.1016/j.jss.2003.08.007, 14732366.
16. Oh YM, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7 - Recombinant human mac25 protein specifically binds IGF-I and II. J Biol Chem 1996, 271:30322-30325. 10.1074/jbc.271.48.30322, 8939990.
17. Tian QS, Streuli M, Saito H, Schlossman SF, Anderson P. A Polyadenylate Binding-Protein Localized to the Granules of Cytolytic Lymphocytes Induces Dna Fragmentation in Target-Cells. Cell 1991, 67:629-639. 10.1016/0092-8674(91)90536-8, 1934064.
18. Lee JH, Takahashi T, Yasuhara N, Inazawa J, Kamada S, Tsujimoto Y. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 1999, 18:6183-6190. 10.1038/sj.onc.1203043, 10597216.
19. Nowak J, Archange C, Tardivel-Lacombe J, Pontarotti P, Pébusque MJ, Vaccaro MI. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell 2009, 3:870-881.
20. Katoh O, Oguri T, Takahashi T, Takai S, Fujiwara Y, Watanabe H. ZK1, a novel Kruppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. Biochem Biophys Res Comm 1998, 249:595-600. 10.1006/bbrc.1998.9201, 9731181.
21. Song EJ, Yim SH, Kim E, Kim NS, Lee KJ. Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol 2005, 6:2511-2524.
22. Nakajima T, Konda Y, Kanai M, Izumi Y, Kanda N, Nanakin A, Kitazawa S, Chiba T. Prohormone convertase furin has a role in gastric cancer cell proliferation with parathyroid hormone-related peptide in a reciprocal manner. Dig Dis Sci 2002, 12:2729-2737.
23. Muchmore AV, Decker JM. Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. Science 1985, 229:479-481. 10.1126/science.2409603, 2409603.
24. Shvarts A, Bazuine M, Dekker P, Ramos YFM, Steegenga WT, Merckx G, van Ham RCA, van Oordt WV, vander Eb AJ, Jochemsen AG. Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. Genomics 1997, 43:34-42. 10.1006/geno.1997.4775, 9226370.
25. Cooney, Robert N. Suppressors of Cytokine Signaling (SOCS): Inhibitors of the JAK/STAT Pathway. Shock 2002, 17:83-90. 10.1097/00024382-200202000-00001, 11837794.
26. Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. Oncogene 1998, 16:2687-2693. 10.1038/sj.onc.1201805, 9632145.
27. Morrell NW, Yang XD, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC. Altered growth responses of muscle cells from patients pulmonary artery smooth with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 2001, 104:790-795. 10.1161/hc3201.094152, 11502704.
28. Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ. DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem 2005, 280:14122-14129. 10.1074/jbc.M410034200, 15671031.
29. Daigo Y, Nishiwaki T, Kawasoe T, Tamari M, Tsuchiya E, Nakamura Y. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Res 1999, 59:1966-1972.
30. The Tob-1 Pathway 2008 http://www.biocarta.com/pathfiles/h_tob1Pathway.asp.
31. Ho KJ, Do NL, Otu HH, Dib MJ, Ren X, Enjyoji K, Robson SC, Terwilliger EF, Karp SJ. Tob1 is a constitutively expressed repressor of liver regeneration. J Exp Med 2010, 207:1197-1208. 10.1084/jem.20092434, 2882843, 20513747.
32. Sakamoto T, Liu ZJ, Murase N, Ezure T, Yokomuro S, Poli V, Demetris AJ. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 1999, 29:403-411. 10.1002/hep.510290244, 9918916.
33. Michalopoulos GK. Liver regeneration. J Cell Physiol 2007, 213:286-300. 10.1002/jcp.21172, 2701258, 17559071.
34. Schnabl B, Hu KH, Muhlbauer M, Hellerbrand C, Stefanovic B, Brenner DA, Scholmerich M. Zinc finger protein 267 is up-regulated during the;activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Comm 2005, 335:87-96. 10.1016/j.bbrc.2005.07.043, 16054593.
35. Duan J, Xia Q, Cheng D, Zha X, Zhao P, Xiang Z. Species-specific expansion of C2H2 zinc-finger genes and their expression profiles in silkworm, Bombyx mori. Insect Biochem Mol Biol 2008, 38:1121-1129. 10.1016/j.ibmb.2008.08.005, 18835444.
36. Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES. CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10. J Biol Chem 2001, 276:11877-11882. 10.1074/jbc.M010512200, 11278692.
37. Yuan B, Dong R, Shi D, Zhou Y, Zhao Y, Miao M, Jiao B. Down-regulation of miR-23b may contribute to activation of the TGF-β1/Smad3 signalling pathway during the termination stage of liver regeneration. FEBS Lett 2011, 585:927-934. 10.1016/j.febslet.2011.02.031, 21354414.
38. Chen H, Sun Y, Dong R, Yang S, Pan C, Xiang D, Miao M, Jiao B. Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation. PLoS One 2011, 6:e20238. 10.1371/journal.pone.0020238, 3105003, 21655280.
39. Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood 2009, 113:4810-4818. 10.1182/blood-2008-07-170316, 19204325.
40. Barrett T, Suzek TO, Troup DB, Wilhite SE, Ngau WC, Ledoux P, Rudnev D, Lash AE, Fujibuchi W, Edgar R. NCBI GEO: mining millions of expression profiles - database and tools. Nucleic Acids Res 2005, 33:D562-D566. 539976, 15608262.
41. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30:207-210. 10.1093/nar/30.1.207, 99122, 11752295.
42. Smyth GK. Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments. Stat Appl Genet Mol Biol 2004, 3. Article 3.
43. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge YC, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang JH. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004, 5:R80. 10.1186/gb-2004-5-10-r80, 545600, 15461798.
44. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate - A Practical and Powerful Approach to Multiple Testing. J R Statist Soc B 1995, 57:289-300.
45. OMIMTM - Online Mendelian Inheritance In ManTM 2011 http://www.ncbi.nlm.nih.gov/omim.
46. Ace View Genes, NCBI 2011 http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/.
47. Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC, Stolz DB. Sinusoidal Ultrastructure Evaluated During the Revascularization of Regenerating Rat Liver. Hepatology 2001, 33:363-378. 10.1053/jhep.2001.21998, 11172338.