메뉴 건너뛰기




Volumn 34, Issue 12, 2013, Pages 3098-3109

Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs

Author keywords

Cancer therapy; Crosslinked multilamellar liposome; Doxorubicin; Intracellular trafficking; Nanomedicine; Positron emission tomography (PET)

Indexed keywords

ANTICANCER DRUG; CANCER THERAPEUTICS; CANCER THERAPY; CONTROLLED DELIVERY; CROSSLINKED; DOXORUBICIN; DRUG PACKAGING; DRUG RELEASE; DRUG RELEASE KINETICS; IN-VIVO EXPERIMENTS; INHERENT INSTABILITY; INTRACELLULAR TRAFFICKING; LIPID COMPOSITION; LIPOSOMAL FORMULATION; MULTILAMELLAR LIPOSOMES; NANOCARRIERS; THERAPEUTIC ACTIVITY; TUMOR GROWTH; UNILAMELLAR LIPOSOMES;

EID: 84873455346     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.039     Document Type: Article
Times cited : (100)

References (52)
  • 2
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain R.K., Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 2010, 7:653-664.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 3
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • Davis M.E., Chen Z., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008, 7:771-782.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 4
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 5
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • Cho K.J., Wang X., Nie S.M., Chen Z., Shin D.M. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008, 14:1310-1316.
    • (2008) Clin Cancer Res , vol.14 , pp. 1310-1316
    • Cho, K.J.1    Wang, X.2    Nie, S.M.3    Chen, Z.4    Shin, D.M.5
  • 6
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: opportunities and challenges
    • Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005, 5:161-171.
    • (2005) Nat Rev Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 7
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005, 4:145-160.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 8
    • 0036096806 scopus 로고    scopus 로고
    • Liposome-based drug delivery in breast cancer treatment
    • Park J.W. Liposome-based drug delivery in breast cancer treatment. Breast Cancer Res 2002, 4:93-97.
    • (2002) Breast Cancer Res , vol.4 , pp. 93-97
    • Park, J.W.1
  • 9
    • 49149083694 scopus 로고    scopus 로고
    • Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development
    • Drummond D.C., Noble C.O., Hayes M.E., Park J.W., Kirpotin D.B. Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development. J Pharm Sci 2008, 97:4696-4740.
    • (2008) J Pharm Sci , vol.97 , pp. 4696-4740
    • Drummond, D.C.1    Noble, C.O.2    Hayes, M.E.3    Park, J.W.4    Kirpotin, D.B.5
  • 10
    • 0027514941 scopus 로고
    • Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases
    • Haran G., Cohen R., Bar L., Barenholz Y. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993, 1151:201-215.
    • (1993) Biochim Biophys Acta , vol.1151 , pp. 201-215
    • Haran, G.1    Cohen, R.2    Bar, L.3    Barenholz, Y.4
  • 11
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy
    • Gabizon A.A. Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest 2001, 19:424-436.
    • (2001) Cancer Invest , vol.19 , pp. 424-436
    • Gabizon, A.A.1
  • 12
    • 0942277118 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin in the treatment of breast cancer
    • O'Shaughnessy J.A. Pegylated liposomal doxorubicin in the treatment of breast cancer. Clin Breast Cancer 2003, 4:318-328.
    • (2003) Clin Breast Cancer , vol.4 , pp. 318-328
    • O'Shaughnessy, J.A.1
  • 13
    • 0035120280 scopus 로고    scopus 로고
    • Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet
    • Gabizon A.A. Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin Cancer Res 2001, 7:223-225.
    • (2001) Clin Cancer Res , vol.7 , pp. 223-225
    • Gabizon, A.A.1
  • 14
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: entering the mainstream
    • Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818-1822.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 15
    • 26444500499 scopus 로고    scopus 로고
    • Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors
    • Laginha K.M., Verwoert S., Charrois G.J.R., Allen T.M. Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors. Clin Cancer Res 2005, 11:6944-6949.
    • (2005) Clin Cancer Res , vol.11 , pp. 6944-6949
    • Laginha, K.M.1    Verwoert, S.2    Charrois, G.J.R.3    Allen, T.M.4
  • 16
    • 84859831666 scopus 로고    scopus 로고
    • Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia
    • Al-Jamal W.T., Al-Ahmady Z.S., Kostarelos K. Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia. Biomaterials 2012, 33:4608-4617.
    • (2012) Biomaterials , vol.33 , pp. 4608-4617
    • Al-Jamal, W.T.1    Al-Ahmady, Z.S.2    Kostarelos, K.3
  • 17
    • 79251547946 scopus 로고    scopus 로고
    • Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors
    • van Lummel M., van Blitterswijk W.J., Vink S.R., Veldman R.J., van der Valk M.A., Schipper D., et al. Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors. FASEB J 2011, 25:280-289.
    • (2011) FASEB J , vol.25 , pp. 280-289
    • van Lummel, M.1    van Blitterswijk, W.J.2    Vink, S.R.3    Veldman, R.J.4    van der Valk, M.A.5    Schipper, D.6
  • 18
    • 84861669644 scopus 로고    scopus 로고
    • Doxil - the first FDA-approved nano-drug: lessons learned
    • Barenholz Y. Doxil - the first FDA-approved nano-drug: lessons learned. J Control Release 2012, 160:117-134.
    • (2012) J Control Release , vol.160 , pp. 117-134
    • Barenholz, Y.1
  • 19
    • 2442551191 scopus 로고    scopus 로고
    • Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer
    • Charrois G.J.R., Allen T.M. Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer. Biochim Biophys Acta 2004, 1663:167-177.
    • (2004) Biochim Biophys Acta , vol.1663 , pp. 167-177
    • Charrois, G.J.R.1    Allen, T.M.2
  • 20
    • 79951899834 scopus 로고    scopus 로고
    • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
    • Moon J.J., Suh H., Bershteyn A., Stephan M.T., Liu H.P., Huang B., et al. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater 2011, 10:243-251.
    • (2011) Nat Mater , vol.10 , pp. 243-251
    • Moon, J.J.1    Suh, H.2    Bershteyn, A.3    Stephan, M.T.4    Liu, H.P.5    Huang, B.6
  • 21
    • 0013946834 scopus 로고
    • A new micromethod for the colorimetric determination of inorganic phosphate
    • Itaya K., Ui M. A new micromethod for the colorimetric determination of inorganic phosphate. Clin Chim Acta 1966, 14:361-366.
    • (1966) Clin Chim Acta , vol.14 , pp. 361-366
    • Itaya, K.1    Ui, M.2
  • 22
    • 72449155498 scopus 로고    scopus 로고
    • An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane-1-ylamino)methyl) benzoic acid, for 64Cu radiopharmaceuticals
    • Cai H., Li Z., Huang C.W., Park R., Shahinian A.H., Conti P.S. An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane-1-ylamino)methyl) benzoic acid, for 64Cu radiopharmaceuticals. Nucl Med Biol 2010, 37:57-65.
    • (2010) Nucl Med Biol , vol.37 , pp. 57-65
    • Cai, H.1    Li, Z.2    Huang, C.W.3    Park, R.4    Shahinian, A.H.5    Conti, P.S.6
  • 23
    • 34249044829 scopus 로고    scopus 로고
    • Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding
    • Dos Santos N., Allen C., Doppen A.M., Anantha M., Cox K.A.K., Gallagher R.C., et al. Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochim Biophys Acta 2007, 1768:1367-1377.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 1367-1377
    • Dos Santos, N.1    Allen, C.2    Doppen, A.M.3    Anantha, M.4    Cox, K.A.K.5    Gallagher, R.C.6
  • 25
    • 18244362593 scopus 로고    scopus 로고
    • Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates
    • Allen T.M., Mumbengegwi D.R., Charrois G.J.R. Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates. Clin Cancer Res 2005, 11:3567-3573.
    • (2005) Clin Cancer Res , vol.11 , pp. 3567-3573
    • Allen, T.M.1    Mumbengegwi, D.R.2    Charrois, G.J.R.3
  • 26
    • 0041430798 scopus 로고    scopus 로고
    • Multiple injections of pegylated liposomal doxorubicin: pharmacokinetics and therapeutic activity
    • Charrois G.J.R., Allen T.M. Multiple injections of pegylated liposomal doxorubicin: pharmacokinetics and therapeutic activity. J Pharmacol Exp Ther 2003, 306:1058-1067.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 1058-1067
    • Charrois, G.J.R.1    Allen, T.M.2
  • 27
    • 0037427961 scopus 로고    scopus 로고
    • Rate of biodistribution of stealth liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity
    • Charrois G.J.R., Allen T.M. Rate of biodistribution of stealth liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity. Biochim Biophys Acta 2003, 1609:102-108.
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 102-108
    • Charrois, G.J.R.1    Allen, T.M.2
  • 28
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • Petros R.A., DeSimone J.M. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 2010, 9:615-627.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 615-627
    • Petros, R.A.1    DeSimone, J.M.2
  • 29
    • 40049110714 scopus 로고    scopus 로고
    • Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
    • Dobson P.D., Kell D.B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?. Nat Rev Drug Discov 2008, 7:205-220.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 205-220
    • Dobson, P.D.1    Kell, D.B.2
  • 30
    • 13444263549 scopus 로고    scopus 로고
    • Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
    • Le Roy C., Wrana J.L. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005, 6:112-126.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 112-126
    • Le Roy, C.1    Wrana, J.L.2
  • 31
    • 34547114456 scopus 로고    scopus 로고
    • Pathways of clathrin-independent endocytosis
    • Mayor S., Pagano R.E. Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol 2007, 8:603-612.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 603-612
    • Mayor, S.1    Pagano, R.E.2
  • 32
    • 0036239115 scopus 로고    scopus 로고
    • Endocytosis via caveolae
    • Pelkmans L., Helenius A. Endocytosis via caveolae. Traffic 2002, 3:311-320.
    • (2002) Traffic , vol.3 , pp. 311-320
    • Pelkmans, L.1    Helenius, A.2
  • 35
    • 0027520440 scopus 로고
    • Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation
    • Wang L.H., Rothberg K.G., Anderson R.G.W. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 1993, 123:1107-1117.
    • (1993) J Cell Biol , vol.123 , pp. 1107-1117
    • Wang, L.H.1    Rothberg, K.G.2    Anderson, R.G.W.3
  • 36
    • 4544375506 scopus 로고    scopus 로고
    • Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic
    • Pelkmans L., Burli T., Zerial M., Helenius A. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell 2004, 118:767-780.
    • (2004) Cell , vol.118 , pp. 767-780
    • Pelkmans, L.1    Burli, T.2    Zerial, M.3    Helenius, A.4
  • 38
    • 78049508213 scopus 로고    scopus 로고
    • Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
    • Hayer A., Stoeber M., Ritz D., Engel S., Meyer H.H., Helenius A. Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. J Cell Biol 2010, 191:615-629.
    • (2010) J Cell Biol , vol.191 , pp. 615-629
    • Hayer, A.1    Stoeber, M.2    Ritz, D.3    Engel, S.4    Meyer, H.H.5    Helenius, A.6
  • 39
    • 0033580299 scopus 로고    scopus 로고
    • The Rab5 effector EEA1 is a core component of endosome docking
    • Christoforidis S., McBride H.M., Burgoyne R.D., Zerial M. The Rab5 effector EEA1 is a core component of endosome docking. Nature 1999, 397:621-625.
    • (1999) Nature , vol.397 , pp. 621-625
    • Christoforidis, S.1    McBride, H.M.2    Burgoyne, R.D.3    Zerial, M.4
  • 40
    • 0024245391 scopus 로고
    • Isolation and characterization of human lysosomal membrane-glycoproteins, h-lamp-1 and h-lamp-2-major sialoglycoproteins carrying polylactosaminoglycan
    • Carlsson S.R., Roth J., Piller F., Fukuda M. Isolation and characterization of human lysosomal membrane-glycoproteins, h-lamp-1 and h-lamp-2-major sialoglycoproteins carrying polylactosaminoglycan. J Biol Chem 1988, 263:18911-18919.
    • (1988) J Biol Chem , vol.263 , pp. 18911-18919
    • Carlsson, S.R.1    Roth, J.2    Piller, F.3    Fukuda, M.4
  • 41
    • 0025148186 scopus 로고
    • Identification, sequencing and expression of an integral membrane-protein of the trans-golgi network (TGN38)
    • Luzio J.P., Brake B., Banting G., Howell K.E., Braghetta P., Stanley K.K. Identification, sequencing and expression of an integral membrane-protein of the trans-golgi network (TGN38). Biochem J 1990, 270:97-102.
    • (1990) Biochem J , vol.270 , pp. 97-102
    • Luzio, J.P.1    Brake, B.2    Banting, G.3    Howell, K.E.4    Braghetta, P.5    Stanley, K.K.6
  • 42
    • 84862685336 scopus 로고    scopus 로고
    • Trackable and targeted phage as positron emission tomography (PET) agent for cancer imaging
    • Li Z., Jin Q., Huang C., Dasa S., Chen L., Yap L.-P., et al. Trackable and targeted phage as positron emission tomography (PET) agent for cancer imaging. Theranostics 2011, 1:371-380.
    • (2011) Theranostics , vol.1 , pp. 371-380
    • Li, Z.1    Jin, Q.2    Huang, C.3    Dasa, S.4    Chen, L.5    Yap, L.-P.6
  • 43
    • 67749114523 scopus 로고    scopus 로고
    • Synthesis of a novel bifunctional chelator AmBaSar based on sarcophagine for peptide conjugation and 64Cu radiolabelling
    • Cai H., Fissekis J., Conti P.S. Synthesis of a novel bifunctional chelator AmBaSar based on sarcophagine for peptide conjugation and 64Cu radiolabelling. Dalton Trans 2009, 5395-5400.
    • (2009) Dalton Trans , pp. 5395-5400
    • Cai, H.1    Fissekis, J.2    Conti, P.S.3
  • 44
    • 0029968126 scopus 로고    scopus 로고
    • Role of Fenton chemistry in thiol-induced toxicity and apoptosis
    • Held K., Sylvester F., Hopcia K., Biaglow J. Role of Fenton chemistry in thiol-induced toxicity and apoptosis. Radiat Res 1996, 145:542-553.
    • (1996) Radiat Res , vol.145 , pp. 542-553
    • Held, K.1    Sylvester, F.2    Hopcia, K.3    Biaglow, J.4
  • 45
    • 31644440095 scopus 로고    scopus 로고
    • Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging
    • Huth U.S., Schubert R., Peschka-Suss R. Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging. J Control Release 2006, 110:490-504.
    • (2006) J Control Release , vol.110 , pp. 490-504
    • Huth, U.S.1    Schubert, R.2    Peschka-Suss, R.3
  • 46
    • 77953503043 scopus 로고    scopus 로고
    • Uptake and trafficking of liposomes to the endoplasmic reticulum
    • Pollock S., Antrobus R., Newton L., Kampa B., Rossa J., Latham S., et al. Uptake and trafficking of liposomes to the endoplasmic reticulum. FASEB J 2010, 24:1866-1878.
    • (2010) FASEB J , vol.24 , pp. 1866-1878
    • Pollock, S.1    Antrobus, R.2    Newton, L.3    Kampa, B.4    Rossa, J.5    Latham, S.6
  • 47
    • 0035017308 scopus 로고    scopus 로고
    • Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
    • Pelkmans L., Kartenbeck J., Helenius A. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat Cell Biol 2001, 3:473-483.
    • (2001) Nat Cell Biol , vol.3 , pp. 473-483
    • Pelkmans, L.1    Kartenbeck, J.2    Helenius, A.3
  • 48
    • 0034762332 scopus 로고    scopus 로고
    • Internalization of cholera toxin by different endocytic mechanisms
    • Torgersen M.L., Skretting G., van Deurs B., Sandvig K. Internalization of cholera toxin by different endocytic mechanisms. J Cell Sci 2001, 114:3737-3747.
    • (2001) J Cell Sci , vol.114 , pp. 3737-3747
    • Torgersen, M.L.1    Skretting, G.2    van Deurs, B.3    Sandvig, K.4
  • 49
    • 52649120857 scopus 로고    scopus 로고
    • Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating
    • Smith J.L., Campos S.K., Wandinger-Ness A., Ozbun M.A. Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating. J Virol 2008, 82:9505-9512.
    • (2008) J Virol , vol.82 , pp. 9505-9512
    • Smith, J.L.1    Campos, S.K.2    Wandinger-Ness, A.3    Ozbun, M.A.4
  • 50
    • 0037681850 scopus 로고    scopus 로고
    • Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies
    • Gabizon A., Shmeeda H., Barenholz Y. Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies. Clin Pharmacokinet 2003, 42:419-436.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 419-436
    • Gabizon, A.1    Shmeeda, H.2    Barenholz, Y.3
  • 51
    • 14644399827 scopus 로고    scopus 로고
    • Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release
    • Andresen T.L., Jensen S.S., Jorgensen K. Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog Lipid Res 2005, 44:68-97.
    • (2005) Prog Lipid Res , vol.44 , pp. 68-97
    • Andresen, T.L.1    Jensen, S.S.2    Jorgensen, K.3
  • 52
    • 0031695897 scopus 로고    scopus 로고
    • A new look at lipid-membrane structure in relation to drug research
    • Mouritsen O.G., Jorgensen K. A new look at lipid-membrane structure in relation to drug research. Pharm Res 1998, 15:1507-1519.
    • (1998) Pharm Res , vol.15 , pp. 1507-1519
    • Mouritsen, O.G.1    Jorgensen, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.